trimethoprim has been researched along with Catheter-Associated Infections in 6 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The triple combination trimethoprim, EDTA, and ethanol (B-Lock), is an antimicrobial lock solution for use in indwelling intravascular catheters to prevent and treat catheter-associated infections." | 3.77 | Antimicrobial activity of B-Lock against bacterial and Candida spp. causing catheter-related bloodstream infections. ( Ghannoum, MA; Isham, N; Jacobs, MR, 2011) |
| "Hydrocephalus is a neurological disease caused by an unusually high level of cerebrospinal fluid (CSF), which can be relieved by external ventricular drainage (EVD) insertion." | 1.91 | Antibacterial and biocompatibility studies of triple antibiotics-impregnated external ventricular drainage: In vitro and in vivo evaluation. ( Apasuthirat, A; Boongird, A; Meemai, A; Nasongkla, N; Wongsuwan, N, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Nasongkla, N | 1 |
| Wongsuwan, N | 1 |
| Meemai, A | 1 |
| Apasuthirat, A | 1 |
| Boongird, A | 1 |
| Rijnders, B | 1 |
| DiSciullo, GJ | 1 |
| Csiky, B | 1 |
| Rutkowski, B | 1 |
| Appelt, K | 1 |
| Cheronis, J | 1 |
| Aitchison, R | 1 |
| Gordon, G | 1 |
| Jadoul, M | 1 |
| Fluck, R | 1 |
| Bayston, R | 2 |
| Ashraf, W | 1 |
| Pelegrin, I | 1 |
| Fowkes, K | 1 |
| Bienemann, AS | 1 |
| Singleton, WGB | 1 |
| Scott, IS | 1 |
| Bousquet, A | 1 |
| Bigaillon, C | 1 |
| Dumitrescu, N | 1 |
| Larréché, S | 1 |
| Godreuil, C | 1 |
| Mestiri, R | 1 |
| Le Caruyer, N | 1 |
| Mérens, A | 1 |
| Andriamanantena, D | 1 |
| Fisher, LE | 1 |
| Weber, K | 1 |
| Ghannoum, MA | 1 |
| Isham, N | 1 |
| Jacobs, MR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multi-Center, Prospective, Randomized, Open-Label, Sponsor-Blinded, Active-Control (Heparin) Clinical Investigation to Evaluate the Safety and Effectiveness of B-Lock™ as an Antimicrobial Catheter Lock Solution in Dialysis Patients With a Central Venous C[NCT01989091] | Phase 3 | 270 participants (Actual) | Interventional | 2012-07-31 | Terminated (stopped due to Did not meet predetermined primary endpoint) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for trimethoprim and Catheter-Associated Infections
| Article | Year |
|---|---|
Locking Hemodialysis Catheters With Trimethoprim-Ethanol-Ca-EDTA to Prevent Bloodstream Infections: A Randomized, Evaluator-blinded Clinical Trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Anti-Infective Agents, Local; Bac | 2019 |
5 other studies available for trimethoprim and Catheter-Associated Infections
| Article | Year |
|---|---|
Antibacterial and biocompatibility studies of triple antibiotics-impregnated external ventricular drainage: In vitro and in vivo evaluation.
Topics: Animals; Anti-Bacterial Agents; Catheter-Related Infections; Cerebrospinal Fluid Shunts; Clindamycin | 2023 |
An external ventricular drainage catheter impregnated with rifampicin, trimethoprim and triclosan, with extended activity against MDR Gram-negative bacteria: an in vitro and in vivo study.
Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; Catheter-Related Infections; Catheterization; | 2019 |
Acute myocarditis in an immunocompetent young man: Don't forget Toxoplasma gondii.
Topics: Catheter-Related Infections; Diagnosis, Differential; Humans; Magnetic Resonance Imaging, Cine; Male | 2016 |
An antimicrobial modified silicone peritoneal catheter with activity against both Gram-positive and Gram-negative bacteria.
Topics: Animals; Catheter-Related Infections; Catheters, Indwelling; Coated Materials, Biocompatible; Drug R | 2009 |
Antimicrobial activity of B-Lock against bacterial and Candida spp. causing catheter-related bloodstream infections.
Topics: Anti-Infective Agents; Bacteria; Candida; Catheter-Related Infections; Catheters, Indwelling; Drug C | 2011 |