trimethoprim has been researched along with Graft-Versus-Host Disease in 6 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Skin and cerebral dissemination of nocardiosis was observed and TMP/SMZ doses were increased." | 1.30 | Clinical features and successful recovery from disseminated nocardiosis after BMT. ( Castelli, JB; Chamone, DF; Dulley, FL; Macedo, MC; Machado, CM; Massumoto, C; Ostronoff, M; Silva, AC; Zambon, E, 1997) |
| "We report a case of late cerebral toxoplasmosis reactivation, which was probably triggered by a brief course of corticosteroids, administered for chronic graft-versus-host disease (cGVHD)." | 1.30 | Cerebral toxoplasmosis - a late complication of allogeneic haematopoietic stem cell transplantation. ( Cernelc, P; Mlakar, U; Pretnar, J; Zver, S, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Winston, DJ | 1 |
| Ho, WG | 1 |
| Champlin, RE | 1 |
| Gale, RP | 1 |
| Machado, CM | 1 |
| Macedo, MC | 1 |
| Castelli, JB | 1 |
| Ostronoff, M | 1 |
| Silva, AC | 1 |
| Zambon, E | 1 |
| Massumoto, C | 1 |
| Chamone, DF | 1 |
| Dulley, FL | 1 |
| Wu, D | 1 |
| Hockenberry, DM | 1 |
| Brentnall, TA | 1 |
| Baehr, PH | 1 |
| Ponec, RJ | 1 |
| Kuver, R | 1 |
| Tzung, SP | 1 |
| Todaro, JL | 1 |
| McDonald, GB | 1 |
| Zver, S | 1 |
| Cernelc, P | 1 |
| Mlakar, U | 1 |
| Pretnar, J | 1 |
| Vasconcelles, MJ | 1 |
| Bernardo, MV | 1 |
| King, C | 1 |
| Weller, EA | 1 |
| Antin, JH | 1 |
| First, LR | 1 |
| Smith, BR | 1 |
| Lipton, J | 1 |
| Nathan, DG | 1 |
| Parkman, R | 1 |
| Rappeport, JM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Azacitidine (AZA) Combined With N-Acetyl-L-cysteine (NAC) for Prolonged Isolated Thrombocytopenia (PIT) After Hematopoietic Stem Cell Transplantation (HSCT)[NCT05126004] | Phase 2 | 100 participants (Anticipated) | Interventional | 2021-12-01 | Not yet recruiting | ||
| A Prospective Study of Patients With Isolated Thrombocytopenia Following Hematopoietic Stem Cell Transplantation[NCT02487563] | Phase 3 | 97 participants (Actual) | Interventional | 2015-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The total number of megakaryocytes as well as the platelet-shedding megakaryocytes of bone marrow smears (per cm2) was counted and cross-checked by blinded observers. (NCT02487563)
Timeframe: Up to 4 weeks after the treatment
| Intervention | cells/cm^2 (Median) |
|---|---|
| Experimental Group 1 | 6.7 |
| Experimental Group 2 | 7.5 |
| Control Group | 3.3 |
Platelet response refers to a sustained increase (stable or increasing level) of at least 30×10E9/L independent of transfusion for 3 days. (NCT02487563)
Timeframe: Up to 4 weeks after the treatment
| Intervention | Participants (Count of Participants) |
|---|---|
| Experimental Group 1 | 20 |
| Experimental Group 2 | 22 |
| Control Group | 6 |
1 review available for trimethoprim and Graft-Versus-Host Disease
| Article | Year |
|---|---|
Infectious complications of bone marrow transplantation.
Topics: Aminoglycosides; Amphotericin B; Anemia, Aplastic; Bacterial Infections; Bone Marrow Transplantation | 1984 |
1 trial available for trimethoprim and Graft-Versus-Host Disease
| Article | Year |
|---|---|
Aerosolized pentamidine as pneumocystis prophylaxis after bone marrow transplantation is inferior to other regimens and is associated with decreased survival and an increased risk of other infections.
Topics: Administration, Inhalation; Adolescent; Adult; Aerosol Propellants; Aged; Antifungal Agents; Bone Ma | 2000 |
4 other studies available for trimethoprim and Graft-Versus-Host Disease
| Article | Year |
|---|---|
Clinical features and successful recovery from disseminated nocardiosis after BMT.
Topics: Anti-Bacterial Agents; Anti-Infective Agents, Urinary; Bone Marrow Transplantation; Graft vs Host Di | 1997 |
Persistent nausea and anorexia after marrow transplantation: a prospective study of 78 patients.
Topics: Adolescent; Adult; Anorexia; Anti-Infective Agents; Bone Marrow Transplantation; Child; Child, Presc | 1998 |
Cerebral toxoplasmosis - a late complication of allogeneic haematopoietic stem cell transplantation.
Topics: Adrenal Cortex Hormones; Adult; Animals; Female; Graft vs Host Disease; Hematopoietic Stem Cell Tran | 1999 |
Isolated thrombocytopenia after allogeneic bone marrow transplantation: existence of transient and chronic thrombocytopenic syndromes.
Topics: Actuarial Analysis; Adolescent; Adult; Azathioprine; Bone Marrow; Bone Marrow Transplantation; Child | 1985 |
Isolated thrombocytopenia after allogeneic bone marrow transplantation: existence of transient and chronic thrombocytopenic syndromes.
Topics: Actuarial Analysis; Adolescent; Adult; Azathioprine; Bone Marrow; Bone Marrow Transplantation; Child | 1985 |
Isolated thrombocytopenia after allogeneic bone marrow transplantation: existence of transient and chronic thrombocytopenic syndromes.
Topics: Actuarial Analysis; Adolescent; Adult; Azathioprine; Bone Marrow; Bone Marrow Transplantation; Child | 1985 |
Isolated thrombocytopenia after allogeneic bone marrow transplantation: existence of transient and chronic thrombocytopenic syndromes.
Topics: Actuarial Analysis; Adolescent; Adult; Azathioprine; Bone Marrow; Bone Marrow Transplantation; Child | 1985 |