Page last updated: 2024-11-05

trimethoprim and Exanthem

trimethoprim has been researched along with Exanthem in 18 studies

Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.

Research Excerpts

ExcerptRelevanceReference
"We investigated the pharmacokinetics and safety profile of oral ganciclovir coadministered with trimethoprim in HIV-and CMV-seropositive patients."9.09The pharmacokinetics and safety profile of oral ganciclovir in combination with trimethoprim in HIV- and CMV-seropositive patients. ( AbdelHameed, MH; Dorr, A; Griffy, K; Hunter, J; Jung, D; Teitelbaum, P, 1999)
"These results suggest a drug exanthema, in all probability triggered by the leech therapy."5.33[Drug exanthema in connection with trimethoprim and sulfamethoxazole treatment, triggered by leech therapy]. ( Beer, AM; Ciborovius, J; Fey, S; Knorr, M, 2005)
"The observed risks of developing an exanthema are as follows: aminopenicillin without allopurinol 10."5.27[Exanthema during frequent use of antibiotics and antibacterial drugs (penicillin, especially aminopenicillin, cephalosporin and cotrimoxazole) as well as allopurinol. Results of The Berne Comprehensive Hospital Drug Monitoring Program]. ( Buchli, W; Fritschy, D; Hess, T; Hoigné, R; Maibach, R; Sollberger, J; Sonntag, MR; Stocker, F; Zoppi, M, 1986)
"We investigated the pharmacokinetics and safety profile of oral ganciclovir coadministered with trimethoprim in HIV-and CMV-seropositive patients."5.09The pharmacokinetics and safety profile of oral ganciclovir in combination with trimethoprim in HIV- and CMV-seropositive patients. ( AbdelHameed, MH; Dorr, A; Griffy, K; Hunter, J; Jung, D; Teitelbaum, P, 1999)
"Trimethoprim (TMP)-induced skin rash and liver injury are likely to involve the formation of reactive metabolites."1.62Investigating the Mechanism of Trimethoprim-Induced Skin Rash and Liver Injury. ( Bairam, A; Cao, Y; Jee, A; Liu, M; Uetrecht, J, 2021)
"Brucellosis is considered a known widespread zoonotic disease and is endemic in Mediterranean region, like Iran."1.39Clinical manifestations, laboratory findings, and therapeutic regimen in hospitalized children with brucellosis in an Iranian Referral Children Medical Centre. ( Fanni, F; Mahmoudi, S; Mamishi, S; Pourakbari, B; Shahbaznejad, L, 2013)
"These results suggest a drug exanthema, in all probability triggered by the leech therapy."1.33[Drug exanthema in connection with trimethoprim and sulfamethoxazole treatment, triggered by leech therapy]. ( Beer, AM; Ciborovius, J; Fey, S; Knorr, M, 2005)
"We studied an acute generalized exanthematous pustulosis (AGEP) due to sulfamethoxazol in a 48-year-old woman with unusual findings in allergy testing."1.32Acute generalized exanthematous pustulosis due to sulfamethoxazol with positive lymphocyte transformation test (LTT). ( Anliker, MD; Wüthrich, B, 2003)
"The observed risks of developing an exanthema are as follows: aminopenicillin without allopurinol 10."1.27[Exanthema during frequent use of antibiotics and antibacterial drugs (penicillin, especially aminopenicillin, cephalosporin and cotrimoxazole) as well as allopurinol. Results of The Berne Comprehensive Hospital Drug Monitoring Program]. ( Buchli, W; Fritschy, D; Hess, T; Hoigné, R; Maibach, R; Sollberger, J; Sonntag, MR; Stocker, F; Zoppi, M, 1986)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19908 (44.44)18.7374
1990's1 (5.56)18.2507
2000's3 (16.67)29.6817
2010's4 (22.22)24.3611
2020's2 (11.11)2.80

Authors

AuthorsStudies
Connolly, A1
Walsh, S1
Philippidou, M1
Salisbury, J1
Creamer, D1
Cao, Y1
Bairam, A1
Jee, A1
Liu, M1
Uetrecht, J1
Piper, KJ1
Foster, H1
Susanto, D1
Maree, CL1
Thornton, SD1
Cobbs, CS1
Fanni, F1
Shahbaznejad, L1
Pourakbari, B1
Mahmoudi, S1
Mamishi, S1
Boyd, A1
Mills, D1
Hook, K1
Kaila, R1
Iaccheri, B1
Fiore, T1
Papadaki, T1
Androudi, S1
Janjua, S1
Bhaila, I1
Stephen Foster, C1
El-Ghaiesh, S1
Sanderson, JP1
Farrell, J1
Lavergne, SN1
Syn, WK1
Pirmohamed, M1
Park, BK1
Naisbitt, DJ1
Anliker, MD1
Wüthrich, B1
Beer, AM1
Fey, S1
Ciborovius, J1
Knorr, M1
Christensen, G1
Jans, H1
Larsen, S1
Jung, D1
AbdelHameed, MH1
Hunter, J1
Teitelbaum, P1
Dorr, A1
Griffy, K1
Hauser, GA1
Jans, J1
Sonntag, MR1
Zoppi, M1
Fritschy, D1
Maibach, R1
Stocker, F1
Sollberger, J1
Buchli, W1
Hess, T1
Hoigné, R1
Kerstan, J1
Wolf, H1
Schulz, KH1
Wahnbeck, D1
Hohenauer, L1
Lalla, M1
Virolainen, M1
Melén, B1
Orsten, PA1

Trials

1 trial available for trimethoprim and Exanthem

ArticleYear
The pharmacokinetics and safety profile of oral ganciclovir in combination with trimethoprim in HIV- and CMV-seropositive patients.
    British journal of clinical pharmacology, 1999, Volume: 47, Issue:3

    Topics: Administration, Oral; Adult; Anti-Infective Agents; Area Under Curve; Cross-Over Studies; Cytomegalo

1999

Other Studies

17 other studies available for trimethoprim and Exanthem

ArticleYear
Acute hepatic failure in trimethoprim-induced drug rash with eosinophilia and systemic symptoms (DRESS).
    The British journal of dermatology, 2023, 07-07, Volume: 189, Issue:1

    Topics: Drug Eruptions; Drug Hypersensitivity Syndrome; Eosinophilia; Exanthema; Humans; Liver Failure, Acut

2023
Investigating the Mechanism of Trimethoprim-Induced Skin Rash and Liver Injury.
    Toxicological sciences : an official journal of the Society of Toxicology, 2021, 02-26, Volume: 180, Issue:1

    Topics: Animals; Exanthema; Humans; Liver; Mice; Nevirapine; Rats; Skin; Trimethoprim

2021
Fatal Balamuthia mandrillaris brain infection associated with improper nasal lavage.
    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2018, Volume: 77

    Topics: Aged; Balamuthia mandrillaris; Brain; Brain Diseases; Exanthema; Fatal Outcome; Female; Humans; Nasa

2018
Clinical manifestations, laboratory findings, and therapeutic regimen in hospitalized children with brucellosis in an Iranian Referral Children Medical Centre.
    Journal of health, population, and nutrition, 2013, Volume: 31, Issue:2

    Topics: Adolescent; Anti-Infective Agents; Arthritis; Brucellosis; Child; Child, Hospitalized; Child, Presch

2013
Seventeen-year-old sexually active male with rash.
    The American journal of emergency medicine, 2016, Volume: 34, Issue:4

    Topics: Acne Vulgaris; Adolescent; Anti-Infective Agents; Drug Hypersensitivity Syndrome; Exanthema; Fever;

2016
Adverse drug reactions to treatments for ocular toxoplasmosis: a retrospective chart review.
    Clinical therapeutics, 2008, Volume: 30, Issue:11

    Topics: Adolescent; Adult; Atovaquone; Clindamycin; Drug Combinations; Drug-Related Side Effects and Adverse

2008
Characterization of drug-specific lymphocyte responses in a patient with drug-induced liver injury.
    The Journal of allergy and clinical immunology, 2011, Volume: 128, Issue:3

    Topics: Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Eosinophilia; Exanthema; Female; Huma

2011
Acute generalized exanthematous pustulosis due to sulfamethoxazol with positive lymphocyte transformation test (LTT).
    Journal of investigational allergology & clinical immunology, 2003, Volume: 13, Issue:1

    Topics: Administration, Topical; Anti-Infective Agents; Anti-Inflammatory Agents; Betamethasone; Drug Erupti

2003
[Drug exanthema in connection with trimethoprim and sulfamethoxazole treatment, triggered by leech therapy].
    Forschende Komplementarmedizin und klassische Naturheilkunde = Research in complementary and natural classical medicine, 2005, Volume: 12, Issue:1

    Topics: Anti-Infective Agents; Drug Eruptions; Exanthema; Female; Humans; Leeching; Lymphocyte Activation; M

2005
[Multiple organ involvement following treatment with sulphamethoxazole-trimethoprim (Bactrim)].
    Ugeskrift for laeger, 1982, Jul-05, Volume: 144, Issue:27

    Topics: Anti-Infective Agents, Urinary; Arteritis; Drug Combinations; Exanthema; Female; Humans; Liver Funct

1982
[The effect of Bactrim and Tandearil on abnormal tubal patency in cases of infertility (author's transl)].
    Geburtshilfe und Frauenheilkunde, 1975, Volume: 35, Issue:5

    Topics: Drug Combinations; Endometriosis; Exanthema; Fallopian Tube Patency Tests; Female; Humans; Infertili

1975
[Exanthema during frequent use of antibiotics and antibacterial drugs (penicillin, especially aminopenicillin, cephalosporin and cotrimoxazole) as well as allopurinol. Results of The Berne Comprehensive Hospital Drug Monitoring Program].
    Schweizerische medizinische Wochenschrift, 1986, Feb-01, Volume: 116, Issue:5

    Topics: Allopurinol; Amoxicillin; Ampicillin; Anti-Bacterial Agents; Cephalosporins; Dose-Response Relations

1986
[Therapeutic experience with trimethoprim and sulfamethoxazole in infections of infancy and childhood].
    Klinische Padiatrie, 1972, Volume: 184, Issue:6

    Topics: Adolescent; Anti-Infective Agents; Bacterial Infections; Bronchitis; Child; Child, Preschool; Drug S

1972
[Lymphocyte transformation test in drug hypersensitivity].
    Archiv fur dermatologische Forschung, 1972, Volume: 244

    Topics: Ampicillin; Drug Hypersensitivity; Exanthema; Humans; Immunologic Techniques; Lymphocyte Activation;

1972
[Clinical experiences with the combination of trimethoprim and sulfamethoxazol (Bactrim) in pediatric patients].
    Padiatrie und Padologie, 1972, Volume: 7, Issue:2

    Topics: Anti-Infective Agents; Bacterial Infections; Child; Child, Preschool; Drug Combinations; Exanthema;

1972
Blood lymphoblast proliferation in vivo in cutaneous drug hypersensitivity reactions.
    International archives of allergy and applied immunology, 1974, Volume: 46, Issue:2

    Topics: Blood Cell Count; Carbamazepine; Chlorpromazine; Drug Hypersensitivity; Exanthema; Humans; Lymphocyt

1974
[Results of trimethoprim and sulfamethoxazole therapy in chronic urinary tract infections].
    Lakartidningen, 1971, Oct-18, Volume: 68

    Topics: Adult; Aged; Anti-Infective Agents; Chronic Disease; Drug Resistance, Microbial; Drug Synergism; Exa

1971