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trimethoprim and Leukemia

trimethoprim has been researched along with Leukemia in 51 studies

Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.

Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)

Research Excerpts

ExcerptRelevanceReference
"A total of 63 neutropenic patients receiving cytotoxic therapy for acute leukemia were randomly allocated to receive norfloxacin (400 mg every 12 hours) or cotrimoxazole (160/800 mg every 12 hours) to prevent bacterial infection."9.06Comparison of norfloxacin with cotrimoxazole for infection prophylaxis in acute leukemia. The trade-off for reduced gram-negative sepsis. ( Bow, EJ; Louie, TJ; Rayner, E, 1988)
"Ciprofloxacin, a new quinolone derivative, was given prophylactically (500 mg twice daily) to 15 patients with acute leukemia during remission induction treatment."9.06Ciprofloxacin for infection prevention in patients with acute leukemia. ( Dekker, AW; Rozenberg-Arska, M, 1987)
"Fifty-six patients receiving remission induction treatment for acute leukemia were studied in a randomized trial comparing ciprofloxacin with trimethoprim-sulfamethoxazole plus colistin for prevention of infections."9.06Infection prophylaxis in acute leukemia: a comparison of ciprofloxacin with trimethoprim-sulfamethoxazole and colistin. ( Dekker, AW; Rozenberg-Arska, M; Verhoef, J, 1987)
"In a comparative study of infection prophylaxis, patients with acute leukemia receiving remission induction therapy were assigned either no prophylaxis, sulfamethoxazole and trimethoprim, ketoconazole, or the combination of sulfamethoxazole and trimethoprim and ketoconazole."9.05Infection prophylaxis in acute leukemia. Comparative effectiveness of sulfamethoxazole and trimethoprim, ketoconazole, and a combination of the two. ( Bodey, GP; Estey, E; Fainstein, V; Freireich, EJ; Keating, M; Maksymiuk, A; McCredie, KB; Smith, T, 1984)
"The efficacy of orally administered trimethoprim/sulfamethoxazole for infection prevention following induction chemotherapy was evaluated in 43 patients with acute leukemia."9.05Oral trimethoprim/sulfamethoxazole in attempt to prevent infection after induction chemotherapy for acute leukemia. ( Arlin, Z; Armstrong, D; Clarkson, B; Gee, T; Henry, SA; Kempin, S, 1984)
"Fifty-three profoundly granulocytopenic patients with relapsed acute leukemia who were undergoing reinduction chemotherapy were prospectively randomized to receive either trimethoprim-sulfamethoxazole plus nystatin or gentamicin plus nystatin for prevention of infections."9.05A comparison of trimethoprim-sulfamethoxazole plus nystatin with gentamicin plus nystatin in the prevention of infections in acute leukemia. ( Fortner, CL; Hargadon, MT; Schimpff, SC; Wade, JC; Wiernik, PH; Young, VM, 1981)
"Fifty-two patients with nonlymphocytic leukaemia were studied during remission induction treatment in a randomized trial to ascertain the effect of prophylactic oral trimethoprim-sulfamethoxazole on infection and fever rate."9.05Prevention of infection by trimethoprim-sulfamethoxazole plus amphotericin B in patients with acute nonlymphocytic leukaemia. ( Dekker, AW; Rozenberg-Arska, M; Sixma, JJ; Verhoef, J, 1981)
"We conducted a prospective, controlled, randomized trial of oral trimethoprim-sulfamethoxazole treatment in patients with acute leukemia receiving consolidation chemotherapy."9.05Prophylactic trimethoprim-sulfamethoxazole during consolidation chemotherapy for acute leukemia: a controlled trial. ( Armstrong, D; Fialk, MA; Lange, M; Singer, C; Szatrowski, TH; Weiser, B, 1981)
"The amikacin-carbenicillin-cotrimoxazole combination was used as an empiric treatment for febrile episodes in patients with acute leukemia and severe granulocytopenia."7.66Empiric treatment of infections in granulocytopenic patients with acute leukemia: a study on amikacin-carbenicillin-cotrimoxazole. ( Cortelezzi, A; Penagini, R; Pogliani, EM; Radaelli, F, 1982)
"A combination of sulfamethoxazole and trimethoprim was given orally to 13 children with acute leukemia on 16 occasions of hospitalization during remission induction chemotherapy for the prophylaxis of bacterial infection."7.66Prophylaxis of bacterial infection by sulfamethoxazole-trimethoprim (SMX-TMP) during chemotherapy in patients with childhood acute leukemia. ( Matsumoto, S; Nakajima, T; Nakayama, M; Ohkawa, M; Takeda, T; Tono-oka, T, 1981)
"A total of 63 neutropenic patients receiving cytotoxic therapy for acute leukemia were randomly allocated to receive norfloxacin (400 mg every 12 hours) or cotrimoxazole (160/800 mg every 12 hours) to prevent bacterial infection."5.06Comparison of norfloxacin with cotrimoxazole for infection prophylaxis in acute leukemia. The trade-off for reduced gram-negative sepsis. ( Bow, EJ; Louie, TJ; Rayner, E, 1988)
"Ciprofloxacin, a new quinolone derivative, was given prophylactically (500 mg twice daily) to 15 patients with acute leukemia during remission induction treatment."5.06Ciprofloxacin for infection prevention in patients with acute leukemia. ( Dekker, AW; Rozenberg-Arska, M, 1987)
"Fifty-six patients receiving remission induction treatment for acute leukemia were studied in a randomized trial comparing ciprofloxacin with trimethoprim-sulfamethoxazole plus colistin for prevention of infections."5.06Infection prophylaxis in acute leukemia: a comparison of ciprofloxacin with trimethoprim-sulfamethoxazole and colistin. ( Dekker, AW; Rozenberg-Arska, M; Verhoef, J, 1987)
"Patients with acute nonlymphocytic leukemia were randomized to receive remission induction therapy consisting of seven days of cytosine arabinoside and three days of daunorubicin ("7 + 3") or to receive the same regimen intensified by either the addition of 6-thioguanine or by extension of the administration of cytosine arabinoside to ten days."5.06Comparison of three remission induction regimens and two postinduction strategies for the treatment of acute nonlymphocytic leukemia: a cancer and leukemia group B study. ( Carey, R; Davis, RB; Dupre, E; Hoagland, HC; Kirshner, J; Kopel, S; Levy, RN; Preisler, H; Richards, F; Schulman, P, 1987)
"In a comparative study of infection prophylaxis, patients with acute leukemia receiving remission induction therapy were assigned either no prophylaxis, sulfamethoxazole and trimethoprim, ketoconazole, or the combination of sulfamethoxazole and trimethoprim and ketoconazole."5.05Infection prophylaxis in acute leukemia. Comparative effectiveness of sulfamethoxazole and trimethoprim, ketoconazole, and a combination of the two. ( Bodey, GP; Estey, E; Fainstein, V; Freireich, EJ; Keating, M; Maksymiuk, A; McCredie, KB; Smith, T, 1984)
"43 patients undergoing treatment for acute leukaemia were randomised to receive either co-trimoxazole alone or co-trimoxazole with framycetin and colistin as antibacterial prophylaxis during periods of neutropenia."5.05Co-trimoxazole alone for prevention of bacterial infection in patients with acute leukaemia. ( Catovsky, D; Darrell, J; Donnelly, P; Galton, DA; Goldman, JM; Johnson, SA; Starke, ID, 1982)
"In an attempt to reduce the incidence of fever and infection, we randomized patients with cancer to receive trimethoprim/sulfamethoxazole plus erythromycin (TMP/SMX + E) versus placebos after each cycle of chemotherapy (no crossover) and to continue until granulocytopenia (polymorphonuclear leukocytes less than 500/mm3) resolved or the patient became febrile."5.05Oral antibiotic prophylaxis in patients with cancer: a double-blind randomized placebo-controlled trial. ( Edwards, BK; Johnson, A; Kramer, BS; Pizzo, PA; Robichaud, KJ; Schumaker, C, 1983)
"Of 545 patients expected to develop prolonged neutropenia and randomized to received trimethoprim-sulfamethoxazole (TMP-SMZ) or placebo, 342 were evaluable for occurrence of infection or bacteremia."5.05Trimethoprim-sulfamethoxazole in the prevention of infection in neutropenic patients. EORTC International Antimicrobial Therapy Project Group. ( , 1984)
"The efficacy of orally administered trimethoprim/sulfamethoxazole for infection prevention following induction chemotherapy was evaluated in 43 patients with acute leukemia."5.05Oral trimethoprim/sulfamethoxazole in attempt to prevent infection after induction chemotherapy for acute leukemia. ( Arlin, Z; Armstrong, D; Clarkson, B; Gee, T; Henry, SA; Kempin, S, 1984)
"Fifty-three profoundly granulocytopenic patients with relapsed acute leukemia who were undergoing reinduction chemotherapy were prospectively randomized to receive either trimethoprim-sulfamethoxazole plus nystatin or gentamicin plus nystatin for prevention of infections."5.05A comparison of trimethoprim-sulfamethoxazole plus nystatin with gentamicin plus nystatin in the prevention of infections in acute leukemia. ( Fortner, CL; Hargadon, MT; Schimpff, SC; Wade, JC; Wiernik, PH; Young, VM, 1981)
"Fifty-two patients with nonlymphocytic leukaemia were studied during remission induction treatment in a randomized trial to ascertain the effect of prophylactic oral trimethoprim-sulfamethoxazole on infection and fever rate."5.05Prevention of infection by trimethoprim-sulfamethoxazole plus amphotericin B in patients with acute nonlymphocytic leukaemia. ( Dekker, AW; Rozenberg-Arska, M; Sixma, JJ; Verhoef, J, 1981)
"Sixty-two profoundly granulocytopenic patients with acute leukemia undergoing induction chemotherapy were prospectively randomized to receive either trimethoprim-sulfamethoxazole plus nystatin or nalidixic acid plus nystatin for prevention of infection."5.05Selective antimicrobial modulation as prophylaxis against infection during granulocytopenia: trimethoprim-sulfamethoxazole vs. nalidixic acid. ( Crowley, J; de Jongh, CA; Newman, KA; Schimpff, SC; Wade, JC; Wiernik, PH, 1983)
"We conducted a prospective, controlled, randomized trial of oral trimethoprim-sulfamethoxazole treatment in patients with acute leukemia receiving consolidation chemotherapy."5.05Prophylactic trimethoprim-sulfamethoxazole during consolidation chemotherapy for acute leukemia: a controlled trial. ( Armstrong, D; Fialk, MA; Lange, M; Singer, C; Szatrowski, TH; Weiser, B, 1981)
"Spurious methotrexate (MTX) concentrations in sera and cerebrospinal fluids from leukemia patients who were given trimethoprim (TMP) were estimated using an MTX assay kit which is based on its inhibition of dihydrofolate reductase."3.67Trimethoprim interference in methotrexate assay by an enzyme inhibition assay kit. ( Goto, E; Kitaoka, S; Konno, T; Miyaji, T; Terasawa, M; Tsuchiya, S, 1986)
"The amikacin-carbenicillin-cotrimoxazole combination was used as an empiric treatment for febrile episodes in patients with acute leukemia and severe granulocytopenia."3.66Empiric treatment of infections in granulocytopenic patients with acute leukemia: a study on amikacin-carbenicillin-cotrimoxazole. ( Cortelezzi, A; Penagini, R; Pogliani, EM; Radaelli, F, 1982)
"A combination of sulfamethoxazole and trimethoprim was given orally to 13 children with acute leukemia on 16 occasions of hospitalization during remission induction chemotherapy for the prophylaxis of bacterial infection."3.66Prophylaxis of bacterial infection by sulfamethoxazole-trimethoprim (SMX-TMP) during chemotherapy in patients with childhood acute leukemia. ( Matsumoto, S; Nakajima, T; Nakayama, M; Ohkawa, M; Takeda, T; Tono-oka, T, 1981)
"Norfloxacin has been compared to placebo (136 patients), sulfamethoxazole plus trimethoprim (SXT, 72 patients) and oral vancomycin plus colistin (V/C, 61 patients) for the prevention of alimentary tract-associated infections during and after induction chemotherapy."2.66The tolerability profile of prophylactic norfloxacin in neutropenic patients. ( Corrado, ML; Hesney, M; Struble, WE, 1988)
"Treatment of drug-induced aplastic anemia requires transfusions."2.35Drug-induced anaemias. ( Girdwood, RH, 1976)
"In patients with AIDS a more indolent illness occurred lasting 3 or more weeks and was characterised by fever, dry cough and breathlessness."1.27Management of Pneumocystis carinii pneumonia in the immunocompromised host. ( Carter, JM; Fisher, M; Holloway, L; Jones, MR; McSweeney, P; Town, GI, 1988)
"Between 1976 and 1983, 53 cases of Pneumocystis carinii pneumonia were documented at the Mayo Clinic."1.27Pneumocystis carinii pneumonia. Review of 53 cases. ( Peters, SG; Prakash, UB, 1987)

Research

Studies (51)

TimeframeStudies, this research(%)All Research%
pre-199049 (96.08)18.7374
1990's2 (3.92)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Estey, E1
Maksymiuk, A1
Smith, T1
Fainstein, V1
Keating, M1
McCredie, KB1
Freireich, EJ1
Bodey, GP1
Starke, ID1
Donnelly, P1
Catovsky, D1
Darrell, J1
Johnson, SA1
Goldman, JM1
Galton, DA1
Hargadon, MT2
Young, VM2
Schimpff, SC3
Wade, JC3
Minah, GE1
Pizzo, PA1
Robichaud, KJ1
Edwards, BK1
Schumaker, C1
Kramer, BS1
Johnson, A1
Riben, PD1
Louie, TJ2
Lank, BA2
Kornachuk, E1
Gurwith, MJ2
Harding, GK2
Ronald, AR2
Winston, DJ1
Ho, WG1
Champlin, RE1
Gale, RP1
Henry, SA2
Siegel, SE1
Wolff, LJ2
Baehner, RL1
Hammond, D1
Inoue, M1
Arai, S1
Kamiya, H1
Sakurai, M1
Izawa, T1
Yamakawa, T1
Kamiya, K1
Nishimura, Y1
Kato, T1
Hiratani, Y1
Akatuka, J1
Hirotu, T1
Armstrong, D2
Kempin, S1
Gee, T1
Arlin, Z1
Clarkson, B1
Imoke, E1
Dudgeon, DL1
Colombani, P1
Leventhal, B1
Buck, JR1
Haller, JA1
Fortner, CL1
Wiernik, PH2
Dekker, AW3
Rozenberg-Arska, M4
Sixma, JJ1
Verhoef, J3
Mozzana, R1
Cortelezzi, A2
Radaelli, F2
Polli, EE1
Scaglione, C1
Tormena, AM1
Pavlovsky, S1
de Jongh, CA1
Newman, KA1
Crowley, J1
Beutler, SM1
Barth, NM1
Bayer, AS1
Penagini, R1
Pogliani, EM1
Weiser, B1
Lange, M1
Fialk, MA1
Singer, C1
Szatrowski, TH1
Kersey, JH1
Ramsay, NK1
Kim, T1
McGlave, P1
Krivit, W1
Levitt, S1
Filipovich, A1
Woods, W1
O'Leary, M1
Coccia, P1
Nesbit, ME1
Wilson, JM1
Guiney, DG1
Jacoby, GA1
Young, LS1
Tono-oka, T1
Nakayama, M1
Ohkawa, M1
Nakajima, T1
Takeda, T1
Matsumoto, S1
Ward, TT1
Thomas, RG1
Fye, CL1
Arbeit, R1
Coltman, CA1
Craig, W1
Dana, BW1
Finegold, SM1
Lentino, J1
Penn, RL1
Guiot, HF1
van der Meer, JW1
van Furth, R1
Kunz, HD1
Brunton, JL1
Ezaki, K1
Ohno, R1
Kamiya, T1
Kawashima, K1
Kodera, Y1
Ogata, K1
Kobayashi, M1
Takeyama, H1
Morishima, Y1
Kato, Y1
Watanabe, E1
Suzuki, H1
Tanimoto, M1
Yamada, K1
Minami, S1
Sako, F1
Imamura, K1
Gurwith, M1
Girdwood, RH1
Melikian, V1
Falk, R1
Tuan, IZ1
Dennison, D1
Weisdorf, DJ1
Günther, I1
Kaben, U1
Dunker, H1
Brijmohan-Günther, R1
Konrad, H1
Verhagen, C2
Stalpers, LJ1
de Pauw, BE2
Haanen, C1
Dekker, A2
Gaus, W1
Kurrle, E1
de Vries-Hospers, H1
van der Waaij, D1
Wendt, F1
Novakova, IR1
Ubachs, E1
Hoes, A1
Stalpers, L1
Carter, JM1
Town, GI1
Fisher, M1
Holloway, L1
Jones, MR1
McSweeney, P1
Corrado, ML1
Struble, WE1
Hesney, M1
Bow, EJ1
Rayner, E1
Peters, SG1
Prakash, UB1
Rossi, MR1
Banfi, P1
Cappuccilli, M1
Conter, V1
de Poli, D1
Piacentini, G1
Zurlo, MG1
Masera, G1
Preisler, H1
Davis, RB1
Kirshner, J1
Dupre, E1
Richards, F1
Hoagland, HC1
Kopel, S1
Levy, RN1
Carey, R1
Schulman, P1
Kitaoka, S1
Terasawa, M1
Goto, E1
Miyaji, T1
Tsuchiya, S1
Konno, T1
Magyar, T1
Graber, H1
Arr, M1
Csiba, A1
Kelemen, E1
Péterfy, M1
Jánossa, M1

Reviews

4 reviews available for trimethoprim and Leukemia

ArticleYear
Infectious complications of bone marrow transplantation.
    Experimental hematology, 1984, Volume: 12, Issue:3

    Topics: Aminoglycosides; Amphotericin B; Anemia, Aplastic; Bacterial Infections; Bone Marrow Transplantation

1984
Symposium on infectious complications of neoplastic disease (Part II). Chemoprophylaxis of bacterial infections in granulocytopenic patients.
    The American journal of medicine, 1984, Volume: 76, Issue:4

    Topics: Acute Disease; Agranulocytosis; Anti-Bacterial Agents; Bacterial Infections; Clinical Trials as Topi

1984
Supportive care for children with cancer. Guidelines of the Childrens Cancer Study Group. Use of prophylactic antibiotics.
    The American journal of pediatric hematology/oncology, 1984,Fall, Volume: 6, Issue:3

    Topics: Adolescent; Adult; Amphotericin B; Anti-Bacterial Agents; Bacterial Infections; Candidiasis; Child;

1984
Drug-induced anaemias.
    Drugs, 1976, Volume: 11, Issue:5

    Topics: Anemia; Anemia, Aplastic; Anemia, Megaloblastic; Anemia, Sideroblastic; Anticonvulsants; Bone Marrow

1976

Trials

25 trials available for trimethoprim and Leukemia

ArticleYear
Infection prophylaxis in acute leukemia. Comparative effectiveness of sulfamethoxazole and trimethoprim, ketoconazole, and a combination of the two.
    Archives of internal medicine, 1984, Volume: 144, Issue:8

    Topics: Acute Disease; Adolescent; Adult; Aged; Bacterial Infections; Drug Combinations; Drug Therapy, Combi

1984
Co-trimoxazole alone for prevention of bacterial infection in patients with acute leukaemia.
    Lancet (London, England), 1982, Jan-02, Volume: 1, Issue:8262

    Topics: Acute Disease; Adult; Aged; Bacterial Infections; Clinical Trials as Topic; Colistin; Drug Combinati

1982
Selective suppression of alimentary tract microbial flora as prophylaxis during granulocytopenia.
    Antimicrobial agents and chemotherapy, 1981, Volume: 20, Issue:5

    Topics: Agranulocytosis; Anaerobiosis; Anti-Bacterial Agents; Bacterial Infections; Carcinoma, Small Cell; D

1981
Oral antibiotic prophylaxis in patients with cancer: a double-blind randomized placebo-controlled trial.
    The Journal of pediatrics, 1983, Volume: 102, Issue:1

    Topics: Adolescent; Adult; Agranulocytosis; Bacterial Infections; Child; Child, Preschool; Clinical Trials a

1983
Reduction in mortality from gram-negative sepsis in neutropenic patients receiving trimethoprim/sulfamethoxazole therapy.
    Cancer, 1983, May-01, Volume: 51, Issue:9

    Topics: Adult; Aged; Agranulocytosis; Bacterial Infections; Clinical Trials as Topic; Female; Humans; Leukem

1983
Symposium on infectious complications of neoplastic disease (Part II). Chemoprophylaxis of bacterial infections in granulocytopenic patients.
    The American journal of medicine, 1984, Volume: 76, Issue:4

    Topics: Acute Disease; Agranulocytosis; Anti-Bacterial Agents; Bacterial Infections; Clinical Trials as Topi

1984
Trimethoprim-sulfamethoxazole in the prevention of infection in neutropenic patients. EORTC International Antimicrobial Therapy Project Group.
    The Journal of infectious diseases, 1984, Volume: 150, Issue:3

    Topics: Agranulocytosis; Anti-Bacterial Agents; Bacterial Infections; Clinical Trials as Topic; Drug Combina

1984
Treatment of Pneumocystis carinii pneumonitis. A comparative trial of sulfamethoxazole-trimethoprim v pentamidine in pediatric patients with cancer: report from the Children's Cancer Study Group.
    American journal of diseases of children (1960), 1984, Volume: 138, Issue:11

    Topics: Acute Disease; Adolescent; Adult; Amidines; Child; Child, Preschool; Clinical Trials as Topic; Drug

1984
[The prophylactic effect of trimethoprim-sulfamethoxazole against infection among children with acute leukemia].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1983, Volume: 24, Issue:1

    Topics: Acute Disease; Child; Child, Preschool; Clinical Trials as Topic; Double-Blind Method; Drug Combinat

1983
Oral trimethoprim/sulfamethoxazole in attempt to prevent infection after induction chemotherapy for acute leukemia.
    The American journal of medicine, 1984, Volume: 77, Issue:4

    Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Antineoplastic Agents; Drug Combinations; Dr

1984
A comparison of trimethoprim-sulfamethoxazole plus nystatin with gentamicin plus nystatin in the prevention of infections in acute leukemia.
    The New England journal of medicine, 1981, Apr-30, Volume: 304, Issue:18

    Topics: Acute Disease; Adult; Aged; Clinical Trials as Topic; Drug Combinations; Drug Therapy, Combination;

1981
Prevention of infection by trimethoprim-sulfamethoxazole plus amphotericin B in patients with acute nonlymphocytic leukaemia.
    Annals of internal medicine, 1981, Volume: 95, Issue:5

    Topics: Acute Disease; Agranulocytosis; Amphotericin B; Drug Combinations; Drug Therapy, Combination; Fever;

1981
[Prophylactic controlled trials with cotrimoxazole in afebrile neutropenic patients with malignant hemopathies].
    Sangre, 1982, Volume: 27, Issue:5

    Topics: Adult; Agranulocytosis; Child; Clinical Trials as Topic; Drug Combinations; Fever; Humans; Infection

1982
Selective antimicrobial modulation as prophylaxis against infection during granulocytopenia: trimethoprim-sulfamethoxazole vs. nalidixic acid.
    The Journal of infectious diseases, 1983, Volume: 147, Issue:4

    Topics: Adolescent; Adult; Aged; Agranulocytosis; Bacterial Infections; Child; Drug Combinations; Female; Hu

1983
Prophylactic trimethoprim-sulfamethoxazole during consolidation chemotherapy for acute leukemia: a controlled trial.
    Annals of internal medicine, 1981, Volume: 95, Issue:4

    Topics: Acute Disease; Adult; Aged; Antineoplastic Agents; Bacterial Infections; Clinical Trials as Topic; D

1981
Trimethoprim-sulfamethoxazole prophylaxis in granulocytopenic patients with acute leukemia: evaluation of serum antibiotic levels in a randomized, double-blind, placebo-controlled Department of Veterans Affairs Cooperative Study.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1993, Volume: 17, Issue:3

    Topics: Acute Disease; Adult; Agranulocytosis; Bacterial Infections; Double-Blind Method; Female; Humans; Le

1993
Infection prevention in acute leukaemia.
    Lancet (London, England), 1978, Oct-07, Volume: 2, Issue:8093

    Topics: Acute Disease; Administration, Oral; Anti-Bacterial Agents; Clinical Trials as Topic; Cross Infectio

1978
A prospective controlled investigation of prophylactic trimethoprim/sulfamethoxazole in hospitalized granulocytopenic patients.
    The American journal of medicine, 1979, Volume: 66, Issue:2

    Topics: Acute Disease; Adolescent; Adult; Aged; Agranulocytosis; Anti-Bacterial Agents; Bacteriological Tech

1979
Prevention of infection in patients with acute nonlymphocytic leukemia by several drug treatment regimens.
    Haematology and blood transfusion, 1987, Volume: 30

    Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Clinical Trials as Topic; Colistin; Drug

1987
The tolerability profile of prophylactic norfloxacin in neutropenic patients.
    European journal of cancer & clinical oncology, 1988, Volume: 24 Suppl 1

    Topics: Agranulocytosis; Bacterial Infections; Clinical Trials as Topic; Colistin; Diarrhea; Gastrointestina

1988
Comparison of norfloxacin with cotrimoxazole for infection prophylaxis in acute leukemia. The trade-off for reduced gram-negative sepsis.
    The American journal of medicine, 1988, Volume: 84, Issue:5

    Topics: Acute Disease; Adult; Antineoplastic Agents; Bacterial Infections; Clinical Trials as Topic; Drug Co

1988
Ciprofloxacin for infection prevention in patients with acute leukemia.
    Pharmaceutisch weekblad. Scientific edition, 1987, Dec-11, Volume: 9 Suppl

    Topics: Adult; Bacterial Infections; Ciprofloxacin; Clinical Trials as Topic; Colistin; Drug Combinations; D

1987
Infection prophylaxis in acute leukemia: a comparison of ciprofloxacin with trimethoprim-sulfamethoxazole and colistin.
    Annals of internal medicine, 1987, Volume: 106, Issue:1

    Topics: Acute Disease; Agranulocytosis; Bacterial Infections; Ciprofloxacin; Colistin; Drug Combinations; Dr

1987
Prospective randomized comparison of two prophylactic regimens with trimethoprim-sulfamethoxazole in leukemic children: a two year study.
    European journal of cancer & clinical oncology, 1987, Volume: 23, Issue:11

    Topics: Acute Disease; Adolescent; Child; Child, Preschool; Drug Administration Schedule; Drug Combinations;

1987
Comparison of three remission induction regimens and two postinduction strategies for the treatment of acute nonlymphocytic leukemia: a cancer and leukemia group B study.
    Blood, 1987, Volume: 69, Issue:5

    Topics: Acute Disease; Clinical Trials as Topic; Cytarabine; Daunorubicin; Drug Administration Schedule; Dru

1987

Other Studies

23 other studies available for trimethoprim and Leukemia

ArticleYear
Open lung biopsy in the immunocompromised pediatric patient.
    Journal of pediatric surgery, 1983, Volume: 18, Issue:6

    Topics: Adolescent; Biopsy; Child; Child, Preschool; Drug Combinations; Female; Humans; Immunosuppression Th

1983
Efficacy of the tobramycin - cotrimoxazole - cephalothin combination for febrile episodes in leukemic patients with granulocytopenia.
    Haematologica, 1981, Volume: 66, Issue:5

    Topics: Adolescent; Adult; Aged; Agranulocytosis; Anti-Bacterial Agents; Cephalothin; Child; Drug Combinatio

1981
Preventing infection in neutropenic cancer patients.
    The Western journal of medicine, 1983, Volume: 138, Issue:5

    Topics: Agranulocytosis; Bacterial Infections; Humans; Immunosuppression Therapy; Leukemia; Neutropenia; Sul

1983
Empiric treatment of infections in granulocytopenic patients with acute leukemia: a study on amikacin-carbenicillin-cotrimoxazole.
    International journal of clinical pharmacology, therapy, and toxicology, 1982, Volume: 20, Issue:11

    Topics: Acute Disease; Adolescent; Adult; Aged; Agranulocytosis; Amikacin; Anti-Bacterial Agents; Bacterial

1982
Allogeneic bone marrow transplantation in acute nonlymphocytic leukemia: a pilot study.
    Blood, 1982, Volume: 60, Issue:2

    Topics: Acute Disease; Adolescent; Adult; Bone Marrow Transplantation; Child; Cyclophosphamide; Female; Graf

1982
Failure of oral trimethoprim-sulfamethoxazole prophylaxis in acute leukemia: isolation of resistant plasmids from strains of Enterobacteriaceae causing bacteremia.
    The New England journal of medicine, 1982, Jan-07, Volume: 306, Issue:1

    Topics: Acute Disease; Adult; Agranulocytosis; Anti-Bacterial Agents; Drug Resistance, Microbial; Enterobact

1982
Perils of prophylaxis.
    The New England journal of medicine, 1982, Jan-07, Volume: 306, Issue:1

    Topics: Agranulocytosis; Animals; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Drug Resistance, Mi

1982
Trimethoprim-Sulfamethoxazole and bacterial infections during leukemia therapy.
    Annals of internal medicine, 1981, Volume: 95, Issue:4

    Topics: Bacterial Infections; Drug Therapy, Combination; Humans; Leukemia; Sulfamethoxazole; Trimethoprim

1981
Prophylaxis of bacterial infection by sulfamethoxazole-trimethoprim (SMX-TMP) during chemotherapy in patients with childhood acute leukemia.
    The Tohoku journal of experimental medicine, 1981, Volume: 134, Issue:3

    Topics: Acute Disease; Adolescent; Antineoplastic Agents; Bacterial Infections; Child; Child, Preschool; Dru

1981
Prophylactic co-trimoxazole in leukaemia.
    Lancet (London, England), 1978, Sep-23, Volume: 2, Issue:8091

    Topics: Acute Disease; Anti-Bacterial Agents; Cross Infection; Drug Combinations; Drug Evaluation; Drug Ther

1978
[Allergic-toxic agranulocytosis].
    MMW, Munchener medizinische Wochenschrift, 1979, Dec-14, Volume: 121, Issue:50

    Topics: Abscess; Agranulocytosis; Diagnosis, Differential; Drug Hypersensitivity; Female; Humans; Leukemia;

1979
[Treatment of infection in the patients of acute leukemia with sulfamethoxazole-trimethoprim (author's transl)].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1979, Volume: 20, Issue:9

    Topics: Acute Disease; Adolescent; Adult; Aged; Drug Combinations; Drug Synergism; Enterobacteriaceae Infect

1979
Prevention of infection in leukaemia.
    The Journal of antimicrobial chemotherapy, 1978, Volume: 4, Issue:4

    Topics: Anti-Bacterial Agents; Bacterial Infections; Drug Combinations; Humans; Leukemia; Sulfamethoxazole;

1978
Treatment of febrile episodes in neutropenic patients.
    Scottish medical journal, 1976, Volume: 21, Issue:2

    Topics: Agranulocytosis; Anti-Bacterial Agents; Clindamycin; Drug Combinations; Fever; Humans; Immunosuppres

1976
Pneumocystis carinii pneumonitis following bone marrow transplantation.
    Bone marrow transplantation, 1992, Volume: 10, Issue:3

    Topics: Adolescent; Adult; Bone Marrow Transplantation; Child; Drug Combinations; Female; Humans; Infant; Le

1992
Selective decontamination of the digestive tract and fungal infection in acute leukemia patients.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1988, Volume: 108

    Topics: Acute Disease; Adolescent; Adult; Aged; Bacterial Infections; Digestive System; Drug Administration

1988
Drug-induced skin reactions in patients with acute non-lymphocytic leukaemia.
    European journal of haematology, 1987, Volume: 38, Issue:3

    Topics: Acute Disease; Adult; Allopurinol; Cephalosporins; Drug Combinations; Drug Eruptions; Female; Humans

1987
Selective decontamination of the digestive tract for the prevention of infection in acute leukemia.
    Progress in clinical and biological research, 1985, Volume: 181

    Topics: Acute Disease; Amphotericin B; Bacterial Infections; Digestive System; Drug Combinations; Humans; Le

1985
Co-trimoxazole in patients with haematological malignancies: a review of 10-years' clinical experience.
    Current medical research and opinion, 1988, Volume: 11, Issue:1

    Topics: Anti-Infective Agents; Drug Combinations; Humans; Intestines; Leukemia; Neutropenia; Opportunistic I

1988
Management of Pneumocystis carinii pneumonia in the immunocompromised host.
    The New Zealand medical journal, 1988, Jul-27, Volume: 101, Issue:850

    Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Aged; Drug Combinations; Female; Humans; Immu

1988
Pneumocystis carinii pneumonia. Review of 53 cases.
    The American journal of medicine, 1987, Volume: 82, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Adrenal Cortex Hormones; Drug Combinations; Female; Humans; Leuk

1987
Trimethoprim interference in methotrexate assay by an enzyme inhibition assay kit.
    The Tohoku journal of experimental medicine, 1986, Volume: 150, Issue:4

    Topics: Diagnostic Errors; Folic Acid Antagonists; Humans; Leukemia; Methotrexate; Reagent Kits, Diagnostic;

1986
[Treatment of infections in granulocytopenia patients with a brulamycin-bactrim combination].
    Orvosi hetilap, 1985, Sep-01, Volume: 126, Issue:35

    Topics: Adult; Aged; Agranulocytosis; Bacterial Infections; Drug Combinations; Drug Therapy, Combination; Fe

1985