trimethoprim has been researched along with Kidney Failure, Chronic in 31 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The dosage yielded too high plasma trimethoprim concentrations, while sulfamethoxazole dialysate concentrations were too low." | 5.27 | Pharmacokinetics of cefradine, sulfamethoxazole and trimethoprim and their metabolites in a patient with peritonitis undergoing continuous ambulatory peritoneal dialysis. ( Berden, JH; Hekster, YA; Martea, M; Voets, AJ; Vree, TB, 1987) |
| "Four cases of pneumocystis carinii pneumonia occurred among 38 renal transplant recipients." | 1.28 | [Pneumocystis carinii pneumonia in renal transplant recipients treated with cyclosporin]. ( Arai, Y; Ishida, A; Kim, CJ; Konishi, T; Kounami, T; Okino, K; Pak, K; Sako, H; Tomoyoshi, T; Wakabayashi, Y, 1989) |
| "carinii pneumonia secondary to AIDS and to other known causes of immune deficiency were enrolled." | 1.27 | Assessment of therapy for pneumocystis carinii pneumonia. PCP Therapy Project Group. ( Haverkos, HW, 1984) |
| "It is concluded that initial treatment of CAPD peritonitis with co-trimoxazole is justified by the high proportion of sensitive germs and that it represents a safe, efficient and inexpensive treatment." | 1.27 | Treatment of peritonitis in continuous ambulatory peritoneal dialysis patients with co-trimoxazole. ( Favre, H; Glasson, P, 1984) |
| " The dosage yielded too high plasma trimethoprim concentrations, while sulfamethoxazole dialysate concentrations were too low." | 1.27 | Pharmacokinetics of cefradine, sulfamethoxazole and trimethoprim and their metabolites in a patient with peritonitis undergoing continuous ambulatory peritoneal dialysis. ( Berden, JH; Hekster, YA; Martea, M; Voets, AJ; Vree, TB, 1987) |
| " The elimination half-life during dialysis for TMP was 6." | 1.27 | Pharmacokinetics of intravenous trimethoprim-sulfamethoxazole during hemodialysis. ( Holazo, A; Nissenson, AR; Wilson, C, 1987) |
| " Half-life of the free plasma sulfametrol component is normal even in cases with absent renal function and can be markedly reduced by hemodialysis treatment." | 1.26 | [Pharmacokinetics of trimethoprim and sulfametrol in patients with end stage renal failure and hemodialysis treatment (author's transl)]. ( Hitzenberger, G; Kopsa, H; Korn, A; Pils, P; Schmidt, P; Zazgornik, J, 1980) |
| " cotrimoxazole (Sulprim, Polfa) was administered at a creatinine level to 3 mg/100 ml in a dosage of 3 times 1 tablet a day." | 1.26 | [Therapy of urinary tract infection in kidney insufficiency with cotrimoxazole]. ( Jelińska, S; Kurkus, J; Siciński, A; Siemińska, J, 1980) |
| " Successful treatment was acheived with administration of trimethoprim plus sulfamethoxazole at a dosage adjusted to the degree of renal failure." | 1.26 | Trimethoprim with sulfamethoxazole for treatment of infection with Pneumocystis carinii in renal insufficiency. ( Bourgault, AM; Brewer, NS; Rosenow, EC; Van Scoy, RE, 1978) |
| "Three patients had stable chronic renal failure, and in two of these there was a further permanent impairment of renal function." | 1.26 | Deterioration in renal function in association with co-trimoxazole therapy. ( Bailey, RR; Little, PJ, 1976) |
| "Twenty patients with chronic renal failure and either urinary or respiratory tract infection were treated with co-trimoxazole." | 1.25 | Use of co-trimoxazole in chronic renal failure. ( de Wardener, HE; MacGregor, GA; Tasker, PR, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (96.77) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (3.23) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rhee, JY | 1 |
| Park, YK | 1 |
| Shin, JY | 1 |
| Choi, JY | 1 |
| Lee, MY | 1 |
| Peck, KR | 1 |
| Song, JH | 1 |
| Ko, KS | 1 |
| Haverkos, HW | 1 |
| Glasson, P | 1 |
| Favre, H | 1 |
| Frankel, MC | 1 |
| Leslie, BR | 1 |
| Sax, FL | 1 |
| Soave, R | 1 |
| Sieniawska, M | 2 |
| Białasik, D | 2 |
| Wróblewska-Kałuzewska, M | 2 |
| Korniszewska, J | 2 |
| Wierzbowska-Lange, B | 2 |
| Karczeńska, J | 1 |
| Wierzba, K | 2 |
| de Fremont, JF | 1 |
| Schmit, JL | 1 |
| Thomas, D | 1 |
| Coevoet, B | 1 |
| Eb, F | 1 |
| Laurence, G | 1 |
| Orfila, J | 1 |
| Fournier, A | 1 |
| Kuller, J | 1 |
| First, MR | 2 |
| D'Achiardi, R | 1 |
| Munda, R | 1 |
| Singlas, E | 1 |
| Colin, JN | 1 |
| Rottembourg, J | 1 |
| Meessen, JP | 1 |
| de Martin, A | 1 |
| Legrain, M | 1 |
| Simon, P | 1 |
| Schmidt, P | 1 |
| Korn, A | 1 |
| Hitzenberger, G | 1 |
| Zazgornik, J | 1 |
| Kopsa, H | 1 |
| Pils, P | 1 |
| Chan, MK | 1 |
| Beale, D | 1 |
| Moorhead, JF | 1 |
| Siciński, A | 2 |
| Jelińska, S | 1 |
| Kurkus, J | 1 |
| Siemińska, J | 1 |
| Tasker, PR | 1 |
| MacGregor, GA | 1 |
| de Wardener, HE | 1 |
| Kasanen, A | 1 |
| Anttila, M | 1 |
| Elfving, R | 1 |
| Kahela, P | 1 |
| Saarimaa, H | 1 |
| Sundquist, H | 1 |
| Tikkanen, R | 1 |
| Toivanen, P | 1 |
| Bourgault, AM | 1 |
| Van Scoy, RE | 1 |
| Brewer, NS | 1 |
| Rosenow, EC | 1 |
| Osama, SM | 1 |
| Krishnamurti, S | 1 |
| Robinson, MF | 1 |
| Campbell, GR | 1 |
| Craswell, PW | 1 |
| Bailey, RR | 2 |
| Little, PJ | 2 |
| Kim, CJ | 1 |
| Pak, K | 1 |
| Wakabayashi, Y | 1 |
| Ishida, A | 1 |
| Arai, Y | 1 |
| Konishi, T | 1 |
| Kounami, T | 1 |
| Tomoyoshi, T | 1 |
| Sako, H | 1 |
| Okino, K | 1 |
| Dubois, P | 1 |
| Nouel, O | 1 |
| Davis, RE | 1 |
| Martea, M | 1 |
| Hekster, YA | 1 |
| Vree, TB | 1 |
| Voets, AJ | 1 |
| Berden, JH | 1 |
| Nissenson, AR | 1 |
| Wilson, C | 1 |
| Holazo, A | 1 |
| Myre, SA | 1 |
| McCann, J | 1 |
| Cluxton, RJ | 1 |
| Hoppe-Seyler, G | 1 |
| Schollmeyer, P | 1 |
| Grandpierre, B | 1 |
| Junkers, K | 1 |
| Höffler, D | 1 |
| Craig, WA | 2 |
| Kunin, CM | 2 |
| Welling, PG | 1 |
| Amidon, GL | 1 |
| Gahl, G | 1 |
| Baethke, R | 1 |
| Gassner, O | 1 |
| Kessel, M | 1 |
1 review available for trimethoprim and Kidney Failure, Chronic
| Article | Year |
|---|---|
Clinical chemistry of folic acid.
Topics: Absorption; Aged; Alcoholism; Anemia, Sickle Cell; Anticonvulsants; Arthritis, Rheumatoid; Biologica | 1986 |
2 trials available for trimethoprim and Kidney Failure, Chronic
| Article | Year |
|---|---|
Trimethoprim. Pharmacology, antimicrobial activity and clinical use in urinary tract infections.
Topics: Acute Disease; Adolescent; Adult; Aged; Bacterial Infections; Clinical Trials as Topic; Dose-Respons | 1978 |
Trimethoprim-sulfamethoxazole: pharmacodynamic effects of urinary pH and impaired renal function. Studies in humans.
Topics: Acute Kidney Injury; Administration, Oral; Ammonium Chloride; Anti-Bacterial Agents; Bacteria; Bicar | 1973 |
28 other studies available for trimethoprim and Kidney Failure, Chronic
| Article | Year |
|---|---|
KPC-producing extreme drug-resistant Klebsiella pneumoniae isolate from a patient with diabetes mellitus and chronic renal failure on hemodialysis in South Korea.
Topics: Aged; beta-Lactamases; Diabetic Nephropathies; Humans; Kidney Failure, Chronic; Klebsiella Infection | 2010 |
Assessment of therapy for pneumocystis carinii pneumonia. PCP Therapy Project Group.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Aged; Amidines; Drug Combinations; Female; Hu | 1984 |
Treatment of peritonitis in continuous ambulatory peritoneal dialysis patients with co-trimoxazole.
Topics: Adult; Aged; Anti-Infective Agents, Urinary; Bacterial Infections; Drug Combinations; Female; Humans | 1984 |
Trimethoprim--sulfamethoxazole-related hypoglycemia in a patient with renal failure.
Topics: Anti-Infective Agents, Urinary; Drug Combinations; Humans; Hypoglycemia; Kidney Failure, Chronic; Ma | 1984 |
[Changes in trimethoprim levels and its pharmacokinetic parameters in children with chronic renal failure treated with biseptol. I].
Topics: Adolescent; Child; Child, Preschool; Drug Combinations; Half-Life; Humans; Infant; Kidney Failure, C | 1984 |
[Biseptol dosage in children in relation to the degree of renal failure and body weight. II].
Topics: Acute Kidney Injury; Adolescent; Body Weight; Child; Child, Preschool; Dose-Response Relationship, D | 1984 |
[Treatment of peritonitis in continuous ambulatory peritoneal dialysis ].
Topics: Adult; Aged; Amphotericin B; Anti-Bacterial Agents; Candidiasis; Drug Combinations; Humans; Kidney F | 1982 |
Pneumocystis carinii pneumonia in renal transplant recipients.
Topics: Adolescent; Adult; Drug Combinations; Female; Glomerulonephritis; Graft Rejection; Humans; Kidney Fa | 1982 |
Pharmacokinetics of sulfamethoxazole--trimethoprim combination during chronic peritoneal dialysis: effect of peritonitis.
Topics: Administration, Oral; Adolescent; Adult; Aged; Drug Combinations; Female; Humans; Kidney Failure, Ch | 1982 |
[Pharmacokinetics of trimethoprim and sulfametrol in patients with end stage renal failure and hemodialysis treatment (author's transl)].
Topics: Adult; Aged; Drug Combinations; Female; Half-Life; Humans; Kidney Failure, Chronic; Male; Middle Age | 1980 |
Acute megaloblastosis due to cotrimoxazole.
Topics: Acute Disease; Anemia, Macrocytic; Anemia, Megaloblastic; Drug Combinations; Female; Folic Acid Defi | 1980 |
[Therapy of urinary tract infection in kidney insufficiency with cotrimoxazole].
Topics: Bacterial Infections; Creatinine; Drug Therapy, Combination; Humans; Kidney Failure, Chronic; Recurr | 1980 |
Use of co-trimoxazole in chronic renal failure.
Topics: Adult; Aged; Creatinine; Drug Combinations; Female; Humans; Kidney; Kidney Failure, Chronic; Kidney | 1975 |
Trimethoprim with sulfamethoxazole for treatment of infection with Pneumocystis carinii in renal insufficiency.
Topics: Adolescent; Drug Combinations; Humans; Kidney Failure, Chronic; Male; Pneumonia, Pneumocystis; Sulfa | 1978 |
Co-trimoxazole in chronic renal failure.
Topics: Adolescent; Adult; Creatinine; Drug Combinations; Humans; Kidney Failure, Chronic; Middle Aged; Sulf | 1979 |
[Advances in nephrology. Kidney failure in patients with diabetes mellitus].
Topics: Acute Kidney Injury; Diabetes Complications; Humans; Kidney; Kidney Failure, Chronic; Kidney Transpl | 1976 |
Co-trimoxazole in chronic renal failure--a controlled experiment in Wistar rats.
Topics: Animals; Drug Combinations; Kidney; Kidney Failure, Chronic; Male; Rats; Sulfisoxazole; Trimethoprim | 1977 |
Deterioration in renal function in association with co-trimoxazole therapy.
Topics: Acute Kidney Injury; Adult; Aged; Drug Combinations; Female; Humans; Kidney Diseases; Kidney Failure | 1976 |
Deterioration in renal function in association with co-trimoxazole therapy.
Topics: Humans; Kidney; Kidney Failure, Chronic; Sulfamethoxazole; Trimethoprim | 1976 |
[Pneumocystis carinii pneumonia in renal transplant recipients treated with cyclosporin].
Topics: Adult; Cyclosporins; Cytomegalovirus Infections; Humans; Kidney Failure, Chronic; Kidney Transplanta | 1989 |
[Hypoglycemia induced by sulfamethoxazole-trimethoprim in a chronic renal insufficiency patient].
Topics: Aged; Aged, 80 and over; Female; Humans; Hypoglycemia; Kidney Failure, Chronic; Sulfamethoxazole; Tr | 1986 |
Pharmacokinetics of cefradine, sulfamethoxazole and trimethoprim and their metabolites in a patient with peritonitis undergoing continuous ambulatory peritoneal dialysis.
Topics: Anti-Infective Agents, Urinary; Cephalosporins; Cephradine; Drug Combinations; Half-Life; Humans; Ki | 1987 |
Pharmacokinetics of intravenous trimethoprim-sulfamethoxazole during hemodialysis.
Topics: Adult; Anti-Infective Agents, Urinary; Drug Combinations; Female; Half-Life; Humans; Infusions, Intr | 1987 |
Effect of trimethoprim on serum creatinine in healthy and chronic renal failure volunteers.
Topics: Adult; Aged; Creatinine; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Trimethoprim | 1987 |
[Behavior of trimethoprim and sulfa methoxazol in anuria under conditions of hemo- and peritoneal dialysis].
Topics: Anuria; Humans; Kidney Failure, Chronic; Peritoneal Dialysis; Renal Dialysis; Sulfamethoxazole; Time | 1974 |
[Antibiotic therapy].
Topics: Anti-Bacterial Agents; Bacterial Infections; Cephalosporins; Chloramphenicol; Colistin; Drug Therapy | 1973 |
Pharmacokinetics of trimethoprim and sulfamethoxazole in normal subjects and in patients with renal failure.
Topics: Administration, Oral; Ammonium Chloride; Bicarbonates; Drug Combinations; Humans; Kidney Failure, Ch | 1973 |
[Kinetic studies on a chemotherapeutic drug combination (sulfamethoxazole and trimethoprim) in chronic kidney insufficiency].
Topics: Anti-Infective Agents; Drug Combinations; Folic Acid Antagonists; Humans; Inulin; Kidney Failure, Ch | 1971 |