trimethoprim has been researched along with Kidney Diseases in 47 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To ascertain the efficacy and toxicity of trimethoprim-sulfamethoxazole or pentamidine when either is given alone during the entire treatment period for Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome (AIDS)." | 9.06 | Trimethoprim-sulfamethoxazole compared with pentamidine for treatment of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. A prospective, noncrossover study. ( Cowan, R; Nielsen, DM; Ruskin, J; Sattler, FR, 1988) |
| "Twelve patients with severe renal failure and intercurrent urinary tract infections were treated with either ampicillin trihydrate, 500 mg four times a day, or trimethoprim-sulfamethoxazole, two tablets (80 mg trimethoprim, 400 mg sulfamethoxazole) twice a day." | 7.65 | Urinary tract infections in patients with severe renal disease. Treatment with ampicillin and trimethoprim-sulfamethoxazole. ( Bennett, WM; Craven, R, 1976) |
| "To study the effects of continous low doses of antibacterial agents after eradication of bacteriuria in patients with recurrent urinary tract infection, 31 patients with documented recurrent urinary tract infection were allocated alternately to treatment with either co-trimoxazole (400 mg of suphamethoxazole and 80 mg of trimethoprim each night) or methenamine hippurate (1 g each night)." | 7.65 | Controlled trial comparing co-trimoxazole and methenamine hippurate in the prevention of recurrent urinary tract infections. ( Friedman, A; Kalowski, S; Kincaid-Smith, P; Nanra, RS; Radford, N; Standish, H, 1975) |
| "To ascertain the efficacy and toxicity of trimethoprim-sulfamethoxazole or pentamidine when either is given alone during the entire treatment period for Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome (AIDS)." | 5.06 | Trimethoprim-sulfamethoxazole compared with pentamidine for treatment of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. A prospective, noncrossover study. ( Cowan, R; Nielsen, DM; Ruskin, J; Sattler, FR, 1988) |
| "Ninety patients with urinary tract infections were treated in a randomized double-blind study with either a combination of trimethoprim and sulfamethoxazole (TMP-SMX) or sulfamethoxazole alone (SMX)." | 5.04 | A comparison of trimethorprim-sulfamethoxazole with sulfamethoxazole alone in infections localized to the kidneys. ( Boutros, P; Harding, GK; Lank, B; Ronald, AR, 1975) |
| "Twelve patients with severe renal failure and intercurrent urinary tract infections were treated with either ampicillin trihydrate, 500 mg four times a day, or trimethoprim-sulfamethoxazole, two tablets (80 mg trimethoprim, 400 mg sulfamethoxazole) twice a day." | 3.65 | Urinary tract infections in patients with severe renal disease. Treatment with ampicillin and trimethoprim-sulfamethoxazole. ( Bennett, WM; Craven, R, 1976) |
| "To study the effects of continous low doses of antibacterial agents after eradication of bacteriuria in patients with recurrent urinary tract infection, 31 patients with documented recurrent urinary tract infection were allocated alternately to treatment with either co-trimoxazole (400 mg of suphamethoxazole and 80 mg of trimethoprim each night) or methenamine hippurate (1 g each night)." | 3.65 | Controlled trial comparing co-trimoxazole and methenamine hippurate in the prevention of recurrent urinary tract infections. ( Friedman, A; Kalowski, S; Kincaid-Smith, P; Nanra, RS; Radford, N; Standish, H, 1975) |
| "Since risk of renal scarring is believed to occur more frequently in young people, and since recurrent urinary infections mainly affect girls, the age and sex of subjects are important in the design of a prophylactic regimen." | 2.40 | Antibacterial prophylaxis in children with urinary tract infection. ( Bollgren, I, 1999) |
| " The pharmacokinetic properties of TMP are reviewed with particular emphasis on the renal handling of the drug and its advantages over TMP/sulfonamide combinations in relation to renal function and toxicity." | 2.36 | Trimethoprim: clinical use and pharmacokinetics. ( Friesen, WT; Hekster, YA; Vree, TB, 1981) |
| " Multiple samples were collected over 9 days and the following pharmacokinetic parameters were calculated: total area under the plasma level curve, slow disposition rate constant beta and the corresponding t1/2 beta, plasma clearance and the apparent volume of distribution." | 1.27 | Pharmacokinetic study of the new sulfamethopyrazine-trimethoprim combination (kelfiprim) in renal insufficiency. ( Cantaluppi, A; Grasso, S; Graziani, G; Meinardi, G; Piaia, F; Ponticelli, C; Tamassia, V, 1984) |
| " She recovered after surgical drainage of the abscesses and prolonged treatment with intravenous amikacin and high dosage cotrimoxazole and sulphadimidine." | 1.27 | Abdominal nocardiosis in a Sudanese girl. ( Dickson, JA; Duerden, BI; Milner, RD; Salfield, SA, 1983) |
| " The pharmacokinetic parameters of unchanged metioprim were derived by analyzing plasma level curves using a two-compartment model." | 1.27 | Pharmacokinetics of metioprim in normal subjects and patients with impaired renal function. ( Bishop-Freudling, GB; Kaiser, W; Köhler, M; Reutter, FW; Strobel, K; Vergin, H, 1983) |
| "In patients with AIDS a more indolent illness occurred lasting 3 or more weeks and was characterised by fever, dry cough and breathlessness." | 1.27 | Management of Pneumocystis carinii pneumonia in the immunocompromised host. ( Carter, JM; Fisher, M; Holloway, L; Jones, MR; McSweeney, P; Town, GI, 1988) |
| " In renal impairment although the serum half-life (t1/2) of both active and total SDZ remains similar to that of TMP, the t1/2 of total SMZ becomes several times higher than the t1/2 of TMP." | 1.26 | Pharmacokinetics of sulphadiazine, sulphamethoxazole and trimethoprim in patients with varying renal function. ( Anstad, U; Bergan, T; Brodwall, EK; Vik-Mo, H, 1979) |
| "Elimination half-life times, plasma concentrations, and minimal cumulation factors are being determined resp." | 1.26 | Pharmacokinetics of Lidaprim in cases of impaired renal function. ( Bonelli, J; Hitzenberger, G; Korn, A; Magometschnigg, D; Pichler, H, 1977) |
| "Three patients had stable chronic renal failure, and in two of these there was a further permanent impairment of renal function." | 1.26 | Deterioration in renal function in association with co-trimoxazole therapy. ( Bailey, RR; Little, PJ, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 40 (85.11) | 18.7374 |
| 1990's | 2 (4.26) | 18.2507 |
| 2000's | 3 (6.38) | 29.6817 |
| 2010's | 1 (2.13) | 24.3611 |
| 2020's | 1 (2.13) | 2.80 |
| Authors | Studies |
|---|---|
| Avdeef, A | 1 |
| Tam, KY | 1 |
| Memoli, E | 1 |
| Faré, PB | 1 |
| Camozzi, P | 1 |
| Simonetti, GD | 1 |
| Bianchetti, MG | 1 |
| Lava, SA | 1 |
| Milani, GP | 1 |
| Taskinen, S | 1 |
| Giordano, S | 1 |
| Rintala, R | 1 |
| Sheerin, NS | 1 |
| Bhatacharia, KF | 1 |
| Webb, MC | 1 |
| Klein, I | 1 |
| Vervoort, G | 1 |
| Steenbergen, E | 1 |
| Wetzels, J | 1 |
| Asscher, AW | 1 |
| Thompson, JF | 1 |
| Chalmers, DH | 1 |
| Hunnisett, AG | 1 |
| Wood, RF | 1 |
| Morris, PJ | 1 |
| Cantaluppi, A | 1 |
| Graziani, G | 1 |
| Ponticelli, C | 1 |
| Grasso, S | 1 |
| Meinardi, G | 1 |
| Piaia, F | 1 |
| Tamassia, V | 1 |
| Miller, T | 1 |
| Phillips, S | 1 |
| Salfield, SA | 1 |
| Duerden, BI | 1 |
| Dickson, JA | 1 |
| Milner, RD | 1 |
| Günther, K | 2 |
| Traeger, A | 2 |
| Stein, G | 2 |
| Vergin, H | 1 |
| Bishop-Freudling, GB | 1 |
| Kaiser, W | 1 |
| Köhler, M | 1 |
| Strobel, K | 1 |
| Reutter, FW | 1 |
| Vree, TB | 3 |
| Hekster, CA | 1 |
| van Dalen, R | 1 |
| Hahn-Pedersen, J | 1 |
| Jørgensen, D | 1 |
| Turck, M | 1 |
| Bonal, J | 1 |
| Ronald, AR | 2 |
| Friesen, WT | 1 |
| Hekster, YA | 2 |
| Iravani, A | 1 |
| Richard, GA | 1 |
| Baer, H | 1 |
| Hengstmann, JH | 1 |
| Truckenbrodt, J | 1 |
| Jick, H | 1 |
| Derby, LE | 1 |
| Bollgren, I | 1 |
| Brøckner, J | 1 |
| Bøisen, E | 1 |
| Knudsen, L | 1 |
| Weismann, K | 1 |
| Eichenwald, HF | 1 |
| McCracken, GH | 1 |
| Benn, RA | 1 |
| Bergan, T | 2 |
| Brodwall, EK | 2 |
| Vik-Mo, H | 1 |
| Anstad, U | 1 |
| Follath, F | 1 |
| Hitzenberger, G | 1 |
| Korn, A | 1 |
| Pichler, H | 1 |
| Bonelli, J | 1 |
| Magometschnigg, D | 1 |
| Bailey, RR | 1 |
| Little, PJ | 1 |
| Collins, 2S | 1 |
| Bennett, WM | 1 |
| Craven, R | 1 |
| Harding, GK | 1 |
| Boutros, P | 1 |
| Lank, B | 1 |
| Kalowski, S | 3 |
| Nanra, RS | 2 |
| Friedman, A | 1 |
| Radford, N | 1 |
| Standish, H | 1 |
| Kincaid-Smith, P | 3 |
| Berg, KJ | 2 |
| Gjellestad, A | 1 |
| Nordby, G | 2 |
| Rootwelt, K | 2 |
| Djøseland, O | 2 |
| Fauchald, P | 2 |
| Mehl, A | 2 |
| Narverud, J | 2 |
| Talseth, T | 2 |
| Carter, JM | 1 |
| Town, GI | 1 |
| Fisher, M | 1 |
| Holloway, L | 1 |
| Jones, MR | 1 |
| McSweeney, P | 1 |
| Sattler, FR | 1 |
| Cowan, R | 1 |
| Nielsen, DM | 1 |
| Ruskin, J | 1 |
| Bäckman, L | 1 |
| Appelkvist, EL | 1 |
| Ringdén, O | 1 |
| Dallner, G | 1 |
| Martea, M | 1 |
| Termond, EF | 1 |
| Van Klaveren, R | 1 |
| Lammers, JW | 1 |
| Berden, JH | 1 |
| Mathew, TH | 2 |
| Salter, AJ | 1 |
| Nanra, NS | 1 |
| Rieder, J | 1 |
| Schwartz, DE | 1 |
| Fernex, M | 1 |
| Blumberg, A | 1 |
| Cottier, P | 1 |
| Scheitlin, W | 1 |
| Adam, WR | 1 |
| Henning, M | 1 |
| Dawborn, JK | 1 |
| Fowle, AS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of the Effectiveness of Antibiotic Prophylaxis in Children With a History of Upper Urinary Tract Infections:a Multicentre Randomised Study[NCT00156546] | Phase 4 | 660 participants | Interventional | 2000-05-31 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for trimethoprim and Kidney Diseases
| Article | Year |
|---|---|
Trimethoprim-associated electrolyte and acid-base abnormalities.
Topics: Acidosis; Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Urinary; Bicarbonates; Diabetes Com | 2021 |
Urinary tract infections: the efficacy of trimethoprim/sulfamethoxazole.
Topics: Cystitis; Drug Combinations; Humans; Kidney Diseases; Male; Microbial Sensitivity Tests; Prostatitis | 1980 |
Trimethoprim: clinical use and pharmacokinetics.
Topics: Bacterial Infections; Drug Resistance, Microbial; Drug Therapy, Combination; Humans; Kidney Diseases | 1981 |
Pharmacokinetics of trimethoprim and tetroxoprim. A review.
Topics: Administration, Oral; Anti-Infective Agents; Biological Availability; Chemical Phenomena; Chemistry; | 1982 |
Antibacterial prophylaxis in children with urinary tract infection.
Topics: Anti-Infective Agents, Urinary; Child; Cicatrix; Drug Resistance, Microbial; Female; Humans; Infant; | 1999 |
Antimicrobial therapy in infants and children. Part I. Review of antimicrobial agents.
Topics: Aminoglycosides; Anti-Bacterial Agents; Bacitracin; Bacterial Infections; Cephalosporins; Child; Chi | 1978 |
Antibiotics: use and abuse in office practice.
Topics: Anti-Bacterial Agents; Cephalosporins; Clindamycin; Erythromycin; Fusidic Acid; Humans; Kidney Disea | 1977 |
3 trials available for trimethoprim and Kidney Diseases
| Article | Year |
|---|---|
Treatment of uncomplicated urinary tract infections with trimethoprim versus sulfisoxazole, with special reference to antibody-coated bacteria and fecal flora.
Topics: Adolescent; Adult; Antibody-Coated Bacteria Test, Urinary; Bacteria; Bacterial Infections; Clinical | 1981 |
A comparison of trimethorprim-sulfamethoxazole with sulfamethoxazole alone in infections localized to the kidneys.
Topics: Administration, Oral; Adolescent; Adult; Aged; Bacterial Infections; Clinical Trials as Topic; Drug | 1975 |
Trimethoprim-sulfamethoxazole compared with pentamidine for treatment of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. A prospective, noncrossover study.
Topics: Acquired Immunodeficiency Syndrome; Adult; Amidines; Drug Combinations; Hematologic Diseases; Humans | 1988 |
37 other studies available for trimethoprim and Kidney Diseases
| Article | Year |
|---|---|
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological | 2010 |
Xanthogranulomatous pyelonephritis infiltrating the liver.
Topics: Anti-Bacterial Agents; Cefuroxime; Cephalexin; Child; Clindamycin; Combined Modality Therapy; Divert | 2008 |
Positron emission tomography in a patient with renal malacoplakia.
Topics: Abdominal Pain; Ascorbic Acid; Female; Fever of Unknown Origin; Fluorodeoxyglucose F18; Gastrointest | 2003 |
Progressive renal disease despite immunosuppressive therapy in a patient with Wegener s granulomatosis.
Topics: Aged; Cyclophosphamide; Disease Progression; Granulomatosis with Polyangiitis; Humans; Immunosuppres | 2008 |
Urinary tract infection.
Topics: Adolescent; Adult; Aged; Bacteriuria; Child; Child, Preschool; Cystitis; Escherichia coli; Female; F | 1981 |
Nephrotoxicity of trimethoprim and cotrimoxazole in renal allograft recipients treated with cyclosporine.
Topics: Creatinine; Cyclosporins; Drug Combinations; Drug Interactions; Humans; Kidney Diseases; Kidney Tran | 1983 |
Pharmacokinetic study of the new sulfamethopyrazine-trimethoprim combination (kelfiprim) in renal insufficiency.
Topics: Adult; Aged; Drug Combinations; Female; Humans; Kidney Diseases; Kinetics; Male; Metabolic Clearance | 1984 |
Effect of physiological manipulations on the chemotherapy of experimentally induced renal infection.
Topics: Ampicillin; Animals; Anti-Infective Agents, Urinary; Carbenicillin; Diuresis; Drug Combinations; Fem | 1983 |
Abdominal nocardiosis in a Sudanese girl.
Topics: Abscess; Amikacin; Child; Drainage; Drug Combinations; Female; Humans; Kidney Diseases; Liver Absces | 1983 |
[Pharmacokinetics of the sulfonamide-trimethoprim combinations Berlocombin and Sulprim in patients with various degrees of kidney dysfunction].
Topics: Drug Combinations; Humans; Kidney Diseases; Kinetics; Renal Dialysis; Sulfamerazine; Sulfamethoxazol | 1984 |
Pharmacokinetics of metioprim in normal subjects and patients with impaired renal function.
Topics: Adult; Age Factors; Aged; Anti-Infective Agents; Creatinine; Female; Folic Acid Antagonists; Humans; | 1983 |
Some consequences of drug choice and dosage regimen for patients with impaired kidney function.
Topics: Drug Synergism; Half-Life; Humans; Kidney; Kidney Diseases; Kinetics; Pharmaceutical Preparations; P | 1983 |
Renal malacoplakia. Conservative surgery and prophylactic long-term antibiotic treatment.
Topics: Anti-Bacterial Agents; Drug Combinations; Female; Humans; Kidney Diseases; Malacoplakia; Middle Aged | 1983 |
Urinary tract infections.
Topics: Acute Disease; Adult; Amoxicillin; Bacteriuria; Chronic Disease; Female; Humans; Kidney Diseases; Ma | 1980 |
[Cotrimoxazole and nephrotoxicity].
Topics: Drug Combinations; Humans; Kidney Diseases; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfametho | 1981 |
[Berlocombin and Sulprim therapy in patients with various degrees of kidney failure].
Topics: Creatinine; Humans; Kidney Diseases; Sulfamerazine; Sulfamethoxazole; Trimethoprim | 1980 |
Is co-trimoxazole safe?
Topics: Cephalexin; Chemical and Drug Induced Liver Injury; Follow-Up Studies; Hematologic Diseases; Humans; | 1995 |
Fatal multisystem toxicity after co-trimoxazole.
Topics: Anuria; Central Nervous System; Humans; Kidney Diseases; Male; Middle Aged; Pancreatitis; Pulmonary | 1978 |
[Pustular eruption and damage of internal organs after sulfamethoxazole combined with trimethoprim].
Topics: Aged; Chemical and Drug Induced Liver Injury; Drug Combinations; Drug Eruptions; Humans; Kidney; Kid | 1977 |
Pharmacokinetics of sulphadiazine, sulphamethoxazole and trimethoprim in patients with varying renal function.
Topics: Drug Combinations; Half-Life; Humans; Kidney Diseases; Kidney Function Tests; Kinetics; Sulfadiazine | 1979 |
Pharmacokinetics of long half-life antibacterials.
Topics: Anti-Infective Agents; Half-Life; Humans; Kidney Diseases; Kinetics; Liver Diseases; Sulfonamides; T | 1979 |
Pharmacokinetics of Lidaprim in cases of impaired renal function.
Topics: Adult; Aged; Creatinine; Drug Combinations; Female; Half-Life; Humans; Kidney Diseases; Kinetics; Ma | 1977 |
Deterioration in renal function in association with co-trimoxazole therapy.
Topics: Acute Kidney Injury; Adult; Aged; Drug Combinations; Female; Humans; Kidney Diseases; Kidney Failure | 1976 |
Co-trimoxazole.
Topics: Aged; Drug Combinations; Humans; Infections; Kidney; Kidney Diseases; Male; Sulfamethoxazole; Trimet | 1976 |
Urinary tract infections in patients with severe renal disease. Treatment with ampicillin and trimethoprim-sulfamethoxazole.
Topics: Adult; Ampicillin; Drug Evaluation; Female; Humans; Kidney Diseases; Male; Middle Aged; Sulfamethoxa | 1976 |
Controlled trial comparing co-trimoxazole and methenamine hippurate in the prevention of recurrent urinary tract infections.
Topics: Adult; Aged; Bacteriuria; Drug Combinations; Female; Follow-Up Studies; Hemagglutinins; Hippurates; | 1975 |
Renal effects of trimethoprim in ciclosporin- and azathioprine-treated kidney-allografted patients.
Topics: Adult; Aged; Azathioprine; beta 2-Microglobulin; Creatinine; Cyclosporins; Drug Interactions; Glomer | 1989 |
Management of Pneumocystis carinii pneumonia in the immunocompromised host.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Aged; Drug Combinations; Female; Humans; Immu | 1988 |
Glutathione transferase in the urine: a marker for post-transplant tubular lesions.
Topics: Adolescent; Adult; Aged; Child; Clinical Enzyme Tests; Cyclosporins; Drug Combinations; Drug Therapy | 1988 |
Effects on renal function of combined treatment with trimethoprim and cyclosporine A in kidney transplant patients.
Topics: Adult; Aged; Cyclosporins; Drug Therapy, Combination; Female; Humans; Kidney Diseases; Kidney Functi | 1988 |
Deterioration of kidney function by high doses of co-trimoxazole in man.
Topics: Adult; Anti-Infective Agents, Urinary; Drug Combinations; Humans; Kidney Diseases; Kinetics; Male; P | 1987 |
Deterioration in renal function in association with co-trimoxazole therapy.
Topics: Acute Kidney Injury; Adult; Aged; Anti-Infective Agents; Female; Folic Acid Antagonists; Gastroenter | 1973 |
The toxicity profile of trimethoprim-sulphamethoxazole after four years of widespread use.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Animals; Anti-Infective Agents; Child; Child, Presch | 1973 |
Deterioration in renal function in association with Co-trimoxazole therapy.
Topics: Adult; Aged; Anti-Bacterial Agents; Blood Urea Nitrogen; Creatinine; Drug Combinations; Female; Hear | 1974 |
Pharmacokinetics of the antibacterial combination sulfamethoxazole plus trimethoprim in patients with normal or impaired kidney function.
Topics: Adult; Aged; Drug Combinations; Female; Half-Life; Humans; Kidney; Kidney Diseases; Kinetics; Male; | 1974 |
Excretion of trimethoprim and sulphamethoxazole in patients with renal failure.
Topics: Biological Assay; Creatinine; Drug Combinations; Escherichia coli; Humans; Hydrogen-Ion Concentratio | 1973 |
The dosage of septrin.
Topics: Adult; Age Factors; Anti-Infective Agents; Body Fluids; Child; Child, Preschool; Drug Combinations; | 1973 |