trimethoprim has been researched along with Acute Kidney Failure in 26 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A severe generalized multisystem allergic reaction occurred in a 16-month-old infant following the use of trimethoprim-sulfamethoxazole." | 7.66 | A generalized allergic reaction with acute interstitial nephritis following trimethoprim-sulfamethoxazole use. ( Bierman, CW; Haas, JE; Hickman, RO; Kendall, R; Kraemer, MJ, 1982) |
| " Spironolactone, furosemide, and trimethoprim with sulfamethoxazole are medicines that, in particular, need to be used carefully and monitored closely in patients in the community at risk of acute kidney injury." | 4.12 | Medicine-Induced Acute Kidney Injury Findings from Spontaneous Reporting Systems, Sequence Symmetry Analysis and a Case-Control Study with a Focus on Medicines Used in Primary Care. ( Kassie, GM; Kerr, M; Moffat, A; Pratt, N; Roughead, EE, 2022) |
| "A severe generalized multisystem allergic reaction occurred in a 16-month-old infant following the use of trimethoprim-sulfamethoxazole." | 3.66 | A generalized allergic reaction with acute interstitial nephritis following trimethoprim-sulfamethoxazole use. ( Bierman, CW; Haas, JE; Hickman, RO; Kendall, R; Kraemer, MJ, 1982) |
| " The half-life (t1/2) of trimethoprim was inversely related to the GFR." | 2.66 | Trimethoprim pharmacokinetics in children with renal insufficiency. ( Hoppu, K; Koskimies, O; Tuomisto, J, 1987) |
| " This study investigated the reporting risk of AKI associated with antibacterials using the individual case safety reports (ICSRs) submitted to the Food and Drug Administration Adverse Event Reporting System (FAERS) database." | 1.72 | Antibacterial-associated acute kidney injury among older adults: A post-marketing surveillance study using the FDA adverse events reporting system. ( Chinzowu, T; Chyou, TY; Nishtala, PS, 2022) |
| "Although acute renal failure secondary to infections is relatively common in adult patients, uremia requiring dialysis has not previously been reported in an adult patient with shigella enterocolitis." | 1.26 | Shigella enterocolitis and acute renal failure. ( Brasitus, TA; Cleri, DJ; Goldfarb, JP, 1982) |
| "Three patients had stable chronic renal failure, and in two of these there was a further permanent impairment of renal function." | 1.26 | Deterioration in renal function in association with co-trimoxazole therapy. ( Bailey, RR; Little, PJ, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (80.77) | 18.7374 |
| 1990's | 1 (3.85) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (7.69) | 24.3611 |
| 2020's | 2 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Chinzowu, T | 1 |
| Chyou, TY | 1 |
| Nishtala, PS | 1 |
| Roughead, EE | 1 |
| Kerr, M | 1 |
| Moffat, A | 1 |
| Kassie, GM | 1 |
| Pratt, N | 1 |
| Guzman-Limon, M | 1 |
| Molony, D | 1 |
| Gbinigie, O | 1 |
| Fattah, HA | 1 |
| Khuffash, FA | 1 |
| Wasserheit, JN | 1 |
| Dugdale, DC | 1 |
| Agosti, JM | 1 |
| Sieniawska, M | 1 |
| Wróblewska-Kałuzewska, M | 1 |
| Białasik, D | 1 |
| Korniszewska, J | 1 |
| Wierzbowska-Lange, B | 1 |
| Wierzba, K | 1 |
| Goldfarb, JP | 1 |
| Brasitus, TA | 1 |
| Cleri, DJ | 1 |
| Kraemer, MJ | 1 |
| Kendall, R | 1 |
| Hickman, RO | 1 |
| Haas, JE | 1 |
| Bierman, CW | 1 |
| Smith, GW | 1 |
| Cohen, SB | 1 |
| Schütz, H | 1 |
| Finlayson, WB | 1 |
| Johnson, G | 1 |
| Richmond, JM | 1 |
| Whitworth, JA | 1 |
| Fairley, KF | 1 |
| Kincaid-Smith, P | 3 |
| Pollack, S | 1 |
| Lin, S | 1 |
| Enat, R | 1 |
| Merzbach, D | 1 |
| Barzilai, D | 1 |
| Saltissi, D | 1 |
| Pusey, CD | 1 |
| Rainford, DJ | 1 |
| Chaubey, BS | 1 |
| Grover, S | 1 |
| Patil, SM | 1 |
| Darrell, JH | 1 |
| Uttley, AH | 1 |
| Siciński, A | 1 |
| Bailey, RR | 1 |
| Little, PJ | 1 |
| Rudra, T | 1 |
| Webb, DB | 1 |
| Evans, AG | 1 |
| Blaser, KU | 1 |
| Lämmle, B | 1 |
| Hoppu, K | 1 |
| Koskimies, O | 1 |
| Tuomisto, J | 1 |
| Kalowski, S | 2 |
| Nanra, RS | 2 |
| Mathew, TH | 1 |
| Craig, WA | 1 |
| Kunin, CM | 1 |
1 review available for trimethoprim and Acute Kidney Failure
| Article | Year |
|---|---|
Antibiotics in the peri-operative period.
Topics: Acute Kidney Injury; Aminoglycosides; Anesthesia; Anti-Bacterial Agents; Bronchitis; Cephalosporins; | 1976 |
3 trials available for trimethoprim and Acute Kidney Failure
| Article | Year |
|---|---|
Trimethoprim pharmacokinetics in children with renal insufficiency.
Topics: Absorption; Acute Kidney Injury; Adolescent; Biological Availability; Child; Clinical Trials as Topi | 1987 |
Trimethoprim-sulfamethoxazole: pharmacodynamic effects of urinary pH and impaired renal function. Studies in humans.
Topics: Acute Kidney Injury; Administration, Oral; Ammonium Chloride; Anti-Bacterial Agents; Bacteria; Bicar | 1973 |
Co-trimoxazole in urinary tract infection.
Topics: Acute Kidney Injury; Adult; Anti-Infective Agents; Bacteriuria; Clinical Trials as Topic; Drug Combi | 1973 |
22 other studies available for trimethoprim and Acute Kidney Failure
| Article | Year |
|---|---|
Antibacterial-associated acute kidney injury among older adults: A post-marketing surveillance study using the FDA adverse events reporting system.
Topics: Acute Kidney Injury; Adverse Drug Reaction Reporting Systems; Aged; Anti-Bacterial Agents; Bayes The | 2022 |
Medicine-Induced Acute Kidney Injury Findings from Spontaneous Reporting Systems, Sequence Symmetry Analysis and a Case-Control Study with a Focus on Medicines Used in Primary Care.
Topics: Acute Kidney Injury; Adverse Drug Reaction Reporting Systems; Amlodipine; Amphotericin B; Australia; | 2022 |
In older patients with UTIs, trimethoprim vs amoxicillin was linked to higher risk for AKI at 14 d.
Topics: Acute Kidney Injury; Aged; Amoxicillin; Anti-Bacterial Agents; Cohort Studies; Humans; Trimethoprim; | 2018 |
Trimethoprim is associated with a greater risk of acute kidney injury and hyperkalaemia in older adults compared with other antibiotics used to treat UTIs.
Topics: Acute Kidney Injury; Aged; Anti-Bacterial Agents; Cohort Studies; Humans; Hyperkalemia; Trimethoprim | 2018 |
Reversible renal failure in a child with brucellosis: a case report.
Topics: Acute Kidney Injury; Brucellosis; Drug Combinations; Female; Humans; Infant; Sulfamethoxazole; Trime | 1984 |
Rhabdomyolysis and acute renal failure: a new presentation of acute brucellosis.
Topics: Acute Disease; Acute Kidney Injury; Adult; Brucellosis; Doxycycline; Drug Combinations; Humans; Male | 1984 |
[Biseptol dosage in children in relation to the degree of renal failure and body weight. II].
Topics: Acute Kidney Injury; Adolescent; Body Weight; Child; Child, Preschool; Dose-Response Relationship, D | 1984 |
Shigella enterocolitis and acute renal failure.
Topics: Acute Kidney Injury; Adult; Drug Combinations; Dysentery, Bacillary; Enterocolitis, Pseudomembranous | 1982 |
A generalized allergic reaction with acute interstitial nephritis following trimethoprim-sulfamethoxazole use.
Topics: Acute Kidney Injury; Female; Humans; Hypersensitivity; Infant; Nephritis, Interstitial; Otitis; Sulf | 1982 |
Hyperkalaemia and non-oliguric renal failure associated with trimethoprim.
Topics: Acute Kidney Injury; Aged; Female; Humans; Hyperkalemia; Trimethoprim; Urinary Tract Infections | 1994 |
[Clinical demonstration (author's transl)].
Topics: Acute Kidney Injury; Adult; Aged; Alveolitis, Extrinsic Allergic; Anemia, Macrocytic; Anemia, Megalo | 1978 |
Antibiotic damage to damaged kidneys.
Topics: Acute Kidney Injury; Anti-Bacterial Agents; Drug Combinations; Drug Interactions; Drug Therapy, Comb | 1978 |
Multisystem toxicity after co-trimoxazole.
Topics: Acute Kidney Injury; Aged; Anuria; Drug Combinations; Drug Eruptions; Female; Hepatic Encephalopathy | 1978 |
Co-trimoxazole nephrotoxicity.
Topics: Acute Kidney Injury; Drug Combinations; Drug Hypersensitivity; Erythema; Humans; Kidney; Stevens-Joh | 1979 |
[Acute renal failure and hypocomplementemia associated with Salmonella typhimurium infection].
Topics: Acute Kidney Injury; Aged; Complement System Proteins; Drug Combinations; Humans; Salmonella Infecti | 1979 |
Recurrent acute renal failure due to antibiotic-induced interstitial nephritis.
Topics: Acute Kidney Injury; Drug Combinations; Gentamicins; Humans; Male; Middle Aged; Nephritis, Interstit | 1979 |
Co-trimoxazole induced angiitis presenting as acute renal failure. Report of a case.
Topics: Acute Kidney Injury; Adult; Diagnosis, Differential; Drug Combinations; Drug Hypersensitivity; Human | 1979 |
[Advances in nephrology. Kidney failure in patients with diabetes mellitus].
Topics: Acute Kidney Injury; Diabetes Complications; Humans; Kidney; Kidney Failure, Chronic; Kidney Transpl | 1976 |
Deterioration in renal function in association with co-trimoxazole therapy.
Topics: Acute Kidney Injury; Adult; Aged; Drug Combinations; Female; Humans; Kidney Diseases; Kidney Failure | 1976 |
Acute tubular necrosis following co-trimoxazole therapy.
Topics: Acute Kidney Injury; Aged; Drug Combinations; Drug Eruptions; Humans; Kidney; Kidney Tubular Necrosi | 1989 |
[Acute hyperkalemia and non-oliguric kidney failure during treatment with indomethacin, allopurinol, nifedipine, hydrochlorothiazide/amiloride, trimethoprim/sulfamethoxazole and acetylsalicylic acid].
Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Allopurinol; Amiloride; Aspirin; Drug Combinations; Dr | 1988 |
Deterioration in renal function in association with co-trimoxazole therapy.
Topics: Acute Kidney Injury; Adult; Aged; Anti-Infective Agents; Female; Folic Acid Antagonists; Gastroenter | 1973 |