trimethoprim has been researched along with Hematologic Diseases in 20 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
Hematologic Diseases: Disorders of the blood and blood forming tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To ascertain the efficacy and toxicity of trimethoprim-sulfamethoxazole or pentamidine when either is given alone during the entire treatment period for Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome (AIDS)." | 9.06 | Trimethoprim-sulfamethoxazole compared with pentamidine for treatment of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. A prospective, noncrossover study. ( Cowan, R; Nielsen, DM; Ruskin, J; Sattler, FR, 1988) |
| "To ascertain the efficacy and toxicity of trimethoprim-sulfamethoxazole or pentamidine when either is given alone during the entire treatment period for Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome (AIDS)." | 5.06 | Trimethoprim-sulfamethoxazole compared with pentamidine for treatment of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. A prospective, noncrossover study. ( Cowan, R; Nielsen, DM; Ruskin, J; Sattler, FR, 1988) |
| "Whipple's disease is a systemic bacterial infection that once was uniformly fatal and now is treatable with several different antibiotics in most cases." | 2.37 | Whipple's disease. ( Feldman, M, 1986) |
| "12 AIDS/ARC patients with or suspected of Pneumocystis carinii pneumonia were treated with co-trimoxazole and received supplementary folic or folinic acid to avoid peripheral blood cytopenia." | 1.27 | Effect of folic and folinic acid on cytopenia occurring during co-trimoxazole treatment of Pneumocystis carinii pneumonia. ( Bygbjerg, IC; Hørding, M; Lund, JT, 1988) |
| " Long-term administration does not per se seem to represent an additional hazard provided the dose is the correct one and the hematologic monitoring of the patient is performed regularly." | 1.25 | Adverse reactions to trimethoprim-sulfamethoxazole, with particular reference to long-term therapy. ( Bernstein, LS, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (90.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kinzie, BJ | 1 |
| Taylor, JW | 1 |
| Gualtieri, RJ | 1 |
| Donowitz, GR | 1 |
| Kaiser, DL | 1 |
| Hess, CE | 1 |
| Sande, MA | 1 |
| Jick, H | 1 |
| Derby, LE | 1 |
| Bernstein, LS | 1 |
| Audebert, A | 1 |
| Zittoun, J | 1 |
| Zittoun, R | 1 |
| Bousser, J | 1 |
| Ryckelynck, JP | 1 |
| Potier, J | 1 |
| Beuve-Mery, P | 1 |
| Juul, P | 1 |
| Smellie, JM | 1 |
| Grüneberg, RN | 1 |
| Leakey, A | 1 |
| Atkin, WS | 1 |
| Moriuchi, Y | 1 |
| Kamihira, S | 1 |
| Satoh, T | 1 |
| Yanagisako, T | 1 |
| Miyazaki, Y | 1 |
| Nagai, K | 1 |
| Murata, K | 1 |
| Tokunaga, S | 1 |
| Maeda, T | 1 |
| Atogami, S | 1 |
| Feldman, M | 1 |
| Funada, H | 1 |
| Sattler, FR | 1 |
| Cowan, R | 1 |
| Nielsen, DM | 1 |
| Ruskin, J | 1 |
| Bygbjerg, IC | 1 |
| Lund, JT | 1 |
| Hørding, M | 1 |
| Salter, AJ | 1 |
| Casey, TP | 1 |
| Matthews, JR | 1 |
| Buchanan, JG | 1 |
| Brumfitt, W | 1 |
| Pursell, R | 1 |
| van Hove, W | 1 |
| Hamers, J | 1 |
| Vermeulen, A | 1 |
| Maier, C | 1 |
| Heer, HR | 1 |
2 reviews available for trimethoprim and Hematologic Diseases
| Article | Year |
|---|---|
Whipple's disease.
Topics: Bacterial Infections; Diagnosis, Differential; Drug Combinations; Eye Diseases; Heart Diseases; Hema | 1986 |
[Prophylactic administration of antimicrobiological agents and reflection thereon--prevention of infections in hematologic diseases and malignancies].
Topics: Agranulocytosis; Drug Combinations; Hematologic Diseases; Humans; Infection Control; Neoplasms; Pati | 1986 |
3 trials available for trimethoprim and Hematologic Diseases
| Article | Year |
|---|---|
Double-blind randomized study of prophylactic trimethoprim/sulfamethoxazole in granulocytopenic patients with hematologic malignancies.
Topics: Adolescent; Adult; Aged; Agranulocytosis; Clinical Trials as Topic; Double-Blind Method; Drug Therap | 1983 |
Trimethoprim-sulfamethoxazole compared with pentamidine for treatment of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. A prospective, noncrossover study.
Topics: Acquired Immunodeficiency Syndrome; Adult; Amidines; Drug Combinations; Hematologic Diseases; Humans | 1988 |
Trimethoprim-sulfamethoxazole in the treatment of bacteriuria in women.
Topics: Abnormalities, Drug-Induced; Ambulatory Care; Ampicillin; Bacteriuria; Cephalexin; Clinical Trials a | 1973 |
15 other studies available for trimethoprim and Hematologic Diseases
| Article | Year |
|---|---|
Trimethoprim and folinic acid.
Topics: Drug Therapy, Combination; Hematologic Diseases; Humans; Leucovorin; Trimethoprim | 1984 |
Is co-trimoxazole safe?
Topics: Cephalexin; Chemical and Drug Induced Liver Injury; Follow-Up Studies; Hematologic Diseases; Humans; | 1995 |
Adverse reactions to trimethoprim-sulfamethoxazole, with particular reference to long-term therapy.
Topics: Adult; Aged; Bacterial Infections; Blood Cell Count; Blood Cells; Blood Platelets; Child; Drug Combi | 1975 |
[Macrocytic animia due to the combination trimethoprim-sulfamethoxazole].
Topics: Adult; Alcoholism; Anemia, Macrocytic; Anti-Infective Agents; Drug Therapy, Combination; Female; Fol | 1975 |
[Bone marrow toxicity of a combination of thiamphenicol and trimethoprim-sulfamethoxazole].
Topics: Aged; Bone Marrow; Drug Therapy, Combination; Female; Hematologic Diseases; Humans; Sulfamethoxazole | 1979 |
[Adverse effects of treatment with sulfamethoxazole and trimethoprim. Report to the Adverse Drug Reaction Committee of the National Board of Health and Welfare].
Topics: Aged; Chemical and Drug Induced Liver Injury; Denmark; Drug Combinations; Drug Hypersensitivity; Fem | 1977 |
Long-term low-dose co-trimoxazole in prophylaxis of childhood urinary tract infection: clinical aspects.
Topics: Child; Child, Preschool; Drug Combinations; Female; Follow-Up Studies; Hematologic Diseases; Humans; | 1976 |
[Infection prophylaxis in patients with hematological malignancies (I)--Successful prophylaxis of Pneumocystis carinii pneumonitis with sulfamethoxazole-trimethoprim].
Topics: Administration, Oral; Adult; Aged; Child; Drug Combinations; Hematologic Diseases; Humans; Middle Ag | 1990 |
Effect of folic and folinic acid on cytopenia occurring during co-trimoxazole treatment of Pneumocystis carinii pneumonia.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Anemia; Drug Combinations; Folic Acid; Hem | 1988 |
Trimethoprim-sulfamethoxazole and folinic acid.
Topics: Drug Combinations; Hematologic Diseases; Humans; Leucovorin; Sulfamethoxazole; Trimethoprim; Trimeth | 1985 |
CSM update. Blood dyscrasias.
Topics: Adult; Age Factors; Aged; Drug Combinations; Drug-Related Side Effects and Adverse Reactions; Hemato | 1985 |
The toxicity profile of trimethoprim-sulphamethoxazole after four years of widespread use.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Animals; Anti-Infective Agents; Child; Child, Presch | 1973 |
Adverse haematological effects and trimethoprim-sulphamethoxazole administration.
Topics: Aged; Agranulocytosis; Anemia; Child; Drug Combinations; Female; Hematologic Diseases; Humans; Male; | 1973 |
[Hematological effects of trimethoprim-sulfamethoxazole].
Topics: Blood Cell Count; Blood Cells; Bone Marrow; Bone Marrow Cells; Hematologic Diseases; Humans; Sulfame | 1973 |
[Studies on the hematologic tolerance of Bactrim].
Topics: Anti-Infective Agents; Erythrocytes; Folic Acid Antagonists; Folic Acid Deficiency; Hematologic Dise | 1972 |