trimethoprim has been researched along with Leprosy in 11 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
Leprosy: A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the mucous membranes, and the peripheral nerves. Two polar or principal types are lepromatous and tuberculoid.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Since 1970, when the lifelong monotherapy with dapsone (DDS) in leprosy could be replaced by short-term combination therapy with rifampicin + isoniazid + protionamide + DDS (Isoprodian-RMP), chemotherapeutic research was faced with two problems: (1) to find alternative treatment regimens for cases of intolerance, and (2) to work out forms of therapy allowing a further reduction of the average treatment time of 2 years." | 7.67 | New forms of multidrug therapy for the treatment of leprosy. First report for the practice on rifampicin + sulfamethoxazole-trimethoprim + protionamide and rifampicin + sulfamethoxazole-trimethoprim + isoniazid. ( Freerksen, E; Rosenfeld, M; Spannuth, G, 1989) |
| " Finally the combination of brodimoprim (BDP) and dapsone (DDS) was developed for the treatment of leprosy." | 4.78 | In vitro and in vivo results of brodimoprim and analogues alone and in combination against E. coli and mycobacteria. ( Seydel, JK, 1993) |
| "Since 1970, when the lifelong monotherapy with dapsone (DDS) in leprosy could be replaced by short-term combination therapy with rifampicin + isoniazid + protionamide + DDS (Isoprodian-RMP), chemotherapeutic research was faced with two problems: (1) to find alternative treatment regimens for cases of intolerance, and (2) to work out forms of therapy allowing a further reduction of the average treatment time of 2 years." | 3.67 | New forms of multidrug therapy for the treatment of leprosy. First report for the practice on rifampicin + sulfamethoxazole-trimethoprim + protionamide and rifampicin + sulfamethoxazole-trimethoprim + isoniazid. ( Freerksen, E; Rosenfeld, M; Spannuth, G, 1989) |
| "In Africa leprosy is considered endemic." | 1.28 | [Leprosy in Africa. Current status and epidemiological significance]. ( Stingl, P, 1992) |
| "The antibacterial effect of brodimoprim alone and in combination with dapsone has been studied in vitro in cell-free systems and in whole mycobacterial cells as well as in vivo in mice and humans." | 1.28 | In vitro and in vivo experiments with the new inhibitor of mycobacterium leprae brodimoprim alone and in combination with dapsone. ( Dhople, AM; Jagannathan, R; Mahadevan, PR; Rosenfeld, M; Seydel, JK; Wempe, EG, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (63.64) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bera, S | 1 |
| Mondal, D | 1 |
| Seydel, JK | 2 |
| Stingl, P | 1 |
| Wempe, EG | 1 |
| Rosenfeld, M | 4 |
| Jagannathan, R | 1 |
| Mahadevan, PR | 1 |
| Dhople, AM | 1 |
| Freerksen, E | 3 |
| Spannuth, G | 1 |
| Brown, KG | 1 |
| Molesworth, BD | 1 |
| Gjalt Boerrigter, FG | 1 |
| Tozer, RA | 1 |
| DeGraw, JI | 1 |
| Brown, VH | 1 |
| Colwell, WT | 1 |
| Morrison, NE | 1 |
| Rohde, R | 1 |
| Blenska, W | 1 |
| Kolakowska, E | 1 |
2 reviews available for trimethoprim and Leprosy
| Article | Year |
|---|---|
Insights of synthetic analogues of anti-leprosy agents.
Topics: Humans; Leprostatic Agents; Leprosy; Structure-Activity Relationship | 2019 |
In vitro and in vivo results of brodimoprim and analogues alone and in combination against E. coli and mycobacteria.
Topics: Dapsone; Dihydropteroate Synthase; Escherichia coli; Escherichia coli Infections; Humans; Leprosy; M | 1993 |
9 other studies available for trimethoprim and Leprosy
| Article | Year |
|---|---|
[Leprosy in Africa. Current status and epidemiological significance].
Topics: Adolescent; Adult; Africa; Child; Cross-Sectional Studies; Drug Therapy, Combination; Humans; Isonia | 1992 |
In vitro and in vivo experiments with the new inhibitor of mycobacterium leprae brodimoprim alone and in combination with dapsone.
Topics: Adenosine Triphosphate; Animals; Chromatography, High Pressure Liquid; Dapsone; Drug Interactions; L | 1990 |
New forms of multidrug therapy for the treatment of leprosy. First report for the practice on rifampicin + sulfamethoxazole-trimethoprim + protionamide and rifampicin + sulfamethoxazole-trimethoprim + isoniazid.
Topics: Drug Therapy, Combination; Humans; Isoniazid; Isonicotinic Acids; Leprosy; Prothionamide; Sulfametho | 1989 |
Disseminated Histoplasmosis duboisii in Malawi partial response to sulphonamide-trimethoprim combination.
Topics: Adult; Cystine; Drug Therapy, Combination; Histoplasmosis; Humans; Leprosy; Malawi; Male; Sulfonamid | 1974 |
Potential antileprotic agents. 2. Inhibition of mycobacterial dihydrofolic reductase.
Topics: Aminopterin; Folic Acid Antagonists; Kinetics; Leprosy; Methotrexate; Mycobacterium leprae; Protein | 1974 |
Fundamental data, methods and goals of present research on the treatment of leprosy.
Topics: Animals; Animals, Laboratory; Antitubercular Agents; Clofazimine; Dapsone; Ethionamide; Humans; In V | 1973 |
[Initial clinical results using new, experimentally developed therapeutic forms in leprosy].
Topics: Adolescent; Adult; Aged; Antitubercular Agents; Child; Dapsone; Drug Therapy, Combination; Ethiopia; | 1973 |
A new analogous model for the detection and evaluation of chemotherapeutic products effective in leprosy.
Topics: Aniline Compounds; Animals; Dapsone; Disease Models, Animal; Drug Combinations; Ethionamide; Humans; | 1972 |
A pilot study of leprosy treatment with a combination of various antileprosy drugs. Preliminary report.
Topics: Adult; Antitubercular Agents; Drug Therapy, Combination; Humans; Isoniazid; Leprosy; Male; Pilot Pro | 1973 |