trimethoprim has been researched along with Acute Liver Injury, Drug-Induced in 40 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In patients with AIDS, oral therapy with trimethoprim-sulfamethoxazole and with trimethoprim-dapsone are equally effective for mild-to-moderate first episodes of P." | 6.67 | Oral therapy for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. A controlled trial of trimethoprim-sulfamethoxazole versus trimethoprim-dapsone. ( Benowitz, N; Hopewell, PC; Lee, B; Leoung, G; Medina, I; Mills, J; Modin, G; Wofsy, CB, 1990) |
| "In patients with AIDS, oral therapy with trimethoprim-sulfamethoxazole and with trimethoprim-dapsone are equally effective for mild-to-moderate first episodes of P." | 2.67 | Oral therapy for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. A controlled trial of trimethoprim-sulfamethoxazole versus trimethoprim-dapsone. ( Benowitz, N; Hopewell, PC; Lee, B; Leoung, G; Medina, I; Mills, J; Modin, G; Wofsy, CB, 1990) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| "During the decade 1968-1978 the Danish Board of Adverse Reactions to Drugs received 572 (6% of the total number) reports on hepatotoxicity." | 1.26 | Drug-induced liver disease in Denmark. An analysis of 572 cases of hepatotoxicity reported to the Danish Board of Adverse Reactions to Drugs. ( Andreasen, PB; Døssing, M, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (57.50) | 18.7374 |
| 1990's | 7 (17.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 10 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Morgan, RE | 2 |
| Trauner, M | 1 |
| van Staden, CJ | 2 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 2 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 2 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 2 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Kenna, JG | 1 |
| Stahl, S | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Chen, M | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| El-Ghaiesh, S | 1 |
| Sanderson, JP | 1 |
| Farrell, J | 1 |
| Lavergne, SN | 1 |
| Syn, WK | 1 |
| Pirmohamed, M | 1 |
| Park, BK | 1 |
| Naisbitt, DJ | 1 |
| Thies, PW | 1 |
| Dull, WL | 1 |
| Kossow, AS | 1 |
| Horák, J | 2 |
| Mertl, L | 2 |
| Hrabal, P | 2 |
| Anderson, WI | 1 |
| Campbell, KL | 1 |
| Wilson, RC | 1 |
| Goetsch, DD | 1 |
| Døssing, M | 1 |
| Andreasen, PB | 1 |
| Wist, E | 1 |
| Coto, H | 1 |
| McGowan, WR | 1 |
| Pierce, EH | 1 |
| Thomas, E | 1 |
| Jick, H | 1 |
| Derby, LE | 1 |
| Lindgren, A | 1 |
| Olsson, R | 1 |
| Bunch, SE | 1 |
| Knudsen, L | 1 |
| Weismann, K | 1 |
| Stevenson, DK | 1 |
| Christie, DL | 1 |
| Haas, JE | 1 |
| Talbot, IC | 1 |
| Juul, P | 1 |
| Moult, PJ | 1 |
| Sherlock, S | 1 |
| Colucci, CF | 1 |
| Lo Cicero, M | 1 |
| Hermansen, K | 1 |
| Baunsgaard, P | 1 |
| Heydenreich, G | 1 |
| Nielsen, G | 1 |
| Hofer, T | 1 |
| Becker, EW | 1 |
| Weigand, K | 1 |
| Berg, PA | 2 |
| Rowland, PH | 1 |
| Center, SA | 1 |
| Dougherty, SA | 1 |
| Muñoz, SJ | 1 |
| Martinez-Hernandez, A | 1 |
| Maddrey, WC | 1 |
| Medina, I | 1 |
| Mills, J | 1 |
| Leoung, G | 1 |
| Hopewell, PC | 1 |
| Lee, B | 1 |
| Modin, G | 1 |
| Benowitz, N | 1 |
| Wofsy, CB | 1 |
| Pavlova, MV | 1 |
| Natov, SN | 1 |
| Badev, IR | 1 |
| Victorino, RM | 1 |
| Maria, VA | 1 |
| Karim, AH | 1 |
| Goldberg, J | 1 |
| Kassel, LE | 1 |
| Bhagavan, BS | 1 |
| Israel, HL | 1 |
| Daniel, PT | 1 |
| Bartlett, JC | 1 |
| Park, H | 1 |
| Moe, R | 1 |
| Acero, D | 1 |
| Masabeu, A | 1 |
| Alabern, C | 1 |
| Oterino, A | 1 |
| Klein, U | 1 |
| Gikalov, I | 1 |
| Keller, M | 1 |
| Hoigné, R | 1 |
3 reviews available for trimethoprim and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Hepatotoxicity associated with pharmacologic agents in dogs and cats.
Topics: Animals; Anthelmintics; Benzimidazoles; Cat Diseases; Cats; Chemical and Drug Induced Liver Injury; | 1993 |
Acute liver injury.
Topics: Acetaminophen; Acute Disease; Chemical and Drug Induced Liver Injury; Cholestasis; Halothane; Hepati | 1975 |
1 trial available for trimethoprim and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Oral therapy for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. A controlled trial of trimethoprim-sulfamethoxazole versus trimethoprim-dapsone.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Adult; Chemical and Drug Induced Liver Inj | 1990 |
36 other studies available for trimethoprim and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Characterization of drug-specific lymphocyte responses in a patient with drug-induced liver injury.
Topics: Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Eosinophilia; Exanthema; Female; Huma | 2011 |
Trimethoprim-sulfamethoxazole-induced cholestatic hepatitis. Inadvertent rechallenge.
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Drug Combinations; Humans | 1984 |
Hepatic injury complicating sulfa therapy: case report.
Topics: Aged; Chemical and Drug Induced Liver Injury; Drug Combinations; Humans; Male; Sulfamethoxazole; Tri | 1984 |
Severe liver injuries due to sulfamethoxazole-trimethoprim and sulfamethoxydiazine.
Topics: Adult; Anti-Infective Agents, Urinary; Chemical and Drug Induced Liver Injury; Drug Combinations; Fe | 1984 |
Hepatitis in a dog given sulfadiazine-trimethoprim and cyclophosphamide.
Topics: Animals; Anti-Infective Agents, Urinary; Chemical and Drug Induced Liver Injury; Cyclophosphamide; D | 1984 |
Drug-induced liver disease in Denmark. An analysis of 572 cases of hepatotoxicity reported to the Danish Board of Adverse Reactions to Drugs.
Topics: Adolescent; Adult; Aged; Anti-Infective Agents, Urinary; Antidepressive Agents, Tricyclic; Antituber | 1982 |
[Pathological liver function tests due to trimethoprim-sulfamethoxazole].
Topics: Aged; Anti-Infective Agents, Urinary; Chemical and Drug Induced Liver Injury; Drug Combinations; Fem | 1982 |
Intrahepatic cholestasis due to trimethoprim-sulfamethoxazole.
Topics: Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Drug Combinations; Humans; Liver; | 1981 |
Is co-trimoxazole safe?
Topics: Cephalexin; Chemical and Drug Induced Liver Injury; Follow-Up Studies; Hematologic Diseases; Humans; | 1995 |
Liver reactions from trimethoprim.
Topics: Adult; Aged; Aged, 80 and over; Alanine Transaminase; Alkaline Phosphatase; Chemical and Drug Induce | 1994 |
[Pustular eruption and damage of internal organs after sulfamethoxazole combined with trimethoprim].
Topics: Aged; Chemical and Drug Induced Liver Injury; Drug Combinations; Drug Eruptions; Humans; Kidney; Kid | 1977 |
Hepatic injury in a child caused by trimethoprim-sulfamethoxazole.
Topics: Adolescent; Biopsy; Chemical and Drug Induced Liver Injury; Cholestasis; Drug Combinations; Drug Hyp | 1978 |
[Adverse effects of treatment with sulfamethoxazole and trimethoprim. Report to the Adverse Drug Reaction Committee of the National Board of Health and Welfare].
Topics: Aged; Chemical and Drug Induced Liver Injury; Denmark; Drug Combinations; Drug Hypersensitivity; Fem | 1977 |
Halothane-related hepatitis. A clinical study of twenty-six cases.
Topics: Adult; Aged; Anesthesia, General; Bilirubin; Chemical and Drug Induced Liver Injury; Diagnosis, Diff | 1975 |
Letter: Hepatic necrosis and trimethoprim-sulfamethoxazole.
Topics: Aged; Chemical and Drug Induced Liver Injury; Humans; Liver; Male; Necrosis; Orchitis; Sulfamethoxaz | 1975 |
[Liver changes after sulfamethoxazole-trimethoprim (Bactrim, Trisural)].
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Combinations; Female; Humans; Liver; Male; Sulfa | 1976 |
Demonstration of sensitized lymphocytes to trimethoprim/sulfamethoxazole and ofloxacin in a patient with cholestatic hepatitis.
Topics: Adult; Chemical and Drug Induced Liver Injury; Cholestasis; Drug Hypersensitivity; Female; Humans; O | 1992 |
Presumptive trimethoprim-sulfadiazine-related hepatotoxicosis in a dog.
Topics: Animals; Chemical and Drug Induced Liver Injury; Dog Diseases; Dogs; Drug Combinations; Follow-Up St | 1992 |
Intrahepatic cholestasis and phospholipidosis associated with the use of trimethoprim-sulfamethoxazole.
Topics: Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Drug Combinations; Female; Humans | 1990 |
[A case of drug-induced recurrent cholestatic hepatitis].
Topics: Adult; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Drug Combinations; Humans; | 1989 |
Drug-induced hepatitis and lymphocyte transformation test in presence of prostaglandin inhibitor.
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Combinations; Humans; In Vitro Techniques; Lymph | 1986 |
Postantibiotic fever, jaundice, dysuria.
Topics: Aged; Anti-Infective Agents; Chemical and Drug Induced Liver Injury; Drug Combinations; Fever; Human | 1986 |
Sulfamethoxazole-trimethoprim therapy for Wegener's granulomatosis.
Topics: Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Drug Combinations; Female; Granulom | 1988 |
Co-trimoxazole-induced hepatic injury--an analysis of cases with hypersensitivity-like reactions.
Topics: Adult; Aged; Anti-Infective Agents; Chemical and Drug Induced Liver Injury; Drug Combinations; Drug | 1987 |
[Acute liver failure and severe cholestasis due to sulfonamides].
Topics: Adult; Chemical and Drug Induced Liver Injury; Cholestasis; Drug Combinations; Female; Hepatic Encep | 1985 |
Hepatic toxicity associated with trimethoprim-sulfamethoxazole: report of a case.
Topics: Aged; Anti-Infective Agents, Urinary; Chemical and Drug Induced Liver Injury; Drug Combinations; Hum | 1985 |
[Cholestasis caused by co-trimoxazole. Presentation of a new patient and review of the literature].
Topics: Aged; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Drug Combinations; Drug Hyp | 1985 |
[Drug monitoring in the medical ward of a regional hospital].
Topics: Adult; Ampicillin; Anticoagulants; Antidepressive Agents; Central Nervous System Stimulants; Chemica | 1972 |