trimethoprim has been researched along with Hyperkalemia in 22 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
Hyperkalemia: Abnormally high potassium concentration in the blood, most often due to defective renal excretion. It is characterized clinically by electrocardiographic abnormalities (elevated T waves and depressed P waves, and eventually by atrial asystole). In severe cases, weakness and flaccid paralysis may occur. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Trimethoprim therapy can cause hyperkalemia and is often coprescribed with angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs)." | 7.76 | Trimethoprim-sulfamethoxazole-induced hyperkalemia in patients receiving inhibitors of the renin-angiotensin system: a population-based study. ( Antoniou, T; Glazier, RH; Gomes, T; Juurlink, DN; Loutfy, MR; Mamdani, MM, 2010) |
| "1) To determine the incidence and severity of hyperkalemia during trimethoprim therapy." | 7.68 | Renal mechanism of trimethoprim-induced hyperkalemia. ( Ellison, DH; Perazella, MA; Velázquez, H; Wright, FS, 1993) |
| "Trimethoprim therapy can cause hyperkalemia and is often coprescribed with angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs)." | 3.76 | Trimethoprim-sulfamethoxazole-induced hyperkalemia in patients receiving inhibitors of the renin-angiotensin system: a population-based study. ( Antoniou, T; Glazier, RH; Gomes, T; Juurlink, DN; Loutfy, MR; Mamdani, MM, 2010) |
| "In this study, the membrane mechanisms of hyperkalemia caused by trimethoprim-sulfamethoxazole (TMP-SMX) combination antibiotics were assessed in the cortical collecting duct (CCD)." | 3.73 | Effect of trimethoprim-sulfamethoxazole on Na and K+ transport properties in the rabbit cortical collecting duct perfused in vitro. ( Fujimura, A; Kusano, E; Miyata, Y; Muto, S; Tsuruoka, S, 2006) |
| " We describe what we believe to be the first reported case of life-threatening hyperkalemia presenting as an ascending paralysis which was associated with standard-dose trimethoprim-sulfamethoxazole therapy." | 3.70 | Hyperkalemic ascending paralysis. ( Fairweather, P; Jagoda, A; McCarty, M, 1998) |
| "High-dose trimethoprim-sulfamethoxazole (TMP-SMX) causes hyperkalemia, thought to result from TMP-induced blockade of amiloride-sensitive Na(+)-channels in the distal nephron." | 3.69 | Reversal of trimethoprim-induced antikaliuresis. ( Brown, MI; Chou, SY; Porush, JG; Reiser, IW, 1996) |
| "1) To determine the incidence and severity of hyperkalemia during trimethoprim therapy." | 3.68 | Renal mechanism of trimethoprim-induced hyperkalemia. ( Ellison, DH; Perazella, MA; Velázquez, H; Wright, FS, 1993) |
| "Trimethoprim was found to reduce renal potassium excretion through the competitive inhibition of epithelial sodium channels in the distal nephron, in a manner identical to the potassium-sparing diuretic amiloride." | 2.41 | Trimethoprim-induced hyperkalaemia: clinical data, mechanism, prevention and management. ( Perazella, MA, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.55) | 18.7374 |
| 1990's | 11 (50.00) | 18.2507 |
| 2000's | 4 (18.18) | 29.6817 |
| 2010's | 4 (18.18) | 24.3611 |
| 2020's | 2 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Faré, PB | 2 |
| Memoli, E | 2 |
| Treglia, G | 1 |
| Bianchetti, MG | 2 |
| Milani, GP | 2 |
| Marchisio, P | 1 |
| Lava, SAG | 1 |
| Janett, S | 1 |
| Camozzi, P | 1 |
| Simonetti, GD | 1 |
| Lava, SA | 1 |
| Gbinigie, O | 1 |
| Du Plooy, N | 1 |
| Rayner, B | 1 |
| Jolobe, O | 1 |
| Antoniou, T | 1 |
| Gomes, T | 1 |
| Juurlink, DN | 1 |
| Loutfy, MR | 1 |
| Glazier, RH | 1 |
| Mamdani, MM | 1 |
| Bonatti, HJ | 1 |
| Colon, N | 1 |
| Ott, M | 1 |
| Morris, JA | 1 |
| Miller, RS | 1 |
| Riordan, WP | 1 |
| May, AK | 1 |
| Hauben, M | 1 |
| Muto, S | 1 |
| Tsuruoka, S | 1 |
| Miyata, Y | 1 |
| Fujimura, A | 1 |
| Kusano, E | 1 |
| Smith, GW | 1 |
| Cohen, SB | 1 |
| Schreiber, M | 1 |
| Halperin, ML | 1 |
| Velázquez, H | 1 |
| Perazella, MA | 2 |
| Wright, FS | 1 |
| Ellison, DH | 1 |
| Choi, MJ | 1 |
| Fernandez, PC | 1 |
| Patnaik, A | 1 |
| Coupaye-Gerard, B | 1 |
| D'Andrea, D | 1 |
| Szerlip, H | 1 |
| Kleyman, TR | 1 |
| Eiam-Ong, S | 1 |
| Kurtzman, NA | 1 |
| Sabatini, S | 1 |
| Thomas, RJ | 1 |
| Reiser, IW | 1 |
| Chou, SY | 1 |
| Brown, MI | 1 |
| Porush, JG | 1 |
| Jolobe, OM | 1 |
| McCarty, M | 1 |
| Jagoda, A | 1 |
| Fairweather, P | 1 |
| Siamopoulos, KC | 1 |
| Elisaf, M | 1 |
| Katopodis, K | 1 |
| Gabriëls, G | 1 |
| Stockem, E | 1 |
| Greven, J | 1 |
| Blaser, KU | 1 |
| Lämmle, B | 1 |
4 reviews available for trimethoprim and Hyperkalemia
| Article | Year |
|---|---|
Trimethoprim-associated hyperkalaemia: a systematic review and meta-analysis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diuretics; Humans; Hyperkalemia; Potassium; Trimethoprim; U | 2022 |
Trimethoprim-associated electrolyte and acid-base abnormalities.
Topics: Acidosis; Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Urinary; Bicarbonates; Diabetes Com | 2021 |
[Hyperkalemia after trimethoprim or pentamidine. Until now, a little noticed side effect of antimicrobial therapeutic measures in AIDS patients].
Topics: AIDS-Related Opportunistic Infections; Anti-Infective Agents; Antiprotozoal Agents; Folic Acid Antag | 1998 |
Trimethoprim-induced hyperkalaemia: clinical data, mechanism, prevention and management.
Topics: Aged; Anti-Infective Agents, Urinary; Dose-Response Relationship, Drug; Humans; Hyperkalemia; Kidney | 2000 |
18 other studies available for trimethoprim and Hyperkalemia
| Article | Year |
|---|---|
Trimethoprim is associated with a greater risk of acute kidney injury and hyperkalaemia in older adults compared with other antibiotics used to treat UTIs.
Topics: Acute Kidney Injury; Aged; Anti-Bacterial Agents; Cohort Studies; Humans; Hyperkalemia; Trimethoprim | 2018 |
Life-threatening hyperkalaemia due to trimethoprim in a patient treated for Pneumocystis jirovecii pneumonia.
Topics: AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Female; HIV Infections; Humans; Hyperk | 2019 |
Can pharmacists help prevent adverse drug interaction from newly prescribed drugs?
Topics: Angiotensin-Converting Enzyme Inhibitors; Drug Interactions; Humans; Hyperkalemia; Pharmaceutical Se | 2009 |
Trimethoprim-sulfamethoxazole-induced hyperkalemia in patients receiving inhibitors of the renin-angiotensin system: a population-based study.
Topics: Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhi | 2010 |
Trimethoprim-associated hyperkalemia in a young trauma victim.
Topics: Acinetobacter baumannii; Adult; Anti-Bacterial Agents; Female; Humans; Hyperkalemia; Pneumonia, Bact | 2011 |
Trimethoprim-induced hyperkalaemia -- lessons in data mining.
Topics: Data Collection; Humans; Hyperkalemia; Trimethoprim | 2004 |
Effect of trimethoprim-sulfamethoxazole on Na and K+ transport properties in the rabbit cortical collecting duct perfused in vitro.
Topics: Animals; Biological Transport, Active; Cell Membrane; Cells, Cultured; Dose-Response Relationship, D | 2006 |
Hyperkalaemia and non-oliguric renal failure associated with trimethoprim.
Topics: Acute Kidney Injury; Aged; Female; Humans; Hyperkalemia; Trimethoprim; Urinary Tract Infections | 1994 |
Urea excretion rate as a contributor to trimethoprim-induced hyperkalemia.
Topics: Humans; Hyperkalemia; Trimethoprim; Urea | 1994 |
Renal mechanism of trimethoprim-induced hyperkalemia.
Topics: AIDS-Related Opportunistic Infections; Animals; Humans; Hyperkalemia; Kidney; Kidney Tubules, Distal | 1993 |
Brief report: trimethoprim-induced hyperkalemia in a patient with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Animals; Cell Line; Drug Therapy, Combination; Electrophysiology | 1993 |
Studies on the mechanism of trimethoprim-induced hyperkalemia.
Topics: Adenosine Triphosphatases; Animals; Anti-Infective Agents; Hyperkalemia; Infusions, Intravenous; Inj | 1996 |
Hyperkalemia and trimethoprim-sulfamethoxazole.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Anti-Infective Agents; Antihypertensive Agents; Drug | 1996 |
Reversal of trimethoprim-induced antikaliuresis.
Topics: Animals; Anti-Infective Agents, Urinary; Blood Pressure; Dogs; Female; Furosemide; Hydrogen-Ion Conc | 1996 |
Severe hyperkalaemia induced by trimethoprim in combination with an angiotensin-converting enzyme inhibitor in a patient with transplanted lungs.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Anti-Infective Agents, Urinary; Antihypertensive Age | 1997 |
Hyperkalemic ascending paralysis.
Topics: Adult; Anti-Infective Agents, Urinary; Diagnosis, Differential; Electrocardiography; Humans; Hyperka | 1998 |
Iatrogenic hyperkalaemia--points to consider in diagnosis and management.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Diuretics; Female; Humans; Hyperkalemia; Hypolipidem | 1998 |
[Acute hyperkalemia and non-oliguric kidney failure during treatment with indomethacin, allopurinol, nifedipine, hydrochlorothiazide/amiloride, trimethoprim/sulfamethoxazole and acetylsalicylic acid].
Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Allopurinol; Amiloride; Aspirin; Drug Combinations; Dr | 1988 |