trimethoprim has been researched along with Leukemia, Myeloid, Acute in 15 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
Leukemia, Myeloid, Acute: Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We conducted a randomized, double-blind, placebo-controlled study to evaluate the efficacy of oral trimethoprim/sulfamethoxazole (TMP/SMX) in the prevention of bacterial infections in children with cancer." | 5.05 | Oral trimethoprim/sulfamethoxazole for prevention of bacterial infection during the induction phase of cancer chemotherapy in children. ( Albo, VC; Kovatch, AL; Orlando, SJ; Phebus, CK; Prin, W; Shapiro, ED; Wald, ER; Wollman, MR, 1985) |
| "Continuous infusion of amikacin, cotrimoxazole and carbenicillin was the second empirically established combination of antibiotics used when fever occurred during the induction phase of chemotherapy in sixty-five patients (58 acute myeloid leukemias, 5 acute lymphoid leukemias, 2 non Hodgkin lymphomas)." | 3.66 | [An empirical combination of antibiotics used in aplasias during chemotherapy for acute malignant hemopathies (author's transl)]. ( Bryon, PA; Coiffier, B; Extra, JM; Ffrench, M; Fiere, D; Gonnaud, P; Guyotat, D; Imbert, C; Rebattu, P; Viala, JJ; Vuvan, H, 1982) |
| "The treatment of acute myelocytic leukemia in childhood and young adults has lagged behind that for acute lymphocytic leukemia." | 1.26 | The treatment of acute myelocytic leukemia in patients 30 years of age and younger. ( Brecher, M; Browman, G; Early, AP; Freeman, A; Preisler, HD; Raza, A; Walker, IR, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (93.33) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fiere, D | 1 |
| Vuvan, H | 1 |
| Guyotat, D | 1 |
| Ffrench, M | 1 |
| Gonnaud, P | 1 |
| Extra, JM | 1 |
| Imbert, C | 1 |
| Coiffier, B | 1 |
| Bryon, PA | 1 |
| Rebattu, P | 1 |
| Viala, JJ | 1 |
| Pizzo, PA | 1 |
| Preisler, HD | 2 |
| Early, A | 1 |
| Hryniuk, W | 1 |
| Brecher, M | 1 |
| Browman, G | 1 |
| Early, AP | 1 |
| Walker, IR | 1 |
| Raza, A | 1 |
| Freeman, A | 1 |
| Fernández-Rañada, J | 1 |
| Vázquez, L | 1 |
| Escudero, A | 1 |
| Merino, JL | 1 |
| Gómez-Reino, F | 1 |
| Olmeda, F | 1 |
| Lahuerta, J | 1 |
| Larregla, S | 1 |
| Martelli, MF | 1 |
| Aversa, F | 1 |
| Rambotti, P | 1 |
| Velardi, A | 1 |
| Enno, A | 1 |
| Catovsky, D | 1 |
| Darrell, J | 1 |
| Goldman, JM | 1 |
| Hows, J | 1 |
| Galton, DA | 1 |
| Bateman, CJ | 1 |
| Wahlin, YB | 1 |
| Granström, S | 1 |
| Persson, S | 1 |
| Sjöström, M | 1 |
| Bartoloni, A | 1 |
| Fanci, R | 1 |
| Orsi, A | 1 |
| Aquilini, D | 1 |
| Bosi, A | 1 |
| Rossi Ferrini, P | 1 |
| Paradisi, F | 1 |
| Rai, KR | 1 |
| Cuttner, J | 1 |
| Holland, JF | 1 |
| Davis, R | 1 |
| Mayer, R | 1 |
| McIntyre, OR | 1 |
| Preisler, H | 1 |
| Yates, J | 1 |
| Curtis, JE | 1 |
| Messner, HA | 1 |
| Minden, MD | 1 |
| Minkin, S | 1 |
| McCulloch, EA | 1 |
| Kovatch, AL | 1 |
| Wald, ER | 1 |
| Albo, VC | 1 |
| Prin, W | 1 |
| Orlando, SJ | 1 |
| Wollman, MR | 1 |
| Phebus, CK | 1 |
| Shapiro, ED | 1 |
| Spiers, AS | 1 |
| Tattersall, MH | 1 |
| Gaya, H | 1 |
| Toghill, PJ | 1 |
| Ryrie, DR | 1 |
| Tanna, MK | 1 |
| Tattersall, RB | 1 |
6 trials available for trimethoprim and Leukemia, Myeloid, Acute
| Article | Year |
|---|---|
[Sulphatrimethoprim-nystatin combination in the prophylaxis of infection in acute leukaemia (author's transl)].
Topics: Bacterial Infections; Clinical Trials as Topic; Drug Evaluation; Drug Therapy, Combination; Humans; | 1980 |
Co-trimoxazole for prevention of infection in acute leukaemia.
Topics: Administration, Oral; Adolescent; Adult; Aged; Clinical Trials as Topic; Colistin; Cross Infection; | 1978 |
The influence of ofloxacin versus trimethoprim-sulfamethoxazole on the aerobic flora in granulocytopenic subjects.
Topics: Adult; Aged; Agranulocytosis; Bacteria, Aerobic; Drug Combinations; Female; Humans; Intestines; Leuk | 1989 |
Therapeutic strategies in acute myelocytic leukemia: a status report of the experience of CALGB. Cancer and Leukemia Group B.
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Cytarabine; Daunorubicin; | 1987 |
High-dose cytosine arabinoside in the treatment of acute myelogenous leukemia: contributions to outcome of clinical and laboratory attributes.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation | 1987 |
Oral trimethoprim/sulfamethoxazole for prevention of bacterial infection during the induction phase of cancer chemotherapy in children.
Topics: Adolescent; Anti-Infective Agents; Antineoplastic Agents; Bacterial Infections; Child; Child, Presch | 1985 |
9 other studies available for trimethoprim and Leukemia, Myeloid, Acute
| Article | Year |
|---|---|
[An empirical combination of antibiotics used in aplasias during chemotherapy for acute malignant hemopathies (author's transl)].
Topics: Adult; Aged; Amikacin; Anti-Bacterial Agents; Bacterial Infections; Carbenicillin; Drug Combinations | 1982 |
Infectious complications in the child with cancer. III. Prevention.
Topics: Anti-Bacterial Agents; Child; Cross Infection; Filtration; Humans; Immunization; Immunization, Passi | 1981 |
Prevention of infection and bleeding in leukemic patients receiving intensive remission maintenance therapy.
Topics: Adult; Aged; Agranulocytosis; Antineoplastic Agents; Bacterial Infections; Drug Combinations; Female | 1981 |
The treatment of acute myelocytic leukemia in patients 30 years of age and younger.
Topics: Adolescent; Adult; Age Factors; Antineoplastic Agents; Cytarabine; Daunorubicin; Doxorubicin; Drug C | 1982 |
Trimethoprim-induced elevation of dihydrofolate reductase activity in human leukocytes.
Topics: Electrophoresis, Cellulose Acetate; Enzyme Activation; Folic Acid Antagonists; Humans; Hydrogen-Ion | 1978 |
Prophylactic co-trimoxazole in leukaemia.
Topics: Drug Combinations; Humans; Infection Control; Leukemia, Myeloid, Acute; Neutropenia; Sulfamethoxazol | 1978 |
Multivariate study of enterobacteria and Pseudomonas in saliva of patients with acute leukemia.
Topics: Adolescent; Adult; Aged; Aminoglycosides; Ampicillin; Ampicillin Resistance; Anti-Bacterial Agents; | 1991 |
Indications for systemic antibiotic prophylaxis in neutropenic patients.
Topics: Adult; Agranulocytosis; Anti-Bacterial Agents; Biguanides; Blood Cell Count; Carbenicillin; Cephalot | 1974 |
Induction of remission in myeloblastic and monoblastic leukaemia in adults with rubidomycin.
Topics: Adolescent; Adult; Aged; Alopecia; Ampicillin; Anemia, Aplastic; Antibiotics, Antineoplastic; Blood | 1971 |