trimethoprim has been researched along with Infections, Plasmodium in 58 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Responses of parasitemia and fever in vivax malaria to standard doses of chloroquine and different dosage schedules of co-trimoxazole were compared in 165 children." | 9.05 | A comparative trial of oral chloroquine and oral co-trimoxazole in vivax malaria in children. ( Lal, H, 1982) |
| "Two field trials to detect chloroquine-resistant malaria were conducted according to WHO recommendations in a malaria free area near Rangoon." | 9.04 | Chloroquine-resistant malaria in Burma. ( Hlaing, N; Htun Nyun, R; Kyi, KK; Myint, T; Tin, F; U, T, 1975) |
| "6 out of 7 patients with severe neutropenia associated with the use of amodiaquine for malaria prophylaxis amodiaquine (400 mg weekly) plus proguanil (200 mg daily); 1 of these patients had also taken cotrimoxazole and another had taken sulphaguanidine." | 7.67 | Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria. ( Bunch, C; Edwards, G; Hatton, CS; Pasvol, G; Peto, TE; Russell, SJ; Singer, CR; Winstanley, P, 1986) |
| " Many of the thioquinazolines (VIII) showed suppressive antimalarial activity comparable with or superior to chloroquine, cycloguanil, and pyrimethamine against drug-sensitive lines of Plasmodium berghei in mice and Plasmodium gallinaceum in chicks, and several displayed potent prophylactic activity with P." | 7.66 | Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects. ( Elslager, EF; Jacob, P; Johnson, J; Rane, L; Werbel, LM; Worth, DF, 1978) |
| "Patients with enteric fever confirmed by isolation of Salmonella species from blood culture, were treated with the combination of trimethoprim-sulphamethoxazole (co-trimoxazole)." | 7.66 | Trimethoprim-sulphamethoxazole in the treatment of enteric fever in the Sudan. ( Mekki, MO; Mukhtar, ED, 1981) |
| "Malaria is still one of the most serious diseases in tropical regions." | 5.46 | A novel prediction approach for antimalarial activities of Trimethoprim, Pyrimethamine, and Cycloguanil analogues using extremely randomized trees. ( Hannongbua, S; Khamsemanan, N; Lawtrakul, L; Nattee, C; Toochinda, P, 2017) |
| "Our exploratory analyses support the hypothesis that IRS may significantly reduce malaria and preterm birth risk among pregnant women with HIV receiving bed nets, daily trimethoprim-sulfamethoxazole, and combination antiretroviral therapy." | 5.24 | Protective Effect of Indoor Residual Spraying of Insecticide on Preterm Birth Among Pregnant Women With HIV Infection in Uganda: A Secondary Data Analysis. ( Awori, P; Clark, TD; Cohan, D; Dorsey, G; Gosling, R; Havlir, DV; Jagannathan, P; Kakuru, A; Kamya, MR; Koss, CA; Muhindo, M; Nakalambe, M; Natureeba, P; Ochieng, T; Plenty, A; Roh, ME; Shiboski, S, 2017) |
| "Intermittent preventive treatment in pregnancy with sulfadoxine/pyrimethamine is contra-indicated in HIV-positive pregnant women receiving sulfamethoxazole/trimethoprim prophylaxis." | 5.22 | Pharmacokinetics of mefloquine and its effect on sulfamethoxazole and trimethoprim steady-state blood levels in intermittent preventive treatment (IPTp) of pregnant HIV-infected women in Kenya. ( Desai, M; González, R; Green, M; Kariuki, S; Katana, A; Menendez, C; Otieno, K; Ouma, P; Slutsker, L; ter Kuile, F, 2016) |
| "Responses of parasitemia and fever in vivax malaria to standard doses of chloroquine and different dosage schedules of co-trimoxazole were compared in 165 children." | 5.05 | A comparative trial of oral chloroquine and oral co-trimoxazole in vivax malaria in children. ( Lal, H, 1982) |
| "Two field trials to detect chloroquine-resistant malaria were conducted according to WHO recommendations in a malaria free area near Rangoon." | 5.04 | Chloroquine-resistant malaria in Burma. ( Hlaing, N; Htun Nyun, R; Kyi, KK; Myint, T; Tin, F; U, T, 1975) |
| "Malawian children found to be HIV-infected through VCT had a high morbidity and mortality rate, highlighting the potential benefit of trimethoprim-sulfamethizole prophylaxis and available antiretroviral therapy." | 3.73 | Observational cohort study of HIV-infected African children. ( Graham, SM; Kanyanganlika, J; Laufer, MK; Perez, MA; Plowe, CV; Taylor, TE; van Oosterhout, JJ, 2006) |
| "6 out of 7 patients with severe neutropenia associated with the use of amodiaquine for malaria prophylaxis amodiaquine (400 mg weekly) plus proguanil (200 mg daily); 1 of these patients had also taken cotrimoxazole and another had taken sulphaguanidine." | 3.67 | Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria. ( Bunch, C; Edwards, G; Hatton, CS; Pasvol, G; Peto, TE; Russell, SJ; Singer, CR; Winstanley, P, 1986) |
| " Many of the thioquinazolines (VIII) showed suppressive antimalarial activity comparable with or superior to chloroquine, cycloguanil, and pyrimethamine against drug-sensitive lines of Plasmodium berghei in mice and Plasmodium gallinaceum in chicks, and several displayed potent prophylactic activity with P." | 3.66 | Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects. ( Elslager, EF; Jacob, P; Johnson, J; Rane, L; Werbel, LM; Worth, DF, 1978) |
| "Patients with enteric fever confirmed by isolation of Salmonella species from blood culture, were treated with the combination of trimethoprim-sulphamethoxazole (co-trimoxazole)." | 3.66 | Trimethoprim-sulphamethoxazole in the treatment of enteric fever in the Sudan. ( Mekki, MO; Mukhtar, ED, 1981) |
| "As part of the search for new antimalarial drugs, a screening program was developed using sensitive and chlorguanide triazine (CGT, cycloguanil) resistant strains of the folate-requiring bacteria, Streptococcus faecium durans, Lactobacillus casei, and Pediococcus cerevisiae." | 3.65 | Antifolate studies. Activities of 40 potential antimalarial compounds against sensitive and chlorguanide triazine resistant strains of folate-requiring bacteria and Escherichia coli. ( Genther, CS; Smith, CS, 1977) |
| "Two dosage schedules of co-trimoxazole, the standard antibacterial and a 2-day high-dose schedule, were compared with a standard course of chloroquine in the treatment of uncomplicated Plasmodium falciparum malaria." | 2.65 | An evaluation of co-trimoxazole in the treatment of Plasmodium falciparum malaria. ( Hansford, CF; Hoyland, J, 1982) |
| "For the treatment of malaria, combinations of drugs with antifolic action have the great advantage, compared with other drug associations, of synergic action, which increases the effectiveness of the preparation, limits its toxicity, and reduces the risk of resistance." | 2.35 | Antifolic combinations in the treatment of malaria. ( Conno, L, 1974) |
| "Malaria is still one of the most serious diseases in tropical regions." | 1.46 | A novel prediction approach for antimalarial activities of Trimethoprim, Pyrimethamine, and Cycloguanil analogues using extremely randomized trees. ( Hannongbua, S; Khamsemanan, N; Lawtrakul, L; Nattee, C; Toochinda, P, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 51 (87.93) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (1.72) | 29.6817 |
| 2010's | 6 (10.34) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Elslager, EF | 3 |
| Davoll, J | 1 |
| Jacob, P | 3 |
| Johnson, AM | 1 |
| Johnson, J | 3 |
| Werbel, LM | 3 |
| Worth, DF | 2 |
| Rane, L | 2 |
| Hutt, MP | 1 |
| Temporelli, B | 1 |
| Genther, CS | 1 |
| Smith, CS | 1 |
| Roh, ME | 1 |
| Shiboski, S | 1 |
| Natureeba, P | 1 |
| Kakuru, A | 1 |
| Muhindo, M | 1 |
| Ochieng, T | 1 |
| Plenty, A | 1 |
| Koss, CA | 1 |
| Clark, TD | 1 |
| Awori, P | 1 |
| Nakalambe, M | 1 |
| Cohan, D | 1 |
| Jagannathan, P | 1 |
| Gosling, R | 1 |
| Havlir, DV | 1 |
| Kamya, MR | 1 |
| Dorsey, G | 1 |
| Hobbs, CV | 1 |
| Dixit, S | 1 |
| Penzak, SR | 1 |
| Sahu, T | 1 |
| Orr-Gonzalez, S | 1 |
| Lambert, L | 1 |
| Zeleski, K | 1 |
| Chen, J | 1 |
| Neal, J | 1 |
| Borkowsky, W | 1 |
| Wu, Y | 1 |
| Duffy, PE | 1 |
| Polyak, CS | 1 |
| Yuhas, K | 1 |
| Singa, B | 1 |
| Khaemba, M | 1 |
| Walson, J | 1 |
| Richardson, BA | 1 |
| John-Stewart, G | 1 |
| Green, M | 1 |
| Otieno, K | 1 |
| Katana, A | 1 |
| Slutsker, L | 1 |
| Kariuki, S | 1 |
| Ouma, P | 1 |
| González, R | 1 |
| Menendez, C | 1 |
| ter Kuile, F | 1 |
| Desai, M | 1 |
| Hawkes, N | 1 |
| Nattee, C | 1 |
| Khamsemanan, N | 1 |
| Lawtrakul, L | 1 |
| Toochinda, P | 1 |
| Hannongbua, S | 1 |
| Laufer, MK | 1 |
| van Oosterhout, JJ | 1 |
| Perez, MA | 1 |
| Kanyanganlika, J | 1 |
| Taylor, TE | 1 |
| Plowe, CV | 1 |
| Graham, SM | 1 |
| Shann, F | 1 |
| Williams, GR | 1 |
| Law, TL | 1 |
| Kennedy, DH | 1 |
| Love, WC | 1 |
| Mukhtar, ED | 1 |
| Mekki, MO | 1 |
| Höfler, W | 1 |
| Hansford, CF | 1 |
| Hoyland, J | 1 |
| Lal, H | 1 |
| Ansdell, VE | 1 |
| Wright, SG | 1 |
| Hutchinson, DB | 1 |
| Htun Nyun, R | 1 |
| Hlaing, N | 1 |
| Tin, F | 1 |
| U, T | 1 |
| Myint, T | 1 |
| Kyi, KK | 1 |
| Bruce-Chwatt, LJ | 2 |
| Wormser, GP | 1 |
| Eichenlaub, D | 1 |
| Reimann, E | 1 |
| Bunjes, R | 1 |
| Neumann, S | 1 |
| Grahlow, WD | 1 |
| Kohlmann, FW | 1 |
| Sous, H | 1 |
| Duggan, MB | 1 |
| Beyer, L | 1 |
| Rollo, IM | 1 |
| Pechere, JC | 1 |
| Davidson, DE | 1 |
| Johnsen, DO | 1 |
| Tanticharoenyos, P | 1 |
| Hickman, RL | 2 |
| Kinnamon, KE | 1 |
| Hatton, CS | 1 |
| Peto, TE | 1 |
| Bunch, C | 1 |
| Pasvol, G | 1 |
| Russell, SJ | 1 |
| Singer, CR | 1 |
| Edwards, G | 1 |
| Winstanley, P | 1 |
| Barkakaty, BN | 1 |
| Sharma, GK | 1 |
| Chakravorty, NK | 1 |
| Davis, RE | 1 |
| Yamaguchi, K | 1 |
| Koga, H | 1 |
| Kohno, S | 1 |
| Shigeno, Y | 1 |
| Suzuyama, Y | 1 |
| Hirota, M | 1 |
| Saito, A | 1 |
| Hara, K | 1 |
| Amagasaki, T | 1 |
| Iwanaga, S | 1 |
| Mittal, R | 1 |
| Chopra, A | 1 |
| Chopra, BK | 1 |
| Chen, GX | 1 |
| Mueller, C | 1 |
| Wendlinger, M | 1 |
| Zolg, JW | 1 |
| Fleming, AF | 1 |
| Warrell, DA | 1 |
| Dickmeiss, H | 1 |
| Willerson, D | 1 |
| Rieckmann, KH | 1 |
| Kass, L | 1 |
| Carson, PE | 1 |
| Frischer, H | 1 |
| Richard, L | 1 |
| Bowman, JE | 1 |
| Stogryn, EL | 1 |
| Terzian, LA | 1 |
| Stahler, N | 1 |
| Dawkins, AT | 1 |
| Balcerzak, SP | 1 |
| Arnold, JD | 1 |
| Martin, DC | 1 |
| Colwell, EJ | 4 |
| Chin, W | 1 |
| Bear, DM | 1 |
| Kosakal, S | 2 |
| Wood, A | 1 |
| Wilkinson, RN | 1 |
| Neoypatimanond, S | 1 |
| Botelho, A | 1 |
| Botha, D | 1 |
| Conno, L | 1 |
| Laing, AB | 1 |
| Donno, L | 1 |
| Catarinella, G | 1 |
| Clyde, DF | 1 |
| Miller, RM | 1 |
| Schwartz, AR | 1 |
| Levine, MM | 1 |
| Burchall, JJ | 1 |
| Hitchings, GH | 1 |
| Heischkeil, R | 1 |
| Huys, J | 1 |
| Kayihigi, J | 1 |
| Freyens, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Reducing the Burden of Malaria in HIV-Infected Pregnant Women and Their HIV-Exposed Children (PROMOTE Birth Cohort 2)[NCT02282293] | Phase 3 | 200 participants (Actual) | Interventional | 2014-12-09 | Completed | ||
| Discontinuation of Trimethoprim-sulfamethoxazole Prophylaxis in Adults on Antiretroviral Therapy in Kenya: a Randomized Trial[NCT01425073] | 500 participants (Actual) | Interventional | 2012-02-29 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Proportion with low birth weight (<2500 gm), spontaneous abortion (<28 weeks), stillbirth (fetal demise ≥28 weeks), congenital anomaly, or preterm delivery (<37 weeks) (NCT02282293)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| TS + DP Placebo Pregnancy | 15 |
| Daily TS + Monthly DP Pregnancy | 20 |
The primary outcome will be the incidence of malaria, defined as the number of incident episodes per time at risk. Incident cases will include all treatments for malaria not proceeded by another treatment in the previous 14 days. (NCT02282293)
Timeframe: Time at risk will begin following administration of first dose of study drug to delivery
| Intervention | Events per person-year (Number) |
|---|---|
| TS + DP Placebo Pregnancy | 0.03 |
| Daily TS + Monthly DP Pregnancy | 0.00 |
Proportion of monthly routine blood samples positive by LAMP for parasites (NCT02282293)
Timeframe: Following administration of first dose of study drug to delivery
| Intervention | visits with positive blood sample (Count of Units) |
|---|---|
| TS + DP Placebo Pregnancy | 12 |
| Daily TS + Monthly DP Pregnancy | 5 |
The primary outcome will be the prevalence of placental malaria based on placental histopathology and dichotomized into any evidence of placental infection (parasites or pigment) vs. no evidence of placental infection. (NCT02282293)
Timeframe: at delivery estimated to be within 10 to 30 weeks of study entry
| Intervention | Participants (Count of Participants) |
|---|---|
| TS + DP Placebo Pregnancy | 3 |
| Daily TS + Monthly DP Pregnancy | 6 |
Anemia (hemoglobin less than 11g/dL) measured every 8 weeks during pregnancy (NCT02282293)
Timeframe: Following administration of first dose of study drugs to delivery
| Intervention | Routine visit done every 8 weeks (Count of Units) |
|---|---|
| TS + DP Placebo Pregnancy | 65 |
| Daily TS + Monthly DP Pregnancy | 51 |
Proportion of women with parasitemia detected by microscopy or LAMP at delivery (NCT02282293)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| Microscopy | LAMP | |
| Daily TS + Monthly DP Pregnancy | 1 | 4 |
| TS + DP Placebo Pregnancy | 0 | 2 |
Proportion of placental blood samples positive for malaria by microscopy or PCR (NCT02282293)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| Microscopy of placental blood | LAMP analysis of placental blood | |
| Daily TS + Monthly DP Pregnancy | 1 | 3 |
| TS + DP Placebo Pregnancy | 0 | 1 |
7 reviews available for trimethoprim and Infections, Plasmodium
| Article | Year |
|---|---|
Trimethoprim-sulfamethoxazole. II. Clinical studies.
Topics: Bacterial Infections; Costs and Cost Analysis; Drug Combinations; Endocarditis, Bacterial; Female; H | 1978 |
Clinical chemistry of folic acid.
Topics: Absorption; Aged; Alcoholism; Anemia, Sickle Cell; Anticonvulsants; Arthritis, Rheumatoid; Biologica | 1986 |
A review of the drug sensitivity of Plasmodium falciparum in Thailand.
Topics: Chloroquine; Drug Resistance; Geography; Humans; Malaria; Methylamines; Naphthacenes; Plasmodium fal | 1972 |
Antifolic combinations in the treatment of malaria.
Topics: Adolescent; Adult; Child; Child, Preschool; Drug Resistance; Drug Synergism; Drug Therapy, Combinati | 1974 |
Folate antagonists as antibacterial and antiprotozoal agents.
Topics: Anti-Bacterial Agents; Antimalarials; Antiprotozoal Agents; Escherichia coli; Folic Acid Antagonists | 1971 |
Trimethoprim-sulphamethoxazole.
Topics: Animals; Anti-Bacterial Agents; Bacteria; Drug Combinations; Evaluation Studies as Topic; Female; Fo | 1971 |
Trimethoprim-sulphamethoxazole.
Topics: Animals; Anti-Bacterial Agents; Bacteria; Drug Combinations; Evaluation Studies as Topic; Female; Fo | 1971 |
9 trials available for trimethoprim and Infections, Plasmodium
| Article | Year |
|---|---|
Protective Effect of Indoor Residual Spraying of Insecticide on Preterm Birth Among Pregnant Women With HIV Infection in Uganda: A Secondary Data Analysis.
Topics: Adolescent; Adult; Anti-Retroviral Agents; Chemoprevention; Drug Combinations; Female; HIV Infection | 2017 |
Cotrimoxazole Prophylaxis Discontinuation among Antiretroviral-Treated HIV-1-Infected Adults in Kenya: A Randomized Non-inferiority Trial.
Topics: Adult; Anti-Retroviral Agents; Antimalarials; Drug Combinations; Female; HIV Infections; HIV-1; Huma | 2016 |
Pharmacokinetics of mefloquine and its effect on sulfamethoxazole and trimethoprim steady-state blood levels in intermittent preventive treatment (IPTp) of pregnant HIV-infected women in Kenya.
Topics: Adolescent; Adult; Antimalarials; Double-Blind Method; Female; HIV Infections; Humans; Kenya; Malari | 2016 |
An evaluation of co-trimoxazole in the treatment of Plasmodium falciparum malaria.
Topics: Adolescent; Adult; Antimalarials; Child; Dose-Response Relationship, Drug; Drug Combinations; Drug E | 1982 |
A comparative trial of oral chloroquine and oral co-trimoxazole in vivax malaria in children.
Topics: Administration, Oral; Child; Child, Preschool; Chloroquine; Clinical Trials as Topic; Drug Combinati | 1982 |
Chloroquine-resistant malaria in Burma.
Topics: Chloroquine; Clinical Trials as Topic; Dapsone; Drug Resistance, Microbial; Humans; Malaria; Myanmar | 1975 |
Combinations of 4-aminobenzoic acid competitors and dihydrofolate dehydrogenase inhibitors in the chemotherapy of malaria. A commentary.
Topics: Africa; Antimalarials; Asia; Chloroquine; Clinical Trials as Topic; Dapsone; Drug Evaluation; Drug R | 1974 |
Treatment of Plasmodium falciparum malaria in Cameroon with a single dose of antifolic drugs. 2. Combination of sulfametopyrazine and trimethoprim.
Topics: Adolescent; Adult; Anti-Infective Agents; Cameroon; Child; Child, Preschool; Chloroquine; Clinical T | 1971 |
Treatment of malaria with RO 6-2580.
Topics: Adolescent; Adult; Antimalarials; Female; Folic Acid Antagonists; Humans; Malaria; Male; Middle Aged | 1972 |
42 other studies available for trimethoprim and Infections, Plasmodium
| Article | Year |
|---|---|
Folate antagonists. 12. Antimalarial and antibacterial effects of 2,4-diamino-6-[(aralkyl and alicyclid)thio-, sulfinyl-, and sulfonyl]quinazolines.
Topics: Animals; Anti-Bacterial Agents; Antimalarials; Enterococcus faecalis; Folic Acid Antagonists; Malari | 1978 |
Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects.
Topics: Animals; Anti-Bacterial Agents; Antimalarials; Aotus trivirgatus; Bacteria; Chickens; Folic Acid Ant | 1978 |
Folate antagonists. 15. 2,3-Diamino-6-(2-naphthylsulfonyl)quinazoline and related 2,4-diamino-6-[(phenyl and naphthyl)sulfinyl and sulfonyl]quinazolines, a potent new class of antimetabolites with phenomenal antimalarial activity.
Topics: Animals; Antimalarials; Bacteria; Chemical Phenomena; Chemistry; Chickens; Drug Resistance; Folic Ac | 1979 |
Antifolate studies. Activities of 40 potential antimalarial compounds against sensitive and chlorguanide triazine resistant strains of folate-requiring bacteria and Escherichia coli.
Topics: Animals; Antimalarials; Bacteria; Drug Resistance, Microbial; Escherichia coli; Folic Acid; Folic Ac | 1977 |
Neither the HIV protease inhibitor lopinavir-ritonavir nor the antimicrobial trimethoprim-sulfamethoxazole prevent malaria relapse in plasmodium cynomolgi-infected non-human primates.
Topics: Animals; Antimalarials; Female; HIV Protease Inhibitors; Lopinavir; Macaca mulatta; Malaria; Male; P | 2014 |
Co-trimoxazole in addition to antiretroviral therapy may reduce malaria risk in HIV positive adults.
Topics: Anti-Retroviral Agents; Female; HIV Infections; HIV-1; Humans; Malaria; Male; Post-Exposure Prophyla | 2016 |
A novel prediction approach for antimalarial activities of Trimethoprim, Pyrimethamine, and Cycloguanil analogues using extremely randomized trees.
Topics: Antimalarials; Humans; Hydrophobic and Hydrophilic Interactions; Malaria; Models, Molecular; Plasmod | 2017 |
Observational cohort study of HIV-infected African children.
Topics: Adolescent; Africa; Child; Child, Preschool; Cohort Studies; Drug Combinations; Female; HIV; HIV Inf | 2006 |
Co-trimoxazole toxicity.
Topics: Antimalarials; Drug Combinations; Hemolysis; Humans; Infant; Infant, Newborn; Malaria; Sulfamethoxaz | 1984 |
Delayed diagnosis of malaria.
Topics: Child; Drug Combinations; Female; Humans; Malaria; Male; Middle Aged; Plasmodium falciparum; Sulfame | 1982 |
Trimethoprim-sulphamethoxazole in the treatment of enteric fever in the Sudan.
Topics: Adolescent; Adult; Drug Combinations; Female; Humans; Jaundice; Malaria; Male; Middle Aged; Sudan; S | 1981 |
[Sulfadoxine-pyrimethamine resistant falciparum malaria from Cambodia].
Topics: Child, Preschool; Drug Resistance; Female; Humans; Malaria; Plasmodium falciparum; Sulfadoxine; Trim | 1980 |
Immunizations and chemoprophylaxis for travelers.
Topics: Diarrhea; Doxycycline; Humans; Immunization; Malaria; Preventive Medicine; Sulfamethoxazole; Travel; | 1981 |
Megaloblastic anaemia associated with combined pyrimethamine and co-trimoxazole administration.
Topics: Adult; Anemia, Macrocytic; Anemia, Megaloblastic; Drug Combinations; Drug Therapy, Combination; Fema | 1976 |
Prevention and treatment of malaria.
Topics: Amodiaquine; Chloroquine; Drug Resistance; Humans; Malaria; Plasmodium falciparum; Pyrimethamine; Qu | 1977 |
[Tertian malaria in children and adults from an epidemic region in southern Turkey (author's transl)].
Topics: Adolescent; Adult; Appendicitis; Berlin; Child; Diagnosis, Differential; Disease Outbreaks; Female; | 1979 |
[Cholera today].
Topics: Acid-Base Equilibrium; Asia; Cholera; Dehydration; Diagnosis, Differential; Drug Combinations; Elect | 1979 |
[Antimicrobial action of the combination sulfamoxole/trimethoprim in vivo (author's transl)].
Topics: Animals; Bacterial Infections; Chickens; Cystitis; Drug Combinations; Female; Malaria; Malaria, Avia | 1976 |
Enteric fever in young Yoruba children.
Topics: Age Factors; Anemia; Arthritis, Infectious; Blood Transfusion; Child, Preschool; Chloramphenicol; Di | 1975 |
Antiplasmodial efficacy of 2,4--diaminopyrimidine0sylfonamide combinations, especially against chloroquine-resistant malaria.
Topics: Antimalarials; Chloroquine; Drug Combinations; Drug Evaluation, Preclinical; Drug Resistance, Microb | 1975 |
Combination chemotherapy of infectious diseases. Chairman's summing-up and conclusions.
Topics: Bacterial Infections; Bronchitis; Drug Combinations; Drug Evaluation; Dysentery, Bacillary; Female; | 1975 |
Evaluating new antimalarial drugs against trophozoite induced Plasmodium cynomolgi malaria in rhesus monkeys.
Topics: Amodiaquine; Animals; Antimalarials; Dapsone; Disease Models, Animal; Dose-Response Relationship, Dr | 1976 |
Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria.
Topics: Acute Disease; Adult; Agranulocytosis; Amodiaquine; Drug Combinations; Drug Therapy, Combination; Fe | 1986 |
Studies on efficacy of treatment with sulfamethoxazole + trimethoprim and sulfalene + pyrimethamine combinations in Plasmodium falciparum malaria of known and unknown resistant status.
Topics: Animals; Drug Evaluation; Drug Resistance, Microbial; Drug Therapy, Combination; Humans; India; Mala | 1988 |
[Clinical evaluation of SMX/TMP in treatment of patients with malaria].
Topics: Adult; Antimalarials; Drug Combinations; Humans; Malaria; Male; Plasmodium falciparum; Plasmodium vi | 1986 |
Co-trimoxazole in the treatment of malaria in psoriatics.
Topics: Drug Combinations; Humans; Malaria; Psoriasis; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfame | 1986 |
Kinetic and molecular properties of the dihydrofolate reductase from pyrimethamine-sensitive and pyrimethamine-resistant clones of the human malaria parasite Plasmodium falciparum.
Topics: Chromatography, Affinity; Drug Resistance; Folic Acid Antagonists; Humans; Kinetics; Malaria; Methot | 1987 |
Letter: Co-trimoxazole and the blood.
Topics: Administration, Oral; Adult; Anemia, Macrocytic; Blood Cell Count; Drug Therapy, Combination; Female | 1974 |
Chemotherapeutic results in a multi-drug resistant strain of Plasmodium falciparum malaria from Vietnam.
Topics: Adult; Alanine Transaminase; Anopheles; Antimalarials; Aspartate Aminotransferases; Dapsone; Drug Re | 1974 |
Synthesis of trimethoprim variations. Replacement of CH 2 by polar groupings.
Topics: Animals; Anti-Infective Agents; Antimalarials; Culicidae; Folic Acid Antagonists; Malaria; Mice; Pyr | 1972 |
Differences in drug response of the sporogonous cycles of three strains of Plasmodium falciparum in Anopheles stephensi.
Topics: Animals; Anti-Infective Agents; Antimalarials; Culicidae; Drug Resistance, Microbial; Folic Acid Ant | 1970 |
Anatomy of red cell damage by Plasmodium falciparum in man.
Topics: Erythrocytes; Humans; Malaria; Microscopy, Electron; Microscopy, Electron, Scanning; Plasmodium falc | 1972 |
A comparative evaluation of sulfalene-trimethoprim and sulphormethoxine-pyrimethamine against falciparum malaria in Thailand.
Topics: Adolescent; Adult; Anti-Infective Agents; Antibodies; Antimalarials; Drug Combinations; Evaluation S | 1973 |
Quinine-tetracycline and quinine-bactrim treatment of acute falciparum malaria in Thailand.
Topics: Adolescent; Adult; Anti-Infective Agents; Blood; Child; Drug Combinations; Folic Acid Antagonists; H | 1973 |
Therapeutic screening to differentiate malaria from other tropical syndromes.
Topics: Diagnosis, Differential; Drug Combinations; Humans; Malaria; Mozambique; Plasmodium falciparum; Sulf | 1973 |
Letter: Effect of sulphamethoxazole-trimethoprim on the viability of Plasmodium falciparum gametocytes.
Topics: Adolescent; Adult; Anopheles; Female; Humans; Insect Vectors; Malaria; Male; Middle Aged; Plasmodium | 1973 |
Considerations on the use of sulphones and sulphonamides with a pyrimidine derivative.
Topics: Adult; Amodiaquine; Child; Dapsone; Drug Combinations; Drug Resistance, Microbial; Humans; Malaria; | 1974 |
Some pharmacological aspects of antimalarial drugs.
Topics: Antimalarials; Chloroquine; Dapsone; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falcipa | 1974 |
Treatment of falciparum malaria with sulfalene and trimethoprim.
Topics: Adult; Anti-Infective Agents; Antimalarials; Drug Combinations; Drug Resistance, Microbial; Folic Ac | 1971 |
Comparative biochemistry of dihydrofolate reductase.
Topics: Animals; Anura; Biochemical Phenomena; Biochemistry; Escherichia coli; Fishes; Folic Acid Antagonist | 1971 |
[Criteria for the selection of sulfonamides for the treatment of rodent malaria (Plasmodium vinckei)].
Topics: Animals; Biomechanical Phenomena; Female; Malaria; Male; Mice; Mice, Inbred Strains; Oxazoles; Plasm | 1972 |
The role of drugs in a malaria program.
Topics: Amodiaquine; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Humans; Malaria; Primaqui | 1972 |