trimethoprim has been researched along with Anemia, Macrocytic in 29 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
Anemia, Macrocytic: Anemia characterized by larger than normal erythrocytes, increased mean corpuscular volume (MCV) and increased mean corpuscular hemoglobin (MCH).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Trimethoprim seems not to be a safe form of therapy in patients with a megaloblastic process; many of the toxic reactions reported with this drug may be on the basis of an unrecognized megaloblastic form of haemopoiesis." | 1.25 | Toxicity of trimethoprim-sulphamethoxazole in patients with megaloblastic haemopoiesis. ( Chanarin, I; England, JM, 1972) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (96.55) | 18.7374 |
| 1990's | 1 (3.45) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dan, M | 1 |
| Shapira, I | 1 |
| Kobrinsky, NL | 1 |
| Ramsay, NK | 1 |
| Anguita, T | 1 |
| Magee, F | 1 |
| O'Sullivan, H | 1 |
| McCann, SR | 1 |
| Chan, MK | 1 |
| Beale, D | 1 |
| Moorhead, JF | 1 |
| Schütz, H | 1 |
| Ansdell, VE | 1 |
| Wright, SG | 1 |
| Hutchinson, DB | 1 |
| Audebert, A | 1 |
| Zittoun, J | 1 |
| Zittoun, R | 1 |
| Bousser, J | 1 |
| Heilmann, E | 1 |
| Hellmann, A | 1 |
| Nering, I | 1 |
| Masera, G | 1 |
| Baronciani, D | 1 |
| Conti, A | 1 |
| Jankovic, M | 1 |
| Uderzo, C | 1 |
| Blackwell, EA | 1 |
| Hawson, GA | 1 |
| Leer, J | 1 |
| Bain, BJ | 1 |
| Malfatti, S | 1 |
| Piccini, A | 1 |
| Crosby, WH | 1 |
| Hamblin, TJ | 1 |
| el-Tamtamy, S | 1 |
| Fleming, AF | 1 |
| Warrell, DA | 1 |
| Dickmeiss, H | 1 |
| Girdwood, RH | 2 |
| Frisch, JM | 1 |
| Borgstein, A | 1 |
| Tozer, RA | 1 |
| Koutts, J | 1 |
| Van der Weyden, MB | 1 |
| Cooper, M | 1 |
| Lindahl, A | 2 |
| Da Costa, AJ | 1 |
| Samson, RR | 1 |
| Yuill, GM | 1 |
| Hill, AV | 1 |
| Kerr, DN | 1 |
| Chanarin, I | 1 |
| England, JM | 1 |
| Toft, JE | 1 |
| Christiansen, LV | 1 |
| Dawson, DW | 1 |
| Routledge, RC | 1 |
2 reviews available for trimethoprim and Anemia, Macrocytic
| Article | Year |
|---|---|
[Drug-induced megaloblastic anemia].
Topics: Alcoholism; Anemia, Macrocytic; Anemia, Megaloblastic; Anti-Bacterial Agents; Anticonvulsants; Antim | 1979 |
[Sulfamethoxazole-trimethoprim and megaloblastic anemia].
Topics: Anemia, Macrocytic; Bone Marrow Diseases; Drug Combinations; Folic Acid; Humans; Sulfamethoxazole; T | 1974 |
27 other studies available for trimethoprim and Anemia, Macrocytic
| Article | Year |
|---|---|
Possible role of methotrexate in trimethoprim-sulfamethoxazole-induced acute megaloblastic anemia.
Topics: Acute Disease; Anemia, Macrocytic; Anemia, Megaloblastic; Drug Combinations; Drug Synergism; Female; | 1984 |
Acute megaloblastic anemia induced by high-dose trimethoprim-sulfamethoxazole.
Topics: Adult; Anemia, Macrocytic; Anemia, Megaloblastic; Drug Combinations; Female; Humans; Leucovorin; Sul | 1981 |
[Bone marrow megaloblastosis associated with the use of pyrimethamine, triamterene and trimethoprim-sulfamethoxazole].
Topics: Adult; Aged; Anemia, Macrocytic; Anemia, Megaloblastic; Bone Marrow; Drug Combinations; Female; Foli | 1982 |
Megaloblastosis and low-dose trimethoprim-sulfamethoxazole.
Topics: Aged; Anemia, Macrocytic; Anemia, Megaloblastic; Female; Humans; Sulfamethoxazole; Trimethoprim | 1981 |
Acute megaloblastosis due to cotrimoxazole.
Topics: Acute Disease; Anemia, Macrocytic; Anemia, Megaloblastic; Drug Combinations; Female; Folic Acid Defi | 1980 |
[Clinical demonstration (author's transl)].
Topics: Acute Kidney Injury; Adult; Aged; Alveolitis, Extrinsic Allergic; Anemia, Macrocytic; Anemia, Megalo | 1978 |
Megaloblastic anaemia associated with combined pyrimethamine and co-trimoxazole administration.
Topics: Adult; Anemia, Macrocytic; Anemia, Megaloblastic; Drug Combinations; Drug Therapy, Combination; Fema | 1976 |
[Macrocytic animia due to the combination trimethoprim-sulfamethoxazole].
Topics: Adult; Alcoholism; Anemia, Macrocytic; Anti-Infective Agents; Drug Therapy, Combination; Female; Fol | 1975 |
[Complete bone marrow suppression and megaloblastic anemia as a result of long-term treatment with cotrimoxazole].
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Bone Marrow; Drug Combinations; Humans; Male; Middle Aged | 1977 |
[Hemopathies caused by drugs in children: aplastic anemia, agranulocytosis, megaloblastic anemia].
Topics: Agranulocytosis; Anemia, Aplastic; Anemia, Macrocytic; Anemia, Megaloblastic; Anti-Bacterial Agents; | 1978 |
Co-trimoxazole.
Topics: Aged; Anemia, Macrocytic; Anemia, Megaloblastic; Female; Humans; Sulfamethoxazole; Trimethoprim | 1978 |
[Pancytopenic megaloblastic anaemia following administration of pyrimethamine, trimethoprim and sulphamethoxazole (author's transl)].
Topics: Adult; Anemia, Macrocytic; Anemia, Megaloblastic; Drug Synergism; Folic Acid Antagonists; Humans; Ma | 1976 |
Megaloblastic pancytopenia associated with dapsone and trimethoprim treatment of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Anemia, Macrocytic; Anemia, Megaloblastic; Dapsone; Humans; Leuc | 1990 |
Editorial: Co-trimoxazole and blood.
Topics: Agranulocytosis; Anemia, Aplastic; Anemia, Macrocytic; Bone Marrow; Drug Combinations; Female; Folic | 1973 |
Letter: Co-trimoxazole and the blood.
Topics: Aged; Anemia, Macrocytic; Anemia, Sideroblastic; Blood Platelets; Drug Combinations; Female; Humans; | 1973 |
Letter: Co-trimoxazole and the blood.
Topics: Adult; Aged; Anemia, Macrocytic; Drug Combinations; Female; Folic Acid Deficiency; Humans; Male; Pre | 1974 |
Letter: Co-trimoxazole and the blood.
Topics: Administration, Oral; Adult; Anemia, Macrocytic; Blood Cell Count; Drug Therapy, Combination; Female | 1974 |
Trimethoprim-sulphamethoxazole: long-term therapy and folate levels.
Topics: Ampicillin; Anemia, Macrocytic; Anti-Bacterial Agents; Anticonvulsants; Biological Assay; Chronic Di | 1973 |
Clinical experience with adverse reactions to trimethoprim-sulfamethoxazole.
Topics: Aged; Agranulocytosis; Anemia, Aplastic; Anemia, Macrocytic; Child; Depression; Drug Combinations; D | 1973 |
Infectious mononucleosis and megaloblastic anaemia associated with daraprim and bactrim.
Topics: Adolescent; Anemia, Macrocytic; Anemia, Megaloblastic; Drug Combinations; Female; Folic Acid Deficie | 1974 |
Effect ot trimethoprim on folate metabolism in human bone marrow.
Topics: Adult; Anemia, Macrocytic; Anti-Infective Agents; Bone Marrow; Culture Techniques; Deoxyuridine; Dep | 1973 |
Co-trimoxazole as a possible cause of folate depletion.
Topics: Anemia, Macrocytic; Anti-Infective Agents; Drug Combinations; Folic Acid; Folic Acid Antagonists; Fo | 1973 |
Megaloblastic anaemia due to trimethoprim-sulphamethoxazole therapy in uraemia.
Topics: Adult; Anemia, Macrocytic; Anti-Infective Agents; Female; Folic Acid Antagonists; Humans; Pyrimidine | 1973 |
Toxicity of co-trimoxazole in nutritional haematinic deficiency.
Topics: Anemia, Aplastic; Anemia, Macrocytic; Blood Cell Count; Folic Acid; Folic Acid Deficiency; Humans; I | 1973 |
Toxicity of trimethoprim-sulphamethoxazole in patients with megaloblastic haemopoiesis.
Topics: Adult; Aged; Agranulocytosis; Anemia, Macrocytic; Anemia, Pernicious; Anti-Infective Agents; Arthrit | 1972 |
[Sulfamethoxazole-Trimethoprim. A review of the side-effects in long-term treatment with particular attention to folic acid metabolism and hematological changes].
Topics: Aged; Anemia, Macrocytic; Anti-Infective Agents; Catheterization; Cross Infection; Female; Folic Aci | 1972 |
Trimethoprim and sulphamethoxazole.
Topics: Adult; Anemia, Macrocytic; Anti-Infective Agents; Female; Folic Acid Antagonists; Humans; Pyrimidine | 1971 |