trimethoprim--sulfamethoxazole-drug-combination and Stomatitis

Topics: Antibodies, Antineutrophil Cytoplasmic; Autoantibodies; Azathioprine; Biopsy; Cyclophosphamide; Glomerulonephritis; Granulomatosis with Polyangiitis; Humans; Lung; Prednisone; Radiography; Rhinitis; Stomatitis; Trimethoprim, Sulfamethoxazole Drug Combination

Topics: Aged; Anti-Infective Agents; Crohn Disease; Diarrhea; Drug Interactions; Female; Humans; Immunosuppressive Agents; Leucovorin; Methotrexate; Mucositis; Pneumonia, Pneumocystis; Prednisone; Stomatitis; Trimethoprim, Sulfamethoxazole Drug Combination

Toxic epidermal necrolysis (TEN) is a rare, potentially life-threatening bullous drug reaction. Rapid diagnosis of TEN can lower the mortality rate when the offending drug is withdrawn immediately. Simple diagnostic tools such as cytology of skin blisters may be useful if rapid diagnosis is needed, in particular if standard histopathology service fails. An even faster bedside test for TEN in patients with black skin is color evaluation of skin blister fluid.

Topics: Adult; Anti-Bacterial Agents; Black or African American; Body Fluids; Bronchitis; Color; Early Diagnosis; Female; Humans; Keratinocytes; Melanins; Mucositis; Point-of-Care Systems; Stevens-Johnson Syndrome; Stomatitis; Trimethoprim, Sulfamethoxazole Drug Combination

Topics: Adult; Anti-Bacterial Agents; Antiretroviral Therapy, Highly Active; Combined Modality Therapy; Debridement; Drug Therapy, Combination; Female; Gingivitis; Gingivoplasty; Heroin Dependence; HIV Infections; Humans; Mandible; Methadone; Necrosis; Oral Ulcer; Pain; Stomatitis; Substance Abuse, Intravenous; Tooth Extraction; Tooth Loss; Treatment Refusal; Trimethoprim, Sulfamethoxazole Drug Combination