trimethoprim has been researched along with Crohn Disease in 10 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
Crohn Disease: A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Many patients with Crohn's disease present with the complications of infection." | 2.65 | Infection and the use of antibiotics in Crohn's disease. ( Keighley, MR, 1984) |
| "A 51-year-old woman diagnosed with Crohn's disease developed drug-induced hypersensitivity syndrome (DIHS) 12 and six weeks after starting the oral intake of mesalazine and trimethoprim/sulfamethoxazole, respectively." | 1.43 | Drug-induced Hypersensitivity Syndrome Accompanied by Pulmonary Lesions Exhibiting Centrilobular Nodular Shadows. ( Bando, M; Kogawara, H; Mato, N; Nakayama, M; Sawata, T; Sugiyama, Y; Takemura, T; Yamasawa, H, 2016) |
| "Ampicillin was not effective against intracellular E." | 1.35 | Replication of Colonic Crohn's Disease Mucosal Escherichia coli Isolates within Macrophages and Their Susceptibility to Antibiotics. ( Campbell, BJ; Edwards, SW; Hart, CA; Martin, HM; Rhodes, JM; Roberts, CL; Subramanian, S, 2008) |
| "- 203 patients with Crohn's disease (n = 154) or colitis ulcerosa (n = 49) underwent elective surgery from January 1st, 1978 to April 30th, 1985." | 1.27 | [Surgical treatment of Crohn disease and ulcerative colitis in standardized conditions]. ( Pfeiffer, M, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (80.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Subramanian, S | 1 |
| Roberts, CL | 1 |
| Hart, CA | 1 |
| Martin, HM | 1 |
| Edwards, SW | 1 |
| Rhodes, JM | 1 |
| Campbell, BJ | 1 |
| Sawata, T | 1 |
| Bando, M | 1 |
| Kogawara, H | 1 |
| Nakayama, M | 1 |
| Mato, N | 1 |
| Yamasawa, H | 1 |
| Takemura, T | 1 |
| Sugiyama, Y | 1 |
| Hudson, MJ | 1 |
| Hill, MJ | 1 |
| Elliott, PR | 1 |
| Berghouse, LM | 1 |
| Burnham, WR | 1 |
| Lennard-Jones, JE | 2 |
| Keighley, MR | 2 |
| Peters, JW | 1 |
| Sattler, FR | 1 |
| Montgomery, RD | 1 |
| Parsons, RL | 1 |
| Paddock, GM | 1 |
| Pfeiffer, M | 1 |
| Ambrose, NS | 1 |
| Allan, RN | 1 |
| Burdon, DW | 1 |
| Youngs, D | 1 |
| Barnes, P | 1 |
| Stephens, ME | 1 |
2 trials available for trimethoprim and Crohn Disease
| Article | Year |
|---|---|
Infection and the use of antibiotics in Crohn's disease.
Topics: Abscess; Anus Diseases; Bacterial Infections; Clinical Trials as Topic; Crohn Disease; Drug Combinat | 1984 |
Antibiotic therapy for treatment in relapse of intestinal Crohn's disease. A prospective randomized study.
Topics: Adult; Aged; Clinical Trials as Topic; Crohn Disease; Double-Blind Method; Drug Combinations; Drug T | 1985 |
8 other studies available for trimethoprim and Crohn Disease
| Article | Year |
|---|---|
Replication of Colonic Crohn's Disease Mucosal Escherichia coli Isolates within Macrophages and Their Susceptibility to Antibiotics.
Topics: Animals; Anti-Bacterial Agents; Cell Line; Cells, Cultured; Colon; Crohn Disease; Culture Media; Esc | 2008 |
Drug-induced Hypersensitivity Syndrome Accompanied by Pulmonary Lesions Exhibiting Centrilobular Nodular Shadows.
Topics: Crohn Disease; Drug Combinations; Drug Hypersensitivity Syndrome; Female; Humans; Lung; Lung Disease | 2016 |
The microbial flora of the rectal mucosa and faeces of patients with Crohn's disease before and during antimicrobial chemotherapy.
Topics: Adult; Bacteria; Bacteroides; Clostridium; Crohn Disease; Drug Combinations; Drug Therapy, Combinati | 1984 |
Atypical Pneumocystis carinii pneumonia: the potential hazards of empiric treatment.
Topics: Adult; Crohn Disease; Drug Combinations; Female; Humans; Lung; Middle Aged; Pleural Effusion; Pneumo | 1983 |
Letter: Drug treatment in Crohn's disease.
Topics: Crohn Disease; Drug Combinations; Drug Evaluation; Humans; Sulfamethoxazole; Trimethoprim | 1975 |
Absorption of two antibacterial drugs, cephalexin and co-trimoxazole, in malabsorption syndromes.
Topics: Celiac Disease; Cephalexin; Cholestyramine Resin; Crohn Disease; Cystic Fibrosis; Diverticulum; Drug | 1975 |
[Surgical treatment of Crohn disease and ulcerative colitis in standardized conditions].
Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Child; Child, Preschool; Colitis, Ulcerative; Crohn | 1986 |
Transient erythroid hypoplasia in a patient on long-term co-trimoxazole therapy.
Topics: Anemia, Aplastic; Blood Transfusion; Crohn Disease; Erythrocyte Count; Female; Hematocrit; Hemoglobi | 1974 |