trimethoprim has been researched along with Infection, Toxoplasma gondii in 39 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Toxoplasmosis is known to complicate diseases with impaired cellular immunity." | 5.25 | Treatment of toxoplasmosis with trimethoprim-sulphamethoxazole. ( Eilard, T; Lycke, E; Norrby, R; Svedhem, A, 1975) |
| "A safer treatment for toxoplasmosis would be achieved by improving the selectivity and potency of dihydrofolate reductase (DHFR) inhibitors, such as pyrimethamine (1), for Toxoplasma gondii DHFR ( TgDHFR) relative to human DHFR ( hDHFR)." | 3.91 | Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis. ( Barks, J; Brockman, A; Gould, J; Hopper, AT; Radke, JB; Sibley, LD; Thomas, S; Wise, A; Zou, Y, 2019) |
| "The present chemotherapy to treat or prevent toxoplasmosis is deficient and is based on diverse drugs such as atovaquone, trimethoprim, spiramycine, which are effective in acute toxoplasmosis." | 3.01 | An updated review of chemical compounds with anti-Toxoplasma gondii activity. ( Rodriguez, JB; Szajnman, SH, 2023) |
| " Most adverse reactions that required discontinuation were seen within the first month of TMP-SMZ use and were seen more frequently and earlier in the 960-mg group (hazard ratio, 1." | 2.68 | Efficacy and toxicity of two doses of trimethoprim-sulfamethoxazole as primary prophylaxis against Pneumocystis carinii pneumonia in patients with human immunodeficiency virus. Dutch AIDS Treatment Group. ( Borleffs, JC; Eeftinck Schattenkerk, JK; Hoepelman, AI; Kolsters, AF; Nelsing, S; Nielsen, TL; Schneider, MM; van der Graaf, Y, 1995) |
| "The drugs most commonly used for treatment of toxoplasmosis combine folate inhibitors that frequently cause undesirable side effects." | 2.41 | Anti-toxoplasmosis drugs. ( Derouin, F, 2001) |
| "Five drug regimens for the treatment of acute toxoplasmosis were compared in a monkey model." | 1.27 | Five drug regimens for treatment of acute toxoplasmosis in squirrel monkeys. ( Harper, JS; London, WT; Sever, JL, 1985) |
| "Hypothetically, toxoplasmosis is a latent infection which can be activated by other diseases and by immunodepression." | 1.26 | Recurrent toxoplasmosis. ( Eilard, T; Norrby, R, 1976) |
| "Toxoplasmosis is known to complicate diseases with impaired cellular immunity." | 1.25 | Treatment of toxoplasmosis with trimethoprim-sulphamethoxazole. ( Eilard, T; Lycke, E; Norrby, R; Svedhem, A, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (69.23) | 18.7374 |
| 1990's | 4 (10.26) | 18.2507 |
| 2000's | 3 (7.69) | 29.6817 |
| 2010's | 3 (7.69) | 24.3611 |
| 2020's | 2 (5.13) | 2.80 |
| Authors | Studies |
|---|---|
| Piper, JR | 1 |
| Johnson, CA | 1 |
| Krauth, CA | 1 |
| Carter, RL | 1 |
| Hosmer, CA | 1 |
| Queener, SF | 2 |
| Borotz, SE | 1 |
| Pfefferkorn, ER | 1 |
| Gangjee, A | 1 |
| Adair, OO | 1 |
| Hopper, AT | 1 |
| Brockman, A | 1 |
| Wise, A | 1 |
| Gould, J | 1 |
| Barks, J | 1 |
| Radke, JB | 1 |
| Sibley, LD | 1 |
| Zou, Y | 1 |
| Thomas, S | 1 |
| Washino, T | 1 |
| Mikita, K | 1 |
| Kosaka, A | 1 |
| Sakamoto, N | 1 |
| Iwabuchi, S | 1 |
| Nakamura-Uchiyama, F | 1 |
| Rodriguez, JB | 1 |
| Szajnman, SH | 1 |
| Chorlton, SD | 1 |
| Bousquet, A | 1 |
| Bigaillon, C | 1 |
| Dumitrescu, N | 1 |
| Larréché, S | 1 |
| Godreuil, C | 1 |
| Mestiri, R | 1 |
| Le Caruyer, N | 1 |
| Mérens, A | 1 |
| Andriamanantena, D | 1 |
| Peterson, PK | 1 |
| Simmons, RL | 1 |
| Nguyen, BT | 2 |
| Stadtsbaeder, S | 2 |
| Harpey, JP | 1 |
| Veron, P | 1 |
| Hirsch, R | 1 |
| Burke, BA | 1 |
| Kersey, JH | 1 |
| Deroń, Z | 1 |
| Jabłkowski, M | 1 |
| Carosi, G | 1 |
| Ghezzi, L | 1 |
| Minoli, L | 1 |
| Parisi, A | 1 |
| Maccabruni, A | 1 |
| Remington, JS | 1 |
| Schneider, MM | 1 |
| Nielsen, TL | 1 |
| Nelsing, S | 1 |
| Hoepelman, AI | 1 |
| Eeftinck Schattenkerk, JK | 1 |
| van der Graaf, Y | 1 |
| Kolsters, AF | 1 |
| Borleffs, JC | 1 |
| Ajisawa, A | 1 |
| Asencio Marchante, R | 1 |
| Lissen Otero, E | 1 |
| Derouin, F | 1 |
| Horvat, F | 1 |
| Kouba, K | 1 |
| Nevarilová, A | 1 |
| Rajlichová, J | 1 |
| Ryning, FW | 1 |
| Mills, J | 1 |
| Hof, H | 1 |
| Nye, FJ | 1 |
| Williams, M | 1 |
| Savage, DC | 1 |
| Menter, MA | 1 |
| Morrison, JG | 1 |
| Norrby, R | 2 |
| Eilard, T | 2 |
| Svedhem, A | 1 |
| Lycke, E | 1 |
| Werner, H | 1 |
| Egger, I | 1 |
| Soma, K | 1 |
| Teklu, B | 1 |
| Nur, MA | 1 |
| Abdullah, M | 1 |
| Vukmirovits, G | 1 |
| Juhász, P | 1 |
| Jankó, M | 1 |
| Tóth, L | 1 |
| Cohn, JA | 1 |
| McMeeking, A | 1 |
| Cohen, W | 1 |
| Jacobs, J | 1 |
| Holzman, RS | 1 |
| Santana, JL | 1 |
| Ramírez-Ronda, CH | 1 |
| Young, LS | 1 |
| Harper, JS | 1 |
| London, WT | 1 |
| Sever, JL | 1 |
| Terragna, A | 1 |
| Domart, A | 1 |
| Robineau, M | 1 |
| Carbon, C | 1 |
| Feldman, HA | 1 |
| Lafrenz, M | 1 |
| Ziegler, K | 1 |
| Sänger, R | 1 |
| Budde, E | 1 |
| Naumann, G | 1 |
4 reviews available for trimethoprim and Infection, Toxoplasma gondii
| Article | Year |
|---|---|
Disseminated Toxoplasmosis associated with Haemophagocytic Lymphohistiocytosis in a Patient with the Human Immunodeficiency Virus: A Case Report and Literature Review.
Topics: Adult; Clindamycin; Female; HIV; HIV Infections; Humans; Lymphohistiocytosis, Hemophagocytic; Sulfam | 2022 |
An updated review of chemical compounds with anti-Toxoplasma gondii activity.
Topics: Animals; Atovaquone; Female; Humans; Mammals; Pregnancy; Toxoplasma; Toxoplasmosis; Trimethoprim | 2023 |
Toxoplasma gondii and schizophrenia: a review of published RCTs.
Topics: Antiparasitic Agents; Artemether; Artemisinins; Brain; Genotype; Humans; Randomized Controlled Trial | 2017 |
Anti-toxoplasmosis drugs.
Topics: Animals; Anti-Bacterial Agents; Drug Combinations; Folic Acid Antagonists; Humans; Macrolides; Pyrim | 2001 |
1 trial available for trimethoprim and Infection, Toxoplasma gondii
| Article | Year |
|---|---|
Efficacy and toxicity of two doses of trimethoprim-sulfamethoxazole as primary prophylaxis against Pneumocystis carinii pneumonia in patients with human immunodeficiency virus. Dutch AIDS Treatment Group.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Dose-Response Relationship, Drug; Humans; Middle Ag | 1995 |
34 other studies available for trimethoprim and Infection, Toxoplasma gondii
| Article | Year |
|---|---|
Lipophilic antifolates as agents against opportunistic infections. 1. Agents superior to trimetrexate and piritrexim against Toxoplasma gondii and Pneumocystis carinii in in vitro evaluations.
Topics: Animals; Anti-Infective Agents; Folic Acid Antagonists; Opportunistic Infections; Pneumocystis; Pneu | 1996 |
Synthesis and biological evaluation of 2,4-diamino-6-(arylaminomethyl)pyrido[2,3-d]pyrimidines as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase and as antiopportunistic infection and antitumor agents.
Topics: Animals; Anti-Infective Agents; Antineoplastic Agents; Cell Line; Cell Line, Tumor; Cricetinae; Drug | 2003 |
Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis.
Topics: Animals; Antiparasitic Agents; Dogs; Female; Folic Acid Antagonists; Humans; Madin Darby Canine Kidn | 2019 |
Acute myocarditis in an immunocompetent young man: Don't forget Toxoplasma gondii.
Topics: Catheter-Related Infections; Diagnosis, Differential; Humans; Magnetic Resonance Imaging, Cine; Male | 2016 |
Infectious diseases in renal allograft recipients: new developments in therapy and prevention.
Topics: Acyclovir; Bacterial Infections; Cryptococcosis; Cytomegalovirus Infections; Drug Combinations; Huma | 1984 |
[Therapeutic future of trimethoprim-sulfamethoxazole in toxoplasmosis].
Topics: Animals; Drug Combinations; Female; Humans; Mice; Pregnancy; Sulfamethoxazole; Toxoplasmosis; Toxopl | 1983 |
[Treatment of toxoplasmosis with trimethoprim-sulfamethoxazole].
Topics: Drug Combinations; Female; Humans; Pregnancy; Pregnancy Complications, Infectious; Sulfamethoxazole; | 1983 |
Toxoplasmosis in bone marrow transplant recipients.
Topics: Adolescent; Bone Marrow Transplantation; Child; Drug Combinations; Humans; Immunosuppression Therapy | 1984 |
[Side effects of toxoplasmosis treatment].
Topics: Adolescent; Adult; Anemia; Antiprotozoal Agents; Child; Child, Preschool; Drug Eruptions; Dyspepsia; | 1980 |
Diagnostic protocols for lymphoglandular toxoplasmosis.
Topics: Adolescent; Adult; Antibodies; Child; Female; Fluorescent Antibody Technique; Hemagglutination Tests | 1981 |
Acquired toxoplasmosis in children.
Topics: Child; Drug Combinations; Humans; Sulfamethoxazole; Toxoplasmosis; Trimethoprim | 1980 |
[Protozoan infections in AIDS].
Topics: Acquired Immunodeficiency Syndrome; Administration, Inhalation; AIDS-Related Opportunistic Infection | 1993 |
[Secondary prevention of opportunistic infections in HIV-infected patients].
Topics: AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Anti-Infective Agents; Antiprotozoal A | 2001 |
Fluorescence and electron microscope studies on the interaction between lysosomes of mammalian host-cells and Toxoplasma gondii RH following treatment with cotrimoxazole [proceedings].
Topics: Animals; Drug Combinations; Lysosomes; Sulfamethoxazole; Time Factors; Toxoplasma; Toxoplasmosis; Tr | 1978 |
[Septrin in therapy of human toxoplasmosis (author's transl)].
Topics: Adult; Drug Combinations; Female; Humans; Male; Middle Aged; Sulfamethoxazole; Toxoplasmosis; Trimet | 1978 |
Pneumocystis carinii, Toxoplasma gondii, Cytomegalovirus and the compromised host.
Topics: Adolescent; Adult; Animals; Cats; Child; Child, Preschool; Cytomegalovirus Infections; Female; Human | 1979 |
[Toxoplasma gondii. Infection and its prevention].
Topics: Animals; Antibody Formation; Cats; Chorioretinitis; Chronic Disease; Complement Fixation Tests; Dise | 1978 |
Treating toxoplasmosis.
Topics: Drug Therapy, Combination; Humans; Leucomycins; Pyrimethamine; Sulfonamides; Tetracyclines; Toxoplas | 1979 |
Acquired toxoplasmosis in children.
Topics: Child; Drug Combinations; Female; Humans; Sulfamethoxazole; Toxoplasmosis; Trimethoprim | 1978 |
Lichen verrucosus et reticularis of Kaposi (porokeratosis striata of Nékam): a manifestation of acquired adult toxoplasmosis.
Topics: Adult; Drug Combinations; Female; Humans; Kaposi Varicelliform Eruption; Male; Pyrimethamine; Sulfad | 1976 |
Recurrent toxoplasmosis.
Topics: Adult; Drug Combinations; Female; Humans; Recurrence; Sulfamethoxazole; Toxoplasmosis; Trimethoprim | 1976 |
Treatment of toxoplasmosis with trimethoprim-sulphamethoxazole.
Topics: Adolescent; Adult; Child, Preschool; Chorioretinitis; Drug Therapy, Combination; Female; Follow-Up S | 1975 |
[Comparative Chemotherapeutical studies on the effect of Bactrim and other combined preparations on the proliferative and cystforming phase of Toxoplasma gondii in NMRI mice. A contribution to experimental chemotherapy of toxoplasmosis (author's transl)].
Topics: Acute Disease; Animals; Chronic Disease; Drug Combinations; Drug Evaluation; Drug Synergism; Female; | 1975 |
[Diagnosis and therapy of parasitic lung diseases].
Topics: Humans; Lung Diseases, Parasitic; Pentamidine; Pneumocystis; Pneumonia, Pneumocystis; Pyrimethamine; | 1991 |
Two fevers with a common etiology.
Topics: Adult; Aged; Anti-Infective Agents; Diagnosis, Differential; Drug Combinations; Female; Fever of Unk | 1989 |
Acute monosymptomatic aseptic meningitis caused by Toxoplasma gondii.
Topics: Acute Disease; Child, Preschool; Drug Combinations; Folic Acid; Humans; Male; Meningitis; Meningitis | 1985 |
Evaluation of the policy of empiric treatment of suspected Toxoplasma encephalitis in patients with the acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; Biopsy; Brain; Clindamycin; Encephalitis; Female; Humans; | 1989 |
[The pregnant woman infected with the human immunodeficiency virus: recommendations for her management].
Topics: Acquired Immunodeficiency Syndrome; Candidiasis; Cytomegalovirus Infections; Female; Humans; Ketocon | 1988 |
Management of opportunistic infections complicating the acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; Candidiasis; Cryptococcosis; Drug Combinations; Humans; I | 1986 |
Five drug regimens for treatment of acute toxoplasmosis in squirrel monkeys.
Topics: Animals; Clindamycin; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Leuco | 1985 |
[Lymph-node toxoplasmosis: recent clinical, diagnostic and therapeutic acquisitions].
Topics: Anti-Infective Agents; Diagnosis, Differential; Folic Acid Antagonists; Humans; Infectious Mononucle | 1972 |
[Acquired toxoplasmosis: a new chemotherapy: the sulfamethoxazole-trimethoprim combination].
Topics: Administration, Oral; Anti-Infective Agents; Drug Combinations; Female; Humans; Male; Pregnancy; Pro | 1973 |
Effects of trimethoprim and sulfisoxazole alone and in combination on murine toxoplasmosis.
Topics: Animals; Female; Male; Mice; Sulfisoxazole; Toxoplasmosis; Trimethoprim | 1973 |
[New aspects of the treatment of toxoplasmosis (author's transl)].
Topics: Animals; Antibodies; Drug Therapy, Combination; Female; Germany, East; Humans; Male; Mice; Serologic | 1973 |