trimethoprim has been researched along with Infections, Pneumococcal in 24 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the efficacy and safety of brodimoprim (BDP) with those of amoxicillin (AMX) in patients with acute bacterial pharyngitis/tonsillitis." | 9.07 | A multicenter comparative study of brodimoprim and amoxicillin therapy in the treatment of tonsillopharyngitis in adults. ( Bandau, KH; Nouri, ME; Nyffenegger, R; Riebenfeld, D; Schirmböck, U; Streppel, M, 1993) |
| "Seventy-nine children with acute otitis media were the subjects in a study designed to compare the effectiveness of ampicillin and trimethoprim-sulfamethoxazole in this infection." | 9.04 | Comparative efficacy of ampicillin and trimethoprim-sulfamethoxazole in otitis media. ( Cameron, GG; Johnston, MT; Pomahac, AC, 1975) |
| "The combination trimethoprim-sulfamethoxazole was given in high dosage (four tablets twice daily) for either 2 or 5 days to 20 patients with sinusitis diagnosed on clinical grounds." | 7.65 | Use of high-dosage trimethoprim-sulfamethoxazole in sinusitis. ( Whitehead, E, 1975) |
| "To compare the efficacy and safety of brodimoprim (BDP) with those of amoxicillin (AMX) in patients with acute bacterial pharyngitis/tonsillitis." | 5.07 | A multicenter comparative study of brodimoprim and amoxicillin therapy in the treatment of tonsillopharyngitis in adults. ( Bandau, KH; Nouri, ME; Nyffenegger, R; Riebenfeld, D; Schirmböck, U; Streppel, M, 1993) |
| "Seventy-nine children with acute otitis media were the subjects in a study designed to compare the effectiveness of ampicillin and trimethoprim-sulfamethoxazole in this infection." | 5.04 | Comparative efficacy of ampicillin and trimethoprim-sulfamethoxazole in otitis media. ( Cameron, GG; Johnston, MT; Pomahac, AC, 1975) |
| "The combination trimethoprim-sulfamethoxazole was given in high dosage (four tablets twice daily) for either 2 or 5 days to 20 patients with sinusitis diagnosed on clinical grounds." | 3.65 | Use of high-dosage trimethoprim-sulfamethoxazole in sinusitis. ( Whitehead, E, 1975) |
| "Pneumococcal diseases are a leading cause of morbidity and mortality among children globally, and the burden of these diseases might be worsened by antimicrobial resistance." | 2.72 | Antimicrobial resistance in paediatric ( Andrejko, K; Hausdorff, WP; Laxminarayan, R; Lewnard, JA; Ratnasiri, B, 2021) |
| "Patients with multiple myeloma are at risk for bacterial infections such as Streptococcus pneumoniae, Haemophilus influenzae, and Escherichia coli." | 2.44 | [Compromised immune function in multiple myeloma]. ( Yoshida, M, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (50.00) | 18.7374 |
| 1990's | 4 (16.67) | 18.2507 |
| 2000's | 4 (16.67) | 29.6817 |
| 2010's | 3 (12.50) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Andrejko, K | 1 |
| Ratnasiri, B | 1 |
| Hausdorff, WP | 1 |
| Laxminarayan, R | 1 |
| Lewnard, JA | 1 |
| Dayie, NT | 1 |
| Arhin, RE | 1 |
| Newman, MJ | 1 |
| Dalsgaard, A | 1 |
| Bisgaard, M | 1 |
| Frimodt-Møller, N | 1 |
| Slotved, HC | 1 |
| Chi, H | 1 |
| Chiu, NC | 1 |
| Huang, FY | 1 |
| Hsu, CH | 1 |
| Lee, KS | 1 |
| Huang, LM | 1 |
| Hsieh, YC | 1 |
| Vanderkooi, OG | 1 |
| Church, DL | 1 |
| MacDonald, J | 1 |
| Zucol, F | 1 |
| Kellner, JD | 1 |
| Hua, CZ | 1 |
| Shang, SQ | 1 |
| Sun, XF | 1 |
| Li, JP | 1 |
| Chen, ZM | 1 |
| Yu, XL | 1 |
| Blossom, DB | 1 |
| Namayanja-Kaye, G | 1 |
| Nankya-Mutyoba, J | 1 |
| Mukasa, JB | 1 |
| Bakka, H | 1 |
| Rwambuya, S | 1 |
| Windau, A | 1 |
| Bajaksouzian, S | 1 |
| Walker, CJ | 1 |
| Joloba, ML | 1 |
| Kityo, C | 1 |
| Mugyenyi, P | 1 |
| Whalen, CC | 1 |
| Jacobs, MR | 1 |
| Salata, RA | 1 |
| Yoshida, M | 1 |
| Linares, J | 2 |
| Pérez, JL | 2 |
| Garau, J | 2 |
| Martin, R | 2 |
| Kalin, M | 1 |
| Carlsson, B | 1 |
| Karlsson, I | 1 |
| Murgui, L | 1 |
| Markman, M | 1 |
| Mannisi, J | 1 |
| Dick, JD | 1 |
| Filburn, B | 1 |
| Santos, GW | 1 |
| Saral, R | 1 |
| Jossart, GH | 2 |
| Canafax, DM | 2 |
| Erdmann, GR | 2 |
| Lovdahl, MJ | 1 |
| Russlie, HQ | 1 |
| Juhn, SK | 2 |
| Giebink, GS | 2 |
| Nyffenegger, R | 1 |
| Riebenfeld, D | 1 |
| Bandau, KH | 1 |
| Nouri, ME | 1 |
| Schirmböck, U | 1 |
| Streppel, M | 1 |
| Widdowson, CA | 1 |
| Klugman, KP | 2 |
| Maskell, JP | 1 |
| Sefton, AM | 1 |
| Hall, LM | 1 |
| Joly, J | 1 |
| Ninane, G | 1 |
| Kraytman, M | 1 |
| Cameron, GG | 1 |
| Pomahac, AC | 1 |
| Johnston, MT | 1 |
| Whitehead, E | 1 |
| Levitt, DG | 1 |
| Kucera, P | 1 |
| Le, CT | 1 |
| Henderson, FW | 1 |
| Gilligan, PH | 1 |
| Wait, K | 1 |
| Goff, DA | 1 |
| Keren, G | 1 |
| Barzilai, A | 1 |
| Rubinstein, E | 1 |
| Koornhof, HJ | 1 |
| Kuhnle, V | 1 |
| Grunberg, E | 1 |
| Geddes, AM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Study on Pathogenic Surveillance and Nasopharyngeal Carriage of Children and Adolescents Based on Hospitals and Communities in Hainan Province[NCT05912010] | 6,000 participants (Anticipated) | Observational | 2023-04-24 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for trimethoprim and Infections, Pneumococcal
| Article | Year |
|---|---|
Antimicrobial resistance in paediatric
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Cephalosporins; Child; Drug Resistance, Bacterial; Hum | 2021 |
[Compromised immune function in multiple myeloma].
Topics: Antibiotic Prophylaxis; Humans; Immunocompromised Host; Immunoglobulins, Intravenous; Multiple Myelo | 2007 |
Molecular mechanisms of resistance to commonly used non-betalactam drugs in Streptococcus pneumoniae.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Cats; Drug Resistance, Multiple; Erythromycin | 1999 |
The effect of trimethoprim on the activity of sulfonamides and antibiotics in experimental infections.
Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Bacterial Infections; Drug Synergism; Escheric | 1973 |
Chemotherapy.
Topics: Aminoglycosides; Ampicillin; Anti-Infective Agents; Antifungal Agents; Antitubercular Agents; Antivi | 1974 |
3 trials available for trimethoprim and Infections, Pneumococcal
| Article | Year |
|---|---|
A multicenter comparative study of brodimoprim and amoxicillin therapy in the treatment of tonsillopharyngitis in adults.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Amoxicillin; Bacterial Infections; Chi | 1993 |
A double-blind comparative study of ampicillin, co-trimoxazole and josamycin in anthraco-silicotic miners, assessed by transtracheal puncture.
Topics: Ampicillin; Anthracosilicosis; Anti-Bacterial Agents; Bacterial Infections; Bronchitis; Clinical Tri | 1977 |
Comparative efficacy of ampicillin and trimethoprim-sulfamethoxazole in otitis media.
Topics: Administration, Oral; Ampicillin; Bacterial Infections; Body Weight; Child; Clinical Trials as Topic | 1975 |
16 other studies available for trimethoprim and Infections, Pneumococcal
| Article | Year |
|---|---|
Multidrug-Resistant Streptococcus pneumoniae Isolates from Healthy Ghanaian Preschool Children.
Topics: Anti-Bacterial Agents; Asymptomatic Diseases; Cefotaxime; Child; Child, Preschool; Disk Diffusion An | 2015 |
Acute otitis media caused by Streptococcus pneumoniae serotype 19A ST320 clone: epidemiological and clinical characteristics.
Topics: Adolescent; Adult; Amoxicillin; Anti-Bacterial Agents; Child; Child, Preschool; Drug Resistance, Bac | 2018 |
Community-based outbreaks in vulnerable populations of invasive infections caused by Streptococcus pneumoniae serotypes 5 and 8 in Calgary, Canada.
Topics: Alberta; Disease Outbreaks; Drug Combinations; Humans; Microbial Sensitivity Tests; Pneumococcal Inf | 2011 |
[Antibiotics-resistance pattern and genetic type of Streptococcus pneumoniae isolated from children in Hangzhou].
Topics: Anti-Bacterial Agents; Cefotaxime; Child, Preschool; China; Chloramphenicol; Drug Resistance, Bacter | 2004 |
Oropharyngeal colonization by Streptococcus pneumoniae among HIV-infected adults in Uganda: assessing prevalence and antimicrobial susceptibility.
Topics: Adult; Ambulatory Care Facilities; Anti-Infective Agents; Carrier State; Cross-Sectional Studies; Dr | 2006 |
Cotrimoxazole resistance in pneumococci.
Topics: Adult; Child; Drug Combinations; Drug Resistance, Microbial; Humans; Penicillin Resistance; Pneumoco | 1983 |
Frequency and type distribution of pneumococcal strains in the Stockholm region with resistance or reduced susceptibility to antibiotics.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Cephalosporins; Child; Child, Preschool; Chloramphen | 1984 |
Comparative susceptibilities of penicillin-resistant pneumococci to co-trimoxazole, vancomycin, rifampicin and fourteen beta-lactam antibiotics.
Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents, Urinary; beta-Lactams; Carrier State; Child; Dr | 1984 |
Sulfamethoxazole-trimethoprim-resistant pneumococcal sepsis.
Topics: Adolescent; Anemia, Aplastic; Bone Marrow Transplantation; Drug Resistance, Microbial; Female; Graft | 1982 |
Effect of Streptococcus pneumoniae and influenza A virus on middle ear antimicrobial pharmacokinetics in experimental otitis media.
Topics: Amoxicillin; Animals; Anti-Infective Agents; Chinchilla; Half-Life; Influenza A virus; Mucous Membra | 1994 |
Multiple mutations modulate the function of dihydrofolate reductase in trimethoprim-resistant Streptococcus pneumoniae.
Topics: Amino Acid Sequence; Amino Acid Substitution; Anti-Infective Agents, Urinary; Base Sequence; Drug Re | 2001 |
Use of high-dosage trimethoprim-sulfamethoxazole in sinusitis.
Topics: Adolescent; Bacteria; Bacterial Infections; Drug Combinations; Drug Evaluation; Haemophilus Infectio | 1975 |
An experimental model for measuring middle ear antimicrobial drug penetration in otitis media.
Topics: Amoxicillin; Animals; Chinchilla; Ear, Middle; Otitis Media, Suppurative; Pneumococcal Infections; S | 1990 |
Nasopharyngeal carriage of antibiotic-resistant pneumococci by children in group day care.
Topics: Amoxicillin; Carrier State; Cefuroxime; Child Day Care Centers; Child, Preschool; Drug Combinations; | 1988 |
Sepsis caused by sulfamethoxazole-trimethoprim-resistant pneumococci.
Topics: Drug Combinations; Drug Resistance, Microbial; Female; Humans; Infant; Pneumococcal Infections; Stre | 1987 |
Clinical and nasopharyngeal isolates of unusual multiply resistant pneumococci.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Child; Child Day Care Centers; Child, Preschool; Drug Resi | 1986 |