trimethoprim has been researched along with Germinoblastoma in 15 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In an attempt to reduce the incidence of fever and infection, we randomized patients with cancer to receive trimethoprim/sulfamethoxazole plus erythromycin (TMP/SMX + E) versus placebos after each cycle of chemotherapy (no crossover) and to continue until granulocytopenia (polymorphonuclear leukocytes less than 500/mm3) resolved or the patient became febrile." | 5.05 | Oral antibiotic prophylaxis in patients with cancer: a double-blind randomized placebo-controlled trial. ( Edwards, BK; Johnson, A; Kramer, BS; Pizzo, PA; Robichaud, KJ; Schumaker, C, 1983) |
| " The panel members discussed the use of valacyclovir (Valtrex) to provide prophylaxis for herpes zoster, trimethoprim/sulfamethoxazole for Pneumocystis, and acyclovir (Zovirax) for varicella zoster." | 3.70 | Infectious complications of pentostatin therapy. ( Cabanillas, F; Dang, N; Drapkin, R; Foss, F; O'Brien, S; Vose, JM, 2000) |
| "Continuous infusion of amikacin, cotrimoxazole and carbenicillin was the second empirically established combination of antibiotics used when fever occurred during the induction phase of chemotherapy in sixty-five patients (58 acute myeloid leukemias, 5 acute lymphoid leukemias, 2 non Hodgkin lymphomas)." | 3.66 | [An empirical combination of antibiotics used in aplasias during chemotherapy for acute malignant hemopathies (author's transl)]. ( Bryon, PA; Coiffier, B; Extra, JM; Ffrench, M; Fiere, D; Gonnaud, P; Guyotat, D; Imbert, C; Rebattu, P; Viala, JJ; Vuvan, H, 1982) |
| "carinii pneumonia secondary to AIDS and to other known causes of immune deficiency were enrolled." | 1.27 | Assessment of therapy for pneumocystis carinii pneumonia. PCP Therapy Project Group. ( Haverkos, HW, 1984) |
| "Between 1976 and 1983, 53 cases of Pneumocystis carinii pneumonia were documented at the Mayo Clinic." | 1.27 | Pneumocystis carinii pneumonia. Review of 53 cases. ( Peters, SG; Prakash, UB, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (86.67) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fiere, D | 1 |
| Vuvan, H | 1 |
| Guyotat, D | 1 |
| Ffrench, M | 1 |
| Gonnaud, P | 1 |
| Extra, JM | 1 |
| Imbert, C | 1 |
| Coiffier, B | 1 |
| Bryon, PA | 1 |
| Rebattu, P | 1 |
| Viala, JJ | 1 |
| Pizzo, PA | 1 |
| Robichaud, KJ | 1 |
| Edwards, BK | 1 |
| Schumaker, C | 1 |
| Kramer, BS | 1 |
| Johnson, A | 1 |
| Haverkos, HW | 1 |
| Baccanari, DP | 1 |
| Daluge, S | 1 |
| King, RW | 1 |
| Scaglione, C | 1 |
| Tormena, AM | 1 |
| Pavlovsky, S | 1 |
| Vose, JM | 1 |
| Cabanillas, F | 1 |
| O'Brien, S | 1 |
| Dang, N | 1 |
| Drapkin, R | 1 |
| Foss, F | 1 |
| Laugier, P | 1 |
| Olmos, L | 1 |
| Tuan, IZ | 1 |
| Dennison, D | 1 |
| Weisdorf, DJ | 1 |
| Kortsik, CS | 1 |
| Heine, M | 1 |
| Staedt, U | 1 |
| Kirschstein, W | 1 |
| Gladisch, R | 1 |
| Peters, SG | 1 |
| Prakash, UB | 1 |
| Magyar, T | 1 |
| Graber, H | 1 |
| Arr, M | 1 |
| Csiba, A | 1 |
| Kelemen, E | 1 |
| Péterfy, M | 1 |
| Jánossa, M | 1 |
| Nishimoto, K | 1 |
| Ohno, M | 1 |
| Noto, N | 1 |
| Sugaya, N | 1 |
| Wakabayashi, Y | 1 |
| Hirose, S | 1 |
| Spiers, AS | 1 |
| Tattersall, MH | 1 |
| Gaya, H | 1 |
| Terragna, A | 1 |
2 trials available for trimethoprim and Germinoblastoma
| Article | Year |
|---|---|
Oral antibiotic prophylaxis in patients with cancer: a double-blind randomized placebo-controlled trial.
Topics: Adolescent; Adult; Agranulocytosis; Bacterial Infections; Child; Child, Preschool; Clinical Trials a | 1983 |
[Prophylactic controlled trials with cotrimoxazole in afebrile neutropenic patients with malignant hemopathies].
Topics: Adult; Agranulocytosis; Child; Clinical Trials as Topic; Drug Combinations; Fever; Humans; Infection | 1982 |
13 other studies available for trimethoprim and Germinoblastoma
| Article | Year |
|---|---|
[An empirical combination of antibiotics used in aplasias during chemotherapy for acute malignant hemopathies (author's transl)].
Topics: Adult; Aged; Amikacin; Anti-Bacterial Agents; Bacterial Infections; Carbenicillin; Drug Combinations | 1982 |
Assessment of therapy for pneumocystis carinii pneumonia. PCP Therapy Project Group.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Aged; Amidines; Drug Combinations; Female; Hu | 1984 |
Inhibition of dihydrofolate reductase: effect of reduced nicotinamide adenine dinucleotide phosphate on the selectivity and affinity of diaminobenzylpyrimidines.
Topics: Anti-Bacterial Agents; Escherichia coli; Folic Acid Antagonists; Kinetics; Lacticaseibacillus casei; | 1982 |
Infectious complications of pentostatin therapy.
Topics: Acyclovir; Anti-Infective Agents; Anti-Infective Agents, Urinary; Antibiotics, Antineoplastic; Antib | 2000 |
[Drug induced pseudolymphoma].
Topics: Adult; Aged; Aspirin; Diagnosis, Differential; Female; Humans; Keratosis; Lymphoma; Male; Precancero | 1978 |
Pneumocystis carinii pneumonitis following bone marrow transplantation.
Topics: Adolescent; Adult; Bone Marrow Transplantation; Child; Drug Combinations; Female; Humans; Infant; Le | 1992 |
[Malignant tumor-like abdominal lymphoma in Whipple's disease].
Topics: Abdominal Neoplasms; Adult; Diagnosis, Differential; Drug Therapy, Combination; Female; Humans; Lymp | 1989 |
Pneumocystis carinii pneumonia. Review of 53 cases.
Topics: Acquired Immunodeficiency Syndrome; Adrenal Cortex Hormones; Drug Combinations; Female; Humans; Leuk | 1987 |
[Treatment of infections in granulocytopenia patients with a brulamycin-bactrim combination].
Topics: Adult; Aged; Agranulocytosis; Bacterial Infections; Drug Combinations; Drug Therapy, Combination; Fe | 1985 |
Subcutaneous abscesses caused by Nocardia brasiliensis complicated by malignant lymphoma. A survey of cutaneous nocardiosis reported in Japan.
Topics: Abscess; Drug Combinations; Humans; Japan; Lymphoma; Male; Middle Aged; Minocycline; Nocardia Infect | 1985 |
[A case of pulmonary nocardiosis in malignant lymphoma under VEMP therapy].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Drug Therapy, Combination; | 1985 |
Indications for systemic antibiotic prophylaxis in neutropenic patients.
Topics: Adult; Agranulocytosis; Anti-Bacterial Agents; Biguanides; Blood Cell Count; Carbenicillin; Cephalot | 1974 |
[Lymph-node toxoplasmosis: recent clinical, diagnostic and therapeutic acquisitions].
Topics: Anti-Infective Agents; Diagnosis, Differential; Folic Acid Antagonists; Humans; Infectious Mononucle | 1972 |