trimethoprim--sulfamethoxazole-drug-combination and Ureteral-Calculi

We evaluated the efficacy of the alpha1-adrenergic antagonist tamsulosin for conservative expulsive therapy in patients with ureteral colic due to juxtavesical stones.. A total of 60 consecutive symptomatic patients with stones located in the juxtavesical tract of the ureter were randomly divided into group 1--30 who received oral floroglucine-trimetossibenzene 3 times daily and group 2--30 who received 0.4 mg tamsulosin daily. The 2 groups received 30 mg deflazacort daily for 10 days plus cotrimoxazole 2 times daily for 8 days and 75 mg diclofenac injected intramuscularly on demand. Ultrasound followup and medical visits were performed weekly for 4 weeks. Stone passage rate and time, analgesic use, hospitalization and endoscopical intervention were evaluated. Statistical analysis was performed using the Student t test.. The stone expulsion rate was 70% for group 1 and 100% for group 2. Mean stone size was 5.8 and 6.7 mm, respectively (p = 0.001). Mean expulsion time was 111.1 hours for group 1 and 65.7 hours for group 2 (p = 0.020). The mean number of diclofenac injections was 2.83 for group 1 and 0.13 for group 2 (p <0.0001). Ten group 1 patients were hospitalized, of whom 9 underwent ureteroscopy, compared with none in group 2 (p <0.0001 and 0.001, respectively).. Tamsulosin used as a spasmolytic drug during renal colic due to juxtavesical calculi increased the stone expulsion rate and decreased expulsion time, the need for hospitalization and endoscopic procedures, and provided particularly good control of colic pain.

Topics: Administration, Oral; Adolescent; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Adult; Aged; Anti-Infective Agents, Urinary; Anti-Inflammatory Agents; Diclofenac; Drug Therapy, Combination; Female; Hospitalization; Humans; Injections, Intramuscular; Male; Middle Aged; Pain; Pregnenediones; Sulfonamides; Tamsulosin; Trimethoprim, Sulfamethoxazole Drug Combination; Ureteral Calculi

To compare two treatment regimens in patients with ureteral calculi. One regimen (control arm) used routine drugs, and the second regimen (treatment arm) used the same routine drugs plus uncommonly used drugs.. Between February and October 1998, 70 consecutive patients were evaluated for symptomatic ureteral calculi. Thirty-five patients were randomized to a control arm and received ketorolac, oxycodone, and acetaminophen combination tablets and prochlorperazine suppositories. Thirty-five patients were randomized to the treatment arm and received the same medications plus nifedipine XL, prednisone, and trimethoprim/sulfa combination tablets and plain acetaminophen. Stone passage rates, work days lost, emergency room visits, surgical interventions, and possible side effects of the drugs were recorded.. The treatment arm (addition of nifedipine XL, prednisone, trimethoprim/sulfa, and plain acetaminophen) had higher (86% versus 56%) stone passage rates and fewer lost work days (mean 1.76 versus 4.9), emergency room visits (1 versus 4), and surgical interventions (2 versus 15). Both arms exhibited similar potential drug side effects.. The addition of a calcium channel blocking agent, steroids, antibiotics, and more acetaminophen effected a higher stone passage rate and fewer lost work days, emergency room visits, and surgical interventions.

Topics: Absenteeism; Acetaminophen; Anti-Infective Agents, Urinary; Calcium Channel Blockers; Drug Therapy, Combination; Humans; Ketorolac; Nifedipine; Oxycodone; Prednisone; Prochlorperazine; Suppositories; Trimethoprim, Sulfamethoxazole Drug Combination; Ureteral Calculi

We report a case of recurrent urinary tract infections owing to culture proved ureteral infection stones. Although ureteral catheterization studies unilaterally localized the infection to the upper urinary tract, the direct immunofluorescence antibody test indicative of upper tract infection was negative. The patient was cured of persistent urinary tract infection by antibiotics, ureterolithotomy, resection of the stenotic ureteral segment and ureteroureterostomy.

Topics: Adult; Drug Combinations; Humans; Male; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Ureteral Calculi; Urinary Tract Infections

Topics: Adult; Ampicillin; Bacteriuria; Drug Combinations; Female; Humans; Magnesium; Magnesium Compounds; Phosphates; Pregnancy; Pregnancy Complications, Infectious; Recurrence; Staphylococcal Infections; Staphylococcus; Struvite; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Ureteral Calculi