trimethoprim has been researched along with Bacterial Infections, Gram-Negative in 21 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Brodimoprim is a new diaminopyridine derivative suitable for oral therapy which shows good in-vitro activity against most Gram-positive and Gram-negative pathogens." | 6.67 | Efficacy and tolerability of brodimoprim in respiratory tract infections. ( Bisetti, A; Marchioni, CF; Moretti, M, 1993) |
| "Brodimoprim is a new diaminopyridine derivative suitable for oral therapy which shows good in-vitro activity against most Gram-positive and Gram-negative pathogens." | 2.67 | Efficacy and tolerability of brodimoprim in respiratory tract infections. ( Bisetti, A; Marchioni, CF; Moretti, M, 1993) |
| " Tetracycline, trimethoprim and an ineffective concentration of flumequine given 48 h prior to sampling, strongly increased expression of plasmid mobility genes, whereas an effective dosage of flumequine resulted in lower levels of mRNA copies of these genes relative to placebo treatment." | 1.38 | Impact of antibiotic treatments on the expression of the R plasmid tra genes and on the host innate immune activity during pRAS1 bearing Aeromonas hydrophila infection in zebrafish (Danio rerio). ( Cantas, L; Midtlyng, PJ; Sørum, H, 2012) |
| "trimethoprim) studied was observed." | 1.29 | Increase of antimicrobial resistance of faecal aerobic gram-negative bacteria in a geriatric hospital. ( Heikkilä, E; Huovinen, P; Huovinen, S; Kahra, A; Kuistila, M; Lehtonen, A; Leistevuo, T; Osterblad, M; Toivonen, P, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (19.05) | 18.2507 |
| 2000's | 6 (28.57) | 29.6817 |
| 2010's | 11 (52.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Herrera-Heredia, SA | 1 |
| Pezina-Cantú, C | 1 |
| Garza-González, E | 1 |
| Bocanegra-Ibarias, P | 1 |
| Mendoza-Olazarán, S | 1 |
| Morfín-Otero, R | 1 |
| Camacho-Ortiz, A | 1 |
| Villarreal-Treviño, L | 1 |
| Rodríguez-Noriega, E | 1 |
| Paláu-Davila, L | 1 |
| Maldonado-Garza, HJ | 1 |
| Flores-Treviño, S | 1 |
| Watson, L | 1 |
| Esterly, J | 1 |
| Jensen, AO | 1 |
| Postelnick, M | 1 |
| Aguirre, A | 1 |
| McLaughlin, M | 1 |
| Malcolm, W | 1 |
| Fletcher, E | 1 |
| Kavanagh, K | 1 |
| Deshpande, A | 1 |
| Wiuff, C | 1 |
| Marwick, C | 1 |
| Bennie, M | 1 |
| Tokatly Latzer, I | 1 |
| Nahum, E | 1 |
| Cavari, Y | 1 |
| Lazar, I | 1 |
| Ben-Ari, Y | 1 |
| Ben-Shimol, S | 1 |
| Ben-Shalom, G | 1 |
| Geffen, Y | 1 |
| Goldberg, L | 1 |
| Rubinstein, M | 1 |
| Keller, N | 1 |
| Pessach, IM | 1 |
| Paret, G | 1 |
| Worthing, KA | 1 |
| Norris, JM | 1 |
| Briscoe, KA | 1 |
| Livermore, DM | 1 |
| Mushtaq, S | 1 |
| Warner, M | 1 |
| Woodford, N | 1 |
| Kaye, KS | 1 |
| Gales, AC | 1 |
| Dubourg, G | 1 |
| Kiernan, DF | 1 |
| Chin, EK | 1 |
| Sclafani, LA | 1 |
| Saidel, MA | 1 |
| Brolund, A | 1 |
| Sundqvist, M | 1 |
| Kahlmeter, G | 1 |
| Grape, M | 1 |
| Kadlec, K | 1 |
| von Czapiewski, E | 1 |
| Kaspar, H | 1 |
| Wallmann, J | 1 |
| Michael, GB | 1 |
| Steinacker, U | 1 |
| Schwarz, S | 1 |
| Cantas, L | 1 |
| Midtlyng, PJ | 1 |
| Sørum, H | 1 |
| Samonis, G | 1 |
| Karageorgopoulos, DE | 1 |
| Maraki, S | 1 |
| Levis, P | 1 |
| Dimopoulou, D | 1 |
| Spernovasilis, NA | 1 |
| Kofteridis, DP | 1 |
| Falagas, ME | 1 |
| Casas, C | 1 |
| Anderson, EC | 1 |
| Ojo, KK | 1 |
| Keith, I | 1 |
| Whelan, D | 1 |
| Rainnie, D | 1 |
| Roberts, MC | 1 |
| Sankaranarayanan, V | 1 |
| Zeidalski, TM | 1 |
| Chitkara, RK | 1 |
| Al-Jasser, AM | 1 |
| Muder, RR | 1 |
| Rosini, JM | 1 |
| Martinez, E | 1 |
| Jain, R | 1 |
| Moretti, M | 1 |
| Marchioni, CF | 1 |
| Bisetti, A | 1 |
| Grant, AN | 1 |
| Laidler, LA | 1 |
| Leistevuo, T | 1 |
| Osterblad, M | 1 |
| Toivonen, P | 1 |
| Kuistila, M | 1 |
| Huovinen, S | 1 |
| Heikkilä, E | 1 |
| Kahra, A | 1 |
| Lehtonen, A | 1 |
| Huovinen, P | 1 |
| Hufnagel, TJ | 1 |
| Schein, OD | 1 |
2 reviews available for trimethoprim and Bacterial Infections, Gram-Negative
| Article | Year |
|---|---|
Old antibiotics for multidrug-resistant pathogens: from in vitro activity to clinical outcomes.
Topics: Aminoglycosides; Anti-Bacterial Agents; Drug Combinations; Drug Resistance, Multiple, Bacterial; Fos | 2017 |
Optimizing therapy for Stenotrophomonas maltophilia.
Topics: Cross Infection; Drug Combinations; Drug Resistance, Bacterial; Gram-Negative Bacterial Infections; | 2007 |
1 trial available for trimethoprim and Bacterial Infections, Gram-Negative
| Article | Year |
|---|---|
Efficacy and tolerability of brodimoprim in respiratory tract infections.
Topics: Adult; Erythromycin; Female; Gram-Negative Bacterial Infections; Humans; Male; Middle Aged; Respirat | 1993 |
18 other studies available for trimethoprim and Bacterial Infections, Gram-Negative
| Article | Year |
|---|---|
Risk factors and molecular mechanisms associated with trimethoprim-sulfamethoxazole resistance in Stenotrophomonas maltophilia in Mexico.
Topics: Adult; Anti-Bacterial Agents; Bacterial Proteins; Cross Infection; Drug Resistance, Multiple, Bacter | 2017 |
Sulfamethoxazole/trimethoprim versus fluoroquinolones for the treatment of Stenotrophomonas maltophilia bloodstream infections.
Topics: Adult; Aged; Anti-Bacterial Agents; Bacteremia; Drug Therapy, Combination; Female; Fluoroquinolones; | 2018 |
Risk factors for resistance and MDR in community urine isolates: population-level analysis using the NHS Scotland Infection Intelligence Platform.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacter | 2018 |
Treatment Outcomes of Stenotrophomonas maltophilia Bacteremia in Critically Ill Children: A Multicenter Experience.
Topics: Anti-Bacterial Agents; Child; Child, Preschool; Ciprofloxacin; Comorbidity; Critical Illness; Drug C | 2019 |
Severe acute cellulitis and sepsis caused by Aeromonas spp. in a dog on immunosuppressive therapy.
Topics: Aeromonas; Animals; Anti-Bacterial Agents; Cellulitis; Dog Diseases; Dogs; Drug Combinations; Female | 2019 |
Comparative in vitro activity of sulfametrole/trimethoprim and sulfamethoxazole/trimethoprim and other agents against multiresistant Gram-negative bacteria.
Topics: Anti-Bacterial Agents; Drug Combinations; Drug Resistance, Multiple, Bacterial; Gram-Negative Bacter | 2014 |
Multiple drug-resistant Alcaligenes xylosoxidans keratitis in a sanitation worker.
Topics: Achromobacter denitrificans; Administration, Topical; Adult; Aminoglycosides; Anti-Bacterial Agents; | 2009 |
Molecular characterisation of trimethoprim resistance in Escherichia coli and Klebsiella pneumoniae during a two year intervention on trimethoprim use.
Topics: Anti-Infective Agents, Urinary; Bacterial Proteins; Escherichia coli; Gene Frequency; Genotype; Gram | 2010 |
Molecular basis of sulfonamide and trimethoprim resistance in fish-pathogenic Aeromonas isolates.
Topics: Aeromonas salmonicida; Animals; Anti-Bacterial Agents; DNA, Bacterial; Drug Resistance, Bacterial; F | 2011 |
Impact of antibiotic treatments on the expression of the R plasmid tra genes and on the host innate immune activity during pRAS1 bearing Aeromonas hydrophila infection in zebrafish (Danio rerio).
Topics: Aeromonas hydrophila; Animals; Anti-Bacterial Agents; Conjugation, Genetic; Drug Resistance, Multipl | 2012 |
Stenotrophomonas maltophilia infections in a general hospital: patient characteristics, antimicrobial susceptibility, and treatment outcome.
Topics: Aged; Ciprofloxacin; Colistin; Colony Count, Microbial; Cross Infection; Drug Resistance, Multiple, | 2012 |
Characterization of pRAS1-like plasmids from atypical North American psychrophilic Aeromonas salmonicida.
Topics: Aeromonas salmonicida; Animals; Anti-Bacterial Agents; Antiporters; Bacterial Proteins; Conjugation, | 2005 |
A 55-year-old smoker with a persistent right lower lobe infiltrate.
Topics: Biopsy, Needle; Bronchoscopy; Diagnosis, Differential; Follow-Up Studies; Gram-Negative Bacterial In | 2005 |
Stenotrophomonas maltophilia resistant to trimethoprim-sulfamethoxazole: an increasing problem.
Topics: Aged; Anti-Bacterial Agents; Cross Infection; Drug Resistance, Bacterial; Drug Therapy, Combination; | 2006 |
Severe hypoglycemia associated with use of trimethoprim/sulfamethoxazole in a patient with chronic renal insufficiency.
Topics: Aged; Anti-Bacterial Agents; Drug Combinations; Endophthalmitis; Gram-Negative Bacterial Infections; | 2008 |
Assessment of the antimicrobial sensitivity of Aeromonas salmonicida isolates from farmed Atlantic salmon in Scotland.
Topics: Aeromonas; Animals; Anti-Bacterial Agents; Aquaculture; Drug Combinations; Drug Resistance, Microbia | 1993 |
Increase of antimicrobial resistance of faecal aerobic gram-negative bacteria in a geriatric hospital.
Topics: Aged; Aged, 80 and over; Ampicillin; Anti-Bacterial Agents; Ceftazidime; Cefuroxime; Cross Infection | 1996 |
Suppurative keratitis from herbal ocular preparation.
Topics: Adolescent; Corneal Ulcer; Drug Contamination; Eye Infections, Bacterial; Female; Gram-Negative Bact | 1992 |