trimethoprim has been researched along with Complications, Infectious Pregnancy in 41 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sixty consecutive pregnant women with asymptomatic (covert) bacteriuria detected between 16 and 30 weeks gestation were randomly allocated to treatment with either a single 600 mg dose or a standard five-day course of trimethoprim." | 9.06 | Comparison of single dose with a five-day course of trimethoprim for asymptomatic (covert) bacteriuria of pregnancy. ( Bailey, RR; Bishop, V; Peddie, BA, 1986) |
| "Data available on the fetal safety of trimethoprim-sulfamethoxazole (TMP-SMX) exposure during pregnancy remains scarce and inconclusive." | 7.88 | Use of trimethoprim-sulfamethoxazole during pregnancy and risk of spontaneous abortion: a nested case control study. ( Bérard, A; Muanda, FT; Sheehy, O, 2018) |
| "Our exploratory analyses support the hypothesis that IRS may significantly reduce malaria and preterm birth risk among pregnant women with HIV receiving bed nets, daily trimethoprim-sulfamethoxazole, and combination antiretroviral therapy." | 5.24 | Protective Effect of Indoor Residual Spraying of Insecticide on Preterm Birth Among Pregnant Women With HIV Infection in Uganda: A Secondary Data Analysis. ( Awori, P; Clark, TD; Cohan, D; Dorsey, G; Gosling, R; Havlir, DV; Jagannathan, P; Kakuru, A; Kamya, MR; Koss, CA; Muhindo, M; Nakalambe, M; Natureeba, P; Ochieng, T; Plenty, A; Roh, ME; Shiboski, S, 2017) |
| "Intermittent preventive treatment in pregnancy with sulfadoxine/pyrimethamine is contra-indicated in HIV-positive pregnant women receiving sulfamethoxazole/trimethoprim prophylaxis." | 5.22 | Pharmacokinetics of mefloquine and its effect on sulfamethoxazole and trimethoprim steady-state blood levels in intermittent preventive treatment (IPTp) of pregnant HIV-infected women in Kenya. ( Desai, M; González, R; Green, M; Kariuki, S; Katana, A; Menendez, C; Otieno, K; Ouma, P; Slutsker, L; ter Kuile, F, 2016) |
| "Sixty consecutive pregnant women with asymptomatic (covert) bacteriuria detected between 16 and 30 weeks gestation were randomly allocated to treatment with either a single 600 mg dose or a standard five-day course of trimethoprim." | 5.06 | Comparison of single dose with a five-day course of trimethoprim for asymptomatic (covert) bacteriuria of pregnancy. ( Bailey, RR; Bishop, V; Peddie, BA, 1986) |
| "Data available on the fetal safety of trimethoprim-sulfamethoxazole (TMP-SMX) exposure during pregnancy remains scarce and inconclusive." | 3.88 | Use of trimethoprim-sulfamethoxazole during pregnancy and risk of spontaneous abortion: a nested case control study. ( Bérard, A; Muanda, FT; Sheehy, O, 2018) |
| " Pregnancy termination was refused, and she was treated with intravenous ampicillin and gentamicin followed by oral trimethoprim/sulfamethoxazol." | 3.67 | First-trimester maternal Listeria monocytogenes sepsis and chorioamnionitis with normal neonatal outcome. ( Cruikshank, DP; Warenski, JC, 1989) |
| " It is believed that traditional dosage regimens for uncomplicated UTIs are extravagant." | 2.38 | Management of lower urinary tract infections. ( Bailey, RR, 1993) |
| "Trimethoprim has a lesser propensity to select resistant organisms than most other antimicrobials." | 2.36 | Pharmacological principles in the treatment of urinary tract infections. ( Sommers, DK, 1983) |
| "Ethical and medical problems arise with typhoid infections in pregnant women." | 1.27 | Treatment of typhoid fever in pregnancy. ( Buongiorno, R; Schiraldi, O, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (78.05) | 18.7374 |
| 1990's | 2 (4.88) | 18.2507 |
| 2000's | 3 (7.32) | 29.6817 |
| 2010's | 4 (9.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Roh, ME | 1 |
| Shiboski, S | 1 |
| Natureeba, P | 1 |
| Kakuru, A | 1 |
| Muhindo, M | 1 |
| Ochieng, T | 1 |
| Plenty, A | 1 |
| Koss, CA | 1 |
| Clark, TD | 1 |
| Awori, P | 1 |
| Nakalambe, M | 1 |
| Cohan, D | 1 |
| Jagannathan, P | 1 |
| Gosling, R | 1 |
| Havlir, DV | 1 |
| Kamya, MR | 1 |
| Dorsey, G | 1 |
| Muanda, FT | 1 |
| Sheehy, O | 1 |
| Bérard, A | 1 |
| Green, M | 1 |
| Otieno, K | 1 |
| Katana, A | 1 |
| Slutsker, L | 1 |
| Kariuki, S | 1 |
| Ouma, P | 1 |
| González, R | 1 |
| Menendez, C | 1 |
| ter Kuile, F | 1 |
| Desai, M | 1 |
| Orden-Martínez, B | 1 |
| Martínez-Ruiz, R | 1 |
| Millán-Pérez, R | 1 |
| Melendez, J | 1 |
| Claxton, A | 1 |
| Erskine, K | 1 |
| Barwitz, HJ | 1 |
| Smithells, RW | 1 |
| Johnson, CA | 1 |
| Bennett, M | 1 |
| Jensen, RK | 1 |
| Schirmer, R | 1 |
| Harpey, JP | 1 |
| Veron, P | 1 |
| Harris, RE | 1 |
| Buongiorno, R | 1 |
| Schiraldi, O | 1 |
| Abraham, E | 1 |
| Brenner, BE | 1 |
| Simon, RR | 1 |
| Sommers, DK | 1 |
| Bailey, RR | 4 |
| Bishop, V | 2 |
| Peddie, BA | 2 |
| Brumfitt, W | 4 |
| Hamilton-Miller, JM | 1 |
| Martens, M | 1 |
| Wiersma, TJ | 1 |
| Timmermans, AE | 1 |
| Cruikshank, DP | 1 |
| Warenski, JC | 1 |
| Santana, JL | 1 |
| Ramírez-Ronda, CH | 1 |
| Soper, DE | 1 |
| Merrill-Nach, S | 1 |
| Berg, AO | 1 |
| Soman, MP | 1 |
| Kelly, RT | 1 |
| Bibbins, B | 1 |
| Fowler, JE | 1 |
| Awadalla, SG | 1 |
| Mercer, LJ | 1 |
| Brown, LG | 1 |
| Nguyen, BT | 1 |
| Stadtsbaeder, S | 1 |
| van Spreeuwel, JP | 1 |
| Remmert, BP | 1 |
| Le Loux, AM | 1 |
| Nadorp, JH | 1 |
| Mevissen-Verhage, EA | 1 |
| Heilmann, FG | 1 |
| Verbrugh, HA | 1 |
| Kayser, AM | 1 |
| Landheer, JE | 1 |
| el-Tamtamy, S | 1 |
| Hing, NK | 1 |
| Hai, CK | 1 |
| Ping, WW | 1 |
| Pursell, R | 3 |
| Bailey, MJ | 1 |
| Neary, JT | 1 |
| Notelovitz, M | 1 |
| Coggiola, F | 1 |
| Shaw, EJ | 1 |
| Clark, AD | 1 |
| Anderson, FM | 1 |
| Samim, F | 1 |
| Finland, M | 2 |
| Kass, EH | 1 |
| Villard, J | 1 |
| Bobichon, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Reducing the Burden of Malaria in HIV-Infected Pregnant Women and Their HIV-Exposed Children (PROMOTE Birth Cohort 2)[NCT02282293] | Phase 3 | 200 participants (Actual) | Interventional | 2014-12-09 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Proportion with low birth weight (<2500 gm), spontaneous abortion (<28 weeks), stillbirth (fetal demise ≥28 weeks), congenital anomaly, or preterm delivery (<37 weeks) (NCT02282293)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| TS + DP Placebo Pregnancy | 15 |
| Daily TS + Monthly DP Pregnancy | 20 |
The primary outcome will be the incidence of malaria, defined as the number of incident episodes per time at risk. Incident cases will include all treatments for malaria not proceeded by another treatment in the previous 14 days. (NCT02282293)
Timeframe: Time at risk will begin following administration of first dose of study drug to delivery
| Intervention | Events per person-year (Number) |
|---|---|
| TS + DP Placebo Pregnancy | 0.03 |
| Daily TS + Monthly DP Pregnancy | 0.00 |
Proportion of monthly routine blood samples positive by LAMP for parasites (NCT02282293)
Timeframe: Following administration of first dose of study drug to delivery
| Intervention | visits with positive blood sample (Count of Units) |
|---|---|
| TS + DP Placebo Pregnancy | 12 |
| Daily TS + Monthly DP Pregnancy | 5 |
The primary outcome will be the prevalence of placental malaria based on placental histopathology and dichotomized into any evidence of placental infection (parasites or pigment) vs. no evidence of placental infection. (NCT02282293)
Timeframe: at delivery estimated to be within 10 to 30 weeks of study entry
| Intervention | Participants (Count of Participants) |
|---|---|
| TS + DP Placebo Pregnancy | 3 |
| Daily TS + Monthly DP Pregnancy | 6 |
Anemia (hemoglobin less than 11g/dL) measured every 8 weeks during pregnancy (NCT02282293)
Timeframe: Following administration of first dose of study drugs to delivery
| Intervention | Routine visit done every 8 weeks (Count of Units) |
|---|---|
| TS + DP Placebo Pregnancy | 65 |
| Daily TS + Monthly DP Pregnancy | 51 |
Proportion of women with parasitemia detected by microscopy or LAMP at delivery (NCT02282293)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| Microscopy | LAMP | |
| Daily TS + Monthly DP Pregnancy | 1 | 4 |
| TS + DP Placebo Pregnancy | 0 | 2 |
Proportion of placental blood samples positive for malaria by microscopy or PCR (NCT02282293)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| Microscopy of placental blood | LAMP analysis of placental blood | |
| Daily TS + Monthly DP Pregnancy | 1 | 3 |
| TS + DP Placebo Pregnancy | 0 | 1 |
6 reviews available for trimethoprim and Complications, Infectious Pregnancy
| Article | Year |
|---|---|
Cystitis and pyelonephritis.
Topics: Amoxicillin; Bacterial Infections; Bacteriuria; Cystitis; Diagnosis, Differential; Drug Therapy, Com | 1983 |
Pharmacological principles in the treatment of urinary tract infections.
Topics: Aminoglycosides; Anti-Bacterial Agents; Anti-Infective Agents, Urinary; Cephalosporins; Female; Huma | 1983 |
Trimethoprim.
Topics: Anti-Infective Agents, Urinary; Bacteriuria; Drug Resistance, Microbial; Drug Therapy, Combination; | 1980 |
Management of lower urinary tract infections.
Topics: 4-Quinolones; Anti-Bacterial Agents; Anti-Infective Agents; Female; Humans; Pregnancy; Pregnancy Com | 1993 |
[Summary of the 'Urinary tract infections' guideline (first revision) of the Dutch College of General Practitioners].
Topics: Adult; Amoxicillin; Anti-Infective Agents, Urinary; Diagnosis, Differential; Female; Humans; Netherl | 2001 |
Lower genitourinary infections in women.
Topics: Amoxicillin; Anti-Infective Agents, Urinary; Cystitis; Diagnosis, Differential; Drug Combinations; F | 1986 |
8 trials available for trimethoprim and Complications, Infectious Pregnancy
| Article | Year |
|---|---|
Protective Effect of Indoor Residual Spraying of Insecticide on Preterm Birth Among Pregnant Women With HIV Infection in Uganda: A Secondary Data Analysis.
Topics: Adolescent; Adult; Anti-Retroviral Agents; Chemoprevention; Drug Combinations; Female; HIV Infection | 2017 |
Pharmacokinetics of mefloquine and its effect on sulfamethoxazole and trimethoprim steady-state blood levels in intermittent preventive treatment (IPTp) of pregnant HIV-infected women in Kenya.
Topics: Adolescent; Adult; Antimalarials; Double-Blind Method; Female; HIV Infections; Humans; Kenya; Malari | 2016 |
Comparison of single dose with a 5-day course of co-trimoxazole for asymptomatic (covert) bacteriuria of pregnancy.
Topics: Adult; Anti-Infective Agents, Urinary; Drug Administration Schedule; Drug Combinations; Female; Huma | 1983 |
Comparison of single dose with a five-day course of trimethoprim for asymptomatic (covert) bacteriuria of pregnancy.
Topics: Adolescent; Adult; Bacteriuria; Drug Administration Schedule; Drug Evaluation; Female; Humans; Pregn | 1986 |
Double-blind trial to compare ampicillin, cephalexin, co-trimoxazole, and trimethoprim in treatment of urinary infection.
Topics: Ampicillin; Bacteriuria; Cephalexin; Cephalosporins; Drug Hypersensitivity; Escherichia coli Infecti | 1972 |
[Preliminary results of treatment of symptomatic and asymptomatic bacteriuria in pregnancy with a new chemotherapeutic agent].
Topics: Adult; Anti-Infective Agents; Bacteriuria; Clinical Trials as Topic; Evaluation Studies as Topic; Fe | 1973 |
Trimethoprim-sulphamethoxazole in the treatment of urinary infection.
Topics: Abnormalities, Drug-Induced; Ampicillin; Anti-Infective Agents; Cephalexin; Clinical Trials as Topic | 1973 |
Trimethoprim-sulfamethoxazole in the treatment of bacteriuria in women.
Topics: Abnormalities, Drug-Induced; Ambulatory Care; Ampicillin; Bacteriuria; Cephalexin; Clinical Trials a | 1973 |
27 other studies available for trimethoprim and Complications, Infectious Pregnancy
| Article | Year |
|---|---|
Use of trimethoprim-sulfamethoxazole during pregnancy and risk of spontaneous abortion: a nested case control study.
Topics: Abortion, Spontaneous; Adolescent; Adult; Anti-Bacterial Agents; Case-Control Studies; Drug Combinat | 2018 |
[What are we learning about Staphylococcus saprophyticus?].
Topics: Adolescent; Adult; Anti-Bacterial Agents; Contraindications; Drug Combinations; Drug Resistance, Mul | 2008 |
MRSA bacteraemia after caesarean section wound infection: when screening is missed and things go wrong.
Topics: Adult; Amikacin; Anti-Bacterial Agents; Antibiotic Prophylaxis; Bacteremia; Cefuroxime; Cesarean Sec | 2012 |
[Dysuria].
Topics: Adult; Anti-Infective Agents, Urinary; Child; Cystitis; Female; Humans; Male; Pregnancy; Pregnancy C | 2003 |
Co-trimoxazole in pregnancy.
Topics: Anti-Infective Agents; Drug Combinations; Female; Humans; Pregnancy; Pregnancy Complications, Infect | 1983 |
Effect of combined antibiotic therapy on fertility in brood bitches infected with Brucella canis.
Topics: Abortion, Septic; Abortion, Veterinary; Animals; Brucellosis; Dihydrostreptomycin Sulfate; Dog Disea | 1982 |
[Treatment of toxoplasmosis with trimethoprim-sulfamethoxazole].
Topics: Drug Combinations; Female; Humans; Pregnancy; Pregnancy Complications, Infectious; Sulfamethoxazole; | 1983 |
Acute urinary tract infections and subsequent problems.
Topics: Acute Disease; Aminoglycosides; Anti-Bacterial Agents; Bacteriuria; Cystitis; Drug Combinations; Fem | 1984 |
Treatment of typhoid fever in pregnancy.
Topics: Adolescent; Adult; Ampicillin; Chloramphenicol; Drug Combinations; Female; Humans; Pregnancy; Pregna | 1984 |
Single-dose antibacterial treatment for bacteriuria in pregnancy.
Topics: Bacteriuria; Cephaloridine; Drug Combinations; Drug Therapy, Combination; Female; Humans; Nitrofuran | 1984 |
[Careful with trimethoprim in pregnant sows].
Topics: Abnormalities, Drug-Induced; Animals; Female; Pregnancy; Pregnancy Complications, Infectious; Swine; | 1993 |
First-trimester maternal Listeria monocytogenes sepsis and chorioamnionitis with normal neonatal outcome.
Topics: Adult; Ampicillin; Anti-Infective Agents; Chorioamnionitis; Drug Combinations; Drug Therapy, Combina | 1989 |
[The pregnant woman infected with the human immunodeficiency virus: recommendations for her management].
Topics: Acquired Immunodeficiency Syndrome; Candidiasis; Cytomegalovirus Infections; Female; Humans; Ketocon | 1988 |
Successful therapy of penicillinase-producing Neisseria gonorrhoeae pharyngeal infection during pregnancy.
Topics: Adult; Anti-Bacterial Agents; Drug Combinations; Female; Gonorrhea; Humans; Infant, Newborn; Neisser | 1986 |
Pregnancy and brucellosis.
Topics: Adult; Brucellosis; Female; Humans; Pregnancy; Pregnancy Complications, Infectious; Recurrence; Sulf | 1987 |
Staphylococcus saprophyticus as the cause of infected urinary calculus.
Topics: Adult; Ampicillin; Bacteriuria; Drug Combinations; Female; Humans; Magnesium; Magnesium Compounds; P | 1985 |
Pregnancy complicated by intraamniotic infection by Salmonella typhi.
Topics: Abortion, Spontaneous; Adult; Amniotic Fluid; Ampicillin; Clindamycin; Disseminated Intravascular Co | 1985 |
Comparative effects of cotrimoxazole (trimethoprim-sulphamethoxazole) and spiramycin in pregnant mice infected with Toxoplasma gondii (Beverley strain).
Topics: Animals; Antibodies; Birth Weight; Congenital Abnormalities; Delivery, Obstetric; Drug Combinations; | 1985 |
[Clinical observations during an epidemic caused by Shigella flexneri].
Topics: Adult; Aged; Arthritis, Infectious; Child, Preschool; Drug Combinations; Dysentery, Bacillary; Femal | 1985 |
Letter: Co-trimoxazole and the blood.
Topics: Adult; Aged; Anemia, Macrocytic; Drug Combinations; Female; Folic Acid Deficiency; Humans; Male; Pre | 1974 |
Trimethoprim-sulphamethoxazole in the treatment of infections in obstetrical and gynaecological practice. A bacteriological and clinical study.
Topics: Bacterial Infections; Drug Therapy, Combination; Female; Humans; Pregnancy; Pregnancy Complications, | 1974 |
The Uricult dip-slide in significant bacteriuria.
Topics: Ampicillin; Bacteria; Bacteriological Techniques; Bacteriuria; Female; Humans; Microbial Sensitivity | 1972 |
R factors in Enterobacteriaceae causing asymptomatic bacteriuria of pregnancy.
Topics: Ampicillin; Bacteriuria; Chloramphenicol; Enterobacteriaceae; Enterobacteriaceae Infections; Escheri | 1973 |
[Ad hoc administration of Bactrim(Roche) erfusion in obstetrics and gynecology].
Topics: Anti-Infective Agents; Drug Combinations; Female; Folic Acid Antagonists; Genital Diseases, Female; | 1973 |
Trimethoprim-sulfamethoxazole. Summary and comments on the conference.
Topics: Bacteria; Bacterial Infections; Carrier State; Child; Child, Preschool; Drug Combinations; Drug Resi | 1973 |
Editorial: Combinations of antimicrobial drugs: trimethoprim-sulfamethoxazole.
Topics: Adult; American Medical Association; Ascorbic Acid; Attitude of Health Personnel; Bacterial Infectio | 1974 |
[Study of the sulfamethoxazole-trimethoprim combination in gynecology and obstetrics].
Topics: Abortion, Septic; Anti-Infective Agents; Female; Folic Acid Antagonists; Humans; Pregnancy; Pregnanc | 1971 |