trimethoprim has been researched along with AIDS-Related Opportunistic Infections in 44 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
AIDS-Related Opportunistic Infections: Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). The most common include PNEUMOCYSTIS PNEUMONIA, Kaposi's sarcoma, cryptosporidiosis, herpes simplex, toxoplasmosis, cryptococcosis, and infections with Mycobacterium avium complex, Microsporidium, and Cytomegalovirus.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To describe a retrospective study of six HIV-positive individuals with compensated metabolic acidosis while receiving intravenous trimethoprim/sulfamethoxazole (TMP/SMX)." | 7.70 | Trimethoprim/sulfamethoxazole and metabolic acidosis in HIV-infected patients. ( Castrillón, JL; Lecumberri, JN; Porras, MC, 1998) |
| "To report a case of trimethoprim/sulfamethoxazole (TMP/SMX)-induced tremor responsive to a reduction in dosage." | 7.70 | Trimethoprim/sulfamethoxazole-induced tremor in a patient with AIDS. ( Lerner, SA; Rybak, MJ; Slavik, RS, 1998) |
| "1) To determine the incidence and severity of hyperkalemia during trimethoprim therapy." | 7.68 | Renal mechanism of trimethoprim-induced hyperkalemia. ( Ellison, DH; Perazella, MA; Velázquez, H; Wright, FS, 1993) |
| "To describe a retrospective study of six HIV-positive individuals with compensated metabolic acidosis while receiving intravenous trimethoprim/sulfamethoxazole (TMP/SMX)." | 3.70 | Trimethoprim/sulfamethoxazole and metabolic acidosis in HIV-infected patients. ( Castrillón, JL; Lecumberri, JN; Porras, MC, 1998) |
| "To report a case of trimethoprim/sulfamethoxazole (TMP/SMX)-induced tremor responsive to a reduction in dosage." | 3.70 | Trimethoprim/sulfamethoxazole-induced tremor in a patient with AIDS. ( Lerner, SA; Rybak, MJ; Slavik, RS, 1998) |
| "1) To determine the incidence and severity of hyperkalemia during trimethoprim therapy." | 3.68 | Renal mechanism of trimethoprim-induced hyperkalemia. ( Ellison, DH; Perazella, MA; Velázquez, H; Wright, FS, 1993) |
| "Trimetrexate is a powerful inhibitor of the dihydrofolate reductase of Pneumocystis carinii." | 2.67 | Trimetrexate with leucovorin versus trimethoprim-sulfamethoxazole for moderate to severe episodes of Pneumocystis carinii pneumonia in patients with AIDS: a prospective, controlled multicenter investigation of the AIDS Clinical Trials Group Protocol 029/0 ( Akil, B; Baughman, R; Boylen, CT; Davis, R; Frame, P; Hughlett, C; Nichols, L; Sattler, FR; Shelton, B; Weiss, W, 1994) |
| "Standard treatments of HIV-associated Pneumocystis carinii pneumonia (PCP) consist of high dose intravenous or oral cotrimoxazole or intravenous pentamidine." | 2.67 | [Successful treatment of HIV-associated pneumocystis carinii pneumonia with dapsone plus trimethoprim]. ( Laifer, G; Rüttimann, S, 1992) |
| "We report a case of P carinii infection presenting as bilateral aural polyps, otitis media and mastoiditis in human immunodeficiency (HIV)-positive patient with no history of prior or concomitant P carinii infection." | 2.41 | Pneumocystis carinii infection in bilateral aural polyps in a human immunodeficiency virus-positive patient. ( Elmahallawy, M; Horsfield, C; Praveen, CV; Terry, RM, 2002) |
| "Pneumocystis jirovecii pneumonia has historically been one of the most common opportunistic pneumonias and life-threatening infectious complications in HIV-infected patients." | 1.33 | [Pneumocystis jirovecii pneumonia: an old disease with a new name]. ( Aleksoniene, R; Ambrozaitis, A; Matulionyte, R; Paulauskiene, R, 2006) |
| "Nine patients had cervical lymphadenitis; 2 had disseminated infection." | 1.31 | Clinical and pathologic features of Mycobacterium fortuitum infections. An emerging pathogen in patients with AIDS. ( Boyars, MC; Schnadig, VJ; Smith, MB; Woods, GL, 2001) |
| "aureus bacteremia were compared against 188 controls selected from patients with CD4 cell counts < 200 x 10(6)/l." | 1.30 | Prior antimicrobials and staphylococcal bacteremia in HIV-infected patients. ( Chaisson, RE; Moore, RD; Styrt, BA, 1997) |
| "A population pharmacokinetic model of intravenously and orally administered trimethoprim in patients with acquired immunodeficiency syndrome and Pneumocystis carinii pneumonia has been made using a parametric iterative two-stage Bayesian and a nonparametric expectation maximization computer program." | 1.30 | A population pharmacokinetic model of trimethoprim in patients with pneumocystis pneumonia, made with parametric and nonparametric methods. ( Gomis, P; Jelliffe, RW; Ruskin, J; Sattler, FR; Tahani, B, 1997) |
| " Ro 11-8958, TMP, and diaveridine used at a dosage of 20 mg/kg/day with SMX were only slightly more effective than SMX used alone." | 1.29 | Synergistic combinations of Ro 11-8958 and other dihydrofolate reductase inhibitors with sulfamethoxazole and dapsone for therapy of experimental pneumocystosis. ( Foy, J; Steele, P; Walzer, PD; White, M, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 30 (68.18) | 18.2507 |
| 2000's | 11 (25.00) | 29.6817 |
| 2010's | 3 (6.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gangjee, A | 3 |
| Devraj, R | 1 |
| Queener, SF | 5 |
| Vasudevan, A | 2 |
| Rosowsky, A | 2 |
| Forsch, RA | 2 |
| Sibley, CH | 1 |
| Inderlied, CB | 1 |
| Du Plooy, N | 1 |
| Rayner, B | 1 |
| Babayev, R | 1 |
| Terner, S | 1 |
| Chandra, S | 1 |
| Radhakrishnan, J | 1 |
| Mohan, S | 1 |
| Cho, JY | 1 |
| Kim, DM | 1 |
| Kwon, YE | 1 |
| Yoon, SH | 1 |
| Lee, SI | 1 |
| Francesconi, F | 1 |
| Rocha, MA | 1 |
| Bonilla, LF | 1 |
| da Silva, LA | 1 |
| Francesconi, VA | 1 |
| Goussard, P | 1 |
| Kling, S | 1 |
| Gie, RP | 1 |
| Nel, ED | 1 |
| Heyns, L | 1 |
| Rossouw, GJ | 1 |
| Janson, JT | 1 |
| Rodriguez, M | 1 |
| Fishman, JA | 1 |
| Nomura, T | 1 |
| Abe, R | 1 |
| Fujimoto, K | 1 |
| Endo, T | 1 |
| Shimizu, H | 1 |
| Koike, T | 1 |
| Matulionyte, R | 1 |
| Ambrozaitis, A | 1 |
| Paulauskiene, R | 1 |
| Aleksoniene, R | 1 |
| Ruga, E | 1 |
| Giaquinto, C | 1 |
| Cozzani, S | 1 |
| Giacomelli, A | 1 |
| Pagliaro, A | 1 |
| Mazza, A | 1 |
| De Manzini, A | 1 |
| Laverda, AM | 1 |
| D'Elia, R | 1 |
| Raszka, WV | 1 |
| Skillman, LP | 1 |
| McEvoy, PL | 1 |
| Pastor, C | 1 |
| Lumbreras, C | 1 |
| Lizasoain, M | 1 |
| Sattler, FR | 2 |
| Frame, P | 1 |
| Davis, R | 1 |
| Nichols, L | 1 |
| Shelton, B | 1 |
| Akil, B | 1 |
| Baughman, R | 1 |
| Hughlett, C | 1 |
| Weiss, W | 1 |
| Boylen, CT | 1 |
| Ajisawa, A | 1 |
| Velázquez, H | 1 |
| Perazella, MA | 1 |
| Wright, FS | 1 |
| Ellison, DH | 1 |
| Patey, O | 1 |
| Salvanet, A | 1 |
| Serrhini, A | 1 |
| Lafaix, C | 1 |
| Walzer, PD | 1 |
| Foy, J | 1 |
| Steele, P | 1 |
| White, M | 1 |
| Lang, W | 1 |
| Osmond, D | 1 |
| Page-Bodkin, K | 1 |
| Moss, A | 1 |
| Winkelstein, W | 1 |
| Martinez, M | 1 |
| Soriano, V | 1 |
| González-Lahoz, J | 1 |
| Stammers, DK | 1 |
| Delves, C | 1 |
| Ballantine, S | 1 |
| Jones, EY | 1 |
| Stuart, DI | 1 |
| Achari, A | 1 |
| Bryant, PK | 1 |
| Champness, JN | 1 |
| Teuscher, AU | 1 |
| Opravil, M | 1 |
| Theiler, R | 1 |
| Speich, R | 1 |
| Kuster, H | 1 |
| Siegenthaler, W | 1 |
| Russi, EW | 1 |
| Lüthy, R | 1 |
| Korraa, H | 1 |
| Saadeh, C | 1 |
| Kaplan, JE | 1 |
| Hu, DJ | 1 |
| Holmes, KK | 1 |
| Jaffe, HW | 1 |
| Masur, H | 1 |
| De Cock, KM | 1 |
| Tumbarello, M | 1 |
| Tacconelli, E | 1 |
| Cauda, R | 1 |
| Ortona, L | 1 |
| Styrt, BA | 1 |
| Chaisson, RE | 1 |
| Moore, RD | 1 |
| Jelliffe, RW | 1 |
| Gomis, P | 1 |
| Tahani, B | 1 |
| Ruskin, J | 1 |
| Bernard, E | 1 |
| Delgiudice, P | 1 |
| Carles, M | 1 |
| Boissy, C | 1 |
| Saint-Paul, MC | 1 |
| Le Fichoux, Y | 1 |
| Michiels, JF | 1 |
| Dellamonica, P | 1 |
| Gambini, D | 1 |
| Brambilla, AM | 1 |
| Galli, C | 1 |
| Castagna, A | 1 |
| Veglia, F | 1 |
| Lazzarin, A | 1 |
| Ruggli, GM | 1 |
| Weber, R | 1 |
| Messmer, EP | 1 |
| Font, RL | 1 |
| Moll, C | 1 |
| Bernauer, W | 1 |
| Porras, MC | 1 |
| Lecumberri, JN | 1 |
| Castrillón, JL | 1 |
| Slavik, RS | 1 |
| Rybak, MJ | 1 |
| Lerner, SA | 1 |
| Gabriëls, G | 1 |
| Stockem, E | 1 |
| Greven, J | 1 |
| al-Tawfiq, JA | 1 |
| Sorensen, SJ | 1 |
| Cushing, HE | 1 |
| Chan, C | 1 |
| Montaner, J | 1 |
| Lefebvre, EA | 1 |
| Morey, G | 1 |
| Dohn, M | 1 |
| McIvor, RA | 1 |
| Scott, J | 1 |
| Marina, R | 1 |
| Caldwell, P | 1 |
| Patel, SK | 1 |
| Philpott, JM | 1 |
| McPartlin, DW | 1 |
| Asencio Marchante, R | 1 |
| Lissen Otero, E | 1 |
| Smith, MB | 1 |
| Schnadig, VJ | 1 |
| Boyars, MC | 1 |
| Woods, GL | 1 |
| Navin, TR | 1 |
| Beard, CB | 1 |
| Huang, L | 1 |
| del Rio, C | 1 |
| Lee, S | 1 |
| Pieniazek, NJ | 1 |
| Carter, JL | 1 |
| Le, T | 1 |
| Hightower, A | 1 |
| Rimland, D | 1 |
| Praveen, CV | 1 |
| Terry, RM | 1 |
| Elmahallawy, M | 1 |
| Horsfield, C | 1 |
| Rüttimann, S | 1 |
| Laifer, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Comparative, Double-Blind Trial of Trimetrexate (CI-898) With Leucovorin Calcium Rescue Versus Trimethoprim / Sulfamethoxazole for Moderately Severe Pneumocystis Carinii Pneumonia in Patients With AIDS[NCT00001014] | Phase 3 | 302 participants | Interventional | Completed | |||
| A Randomized, Comparative, Double-Blind Trial of Trimetrexate (CI-898) With Leucovorin Calcium Rescue Versus Trimethoprim / Sulfamethoxazole for Moderately Severe Pneumocystis Carinii Pneumonia in Patients With AIDS[NCT00001013] | Phase 3 | 364 participants | Interventional | Completed | |||
| A Randomized, Open-Label Trial of High Dose Atovaquone Versus Low Dose Atovaquone Versus Aerosolized Pentamidine for Prophylaxis of Pneumocystis Carinii Pneumonia in Patients With HIV Infection Who Are Intolerant of TMP/SMX[NCT00002340] | Phase 3 | 615 participants | Interventional | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for trimethoprim and AIDS-Related Opportunistic Infections
| Article | Year |
|---|---|
Prevention of infection due to Pneumocystis spp. in human immunodeficiency virus-negative immunocompromised patients.
Topics: AIDS-Related Opportunistic Infections; Antifungal Agents; Bone Marrow Transplantation; Humans; Immun | 2004 |
The use of antibiotics in the treatment and prevention of infection in HIV-infected children.
Topics: AIDS-Related Opportunistic Infections; Child; Clinical Trials as Topic; Drug Therapy, Combination; H | 1994 |
[Current alternatives in the treatment of Pneumocystis carinii pneumonia in patients with AIDS].
Topics: AIDS-Related Opportunistic Infections; Antifungal Agents; Atovaquone; Clindamycin; Dapsone; Eflornit | 1994 |
Options in the management of pneumonia caused by Pneumocystis carinii in patients with acquired immune deficiency syndrome and intolerance to trimethoprim/sulfamethoxazole.
Topics: Adrenal Cortex Hormones; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Antifungal Ag | 1996 |
Preventing opportunistic infections in human immunodeficiency virus-infected persons: implications for the developing world.
Topics: Africa; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Antitubercular Agents; Asia; B | 1996 |
[Hyperkalemia after trimethoprim or pentamidine. Until now, a little noticed side effect of antimicrobial therapeutic measures in AIDS patients].
Topics: AIDS-Related Opportunistic Infections; Anti-Infective Agents; Antiprotozoal Agents; Folic Acid Antag | 1998 |
An unusual case of Pneumocystis carinii presenting as an aural mass.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Dapsone; Drug Therapy, Combinat | 1999 |
Pneumocystis carinii infection in bilateral aural polyps in a human immunodeficiency virus-positive patient.
Topics: Adult; AIDS-Related Opportunistic Infections; Antifungal Agents; Dapsone; Ear Neoplasms; Ear, Middle | 2002 |
5 trials available for trimethoprim and AIDS-Related Opportunistic Infections
31 other studies available for trimethoprim and AIDS-Related Opportunistic Infections
| Article | Year |
|---|---|
Synthesis and dihydrofolate reductase inhibitory activities of 2,4-diamino-5-deaza and 2,4-diamino-5,10-dideaza lipophilic antifolates.
Topics: AIDS-Related Opportunistic Infections; Animals; Folic Acid Antagonists; Liver; Pyrimidines; Rats; Te | 1997 |
Synthesis and biological evaluation of nonclassical 2,4-diamino-5-methylpyrido[2,3-d]pyrimidines with novel side chain substituents as potential inhibitors of dihydrofolate reductases.
Topics: AIDS-Related Opportunistic Infections; Animals; Folic Acid Antagonists; Humans; Liver; Mice; Pneumoc | 1997 |
Further studies on 2,4-diamino-5-(2',5'-disubstituted benzyl)pyrimidines as potent and selective inhibitors of dihydrofolate reductases from three major opportunistic pathogens of AIDS.
Topics: AIDS-Related Opportunistic Infections; Animals; Benzyl Compounds; Folic Acid Antagonists; Liver; Mag | 2003 |
New 2,4-diamino-5-(2',5'-substituted benzyl)pyrimidines as potential drugs against opportunistic infections of AIDS and other immune disorders. Synthesis and species-dependent antifolate activity.
Topics: AIDS-Related Opportunistic Infections; Animals; Folic Acid Antagonists; Humans; Inhibitory Concentra | 2004 |
Life-threatening hyperkalaemia due to trimethoprim in a patient treated for Pneumocystis jirovecii pneumonia.
Topics: AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Female; HIV Infections; Humans; Hyperk | 2019 |
Trimethoprim-associated hyponatremia.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Diagnosis, Differential; Humans | 2013 |
Newly formed cystic lesions for the development of pneumomediastinum in Pneumocystis jirovecii pneumonia.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Humans; Male; Mediastinal Emphy | 2009 |
A rapidly growing lesion on the lip--quiz case.
Topics: Adult; AIDS-Related Opportunistic Infections; Biopsy, Needle; Disease Progression; Drug Therapy, Com | 2009 |
Plasma exchange; a promising treatment for toxic epidermal necrolysis with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Anti-HIV Agents; A | 2004 |
[Pneumocystis jirovecii pneumonia: an old disease with a new name].
Topics: AIDS-Related Opportunistic Infections; Anti-Infective Agents, Urinary; Antifungal Agents; Drug Combi | 2006 |
In vitro susceptibility of clinical isolates of Mycobacterium avium and M. intracellulare to folate antagonists.
Topics: Adult; Aged; Aged, 80 and over; AIDS-Related Opportunistic Infections; Child; Child, Preschool; Drug | 1994 |
[Protozoan infections in AIDS].
Topics: Acquired Immunodeficiency Syndrome; Administration, Inhalation; AIDS-Related Opportunistic Infection | 1993 |
Renal mechanism of trimethoprim-induced hyperkalemia.
Topics: AIDS-Related Opportunistic Infections; Animals; Humans; Hyperkalemia; Kidney; Kidney Tubules, Distal | 1993 |
Pneumocystis carinii choroidopathy in AIDS patients.
Topics: Adult; AIDS-Related Opportunistic Infections; Angiography; Choroiditis; Humans; Male; Pneumocystis I | 1993 |
Synergistic combinations of Ro 11-8958 and other dihydrofolate reductase inhibitors with sulfamethoxazole and dapsone for therapy of experimental pneumocystosis.
Topics: AIDS-Related Opportunistic Infections; Animals; Dapsone; Disease Models, Animal; Dose-Response Relat | 1993 |
Population-based estimates of antiretroviral therapy and anti-Pneumocystis prophylaxis in San Francisco: 1991.
Topics: AIDS-Related Opportunistic Infections; Anti-Infective Agents; Antiviral Agents; Cohort Studies; Daps | 1993 |
Preliminary crystallographic data for Pneumocystis carinii dihydrofolate reductase.
Topics: AIDS-Related Opportunistic Infections; Genes, Bacterial; Humans; NADP; Pneumocystis; Protein Binding | 1993 |
Predictive value of bronchoalveolar lavage in excluding a diagnosis of Pneumocystis carinii pneumonia during prophylaxis with aerosolized pentamidine.
Topics: Administration, Intranasal; Adult; Aerosols; AIDS-Related Opportunistic Infections; Bronchoalveolar | 1993 |
Secondary Pneumocystis carinii pneumonia prophylaxis with trimethoprim-sulphamethoxazole does not prevent bacterial pneumonia in HIV-infected persons.
Topics: Adult; AIDS-Related Opportunistic Infections; Case-Control Studies; Drug Therapy, Combination; Human | 1996 |
Prior antimicrobials and staphylococcal bacteremia in HIV-infected patients.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Bacteremia; Case-Control Studie | 1997 |
A population pharmacokinetic model of trimethoprim in patients with pneumocystis pneumonia, made with parametric and nonparametric methods.
Topics: Administration, Oral; Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Bayes The | 1997 |
Conformationally restricted analogues of trimethoprim: 2,6-diamino-8-substituted purines as potential dihydrofolate reductase inhibitors from Pneumocystis carinii and Toxoplasma gondii.
Topics: AIDS-Related Opportunistic Infections; Animals; Binding Sites; Folic Acid Antagonists; Humans; Indic | 1997 |
Disseminated isosporiasis in an AIDS patient.
Topics: Adult; AIDS-Related Opportunistic Infections; Animals; Anti-Infective Agents; Coccidiosis; Female; H | 1997 |
Increased hyperglycaemia during cotreatment with pentamidine and corticosteroids in AIDS patients.
Topics: Acquired Immunodeficiency Syndrome; Adrenal Cortex Hormones; AIDS-Related Opportunistic Infections; | 1997 |
Pneumocystis carinii infection of the conjunctiva in a patient with acquired immune deficiency syndrome.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Conjunctiva; Conjunctival Disea | 1997 |
Trimethoprim/sulfamethoxazole and metabolic acidosis in HIV-infected patients.
Topics: Acidosis; Adult; Aged; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Female; Humans; | 1998 |
Trimethoprim/sulfamethoxazole-induced tremor in a patient with AIDS.
Topics: AIDS-Related Opportunistic Infections; Anti-Infective Agents; Humans; Male; Middle Aged; Pneumonia, | 1998 |
Therapeutic failure of trimethoprim/sulfamethoxazole in the treatment of Pneumocystis carinii pneumonia.
Topics: AIDS-Related Opportunistic Infections; Anti-Infective Agents; Drug Combinations; Humans; Male; Middl | 1999 |
[Secondary prevention of opportunistic infections in HIV-infected patients].
Topics: AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Anti-Infective Agents; Antiprotozoal A | 2001 |
Clinical and pathologic features of Mycobacterium fortuitum infections. An emerging pathogen in patients with AIDS.
Topics: Abscess; Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Biopsy, N | 2001 |
Effect of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of P carinii pneumonia in patients with HIV-1: a prospective study.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Dapsone; Dihydropteroate Syntha | 2001 |