trimethoprim has been researched along with HIV Coinfection in 31 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
| Excerpt | Relevance | Reference |
|---|---|---|
| "PCP prophylaxis with trimethoprim/sulfamethoxazole does not significantly influence the rate of bacteriuria, probably due to the development of resistance." | 7.69 | The influence of PCP prophylaxis on bacteriuria incidence and resistance development to trimethoprim/sulfamethoxazole in HIV-infected patients. ( Borleffs, JC; Hoepelman, AI; Schneider, MM; van Dooyeweert, DA, 1996) |
| "Our exploratory analyses support the hypothesis that IRS may significantly reduce malaria and preterm birth risk among pregnant women with HIV receiving bed nets, daily trimethoprim-sulfamethoxazole, and combination antiretroviral therapy." | 5.24 | Protective Effect of Indoor Residual Spraying of Insecticide on Preterm Birth Among Pregnant Women With HIV Infection in Uganda: A Secondary Data Analysis. ( Awori, P; Clark, TD; Cohan, D; Dorsey, G; Gosling, R; Havlir, DV; Jagannathan, P; Kakuru, A; Kamya, MR; Koss, CA; Muhindo, M; Nakalambe, M; Natureeba, P; Ochieng, T; Plenty, A; Roh, ME; Shiboski, S, 2017) |
| "Intermittent preventive treatment in pregnancy with sulfadoxine/pyrimethamine is contra-indicated in HIV-positive pregnant women receiving sulfamethoxazole/trimethoprim prophylaxis." | 5.22 | Pharmacokinetics of mefloquine and its effect on sulfamethoxazole and trimethoprim steady-state blood levels in intermittent preventive treatment (IPTp) of pregnant HIV-infected women in Kenya. ( Desai, M; González, R; Green, M; Kariuki, S; Katana, A; Menendez, C; Otieno, K; Ouma, P; Slutsker, L; ter Kuile, F, 2016) |
| "Malawian children found to be HIV-infected through VCT had a high morbidity and mortality rate, highlighting the potential benefit of trimethoprim-sulfamethizole prophylaxis and available antiretroviral therapy." | 3.73 | Observational cohort study of HIV-infected African children. ( Graham, SM; Kanyanganlika, J; Laufer, MK; Perez, MA; Plowe, CV; Taylor, TE; van Oosterhout, JJ, 2006) |
| " Treatment failure rates for culture-proven chancroid were 19% for trimethoprim-sulfamethoxazole, 12." | 3.69 | Sexually transmitted diseases and human immunodeficiency virus control in Malawi: a field study of genital ulcer disease. ( Behets, FM; Cohen, MS; Dallabetta, G; Hamilton, HA; Hoffman, IF; Liomba, G; Lule, G; Moeng, S, 1995) |
| "PCP prophylaxis with trimethoprim/sulfamethoxazole does not significantly influence the rate of bacteriuria, probably due to the development of resistance." | 3.69 | The influence of PCP prophylaxis on bacteriuria incidence and resistance development to trimethoprim/sulfamethoxazole in HIV-infected patients. ( Borleffs, JC; Hoepelman, AI; Schneider, MM; van Dooyeweert, DA, 1996) |
| "The onset of cutaneous adverse effects attributable to sulfamethoxazole-trimethoprim therapy within 3 months after desensitization." | 2.68 | Efficacy and safety of desensitization with sulfamethoxazole and trimethoprim in 48 previously hypersensitive patients infected with human immunodeficiency virus. ( Bricaire, F; Caumes, E; Guermonprez, G; Katlama, C; Lecomte, C, 1997) |
| "Here we determined the prevalence of G6PD deficiency and the occurrence of G6PD-related hemolytic events in a large cohort of patients." | 1.36 | Prevalence of G6PD deficiency in a large cohort of HIV-infected patients. ( Giordano, TP; Serpa, JA; Villarreal-Williams, E, 2010) |
| "aureus bacteremia were compared against 188 controls selected from patients with CD4 cell counts < 200 x 10(6)/l." | 1.30 | Prior antimicrobials and staphylococcal bacteremia in HIV-infected patients. ( Chaisson, RE; Moore, RD; Styrt, BA, 1997) |
| " The mean time to first side effect was 12." | 1.29 | Crossover of human immunodeficiency virus-infected patients from aerosolized pentamidine to trimethoprim-sulfamethoxazole: lack of hematologic toxicity and relationship of side effects to CD4+ lymphocyte count. ( Anderson, MD; Kennedy, CA; Lewis, DE; Oldfield, EC; Pimentel, JA; Weiss, PJ, 1993) |
| "Major aphthous ulcers are associated with a high degree of morbidity in patients infected with human immunodeficiency virus." | 1.29 | Major aphthous ulcers in patients with HIV disease. ( Glick, M; Muzyka, BC, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 15 (48.39) | 18.2507 |
| 2000's | 4 (12.90) | 29.6817 |
| 2010's | 10 (32.26) | 24.3611 |
| 2020's | 2 (6.45) | 2.80 |
| Authors | Studies |
|---|---|
| Washino, T | 1 |
| Mikita, K | 1 |
| Kosaka, A | 1 |
| Sakamoto, N | 1 |
| Iwabuchi, S | 1 |
| Nakamura-Uchiyama, F | 1 |
| Nibamureke, UMC | 1 |
| Wagenaar, GM | 1 |
| Roh, ME | 1 |
| Shiboski, S | 1 |
| Natureeba, P | 1 |
| Kakuru, A | 1 |
| Muhindo, M | 1 |
| Ochieng, T | 1 |
| Plenty, A | 1 |
| Koss, CA | 1 |
| Clark, TD | 1 |
| Awori, P | 1 |
| Nakalambe, M | 1 |
| Cohan, D | 1 |
| Jagannathan, P | 1 |
| Gosling, R | 1 |
| Havlir, DV | 1 |
| Kamya, MR | 1 |
| Dorsey, G | 1 |
| Du Plooy, N | 1 |
| Rayner, B | 1 |
| Parker, SR | 1 |
| Correnti, C | 1 |
| Sikora, K | 1 |
| Parker, DC | 1 |
| Polyak, CS | 1 |
| Yuhas, K | 1 |
| Singa, B | 1 |
| Khaemba, M | 1 |
| Walson, J | 1 |
| Richardson, BA | 1 |
| John-Stewart, G | 1 |
| Green, M | 1 |
| Otieno, K | 1 |
| Katana, A | 1 |
| Slutsker, L | 1 |
| Kariuki, S | 1 |
| Ouma, P | 1 |
| González, R | 1 |
| Menendez, C | 1 |
| ter Kuile, F | 1 |
| Desai, M | 1 |
| Hawkes, N | 1 |
| Suárez, I | 1 |
| Roderus, L | 1 |
| van Gumpel, E | 1 |
| Jung, N | 1 |
| Lehmann, C | 1 |
| Fätkenheuer, G | 1 |
| Hartmann, P | 1 |
| Plum, G | 1 |
| Rybniker, J | 1 |
| Serpa, JA | 1 |
| Villarreal-Williams, E | 1 |
| Giordano, TP | 1 |
| Moon, SM | 1 |
| Kim, T | 1 |
| Sung, H | 1 |
| Kim, MN | 1 |
| Kim, SH | 1 |
| Choi, SH | 1 |
| Jeong, JY | 1 |
| Woo, JH | 1 |
| Kim, YS | 1 |
| Lee, SO | 1 |
| Mutua, FM | 1 |
| M'imunya, JM | 1 |
| Wiysonge, CS | 1 |
| Doczeova, A | 1 |
| Kolenova, A | 1 |
| Beno, P | 1 |
| Liskova, A | 1 |
| Stanova, A | 1 |
| Krcmery, V | 1 |
| Laufer, MK | 1 |
| van Oosterhout, JJ | 1 |
| Perez, MA | 1 |
| Kanyanganlika, J | 1 |
| Taylor, TE | 1 |
| Plowe, CV | 1 |
| Graham, SM | 1 |
| Bellamy, R | 1 |
| Blossom, DB | 1 |
| Namayanja-Kaye, G | 1 |
| Nankya-Mutyoba, J | 1 |
| Mukasa, JB | 1 |
| Bakka, H | 1 |
| Rwambuya, S | 1 |
| Windau, A | 1 |
| Bajaksouzian, S | 1 |
| Walker, CJ | 1 |
| Joloba, ML | 1 |
| Kityo, C | 1 |
| Mugyenyi, P | 1 |
| Whalen, CC | 1 |
| Jacobs, MR | 1 |
| Salata, RA | 1 |
| Ruga, E | 1 |
| Giaquinto, C | 1 |
| Cozzani, S | 1 |
| Giacomelli, A | 1 |
| Pagliaro, A | 1 |
| Mazza, A | 1 |
| De Manzini, A | 1 |
| Laverda, AM | 1 |
| D'Elia, R | 1 |
| Behets, FM | 1 |
| Liomba, G | 1 |
| Lule, G | 1 |
| Dallabetta, G | 1 |
| Hoffman, IF | 1 |
| Hamilton, HA | 1 |
| Moeng, S | 1 |
| Cohen, MS | 1 |
| Kennedy, CA | 1 |
| Pimentel, JA | 1 |
| Lewis, DE | 1 |
| Anderson, MD | 1 |
| Weiss, PJ | 1 |
| Oldfield, EC | 1 |
| Muzyka, BC | 1 |
| Glick, M | 1 |
| Lang, W | 1 |
| Osmond, D | 1 |
| Page-Bodkin, K | 1 |
| Moss, A | 1 |
| Winkelstein, W | 1 |
| van Dooyeweert, DA | 1 |
| Schneider, MM | 1 |
| Borleffs, JC | 1 |
| Hoepelman, AI | 1 |
| Caumes, E | 1 |
| Guermonprez, G | 1 |
| Lecomte, C | 1 |
| Katlama, C | 1 |
| Bricaire, F | 1 |
| Styrt, BA | 1 |
| Chaisson, RE | 1 |
| Moore, RD | 1 |
| Rich, JD | 1 |
| Sullivan, T | 1 |
| Greineder, D | 1 |
| Kazanjian, PH | 1 |
| Lehmann, DF | 1 |
| Newman, N | 1 |
| Morse, PD | 1 |
| Chan, C | 1 |
| Montaner, J | 1 |
| Lefebvre, EA | 1 |
| Morey, G | 1 |
| Dohn, M | 1 |
| McIvor, RA | 1 |
| Scott, J | 1 |
| Marina, R | 1 |
| Caldwell, P | 1 |
| Chatton, JY | 1 |
| Munafo, A | 1 |
| Chave, JP | 1 |
| Steinhäuslin, F | 1 |
| Roch-Ramel, F | 1 |
| Glauser, MP | 1 |
| Biollaz, J | 1 |
| Holdcroft, CJ | 1 |
| Ellison, RT | 1 |
| Costantino, M | 1 |
| Stein, DS | 1 |
| Stevens, RC | 1 |
| Terry, D | 1 |
| Laizure, SC | 1 |
| Palte, S | 1 |
| Lancaster, DJ | 1 |
| Weems, JJ | 1 |
| Williams, CL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Reducing the Burden of Malaria in HIV-Infected Pregnant Women and Their HIV-Exposed Children (PROMOTE Birth Cohort 2)[NCT02282293] | Phase 3 | 200 participants (Actual) | Interventional | 2014-12-09 | Completed | ||
| Discontinuation of Trimethoprim-sulfamethoxazole Prophylaxis in Adults on Antiretroviral Therapy in Kenya: a Randomized Trial[NCT01425073] | 500 participants (Actual) | Interventional | 2012-02-29 | Completed | |||
| A Randomized, Open-Label Trial of High Dose Atovaquone Versus Low Dose Atovaquone Versus Aerosolized Pentamidine for Prophylaxis of Pneumocystis Carinii Pneumonia in Patients With HIV Infection Who Are Intolerant of TMP/SMX[NCT00002340] | Phase 3 | 615 participants | Interventional | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Proportion with low birth weight (<2500 gm), spontaneous abortion (<28 weeks), stillbirth (fetal demise ≥28 weeks), congenital anomaly, or preterm delivery (<37 weeks) (NCT02282293)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| TS + DP Placebo Pregnancy | 15 |
| Daily TS + Monthly DP Pregnancy | 20 |
The primary outcome will be the incidence of malaria, defined as the number of incident episodes per time at risk. Incident cases will include all treatments for malaria not proceeded by another treatment in the previous 14 days. (NCT02282293)
Timeframe: Time at risk will begin following administration of first dose of study drug to delivery
| Intervention | Events per person-year (Number) |
|---|---|
| TS + DP Placebo Pregnancy | 0.03 |
| Daily TS + Monthly DP Pregnancy | 0.00 |
Proportion of monthly routine blood samples positive by LAMP for parasites (NCT02282293)
Timeframe: Following administration of first dose of study drug to delivery
| Intervention | visits with positive blood sample (Count of Units) |
|---|---|
| TS + DP Placebo Pregnancy | 12 |
| Daily TS + Monthly DP Pregnancy | 5 |
The primary outcome will be the prevalence of placental malaria based on placental histopathology and dichotomized into any evidence of placental infection (parasites or pigment) vs. no evidence of placental infection. (NCT02282293)
Timeframe: at delivery estimated to be within 10 to 30 weeks of study entry
| Intervention | Participants (Count of Participants) |
|---|---|
| TS + DP Placebo Pregnancy | 3 |
| Daily TS + Monthly DP Pregnancy | 6 |
Anemia (hemoglobin less than 11g/dL) measured every 8 weeks during pregnancy (NCT02282293)
Timeframe: Following administration of first dose of study drugs to delivery
| Intervention | Routine visit done every 8 weeks (Count of Units) |
|---|---|
| TS + DP Placebo Pregnancy | 65 |
| Daily TS + Monthly DP Pregnancy | 51 |
Proportion of women with parasitemia detected by microscopy or LAMP at delivery (NCT02282293)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| Microscopy | LAMP | |
| Daily TS + Monthly DP Pregnancy | 1 | 4 |
| TS + DP Placebo Pregnancy | 0 | 2 |
Proportion of placental blood samples positive for malaria by microscopy or PCR (NCT02282293)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| Microscopy of placental blood | LAMP analysis of placental blood | |
| Daily TS + Monthly DP Pregnancy | 1 | 3 |
| TS + DP Placebo Pregnancy | 0 | 1 |
4 reviews available for trimethoprim and HIV Coinfection
| Article | Year |
|---|---|
Disseminated Toxoplasmosis associated with Haemophagocytic Lymphohistiocytosis in a Patient with the Human Immunodeficiency Virus: A Case Report and Literature Review.
Topics: Adult; Clindamycin; Female; HIV; HIV Infections; Humans; Lymphohistiocytosis, Hemophagocytic; Sulfam | 2022 |
Genital ulcer disease treatment for reducing sexual acquisition of HIV.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Azithromycin; Chancroid; Female; Fleroxacin; HIV Infec | 2012 |
Pneumocystis pneumonia in people with HIV.
Topics: Anti-Infective Agents; Antiprotozoal Agents; Atovaquone; Clindamycin; Dapsone; Drug Therapy, Combina | 2006 |
The use of antibiotics in the treatment and prevention of infection in HIV-infected children.
Topics: AIDS-Related Opportunistic Infections; Child; Clinical Trials as Topic; Drug Therapy, Combination; H | 1994 |
8 trials available for trimethoprim and HIV Coinfection
| Article | Year |
|---|---|
Protective Effect of Indoor Residual Spraying of Insecticide on Preterm Birth Among Pregnant Women With HIV Infection in Uganda: A Secondary Data Analysis.
Topics: Adolescent; Adult; Anti-Retroviral Agents; Chemoprevention; Drug Combinations; Female; HIV Infection | 2017 |
Cotrimoxazole Prophylaxis Discontinuation among Antiretroviral-Treated HIV-1-Infected Adults in Kenya: A Randomized Non-inferiority Trial.
Topics: Adult; Anti-Retroviral Agents; Antimalarials; Drug Combinations; Female; HIV Infections; HIV-1; Huma | 2016 |
Pharmacokinetics of mefloquine and its effect on sulfamethoxazole and trimethoprim steady-state blood levels in intermittent preventive treatment (IPTp) of pregnant HIV-infected women in Kenya.
Topics: Adolescent; Adult; Antimalarials; Double-Blind Method; Female; HIV Infections; Humans; Kenya; Malari | 2016 |
Efficacy and safety of desensitization with sulfamethoxazole and trimethoprim in 48 previously hypersensitive patients infected with human immunodeficiency virus.
Topics: Adult; Anti-Infective Agents; Desensitization, Immunologic; Drug Administration Schedule; Drug Erupt | 1997 |
The effect of cimetidine on the formation of sulfamethoxazole hydroxylamine in patients with human immunodeficiency virus.
Topics: Adult; Anti-Infective Agents; Anti-Ulcer Agents; Antibiotic Prophylaxis; Cimetidine; Double-Blind Me | 1998 |
Atovaquone suspension compared with aerosolized pentamidine for prevention of Pneumocystis carinii pneumonia in human immunodeficiency virus-infected subjects intolerant of trimethoprim or sulfonamides.
Topics: Adult; Aged; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Antifungal Agents; Atovaq | 1999 |
Trimethoprim, alone or in combination with sulphamethoxazole, decreases the renal excretion of zidovudine and its glucuronide.
Topics: Adult; Drug Interactions; Female; HIV Infections; Humans; Infusions, Intravenous; Male; Trimethoprim | 1992 |
Use of low-dose trimethoprim-sulfamethoxazole thrice weekly for primary and secondary prophylaxis of Pneumocystis carinii pneumonia in human immunodeficiency virus-infected patients.
Topics: Adult; Chromatography, High Pressure Liquid; Complement C4; Drug Administration Schedule; Female; HI | 1991 |
19 other studies available for trimethoprim and HIV Coinfection
| Article | Year |
|---|---|
Histopathological changes in Oreochromis mossambicus (Peters, 1852) ovaries after a chronic exposure to a mixture of the HIV drug nevirapine and the antibiotics sulfamethoxazole and trimethoprim.
Topics: Africa; Animals; Anti-Bacterial Agents; COVID-19; Female; HIV Infections; Humans; Nevirapine; Ovary; | 2021 |
Life-threatening hyperkalaemia due to trimethoprim in a patient treated for Pneumocystis jirovecii pneumonia.
Topics: AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Female; HIV Infections; Humans; Hyperk | 2019 |
Seronegative syphilis: another case for the great imitator.
Topics: Adult; HIV Infections; Humans; Male; Sulfamethoxazole; Syphilis; Treatment Outcome; Treponema; Trime | 2014 |
Co-trimoxazole in addition to antiretroviral therapy may reduce malaria risk in HIV positive adults.
Topics: Anti-Retroviral Agents; Female; HIV Infections; HIV-1; Humans; Malaria; Male; Post-Exposure Prophyla | 2016 |
Low prevalence of DHFR and DHPS mutations in Pneumocystis jirovecii strains obtained from a German cohort.
Topics: Anti-Infective Agents; Dihydropteroate Synthase; Drug Resistance, Bacterial; Female; Fungal Proteins | 2017 |
Prevalence of G6PD deficiency in a large cohort of HIV-infected patients.
Topics: Adult; Aged; Anemia, Hemolytic; Anti-Infective Agents; Black or African American; Cohort Studies; Da | 2010 |
Outcomes of moderate-to-severe Pneumocystis pneumonia treated with adjunctive steroid in non-HIV-infected patients.
Topics: Adrenal Cortex Hormones; Adult; Aged; Antifungal Agents; Drug Combinations; Drug Therapy, Combinatio | 2011 |
Antifungal and antibacterial resistance profiles between Cambodia and Kenyan children with human immunodeficiency virus infections receiving trimethoprim-sulfamethoxazole prophylaxis.
Topics: Bacteria; Bacterial Infections; Cambodia; Child; Colony Count, Microbial; Drug Combinations; Drug Re | 2005 |
Observational cohort study of HIV-infected African children.
Topics: Adolescent; Africa; Child; Child, Preschool; Cohort Studies; Drug Combinations; Female; HIV; HIV Inf | 2006 |
Oropharyngeal colonization by Streptococcus pneumoniae among HIV-infected adults in Uganda: assessing prevalence and antimicrobial susceptibility.
Topics: Adult; Ambulatory Care Facilities; Anti-Infective Agents; Carrier State; Cross-Sectional Studies; Dr | 2006 |
Sexually transmitted diseases and human immunodeficiency virus control in Malawi: a field study of genital ulcer disease.
Topics: Chancroid; Ciprofloxacin; Erythromycin; Genital Diseases, Male; HIV Infections; Humans; Malawi; Male | 1995 |
Crossover of human immunodeficiency virus-infected patients from aerosolized pentamidine to trimethoprim-sulfamethoxazole: lack of hematologic toxicity and relationship of side effects to CD4+ lymphocyte count.
Topics: Adult; Aerosols; Aged; CD4-Positive T-Lymphocytes; Drug Combinations; Female; HIV Infections; Humans | 1993 |
Major aphthous ulcers in patients with HIV disease.
Topics: Adult; Biomarkers; CD4-CD8 Ratio; Dapsone; Ethnicity; Female; HIV Infections; Humans; Immune Toleran | 1994 |
Population-based estimates of antiretroviral therapy and anti-Pneumocystis prophylaxis in San Francisco: 1991.
Topics: AIDS-Related Opportunistic Infections; Anti-Infective Agents; Antiviral Agents; Cohort Studies; Daps | 1993 |
The influence of PCP prophylaxis on bacteriuria incidence and resistance development to trimethoprim/sulfamethoxazole in HIV-infected patients.
Topics: Bacteriuria; Drug Resistance, Microbial; Drug Therapy, Combination; HIV Infections; Humans; Male; Pn | 1996 |
Prior antimicrobials and staphylococcal bacteremia in HIV-infected patients.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Bacteremia; Case-Control Studie | 1997 |
Trimethoprim/sulfamethoxazole incremental dose regimen in human immunodeficiency virus-infected persons.
Topics: Administration, Oral; Adult; CD4-Positive T-Lymphocytes; Dose-Response Relationship, Drug; Drug Admi | 1997 |
Trimethoprim-sulfamethoxazole reaction simulating Pneumocystis carinii pneumonia.
Topics: Diagnosis, Differential; Drug Combinations; HIV Infections; Humans; Hypoxia; Male; Middle Aged; Oppo | 1991 |
[Some aspects of the treatment of HIV infection].
Topics: Acquired Immunodeficiency Syndrome; Clindamycin; Dapsone; HIV Infections; Humans; Primaquine; Trimet | 1991 |