trimethoprim has been researched along with Leukemia, Lymphocytic in 37 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fifty-six patients receiving remission induction treatment for acute leukemia were studied in a randomized trial comparing ciprofloxacin with trimethoprim-sulfamethoxazole plus colistin for prevention of infections." | 9.06 | Infection prophylaxis in acute leukemia: a comparison of ciprofloxacin with trimethoprim-sulfamethoxazole and colistin. ( Dekker, AW; Rozenberg-Arska, M; Verhoef, J, 1987) |
| "Fifty-six patients receiving remission induction treatment for acute leukemia were studied in a randomized trial comparing ciprofloxacin with trimethoprim-sulfamethoxazole plus colistin for prevention of infections." | 5.06 | Infection prophylaxis in acute leukemia: a comparison of ciprofloxacin with trimethoprim-sulfamethoxazole and colistin. ( Dekker, AW; Rozenberg-Arska, M; Verhoef, J, 1987) |
| "We conducted a randomized, double-blind, placebo-controlled study to evaluate the efficacy of oral trimethoprim/sulfamethoxazole (TMP/SMX) in the prevention of bacterial infections in children with cancer." | 5.05 | Oral trimethoprim/sulfamethoxazole for prevention of bacterial infection during the induction phase of cancer chemotherapy in children. ( Albo, VC; Kovatch, AL; Orlando, SJ; Phebus, CK; Prin, W; Shapiro, ED; Wald, ER; Wollman, MR, 1985) |
| "Continuous infusion of amikacin, cotrimoxazole and carbenicillin was the second empirically established combination of antibiotics used when fever occurred during the induction phase of chemotherapy in sixty-five patients (58 acute myeloid leukemias, 5 acute lymphoid leukemias, 2 non Hodgkin lymphomas)." | 3.66 | [An empirical combination of antibiotics used in aplasias during chemotherapy for acute malignant hemopathies (author's transl)]. ( Bryon, PA; Coiffier, B; Extra, JM; Ffrench, M; Fiere, D; Gonnaud, P; Guyotat, D; Imbert, C; Rebattu, P; Viala, JJ; Vuvan, H, 1982) |
| "In a previous acute lymphocytic leukemia (ALL) study of initial therapy, investigators were free to use TS prophylaxis or not." | 2.66 | Effect of trimethoprim/sulfamethoxazole prophylaxis on outcome of childhood lymphocytic leukemia. A Pediatric Oncology Group Study. ( Berry, DM; Crist, W; Doering, EJ; Fernbach, DJ; Pullen, J; Shuster, J; van Eys, J, 1987) |
| "Thirty-seven children with acute lymphocytic leukemia in clinical remission for at least 6 months completed a 1-year trial in which they were randomly assigned in a double-blind fashion to receive co-trimoxazole twice daily for 6 months followed by placebo for 6 months (18 patients) or placebo followed by co-trimoxazole (19 patients)." | 2.65 | Myelosuppression associated with co-trimoxazole as a prophylactic antibiotic in the maintenance phase of childhood acute lymphocytic leukemia. ( Daigle, AE; Hutchinson, RJ; Robison, LL; Woods, WG, 1984) |
| "carinii pneumonia secondary to AIDS and to other known causes of immune deficiency were enrolled." | 1.27 | Assessment of therapy for pneumocystis carinii pneumonia. PCP Therapy Project Group. ( Haverkos, HW, 1984) |
| "A total of 229 pediatric cancer patients considered at high risk for getting PCP received prophylaxis, while 19 additonal low-risk cancer patients did not receive sulfamethoxazole-trimethoprim." | 1.26 | Prevention of pneumocystis pneumonia. Use of continuous sulfamethoxazole-trimethroprim therapy. ( Allen, SA; Baehner, RL; Barton, AS; Harris, RE; McCallister, JA, 1980) |
| "Eleven cases of Pneumocystis carinii pneumonia were diagnosed during a 3 1/2-year period at a pediatric hospital where this infection had never been identified previously despite appropriate studies." | 1.26 | An outbreak of Pneumocystis carinii pneumonia at a pediatric hospital. ( Chusid, MJ; Heyrman, KA, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 37 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Drysdale, HC | 1 |
| Jones, LF | 1 |
| Fiere, D | 1 |
| Vuvan, H | 1 |
| Guyotat, D | 1 |
| Ffrench, M | 1 |
| Gonnaud, P | 1 |
| Extra, JM | 1 |
| Imbert, C | 1 |
| Coiffier, B | 1 |
| Bryon, PA | 1 |
| Rebattu, P | 1 |
| Viala, JJ | 1 |
| Kramer, RF | 1 |
| Woods, WG | 2 |
| Daigle, AE | 1 |
| Hutchinson, RJ | 1 |
| Robison, LL | 1 |
| Haverkos, HW | 1 |
| Melby, K | 1 |
| Kolmannskog, S | 1 |
| Flaegstad, T | 1 |
| Inoue, M | 1 |
| Arai, S | 1 |
| Kamiya, H | 1 |
| Sakurai, M | 1 |
| Izawa, T | 1 |
| Yamakawa, T | 1 |
| Kamiya, K | 1 |
| Nishimura, Y | 1 |
| Kato, T | 1 |
| Hiratani, Y | 1 |
| Akatuka, J | 1 |
| Hirotu, T | 1 |
| Schifman, RB | 1 |
| Ryan, KJ | 1 |
| Rees, CA | 1 |
| Lennard, L | 1 |
| Lilleyman, JS | 1 |
| Maddocks, JL | 1 |
| Hande, K | 1 |
| Gober, J | 1 |
| Fletcher, R | 1 |
| Harris, RE | 1 |
| McCallister, JA | 1 |
| Allen, SA | 1 |
| Barton, AS | 1 |
| Baehner, RL | 2 |
| Rivard, GE | 1 |
| Momparler, LF | 1 |
| Momparler, RL | 1 |
| Morgan, E | 1 |
| Beach, BJ | 1 |
| Howell, SB | 1 |
| Lanzkowsky, P | 1 |
| Schaeffer, J | 1 |
| Lewis, IJ | 1 |
| Mainwaring, D | 1 |
| Martin, J | 2 |
| Fernández-Rañada, J | 1 |
| Vázquez, L | 1 |
| Escudero, A | 1 |
| Merino, JL | 1 |
| Gómez-Reino, F | 1 |
| Olmeda, F | 1 |
| Lahuerta, J | 1 |
| Larregla, S | 1 |
| Jedrzejczak, WW | 1 |
| Siekierzyński, M | 1 |
| Enno, A | 1 |
| Catovsky, D | 1 |
| Darrell, J | 1 |
| Goldman, JM | 1 |
| Hows, J | 1 |
| Galton, DA | 1 |
| Yoshikawa, H | 1 |
| Maruo, K | 1 |
| Wolff, LJ | 1 |
| Chusid, MJ | 1 |
| Heyrman, KA | 1 |
| Hughes, WT | 3 |
| Kuhn, S | 1 |
| Chaudhary, S | 1 |
| Feldman, S | 2 |
| Verzosa, M | 1 |
| Aur, RJ | 1 |
| Pratt, C | 1 |
| George, SL | 1 |
| Westerman, EL | 1 |
| Christensen, RP | 1 |
| Milligan, DW | 1 |
| Smith, GM | 1 |
| Howard, MR | 1 |
| Barnard, DL | 1 |
| Norfolk, DR | 1 |
| Child, JA | 1 |
| Unter, CE | 1 |
| Abbott, GD | 1 |
| Mori, T | 1 |
| Matsumura, M | 1 |
| Takahashi, M | 1 |
| Isonuma, H | 1 |
| Hibiya, I | 1 |
| Yasuma, M | 1 |
| Hamamoto, T | 1 |
| Ikemoto, H | 1 |
| Okada, M | 1 |
| Dekker, AW | 1 |
| Rozenberg-Arska, M | 1 |
| Verhoef, J | 1 |
| McDowell, HP | 1 |
| Shears, P | 1 |
| Hart, CA | 1 |
| van der Steuijt, K | 1 |
| Sonneveld, P | 1 |
| Doolin, EJ | 1 |
| Luck, SR | 1 |
| Sherman, JO | 1 |
| Raffensperger, JG | 1 |
| Rivera, GK | 1 |
| Schell, MJ | 1 |
| Thornton, D | 1 |
| Lott, L | 1 |
| van Eys, J | 1 |
| Berry, DM | 1 |
| Crist, W | 1 |
| Doering, EJ | 1 |
| Fernbach, DJ | 1 |
| Pullen, J | 1 |
| Shuster, J | 1 |
| Kovatch, AL | 1 |
| Wald, ER | 1 |
| Albo, VC | 1 |
| Prin, W | 1 |
| Orlando, SJ | 1 |
| Wollman, MR | 1 |
| Phebus, CK | 1 |
| Shapiro, ED | 1 |
| Gigliotti, F | 1 |
| Shenep, J | 1 |
| Sixbey, J | 1 |
| Spitzer, G | 1 |
| Garson, OM | 1 |
1 review available for trimethoprim and Leukemia, Lymphocytic
| Article | Year |
|---|---|
Prevention of infectious complications in acute lymphoblastic leukemia.
Topics: Acute Disease; Acyclovir; Anti-Bacterial Agents; Bacterial Infections; Catheterization; Chickenpox; | 1985 |
10 trials available for trimethoprim and Leukemia, Lymphocytic
| Article | Year |
|---|---|
Myelosuppression associated with co-trimoxazole as a prophylactic antibiotic in the maintenance phase of childhood acute lymphocytic leukemia.
Topics: Bacterial Infections; Child; Child, Preschool; Double-Blind Method; Drug Combinations; Female; Human | 1984 |
[The prophylactic effect of trimethoprim-sulfamethoxazole against infection among children with acute leukemia].
Topics: Acute Disease; Child; Child, Preschool; Clinical Trials as Topic; Double-Blind Method; Drug Combinat | 1983 |
[Sulphatrimethoprim-nystatin combination in the prophylaxis of infection in acute leukaemia (author's transl)].
Topics: Bacterial Infections; Clinical Trials as Topic; Drug Evaluation; Drug Therapy, Combination; Humans; | 1980 |
Co-trimoxazole for prevention of infection in acute leukaemia.
Topics: Administration, Oral; Adolescent; Adult; Aged; Clinical Trials as Topic; Colistin; Cross Infection; | 1978 |
Successful chemoprophylaxis for Pneumocystis carinii pneumonitis.
Topics: Adolescent; Adult; Bacteria; Child; Child, Preschool; Drug Combinations; Drug Evaluation; Female; Fu | 1977 |
Improvement in treatment for children with acute lymphoblastic leukaemia. The Medical Research Council UKALL trials, 1972-84. Report to the Council by the Working Party on Leukaemia in Childhood.
Topics: Administration, Oral; Adolescent; Asparaginase; Child; Child, Preschool; Clinical Trials as Topic; D | 1986 |
Infection prophylaxis in acute leukemia: a comparison of ciprofloxacin with trimethoprim-sulfamethoxazole and colistin.
Topics: Acute Disease; Agranulocytosis; Bacterial Infections; Ciprofloxacin; Colistin; Drug Combinations; Dr | 1987 |
Successful intermittent chemoprophylaxis for Pneumocystis carinii pneumonitis.
Topics: Anti-Infective Agents; Child; Child, Preschool; Drug Administration Schedule; Drug Combinations; Eva | 1987 |
Effect of trimethoprim/sulfamethoxazole prophylaxis on outcome of childhood lymphocytic leukemia. A Pediatric Oncology Group Study.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Humans; Infections; | 1987 |
Oral trimethoprim/sulfamethoxazole for prevention of bacterial infection during the induction phase of cancer chemotherapy in children.
Topics: Adolescent; Anti-Infective Agents; Antineoplastic Agents; Bacterial Infections; Child; Child, Presch | 1985 |
26 other studies available for trimethoprim and Leukemia, Lymphocytic
| Article | Year |
|---|---|
Co-trimoxazole prophylaxis in leukaemia.
Topics: Child; Drug Combinations; Drug Synergism; Epilepsy; Humans; Leukemia, Lymphoid; Sulfamethoxazole; Tr | 1982 |
[An empirical combination of antibiotics used in aplasias during chemotherapy for acute malignant hemopathies (author's transl)].
Topics: Adult; Aged; Amikacin; Anti-Bacterial Agents; Bacterial Infections; Carbenicillin; Drug Combinations | 1982 |
Pneumocystis carinii pneumonia: a problem revisited.
Topics: Antineoplastic Agents; Child, Preschool; Drug Combinations; Female; Humans; Immunosuppression Therap | 1984 |
Assessment of therapy for pneumocystis carinii pneumonia. PCP Therapy Project Group.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Aged; Amidines; Drug Combinations; Female; Hu | 1984 |
[Failure of peroral trimethoprim/sulfamethoxazole as infection preventive agent in acute lymphatic leukemia].
Topics: Child, Preschool; Drug Combinations; Drug Resistance, Microbial; Escherichia coli Infections; Humans | 1984 |
Neisseria lactamica septicemia in an immunocompromised patient.
Topics: Child; Drug Combinations; Female; Humans; Leukemia, Lymphoid; Neisseria; Penicillin Resistance; Peni | 1983 |
Disturbance of 6-mercaptopurine metabolism by cotrimoxazole in childhood lymphoblastic leukaemia.
Topics: Absorption; Adolescent; Child; Child, Preschool; Drug Combinations; Drug Interactions; Female; Guani | 1984 |
Trimethoprim interferes with serum methotrexate assay by the competitive protein binding technique.
Topics: Adult; Binding, Competitive; Chemical Phenomena; Chemistry; Drug Combinations; False Positive Reacti | 1980 |
Prevention of pneumocystis pneumonia. Use of continuous sulfamethoxazole-trimethroprim therapy.
Topics: Administration, Oral; Child; Child, Preschool; Drug Combinations; Female; Humans; Immunosuppression | 1980 |
Effects of trimethoprim on leukaemic cells in vitro.
Topics: Animals; Cell Survival; Cells, Cultured; Child; Deoxyuridine; Dose-Response Relationship, Drug; Huma | 1981 |
Decreased incidence of nonspecific interstitial pneumonitis in children with acute lymphocytic leukemia treated prophylactically with trimethoprim-sulfamethoxazole.
Topics: Antineoplastic Agents; Drug Combinations; Humans; Immunosuppression Therapy; Leukemia, Lymphoid; Pne | 1981 |
Influence of co-trimoxazole on methotrexate pharmacokinetics in children with acute lymphoblastic leukemia.
Topics: Adolescent; Child; Child, Preschool; Drug Combinations; Drug Interactions; Female; Humans; Intestina | 1981 |
Prophylactic use of TMP-SMZ in leukemia.
Topics: Agranulocytosis; Child; Drug Combinations; Humans; Leukemia, Lymphoid; Neutropenia; Pulmonary Fibros | 1982 |
Enteropathy complicating maintenance therapy in acute lymphoblastic leukaemia.
Topics: Adolescent; Anti-Infective Agents; Antineoplastic Agents; Child; Child, Preschool; Drug Combinations | 1982 |
Nitroblue tetrazolium (NBT) test: criteria for false positivity and its use in practice.
Topics: Adult; Bacterial Infections; Cyclophosphamide; False Positive Reactions; Female; Humans; Leukemia, L | 1976 |
[Sulfamethoxazole-trimethoprim therapy of diffuse interstitial pneumonia complicated in acute lymphocytic leukemia (author's transl)].
Topics: Adolescent; Adult; Aged; Drug Combinations; Female; Humans; Leukemia, Lymphoid; Male; Pulmonary Fibr | 1979 |
Delayed development of pneumocystis pneumonia following administration of short-term high-dose trimethoprim-sulfamethoxazole.
Topics: Acute Disease; Adolescent; Child; Child, Preschool; Drug Combinations; Follow-Up Studies; Humans; In | 1978 |
An outbreak of Pneumocystis carinii pneumonia at a pediatric hospital.
Topics: Antineoplastic Agents; Child; Child, Preschool; Disease Outbreaks; Drug Combinations; Female; Hospit | 1978 |
Chronic Isospora belli infection treated with co-trimoxazole.
Topics: Adult; Coccidiosis; Diarrhea; Drug Combinations; Female; Humans; Isospora; Leukemia, Lymphoid; Sulfa | 1979 |
Pneumocystis carinii pneumonitis in adults with acute lymphoblastic leukaemia.
Topics: Adolescent; Adult; Drug Combinations; Female; Humans; Leukemia, Lymphoid; Male; Middle Aged; Pneumon | 1987 |
Co-trimoxazole red cell aplasia in leukaemia.
Topics: Anti-Infective Agents; Child, Preschool; Drug Combinations; Humans; Leukemia, Lymphoid; Male; Pneumo | 1987 |
Co-trimoxazole treatment of two fatal cases of Pneumocystis carinii pneumonia--changes in protozoan morphology and treatment method.
Topics: Adult; Drug Combinations; Female; Humans; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Middle Aged; Pn | 1987 |
Acute lymphoblastic leukaemia: trimethoprim resistant organisms during treatment.
Topics: Child; Drug Resistance, Microbial; Enterobacteriaceae; Humans; Intestines; Leukemia, Lymphoid; Prosp | 1987 |
Concurrent analysis of methotrexate, trimethoprim, sulphamethoxazole and their major metabolites in plasma by high-performance liquid chromatography.
Topics: Child; Chromatography, High Pressure Liquid; Humans; Leukemia, Lymphoid; Methotrexate; Spectrophotom | 1987 |
Emergency lung biopsy: friend or foe of the immunosuppressed child?
Topics: Acute Disease; Adolescent; Adult; Biopsy; Child; Child, Preschool; Diagnosis, Differential; Drug Com | 1986 |
Lymphoblastic leukemia with marked eosinophilia: a report of two cases.
Topics: Adolescent; Blood Cell Count; Bone Marrow Examination; Cytarabine; Eosinophilia; Female; Humans; Kar | 1973 |