trimethoprim has been researched along with Cholestasis in 6 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
Cholestasis: Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 52-year old woman developed severe cholestasis seven days after the administration of trimethoprim-sulfamethoxazole (RMP-SMZ) The clinical and pathologic features are discussed as well as the various mechanisms of liver injury following TMP-SMZ use." | 7.66 | Trimethoprim-sulfamethoxazole-induced cholestasis. ( Abi-Mansur, P; Allam, C; Ardiaca, MC; Shamma'a, M, 1981) |
| "A 52-year old woman developed severe cholestasis seven days after the administration of trimethoprim-sulfamethoxazole (RMP-SMZ) The clinical and pathologic features are discussed as well as the various mechanisms of liver injury following TMP-SMZ use." | 3.66 | Trimethoprim-sulfamethoxazole-induced cholestasis. ( Abi-Mansur, P; Allam, C; Ardiaca, MC; Shamma'a, M, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Searashi, Y | 1 |
| Matsudaira, H | 1 |
| Takagi, I | 1 |
| Abi-Mansur, P | 1 |
| Ardiaca, MC | 1 |
| Allam, C | 1 |
| Shamma'a, M | 1 |
| Stevenson, DK | 1 |
| Christie, DL | 1 |
| Haas, JE | 1 |
| Talbot, IC | 1 |
| Hofer, T | 1 |
| Becker, EW | 1 |
| Weigand, K | 1 |
| Berg, PA | 1 |
| Horák, J | 1 |
| Mertl, L | 1 |
| Hrabal, P | 1 |
2 reviews available for trimethoprim and Cholestasis
| Article | Year |
|---|---|
[Drug-induced cholestasis].
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antineoplastic Agen | 2007 |
Acute liver injury.
Topics: Acetaminophen; Acute Disease; Chemical and Drug Induced Liver Injury; Cholestasis; Halothane; Hepati | 1975 |
4 other studies available for trimethoprim and Cholestasis
| Article | Year |
|---|---|
Trimethoprim-sulfamethoxazole-induced cholestasis.
Topics: Biopsy; Cholestasis; Female; Humans; Liver; Middle Aged; Sulfamethoxazole; Trimethoprim | 1981 |
Hepatic injury in a child caused by trimethoprim-sulfamethoxazole.
Topics: Adolescent; Biopsy; Chemical and Drug Induced Liver Injury; Cholestasis; Drug Combinations; Drug Hyp | 1978 |
Demonstration of sensitized lymphocytes to trimethoprim/sulfamethoxazole and ofloxacin in a patient with cholestatic hepatitis.
Topics: Adult; Chemical and Drug Induced Liver Injury; Cholestasis; Drug Hypersensitivity; Female; Humans; O | 1992 |
[Acute liver failure and severe cholestasis due to sulfonamides].
Topics: Adult; Chemical and Drug Induced Liver Injury; Cholestasis; Drug Combinations; Female; Hepatic Encep | 1985 |