trimethoprim has been researched along with Body Weight in 27 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Seventy-nine children with acute otitis media were the subjects in a study designed to compare the effectiveness of ampicillin and trimethoprim-sulfamethoxazole in this infection." | 9.04 | Comparative efficacy of ampicillin and trimethoprim-sulfamethoxazole in otitis media. ( Cameron, GG; Johnston, MT; Pomahac, AC, 1975) |
| "Trimethoprim/sulfamethoxazole (TMP/SMX) and clindamycin are frequently prescribed to treat cellulitis." | 7.85 | Clinical outcomes in patients hospitalized with cellulitis treated with oral clindamycin and trimethoprim/sulfamethoxazole: The role of weight-based dosing. ( Alexander, B; Cox, KK; Heintz, BH; Livorsi, DJ, 2017) |
| " the half-life t1/2 of their elimination from the plasma; 4." | 5.25 | [Comparison of pharmacokinetics of the combination trimethoprim and sulfamethoxazole in patients with liver diseases and healthy persons]. ( Rieder, VJ; Schwartz, DE, 1975) |
| "Seventy-nine children with acute otitis media were the subjects in a study designed to compare the effectiveness of ampicillin and trimethoprim-sulfamethoxazole in this infection." | 5.04 | Comparative efficacy of ampicillin and trimethoprim-sulfamethoxazole in otitis media. ( Cameron, GG; Johnston, MT; Pomahac, AC, 1975) |
| "Trimethoprim/sulfamethoxazole (TMP/SMX) and clindamycin are frequently prescribed to treat cellulitis." | 3.85 | Clinical outcomes in patients hospitalized with cellulitis treated with oral clindamycin and trimethoprim/sulfamethoxazole: The role of weight-based dosing. ( Alexander, B; Cox, KK; Heintz, BH; Livorsi, DJ, 2017) |
| " They were aged 2-12 years at the start of prophylaxis which was given in a daily dose of approximately 10 mg sulphamethoxazole (SMX) and 2 mg trimethoprim (TMP)/kg body weight for at least 6 months and for up to 6 years." | 3.66 | Normal somatic growth in children receiving low-dose prophylactic co-trimoxazole. ( Paton, AM; Preece, MA; Smellie, JM, 1983) |
| " The LD50 calculated was 1400 mg kg(-1) body weight (BW) day(-1) in rats and 1130 mg kg(-1) BW day(-1) in mice." | 1.42 | Safety assessment of aditoprim acute, subchronic toxicity and mutagenicity studies. ( Chen, D; Cheng, G; Huang, L; Ihsan, A; Liu, Q; Liu, Z; Pan, Y; Tan, Z; Tao, Y; Wang, X; Yuan, Z, 2015) |
| " Epiroprim represents a challenge for such methods, because it shows large interspecies differences in its pharmacokinetic properties." | 1.32 | Physiologically based pharmacokinetic (PBPK) modeling of disposition of epiroprim in humans. ( Guentert, TW; Lavé, T; Luttringer, O; Poulin, P; Schmitt-Hoffmann, AH; Theil, FP, 2003) |
| "Body weight was the same in all groups." | 1.28 | Ascending pyelonephritis in young rats retards kidney growth. ( Aperia, A; Celsi, G; Eklöf, AC; Hannerz, L; Olling, S; Wikstad, I, 1989) |
| "Fifteen patients with AIDS were hospitalized on the pulmonary service during the period from 1981 to 1983." | 1.27 | Pulmonary manifestations of the acquired immunodeficiency syndrome (AIDS). ( Chitkara, RK; Khan, FA; Shivaram, U; Wollschlager, CM, 1984) |
| " The most important conclusion was that amoxycillin, chloramphenicol, and trimethoprim were suitable for oral administration to veal calves, although the bioavailability of chloramphenicol and trimethoprim was significantly less when concurrently administered with a milk replacer." | 1.27 | Salmonellosis in veal calves. Some therapeutic aspects. ( Groothuis, DG; van Miert, AS, 1987) |
| " They had a shorter elimination half-life (means: 1 to 3 years, 3." | 1.27 | Age differences in trimethoprim pharmacokinetics: need for revised dosing in children? ( Hoppu, K, 1987) |
| " the half-life t1/2 of their elimination from the plasma; 4." | 1.25 | [Comparison of pharmacokinetics of the combination trimethoprim and sulfamethoxazole in patients with liver diseases and healthy persons]. ( Rieder, VJ; Schwartz, DE, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (81.48) | 18.7374 |
| 1990's | 1 (3.70) | 18.2507 |
| 2000's | 2 (7.41) | 29.6817 |
| 2010's | 2 (7.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cox, KK | 1 |
| Alexander, B | 1 |
| Livorsi, DJ | 1 |
| Heintz, BH | 1 |
| Wang, X | 1 |
| Tan, Z | 1 |
| Pan, Y | 1 |
| Ihsan, A | 1 |
| Liu, Q | 1 |
| Huang, L | 1 |
| Cheng, G | 1 |
| Chen, D | 1 |
| Tao, Y | 1 |
| Liu, Z | 1 |
| Yuan, Z | 1 |
| Luttringer, O | 1 |
| Theil, FP | 1 |
| Poulin, P | 1 |
| Schmitt-Hoffmann, AH | 1 |
| Guentert, TW | 1 |
| Lavé, T | 1 |
| Smellie, JM | 2 |
| Preece, MA | 2 |
| Paton, AM | 2 |
| Eastell, R | 1 |
| Edmonds, CJ | 1 |
| Gyrd-Hansen, N | 1 |
| Friis, C | 1 |
| Nielsen, P | 2 |
| Rasmussen, F | 2 |
| Wollschlager, CM | 1 |
| Khan, FA | 1 |
| Chitkara, RK | 1 |
| Shivaram, U | 1 |
| Sieniawska, M | 1 |
| Wróblewska-Kałuzewska, M | 1 |
| Białasik, D | 1 |
| Korniszewska, J | 1 |
| Wierzbowska-Lange, B | 1 |
| Wierzba, K | 1 |
| Pashov, DA | 1 |
| Lashev, LD | 1 |
| Matev, IB | 1 |
| Kanelov, IN | 1 |
| Macintire, DK | 1 |
| Vincent-Johnson, NA | 1 |
| Kane, CW | 1 |
| Lindsay, DS | 1 |
| Blagburn, BL | 1 |
| Dillon, AR | 1 |
| Atef, M | 1 |
| Al-Samarrae, SA | 1 |
| Abdel Hamio, YM | 1 |
| Golebiowski, S | 1 |
| Barancewicz, S | 1 |
| Sabel, KG | 1 |
| Brandberg, A | 1 |
| Cameron, GG | 1 |
| Pomahac, AC | 1 |
| Johnston, MT | 1 |
| Rieder, VJ | 1 |
| Schwartz, DE | 1 |
| Hannerz, L | 1 |
| Celsi, G | 1 |
| Eklöf, AC | 1 |
| Olling, S | 1 |
| Wikstad, I | 1 |
| Aperia, A | 1 |
| Sainsbury, DW | 1 |
| Groothuis, DG | 1 |
| van Miert, AS | 1 |
| Hoppu, K | 1 |
| Van der Waaij, D | 1 |
| Cohen, BJ | 1 |
| Anver, MR | 1 |
| Pohjanpelto, PE | 1 |
| Sarmela, TJ | 1 |
| Raines, T | 1 |
| Wolfsdorf, J | 1 |
| Myer, EC | 1 |
| Swarm, RL | 1 |
| Roberts, GK | 1 |
| Levy, AC | 1 |
| Hines, LR | 1 |
| Suter, HJ | 1 |
| Guggenheim, B | 1 |
| Bach, MC | 1 |
| Gold, O | 1 |
| Finland, M | 1 |
3 trials available for trimethoprim and Body Weight
| Article | Year |
|---|---|
Somatic growth in girls receiving low dose prophylactic co-trimoxazole.
Topics: Anti-Infective Agents, Urinary; Body Weight; Child; Child, Preschool; Drug Combinations; Female; Gro | 1983 |
Comparative efficacy of ampicillin and trimethoprim-sulfamethoxazole in otitis media.
Topics: Administration, Oral; Ampicillin; Bacterial Infections; Body Weight; Child; Clinical Trials as Topic | 1975 |
Trimethoprim-sulphonamide mixture in the treatment of infantile gastro-enteritis.
Topics: Body Weight; Child, Preschool; Clinical Trials as Topic; Diarrhea, Infantile; Drug Combinations; Esc | 1973 |
24 other studies available for trimethoprim and Body Weight
| Article | Year |
|---|---|
Clinical outcomes in patients hospitalized with cellulitis treated with oral clindamycin and trimethoprim/sulfamethoxazole: The role of weight-based dosing.
Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Body Weight; Cellulitis; Clindamycin; Cohort Stud | 2017 |
Safety assessment of aditoprim acute, subchronic toxicity and mutagenicity studies.
Topics: Animals; Body Weight; CHO Cells; Cricetulus; Diet; Dose-Response Relationship, Drug; Female; Kidney; | 2015 |
Physiologically based pharmacokinetic (PBPK) modeling of disposition of epiroprim in humans.
Topics: Animals; Body Weight; Cells, Cultured; Chromatography, High Pressure Liquid; Dogs; Hepatocytes; Huma | 2003 |
Hyponatraemia associated with trimethoprim and a diuretic.
Topics: Aged; Amiloride; Body Weight; Drug Combinations; Drug Therapy, Combination; Female; Humans; Hydrochl | 1984 |
Metabolism of trimethoprim in neonatal and young pigs: comparative in vivo and in vitro studies.
Topics: Aging; Animals; Animals, Newborn; Bile; Body Weight; Female; In Vitro Techniques; Kidney; Liver; Org | 1984 |
Normal somatic growth in children receiving low-dose prophylactic co-trimoxazole.
Topics: Body Height; Body Weight; Child; Child, Preschool; Drug Combinations; Female; Growth; Humans; Sulfam | 1983 |
Pulmonary manifestations of the acquired immunodeficiency syndrome (AIDS).
Topics: Acquired Immunodeficiency Syndrome; Adult; Body Weight; Cough; Female; Humans; Lung; Lung Diseases; | 1984 |
[Biseptol dosage in children in relation to the degree of renal failure and body weight. II].
Topics: Acute Kidney Injury; Adolescent; Body Weight; Child; Child, Preschool; Dose-Response Relationship, D | 1984 |
Interspecies comparisons of plasma half-life of trimethoprim in relation to body mass.
Topics: Animals; Body Weight; Buffaloes; Cattle; Dogs; Folic Acid Antagonists; Goats; Half-Life; Horses; Hum | 1997 |
Treatment of dogs infected with Hepatozoon americanum: 53 cases (1989-1998).
Topics: Alkaline Phosphatase; Animals; Anti-Bacterial Agents; Anti-Infective Agents, Urinary; Antiprotozoal | 2001 |
Half-life and volume of distribution of trimethoprim and sulphadoxine in sheep and its relation to age and weight.
Topics: Age Factors; Animals; Body Weight; Half-Life; Sheep; Sulfadoxine; Sulfanilamides; Trimethoprim | 1979 |
Influence of age on half-life of trimethoprim and sulphadoxine in goats.
Topics: Age Factors; Animals; Body Weight; Goats; Half-Life; Sulfadoxine; Sulfanilamides; Trimethoprim | 1976 |
[Prophylactic use of Trimerazine and Tylavit-Sulfa during early periods of pig fattening].
Topics: Animal Feed; Animals; Body Weight; Drug Combinations; Erysipeloid; Sulfamerazine; Swine; Swine Disea | 1976 |
Treatment of meningitis and septicemia in infancy with a sulphamethoxazole/trimethorpim combination.
Topics: Ampicillin; Anemia, Hypochromic; Body Weight; Drug Synergism; Drug Therapy, Combination; Escherichia | 1975 |
[Comparison of pharmacokinetics of the combination trimethoprim and sulfamethoxazole in patients with liver diseases and healthy persons].
Topics: Adult; Aged; Body Weight; Drug Combinations; Female; Half-Life; Humans; Liver Diseases; Male; Middle | 1975 |
Ascending pyelonephritis in young rats retards kidney growth.
Topics: Aging; Animals; Body Weight; DNA; Drug Combinations; Escherichia coli Infections; Female; Glomerular | 1989 |
Potentiated sulphaquinoxaline used as 'strategic medication' for broiler poultry.
Topics: Animal Feed; Animals; Bacterial Infections; Body Weight; Chickens; Drug Combinations; Drug Synergism | 1988 |
Salmonellosis in veal calves. Some therapeutic aspects.
Topics: Administration, Oral; Amoxicillin; Animal Feed; Animals; Biological Availability; Body Temperature; | 1987 |
Age differences in trimethoprim pharmacokinetics: need for revised dosing in children?
Topics: Adult; Aging; Body Surface Area; Body Weight; Child; Child, Preschool; Female; Fever; Humans; Hydrog | 1987 |
Mitigation of experimental inflammatory bowel disease in guinea pigs by selective elimination of the aerobic gram-negative intestinal microflora.
Topics: Animals; Bacteria; Body Weight; Carrageenan; Cecum; Colitis, Ulcerative; Colon; Disease Models, Anim | 1974 |
Penetration of trimethoprim and sulphamethoxazole into the aqueous humour.
Topics: Administration, Oral; Animals; Aqueous Humor; Body Weight; Drug Synergism; Female; Humans; Male; Rab | 1974 |
Observations on the thyroid gland in rats following the administration of sulfamethoxazole and trimethoprim.
Topics: Animals; Anti-Infective Agents; Appetite; Behavior, Animal; Body Weight; Dose-Response Relationship, | 1973 |
The inhibitory effect of two slightly soluble compounds on rat caries.
Topics: Administration, Topical; Animals; Body Weight; Cariostatic Agents; Dental Caries; Diet, Cariogenic; | 1972 |
Absorption and urinary execretion of trimethoprim, sulfamethoxazole, and trimethoprim-sulfamethoxazole: results with single doses in normal young adults and preliminary observations during therapy with trimethoprim-sulfamethoxazole.
Topics: Administration, Oral; Body Weight; Drug Combinations; Erythrocytes; Female; Humans; Male; Sulfametho | 1973 |