trimethoprim has been researched along with Folic Acid Deficiency in 24 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
Folic Acid Deficiency: A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The authors report a case of fatal pancytopenia associated with sulfamethoxazole-trimethoprim therapy in a patient with folic acid deficiency." | 7.66 | [Fatal pancytopenia associated with sulfamethoxazole-trimethoprim therapy (author's transl)]. ( Bald, P; Barale, F; Boillot, A; Daoudal, P; Rozenbaum, A; Stimmesse, B, 1979) |
| "The authors report a case of fatal pancytopenia associated with sulfamethoxazole-trimethoprim therapy in a patient with folic acid deficiency." | 3.66 | [Fatal pancytopenia associated with sulfamethoxazole-trimethoprim therapy (author's transl)]. ( Bald, P; Barale, F; Boillot, A; Daoudal, P; Rozenbaum, A; Stimmesse, B, 1979) |
| " Long-term administration does not per se seem to represent an additional hazard provided the dose is the correct one and the hematologic monitoring of the patient is performed regularly." | 1.25 | Adverse reactions to trimethoprim-sulfamethoxazole, with particular reference to long-term therapy. ( Bernstein, LS, 1975) |
| "Trimethoprim seems not to be a safe form of therapy in patients with a megaloblastic process; many of the toxic reactions reported with this drug may be on the basis of an unrecognized megaloblastic form of haemopoiesis." | 1.25 | Toxicity of trimethoprim-sulphamethoxazole in patients with megaloblastic haemopoiesis. ( Chanarin, I; England, JM, 1972) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pelliniemi, TT | 1 |
| Junnila, SY | 1 |
| Kasanen, A | 1 |
| Chan, MK | 1 |
| Beale, D | 1 |
| Moorhead, JF | 1 |
| Bernstein, LS | 1 |
| Audebert, A | 1 |
| Zittoun, J | 1 |
| Zittoun, R | 1 |
| Bousser, J | 1 |
| Wickramasinghe, SN | 1 |
| Saunders, JE | 1 |
| Stimmesse, B | 1 |
| Daoudal, P | 1 |
| Boillot, A | 1 |
| Bald, P | 1 |
| Rozenbaum, A | 1 |
| Barale, F | 1 |
| Collins, IS | 1 |
| Blackwell, EA | 1 |
| Hawson, GA | 1 |
| Leer, J | 1 |
| Bain, B | 1 |
| O'Grady, F | 1 |
| Herxheimer, A | 1 |
| Davis, RE | 1 |
| el-Tamtamy, S | 1 |
| Girdwood, RH | 2 |
| Hjortshoj, A | 1 |
| Elsborg, L | 1 |
| Jensen, E | 1 |
| Frisch, JM | 1 |
| Robenberg, IH | 1 |
| Borgstein, A | 1 |
| Tozer, RA | 1 |
| Koutts, J | 1 |
| Van der Weyden, MB | 1 |
| Cooper, M | 1 |
| Spector, I | 1 |
| Green, R | 1 |
| Bowes, D | 1 |
| Cohen, H | 1 |
| Miller, S | 1 |
| Metz, J | 1 |
| Da Costa, AJ | 1 |
| Samson, RR | 1 |
| Hill, AV | 1 |
| Kerr, DN | 1 |
| Chanarin, I | 1 |
| England, JM | 1 |
| Rooney, PJ | 1 |
| Housley, E | 1 |
| Maier, C | 1 |
| Heer, HR | 1 |
1 review available for trimethoprim and Folic Acid Deficiency
| Article | Year |
|---|---|
Clinical chemistry of folic acid.
Topics: Absorption; Aged; Alcoholism; Anemia, Sickle Cell; Anticonvulsants; Arthritis, Rheumatoid; Biologica | 1986 |
23 other studies available for trimethoprim and Folic Acid Deficiency
| Article | Year |
|---|---|
[Trimethoprim does not cause folic acid deficiency].
Topics: Blood Cell Count; Erythrocytes; Female; Folic Acid Deficiency; Humans; Male; Methenamine; Nitrofuran | 1984 |
Acute megaloblastosis due to cotrimoxazole.
Topics: Acute Disease; Anemia, Macrocytic; Anemia, Megaloblastic; Drug Combinations; Female; Folic Acid Defi | 1980 |
Adverse reactions to trimethoprim-sulfamethoxazole, with particular reference to long-term therapy.
Topics: Adult; Aged; Bacterial Infections; Blood Cell Count; Blood Cells; Blood Platelets; Child; Drug Combi | 1975 |
[Macrocytic animia due to the combination trimethoprim-sulfamethoxazole].
Topics: Adult; Alcoholism; Anemia, Macrocytic; Anti-Infective Agents; Drug Therapy, Combination; Female; Fol | 1975 |
Results of three years' experience with the deoxyuridine suppression test.
Topics: Alcoholism; Anemia, Hemolytic; Anemia, Hypochromic; Anticonvulsants; Azathioprine; Deoxyuridine; Epi | 1977 |
[Fatal pancytopenia associated with sulfamethoxazole-trimethoprim therapy (author's transl)].
Topics: Drug Combinations; Folic Acid Deficiency; Humans; Male; Middle Aged; Pancytopenia; Sulfamethoxazole; | 1979 |
Co-trimoxazole.
Topics: Aged; Bone Marrow Diseases; Drug Combinations; Erythrocytes, Abnormal; Female; Folic Acid Deficiency | 1978 |
Acute pancytopenia due to megaloblastic arrest in association with co-trimoxazole.
Topics: Acute Disease; Aged; Anemia, Megaloblastic; Bone Marrow Diseases; Drug Combinations; Erythrocytes, A | 1978 |
Trimethoprim-sulfamethoxazole: A reappraisal.
Topics: Bacteria; Bacterial Infections; Drug Combinations; Drug Resistance, Microbial; Drug Synergism; Folic | 1975 |
Letter: Long-term co-trimoxazole and folate depletion.
Topics: Folic Acid Deficiency; Humans; Sulfamethoxazole; Trimethoprim | 1975 |
Letter: Co-trimoxazole and the blood.
Topics: Adult; Aged; Anemia, Macrocytic; Drug Combinations; Female; Folic Acid Deficiency; Humans; Male; Pre | 1974 |
Trimethoprim-sulphamethoxazole: long-term therapy and folate levels.
Topics: Ampicillin; Anemia, Macrocytic; Anti-Bacterial Agents; Anticonvulsants; Biological Assay; Chronic Di | 1973 |
[Folate levels during long-term therapy with trimethoprim and sulphadiazine].
Topics: Adult; Aged; Biological Assay; Bone Marrow Cells; Bronchitis; Drug Combinations; Feces; Female; Foli | 1973 |
Clinical experience with adverse reactions to trimethoprim-sulfamethoxazole.
Topics: Aged; Agranulocytosis; Anemia, Aplastic; Anemia, Macrocytic; Child; Depression; Drug Combinations; D | 1973 |
Drugs and folic acid absorption.
Topics: Animals; Contraceptives, Oral; Folic Acid; Folic Acid Deficiency; Intestinal Absorption; Methotrexat | 1972 |
Infectious mononucleosis and megaloblastic anaemia associated with daraprim and bactrim.
Topics: Adolescent; Anemia, Macrocytic; Anemia, Megaloblastic; Drug Combinations; Female; Folic Acid Deficie | 1974 |
Effect ot trimethoprim on folate metabolism in human bone marrow.
Topics: Adult; Anemia, Macrocytic; Anti-Infective Agents; Bone Marrow; Culture Techniques; Deoxyuridine; Dep | 1973 |
Trimethoprim-sulphamethoxazole therapy and folate nutrition.
Topics: Adult; Anti-Infective Agents; Blood Cell Count; Bone Marrow Examination; Bronchopneumonia; Female; F | 1973 |
Co-trimoxazole as a possible cause of folate depletion.
Topics: Anemia, Macrocytic; Anti-Infective Agents; Drug Combinations; Folic Acid; Folic Acid Antagonists; Fo | 1973 |
Toxicity of co-trimoxazole in nutritional haematinic deficiency.
Topics: Anemia, Aplastic; Anemia, Macrocytic; Blood Cell Count; Folic Acid; Folic Acid Deficiency; Humans; I | 1973 |
Toxicity of trimethoprim-sulphamethoxazole in patients with megaloblastic haemopoiesis.
Topics: Adult; Aged; Agranulocytosis; Anemia, Macrocytic; Anemia, Pernicious; Anti-Infective Agents; Arthrit | 1972 |
Trimethoprim-solphamethoxazole in folic acid deficiency.
Topics: Aged; Female; Folic Acid Antagonists; Folic Acid Deficiency; Humans; Pyridines; Pyrimidines; Sulfame | 1972 |
[Studies on the hematologic tolerance of Bactrim].
Topics: Anti-Infective Agents; Erythrocytes; Folic Acid Antagonists; Folic Acid Deficiency; Hematologic Dise | 1972 |