trimethoprim has been researched along with Abnormalities, Drug-Induced in 16 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Malformations linked to folic acid depletion following exposure during the 3 months before pregnancy." | 7.83 | Trimethoprim during the 3 months before pregnancy: malformations in children. ( , 2016) |
| "38, respectively] if their mothers had a trimethoprim prescription in the 3 months before pregnancy and subtypes of CM for example in the musculoskeletal system, which were consistent to the previous findings from a cohort study." | 7.80 | Trimethoprim use before pregnancy and risk of congenital malformation: reanalyzed using a case-crossover design and a case-time-control design. ( Olsen, J; Sun, Y; Wu, CS, 2014) |
| "Malformations linked to folic acid depletion following exposure during the 3 months before pregnancy." | 3.83 | Trimethoprim during the 3 months before pregnancy: malformations in children. ( , 2016) |
| "38, respectively] if their mothers had a trimethoprim prescription in the 3 months before pregnancy and subtypes of CM for example in the musculoskeletal system, which were consistent to the previous findings from a cohort study." | 3.80 | Trimethoprim use before pregnancy and risk of congenital malformation: reanalyzed using a case-crossover design and a case-time-control design. ( Olsen, J; Sun, Y; Wu, CS, 2014) |
| " The dosage was 1,500, 1,000, 750 and 200 mg trimethoprim per kg bodyweight." | 1.26 | [Investigation on the influence of trimethoprim at the intrauterine development in the rat (author's transl)]. ( Kreutz, R, 1981) |
| "This case of bilateral clinical anophthalmia presents a host of interrelated drug reactions and potential teratogenic factors." | 1.26 | Bilateral clinical anophthalmia: drugs as potential factors. ( Golden, SM; Perman, KI, 1980) |
| " In this dose range the pup weights and the weight gain of the offspring of dams with continued dosing during lactation were also reduced." | 1.26 | [Investigations on the effect of the combination sulfamoxole/trimethoprim on fertility and fetal development in rats and rabbits (author's tranls)]. ( Helm, F; Kretzschmar, R; Leuschner, F; Neumann, W, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (62.50) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 4 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sun, Y | 1 |
| Wu, CS | 1 |
| Olsen, J | 1 |
| Wang, X | 1 |
| Tan, Z | 1 |
| Cheng, G | 1 |
| Awais, I | 1 |
| Huang, L | 1 |
| Chen, D | 1 |
| Pan, Y | 1 |
| Liu, Z | 1 |
| Yuan, Z | 1 |
| Hansen, C | 1 |
| Andrade, SE | 1 |
| Freiman, H | 1 |
| Dublin, S | 1 |
| Haffenreffer, K | 1 |
| Cooper, WO | 1 |
| Cheetham, TC | 1 |
| Toh, S | 1 |
| Li, DK | 1 |
| Raebel, MA | 1 |
| Kuntz, JL | 1 |
| Perrin, N | 1 |
| Rosales, AG | 1 |
| Carter, S | 1 |
| Pawloski, PA | 1 |
| Maloney, EM | 1 |
| Graham, DJ | 1 |
| Sahin, L | 1 |
| Scott, PE | 1 |
| Yap, J | 1 |
| Davis, R | 1 |
| Kreutz, R | 1 |
| Golden, SM | 1 |
| Perman, KI | 1 |
| Martens, M | 1 |
| Amitai, Y | 1 |
| Leventhal, A | 1 |
| Jaffe, P | 1 |
| Liberman, MM | 1 |
| McFadyen, I | 1 |
| Valman, HB | 1 |
| Haliniarz, W | 1 |
| Sikorski, R | 1 |
| Helm, F | 1 |
| Kretzschmar, R | 1 |
| Leuschner, F | 1 |
| Neumann, W | 1 |
| Salter, AJ | 1 |
| McQueen, EG | 1 |
| Brumfitt, W | 2 |
| Pursell, R | 2 |
| McEwen, LM | 1 |
2 trials available for trimethoprim and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Trimethoprim-sulphamethoxazole in the treatment of urinary infection.
Topics: Abnormalities, Drug-Induced; Ampicillin; Anti-Infective Agents; Cephalexin; Clinical Trials as Topic | 1973 |
Trimethoprim-sulfamethoxazole in the treatment of bacteriuria in women.
Topics: Abnormalities, Drug-Induced; Ambulatory Care; Ampicillin; Bacteriuria; Cephalexin; Clinical Trials a | 1973 |
14 other studies available for trimethoprim and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Trimethoprim use before pregnancy and risk of congenital malformation: reanalyzed using a case-crossover design and a case-time-control design.
Topics: Abnormalities, Drug-Induced; Case-Control Studies; Cross-Over Studies; Denmark; Electronic Health Re | 2014 |
Two-generation reproduction and teratology studies of feeding aditoprim in Wistar rats.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Anti-Bacterial Agents; Dose-Response Rel | 2015 |
Trimethoprim-sulfonamide use during the first trimester of pregnancy and the risk of congenital anomalies.
Topics: Abnormalities, Drug-Induced; Adult; Anti-Bacterial Agents; Cohort Studies; Female; Humans; Infant; I | 2016 |
Trimethoprim during the 3 months before pregnancy: malformations in children.
Topics: Abnormalities, Drug-Induced; Anti-Infective Agents, Urinary; Female; Folic Acid; Folic Acid Antagoni | 2016 |
[Investigation on the influence of trimethoprim at the intrauterine development in the rat (author's transl)].
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Embryo Implantation; Female; Fetal Resor | 1981 |
Bilateral clinical anophthalmia: drugs as potential factors.
Topics: Abnormalities, Drug-Induced; Adult; Amitriptyline; Anophthalmos; Dicyclomine; Drug Combinations; Dru | 1980 |
[Careful with trimethoprim in pregnant sows].
Topics: Abnormalities, Drug-Induced; Animals; Female; Pregnancy; Pregnancy Complications, Infectious; Swine; | 1993 |
Folic acid antagonists during pregnancy and risk of birth defects.
Topics: Abnormalities, Drug-Induced; Cleft Lip; Female; Folic Acid Antagonists; Heart Defects, Congenital; H | 2001 |
Letter: Incidence of congenital limb-reduction deformities.
Topics: Abnormalities, Drug-Induced; Arm; Benzyl Compounds; Birth Weight; Congenital Abnormalities; England; | 1975 |
[Studies on the embryotoxicity of the preparation Biseptol-Polfa in pregnant hamsters].
Topics: Abnormalities, Drug-Induced; Animals; Cricetinae; Drug Combinations; Drug Evaluation, Preclinical; E | 1979 |
[Investigations on the effect of the combination sulfamoxole/trimethoprim on fertility and fetal development in rats and rabbits (author's tranls)].
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Birth Weight; Drug Combinations; Female; Fer | 1976 |
The toxicity profile of trimethoprim-sulphamethoxazole after four years of widespread use.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Animals; Anti-Infective Agents; Child; Child, Presch | 1973 |
New Zealand Committee on Adverse Drug Reactions: Ninth Annual Report 1974.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Aged; Antineoplastic Agents; Drug Interactions; Drug | 1974 |
Trimethoprim-sulphamethoxazole mixture in pregnancy.
Topics: Abnormalities, Drug-Induced; Animals; Anti-Infective Agents; Drug Combinations; Female; Fetus; Folic | 1971 |