trimethoprim has been researched along with Infections, Klebsiella in 45 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Co-trimazine, a new combination of trimethoprim and sulphadiazine intended for treatment of urinary tract infections, was tested and compared to co-trimoxazole in an experimental model of acute, obstructive pyelonephritis in the rat." | 7.66 | Efficacy of two trimethoprim-sulphonamide combinations in experimental pyelonephritis in the rat. ( Ritzerfeld, W, 1979) |
| "Ninety patients with urinary tract infections were treated in a randomized double-blind study with either a combination of trimethoprim and sulfamethoxazole (TMP-SMX) or sulfamethoxazole alone (SMX)." | 5.04 | A comparison of trimethorprim-sulfamethoxazole with sulfamethoxazole alone in infections localized to the kidneys. ( Boutros, P; Harding, GK; Lank, B; Ronald, AR, 1975) |
| "Co-trimazine, a new combination of trimethoprim and sulphadiazine intended for treatment of urinary tract infections, was tested and compared to co-trimoxazole in an experimental model of acute, obstructive pyelonephritis in the rat." | 3.66 | Efficacy of two trimethoprim-sulphonamide combinations in experimental pyelonephritis in the rat. ( Ritzerfeld, W, 1979) |
| "Colonization of the vaginal introitus with Enterobacteriaceae was cleared dramatically in women receiving trimethoprim-sulfamethoxazole for recurrent urinary tract infections." | 3.65 | The diffusion and concentration of trimethoprim in human vaginal fluid. ( Condy, M; Stamey, TA, 1975) |
| "Endophthalmitis is a well-recognized complication of intraocular surgery, penetrating ocular trauma and systemic infection." | 1.28 | Successful treatment of metastatic endophthalmitis. Case reports. ( Lin, CL; Liu, CY; Liu, YC; Wang, FD; Wang, LS; Wong, WW, 1989) |
| "Chronic bronchitis is characterized by chronic, productive cough present on most days for at least three months of the year." | 1.27 | Chronic bronchitis. Managing the disease and related infections. ( Dines, DE, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 38 (84.44) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (2.22) | 29.6817 |
| 2010's | 5 (11.11) | 24.3611 |
| 2020's | 1 (2.22) | 2.80 |
| Authors | Studies |
|---|---|
| Carrër, A | 1 |
| Poirel, L | 1 |
| Eraksoy, H | 1 |
| Cagatay, AA | 1 |
| Badur, S | 1 |
| Nordmann, P | 1 |
| Rhee, JY | 1 |
| Park, YK | 1 |
| Shin, JY | 1 |
| Choi, JY | 1 |
| Lee, MY | 1 |
| Peck, KR | 1 |
| Song, JH | 1 |
| Ko, KS | 1 |
| Su, S | 1 |
| Li, C | 1 |
| Zhao, Y | 1 |
| Yu, L | 1 |
| Wang, Y | 2 |
| Bao, M | 1 |
| Fu, Y | 1 |
| Zhang, J | 1 |
| Zhang, X | 1 |
| Wambaugh, MA | 1 |
| Shakya, VPS | 1 |
| Lewis, AJ | 1 |
| Mulvey, MA | 1 |
| Brown, JCS | 1 |
| Chen, YT | 1 |
| Ahmad Murad, K | 1 |
| Ng, LS | 1 |
| Seah, JT | 1 |
| Park, JJ | 1 |
| Tan, TY | 1 |
| Tang, Y | 1 |
| Shen, P | 1 |
| Liang, W | 1 |
| Jin, J | 1 |
| Jiang, X | 1 |
| Schmiemann, G | 1 |
| Gágyor, I | 1 |
| Hummers-Pradier, E | 1 |
| Bleidorn, J | 1 |
| Leahy, MF | 1 |
| Humble, MW | 1 |
| Casewell, MW | 1 |
| Talsania, HG | 1 |
| Noble, RC | 1 |
| Cooper, RM | 1 |
| Jarvis, AL | 1 |
| Caples, PL | 1 |
| Todd, EP | 1 |
| Hickstein, DD | 1 |
| Dillon, JT | 1 |
| Springer, C | 1 |
| Eyal, F | 1 |
| Michel, J | 1 |
| Gates, RH | 1 |
| McCall, CE | 1 |
| Kocoshis, SA | 1 |
| Riely, CA | 1 |
| Burrell, M | 1 |
| Gryboski, JD | 1 |
| Marks, PJ | 1 |
| Bruten, DM | 2 |
| Speller, DC | 1 |
| Meares, EM | 3 |
| Altmann, G | 1 |
| Ostfeld, E | 1 |
| Zohar, S | 1 |
| Theodor, E | 1 |
| Datta, N | 1 |
| Hughes, VM | 1 |
| Nugent, ME | 1 |
| Richards, H | 1 |
| Ardati, KO | 1 |
| Thirumoorthi, MC | 1 |
| Dajani, AS | 1 |
| Ritzerfeld, W | 1 |
| Brandberg, A | 2 |
| Lindblom, GB | 1 |
| Franzén, C | 1 |
| Stamey, TA | 2 |
| Condy, M | 1 |
| Wong, CK | 1 |
| Harding, GK | 2 |
| Ronald, AR | 2 |
| Hoban, S | 1 |
| Boutros, P | 1 |
| Lank, B | 1 |
| Cox, CE | 1 |
| Drylie, DM | 1 |
| Klimberg, I | 1 |
| Childs, SJ | 1 |
| Wegenke, JD | 1 |
| Malek, GH | 1 |
| Harrison, LH | 1 |
| McCullough, DL | 1 |
| Finegold, SM | 1 |
| George, WL | 1 |
| Wang, FD | 1 |
| Wang, LS | 1 |
| Liu, YC | 1 |
| Liu, CY | 1 |
| Lin, CL | 1 |
| Wong, WW | 1 |
| Dines, DE | 1 |
| Dubini, F | 1 |
| Riviera, L | 1 |
| Visconti, A | 1 |
| Räisänen, S | 1 |
| Ylitalo, P | 1 |
| Toponen, A | 1 |
| Seppänen, J | 1 |
| Tanphaichitra, D | 1 |
| Lacey, RW | 1 |
| Gillespie, WA | 1 |
| Lewis, EL | 1 |
| Grunberg, E | 2 |
| Drach, GW | 1 |
| Hughes, DT | 1 |
| Schach, H | 1 |
| Scheidt, J | 1 |
| Neussel, H | 1 |
| Trolin, C | 1 |
| Schoutens, E | 1 |
| Yourassowsky, E | 1 |
| Hoffer, M | 1 |
| Mitrovic, M | 1 |
| Brossi, A | 1 |
| Tauchnitz, C | 1 |
| Porpáczy, P | 1 |
| Dargie, HJ | 1 |
| Allison, ME | 1 |
| McGeachie, J | 1 |
| Macdonald, GA | 1 |
| Kennedy, AC | 1 |
| Gavras, H | 1 |
| Lawson, DH | 1 |
| Linton, AL | 1 |
| Renzini, G | 1 |
| Ravagnan, G | 1 |
| Bormioli, P | 1 |
| D'Alessandro, A | 1 |
1 review available for trimethoprim and Infections, Klebsiella
| Article | Year |
|---|---|
The effect of trimethoprim on the activity of sulfonamides and antibiotics in experimental infections.
Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Bacterial Infections; Drug Synergism; Escheric | 1973 |
4 trials available for trimethoprim and Infections, Klebsiella
| Article | Year |
|---|---|
Co-trimoxazole in cases of gram-negative septicaemia.
Topics: Adolescent; Adult; Aged; Bacteroides Infections; Clinical Trials as Topic; Drug Combinations; Drug E | 1976 |
A comparison of trimethorprim-sulfamethoxazole with sulfamethoxazole alone in infections localized to the kidneys.
Topics: Administration, Oral; Adolescent; Adult; Aged; Bacterial Infections; Clinical Trials as Topic; Drug | 1975 |
A multicenter, double-blind, trimethoprim-sulfamethoxazole controlled study of enoxacin in the treatment of patients with complicated urinary tract infections.
Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Urinary; Double-Blind Method; Drug Combinatio | 1989 |
[Results of treatment with trimethoprim-sulfamethoxazole in nonspecific urinary tract infections in pediatric urology].
Topics: Adolescent; Anti-Bacterial Agents; Child; Child, Preschool; Chronic Disease; Clinical Trials as Topi | 1972 |
40 other studies available for trimethoprim and Infections, Klebsiella
| Article | Year |
|---|---|
Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey.
Topics: Bacterial Proteins; beta-Lactamases; Carbapenems; Cross Infection; Drug Resistance, Bacterial; Elect | 2008 |
KPC-producing extreme drug-resistant Klebsiella pneumoniae isolate from a patient with diabetes mellitus and chronic renal failure on hemodialysis in South Korea.
Topics: Aged; beta-Lactamases; Diabetic Nephropathies; Humans; Kidney Failure, Chronic; Klebsiella Infection | 2010 |
Outbreak of KPC-2-Producing
Topics: Adhesins, Bacterial; Aminoglycosides; Anti-Bacterial Agents; beta-Lactamases; Carbapenems; China; Co | 2020 |
High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents, Urinary; Bacterial Proteins; Biological Assay | 2017 |
In Vitro Efficacy of Six Alternative Antibiotics against Multidrug Resistant Escherichia Coli and Klebsiella Pneumoniae from Urinary Tract Infections.
Topics: Amdinocillin; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; Cefpodoxime; Ceftibuten; C | 2016 |
A putative multi-replicon plasmid co-harboring beta-lactamase genes blaKPC-2, blaCTX-M-14 and blaTEM-1 and trimethoprim resistance gene dfrA25 from a Klebsiella pneumoniae sequence type (ST) 11 strain in China.
Topics: beta-Lactam Resistance; China; Drug Resistance, Multiple, Bacterial; Humans; Klebsiella Infections; | 2017 |
Resistance profiles of urinary tract infections in general practice--an observational study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Ciprofloxacin; Drug Resistance, B | 2012 |
Outbreak of co-trimoxazole- and gentamicin-resistant Klebsiella aerogenes bacteremia in neutropenic patients receiving oral co-trimoxazole prophylaxis.
Topics: Aged; Drug Combinations; Drug Resistance, Microbial; Drug Therapy, Combination; Female; Gentamicins; | 1983 |
Multiple antibiotic resistance and capsular types of gentamicin-resistant Klebsiella aerogenes.
Topics: Anti-Bacterial Agents; Drug Resistance, Microbial; Gentamicins; Humans; Klebsiella Infections; Klebs | 1981 |
Trimethoprim-sulfamethoxazole therapy for infective endocarditis.
Topics: Acinetobacter Infections; Aneurysm, Infected; Drug Combinations; Endocarditis, Bacterial; Humans; Kl | 1981 |
Klebsiella pneumoniae meningitis. Intravenous trimethoprim-sulfamethoxazole treatment.
Topics: Adult; Cerebrospinal Fluid; Drug Resistance, Microbial; Drug Therapy, Combination; Female; Humans; H | 1982 |
Pharmacology of trimethoprim-sulfamethoxazole in newborn infants.
Topics: Drug Therapy, Combination; Half-Life; Humans; Infant, Newborn; Infant, Newborn, Diseases; Injections | 1982 |
Gram-negative bacillary meningitis.
Topics: Bacterial Infections; Drug Therapy, Combination; Humans; Klebsiella Infections; Meningitis; Sulfamet | 1982 |
Cholangitis in a child due to biliary tract anomalies.
Topics: Bile Ducts, Intrahepatic; Celiac Disease; Child, Preschool; Cholangitis; Humans; Klebsiella Infectio | 1980 |
Trimethoprim-resistant coliforms.
Topics: Cross Infection; Drug Combinations; Drug Resistance, Microbial; England; Escherichia coli; Escherich | 1977 |
Long-term therapy of chronic bacterial prostatitis with trimethoprim-sulfamethoxazole.
Topics: Acinetobacter Infections; Administration, Oral; Adult; Aged; Bacterial Infections; Body Fluids; Drug | 1975 |
Rhinoscleroma.
Topics: Adult; Humans; Klebsiella Infections; Klebsiella pneumoniae; Male; Microbial Sensitivity Tests; Resp | 1977 |
Plasmids and transposons and their stability and mutability in bacteria isolated during an outbreak of hospital infection.
Topics: Disease Outbreaks; Escherichia coli; Klebsiella; Klebsiella Infections; Phenotype; R Factors; Recomb | 1979 |
Intravenous trimethoprim-sulfamethoxazole in the treatment of serious infections in children.
Topics: Adolescent; Bacterial Infections; Child; Child, Preschool; Drug Therapy, Combination; Escherichia co | 1979 |
Efficacy of two trimethoprim-sulphonamide combinations in experimental pyelonephritis in the rat.
Topics: Animals; Disease Models, Animal; Drug Administration Schedule; Drug Combinations; Escherichia coli I | 1979 |
The resistance of 150 Klebsiella and E. coli strains isolated from patients suffering from bacteriaemia.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Drug Combinations; Drug Evaluation; Drug Resistanc | 1976 |
The diffusion and concentration of trimethoprim in human vaginal fluid.
Topics: Adult; Bacteriuria; Body Fluids; Diffusion; Dose-Response Relationship, Drug; Enterobacteriaceae; En | 1975 |
Trimethoprim-resistant Enterobacteriaceae in urinary tract infection.
Topics: Drug Combinations; Drug Resistance, Microbial; Enterobacteriaceae Infections; Escherichia coli; Esch | 1975 |
Successful treatment of metastatic endophthalmitis. Case reports.
Topics: Adult; Ceftriaxone; Endophthalmitis; Enterobacteriaceae Infections; Fluorescein Angiography; Humans; | 1989 |
Chronic bronchitis. Managing the disease and related infections.
Topics: Alcoholism; Amoxicillin; Ampicillin; Animals; Bronchitis; Bronchodilator Agents; Chronic Disease; Di | 1986 |
[Experimental cystitis in the rat and the therapeutic effect of a single dose of fosfomycin trometamol].
Topics: Animals; Cystitis; Drug Combinations; Drug Evaluation, Preclinical; Escherichia coli Infections; Fos | 1987 |
Trimethoprim and methenamine hippurate. A new theoretical combination for the treatment of urinary tract infections.
Topics: Adult; Drug Resistance, Microbial; Drug Synergism; Drug Therapy, Combination; Escherichia coli Infec | 1985 |
Kelfiprim. A new sulfa-trimethoprim combination in urinary tract infections.
Topics: Adult; Aged; Drug Combinations; Escherichia coli Infections; Female; Humans; Klebsiella Infections; | 1985 |
Trimethoprim-resistant coliforms.
Topics: Adult; Aged; Anti-Bacterial Agents; Drug Combinations; Drug Resistance, Microbial; Enterobacteriacea | 1972 |
Trimethoprim sulfamethoxazole therapy of chronic bacterial prostatitis.
Topics: Adolescent; Adult; Aged; Bacterial Infections; Candidiasis, Oral; Child; Drug Eruptions; Escherichia | 1974 |
Use of combinations of trimethoprim and sulfamethoxazole in the treatment of chest infections.
Topics: Acute Disease; Adult; Aged; Ampicillin; Bacterial Infections; Blood Cell Count; Bronchiectasis; Bron | 1973 |
The diagnosis and management of bacterial prostatitis.
Topics: Acute Disease; Bacterial Infections; Bacteriuria; Chronic Disease; Escherichia coli; Escherichia col | 1972 |
[Sensitivity of Klebsiella to antibiotics. Study of 50 strains from cases of "extra" and "intrahospital" septicemia].
Topics: Anti-Bacterial Agents; Cephalothin; Chloramphenicol; Cross Infection; Drug Resistance, Microbial; Dr | 1973 |
Prostatitis. Observations on activity of trimethoprim-sulfamethoxazole in the prostate.
Topics: Adult; Bacterial Infections; Chronic Disease; Drug Combinations; Escherichia coli Infections; Humans | 1973 |
An improved synthesis of diaveridine, trimethoprim, and closely related 2,4-diaminopyrimidines.
Topics: Administration, Oral; Animals; Anti-Infective Agents; Drug Synergism; Escherichia coli Infections; K | 1971 |
[Experiences with trimethoprim-sulfamethoxazole in the chemotherapy of bacterial infections].
Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Bacterial Infections; Bacteriuria; Bronchiectasis; B | 1970 |
[Trimethoprim and sulfamethoxazole (Eusaprim) in chronic urinary tract infections].
Topics: Aged; Anti-Bacterial Agents; Chronic Disease; Escherichia coli; Escherichia coli Infections; Folic A | 1971 |
Long-term trimethoprim-sulphamethoxazole in the management of recurrent urinary infection.
Topics: Anti-Infective Agents; Drug Combinations; Escherichia coli Infections; Female; Folic Acid Antagonist | 1971 |
Extended therapy with a trimethoprim-sulphonamide for the treatment of established urinary tract infection.
Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Drug Combinations; Drug Hypersensitivity; Escherichi | 1971 |
[Antibacterial activity in vitro and in vivo of the trimethoprim-sulphamethoxazole combination].
Topics: Animals; Anti-Bacterial Agents; Drug Combinations; Drug Resistance, Microbial; Escherichia coli; Fol | 1969 |