trimethoprim has been researched along with Aging in 16 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The altered protein binding of TMP affected pharmacokinetic parameters such as total body clearance (CLtot), distribution volume and therefore the elimination rate constant." | 1.29 | Alpha 1-acid glycoprotein-binding as a factor in age-related changes in the pharmacokinetics of trimethoprim in piglets. ( Kokue, E; Shimoda, M; Son, DS; Tagawa, Y, 1994) |
| " The plasma half-life increased moderately with age." | 1.29 | Pharmacokinetics of brodimoprim in special populations. ( Borzio, F; Deroubaix, X; Gaspari, F; Jeanbaptiste, B; Lebacq, E; Lins, R; Pavesio, D; Pelozi, GC; Rosillon, D; Stockis, A, 1993) |
| " After intravenous administration to conventionally fed calves, aditoprim total body clearance increased and elimination half-life decreased with age." | 1.29 | Comparative pharmacokinetics of aditoprim in milk-fed and conventionally fed calves of different ages. ( Riond, JL; Sutter, HM; Wanner, M, 1993) |
| "Some pharmacokinetic parameters of aditoprim were determined in 3- and 6-month-old pigs." | 1.28 | The influence of age on the pharmacokinetics of aditoprim in pigs after intravenous and oral administration. ( Müller, P; Riond, JL; Wanner, M, 1992) |
| "Body weight was the same in all groups." | 1.28 | Ascending pyelonephritis in young rats retards kidney growth. ( Aperia, A; Celsi, G; Eklöf, AC; Hannerz, L; Olling, S; Wikstad, I, 1989) |
| " The half-life (t 1/2) of TMP in the children was 3." | 1.27 | Difference in trimethoprim pharmacokinetics between children and adults. ( Arjomaa, P; Hoppu, K, 1984) |
| " Elimination half-life decreased from 485 minutes at birth to 224 minutes at 1 week, and 120 minutes at 8 weeks leading to a rise in body clearance from 1." | 1.27 | Pharmacokinetics and metabolism of trimethoprim in neonatal and young pigs. ( Friis, C; Gyrd-Hansen, N; Nielsen, P; Nordholm, L; Rasmussen, F, 1984) |
| " The data indicate that, while therapeutic concentrations and optimum ratios of the drugs may be achieved for extended time periods in neonatal life, this dosage is unable to produce optimum serum and synovial fluid concentrations as the calves mature." | 1.27 | Age-related alterations in trimethoprim-sulfadiazine disposition following oral or parenteral administration in calves. ( Blackshear, P; Friedman, DS; Guard, CL; Haluska, M; Schwark, WS, 1986) |
| " They had a shorter elimination half-life (means: 1 to 3 years, 3." | 1.27 | Age differences in trimethoprim pharmacokinetics: need for revised dosing in children? ( Hoppu, K, 1987) |
| " Following oral administration of a single dose, the pharmacokinetic parameters of SMZ and its N4-acetylated metabolite (N4SMZ) were similar in both groups." | 1.27 | Pharmacokinetics of the trimethoprim-sulphamethoxazole combination in the elderly. ( Advenier, C; Cordonnier, P; Ducreuzet, C; Gobert, C; Lajoie, D; Pays, M; Varoquaux, O, 1985) |
| " The pharmacokinetic analysis showed a plasma elimination half-life in the terminal phase of 10." | 1.26 | Pharmacokinetics of co-trimoxazole and co-tetroxazine in geriatric patients. ( Naber, K; Vergin, H; Weigand, W, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (62.50) | 18.7374 |
| 1990's | 5 (31.25) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Carrino, DA | 1 |
| Calabro, A | 1 |
| Darr, AB | 1 |
| Dours-Zimmermann, MT | 1 |
| Sandy, JD | 1 |
| Zimmermann, DR | 1 |
| Sorrell, JM | 1 |
| Hascall, VC | 1 |
| Caplan, AI | 1 |
| Hoppu, K | 2 |
| Arjomaa, P | 1 |
| Friis, C | 2 |
| Gyrd-Hansen, N | 2 |
| Nielsen, P | 2 |
| Nordholm, L | 1 |
| Rasmussen, F | 2 |
| Naber, K | 1 |
| Vergin, H | 1 |
| Weigand, W | 1 |
| Light, RB | 1 |
| Ronald, AR | 1 |
| Harding, G | 1 |
| Fox, L | 1 |
| Buckwold, FJ | 1 |
| Tagawa, Y | 1 |
| Kokue, E | 1 |
| Shimoda, M | 1 |
| Son, DS | 1 |
| Stockis, A | 1 |
| Borzio, F | 1 |
| Deroubaix, X | 1 |
| Gaspari, F | 1 |
| Jeanbaptiste, B | 1 |
| Lebacq, E | 1 |
| Lins, R | 1 |
| Pavesio, D | 1 |
| Pelozi, GC | 1 |
| Rosillon, D | 1 |
| Sutter, HM | 1 |
| Riond, JL | 2 |
| Wanner, M | 2 |
| Ujhelyi, MR | 1 |
| Bottorff, MB | 1 |
| Schur, M | 1 |
| Roll, K | 1 |
| Zhang, H | 1 |
| Stewart, J | 1 |
| Markel, ML | 1 |
| Müller, P | 1 |
| Hannerz, L | 1 |
| Celsi, G | 1 |
| Eklöf, AC | 1 |
| Olling, S | 1 |
| Wikstad, I | 1 |
| Aperia, A | 1 |
| Guard, CL | 1 |
| Schwark, WS | 1 |
| Friedman, DS | 1 |
| Blackshear, P | 1 |
| Haluska, M | 1 |
| Varoquaux, O | 1 |
| Lajoie, D | 1 |
| Gobert, C | 1 |
| Cordonnier, P | 1 |
| Ducreuzet, C | 1 |
| Pays, M | 1 |
| Advenier, C | 1 |
| Mansoldo, G | 1 |
| Luzi Crivellini, A | 1 |
1 trial available for trimethoprim and Aging
| Article | Year |
|---|---|
Aging effects on the organic base transporter and stereoselective renal clearance.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Ammonium Chloride; Antimetabolites; Biological Tran | 1997 |
15 other studies available for trimethoprim and Aging
| Article | Year |
|---|---|
Age-related differences in human skin proteoglycans.
Topics: Adult; Aging; Amino Acid Sequence; Binding Sites, Antibody; Decorin; Drug Combinations; Electrophore | 2011 |
Difference in trimethoprim pharmacokinetics between children and adults.
Topics: Adult; Aging; Child; Child, Preschool; Chromatography, High Pressure Liquid; Female; Half-Life; Huma | 1984 |
Pharmacokinetics and metabolism of trimethoprim in neonatal and young pigs.
Topics: Aging; Animals; Animals, Newborn; Biotransformation; Female; Glucuronates; Kidney; Kinetics; Sulfate | 1984 |
Metabolism of trimethoprim in neonatal and young pigs: comparative in vivo and in vitro studies.
Topics: Aging; Animals; Animals, Newborn; Bile; Body Weight; Female; In Vitro Techniques; Kidney; Liver; Org | 1984 |
Pharmacokinetics of co-trimoxazole and co-tetroxazine in geriatric patients.
Topics: Absorption; Aged; Aging; Anti-Infective Agents, Urinary; Drug Combinations; Female; Half-Life; Human | 1981 |
Epidemiologic features of urinary infections due to enterobacteriaceae resistant to nalidixic acid and trimethoprim.
Topics: Adult; Aged; Aging; Drug Resistance, Microbial; Drug Synergism; Enterobacteriaceae; Enterobacteriace | 1981 |
Alpha 1-acid glycoprotein-binding as a factor in age-related changes in the pharmacokinetics of trimethoprim in piglets.
Topics: Aging; Animals; Blood Proteins; Japan; Metabolic Clearance Rate; Orosomucoid; Protein Binding; Serum | 1994 |
Pharmacokinetics of brodimoprim in special populations.
Topics: Adult; Aged; Aged, 80 and over; Aging; Child; Child, Preschool; Dose-Response Relationship, Drug; Fe | 1993 |
Comparative pharmacokinetics of aditoprim in milk-fed and conventionally fed calves of different ages.
Topics: Administration, Oral; Aging; Animal Feed; Animals; Cattle; Injections, Intravenous; Male; Milk; Trim | 1993 |
The influence of age on the pharmacokinetics of aditoprim in pigs after intravenous and oral administration.
Topics: Administration, Oral; Aging; Animals; Injections, Intravenous; Male; Swine; Trimethoprim | 1992 |
Ascending pyelonephritis in young rats retards kidney growth.
Topics: Aging; Animals; Body Weight; DNA; Drug Combinations; Escherichia coli Infections; Female; Glomerular | 1989 |
Age-related alterations in trimethoprim-sulfadiazine disposition following oral or parenteral administration in calves.
Topics: Administration, Oral; Aging; Animals; Cattle; Drug Combinations; Injections, Subcutaneous; Male; Sul | 1986 |
Age differences in trimethoprim pharmacokinetics: need for revised dosing in children?
Topics: Adult; Aging; Body Surface Area; Body Weight; Child; Child, Preschool; Female; Fever; Humans; Hydrog | 1987 |
Pharmacokinetics of the trimethoprim-sulphamethoxazole combination in the elderly.
Topics: Acetylation; Adult; Aged; Aging; Biological Availability; Blood Proteins; Drug Combinations; Female; | 1985 |
[Clinical study of a new drug combination in geriatric therapy].
Topics: Affective Symptoms; Aged; Aging; Arteriosclerosis; Drug Combinations; Ergoloid Mesylates; Female; Hu | 1971 |