trimethoprim--sulfamethoxazole-drug-combination and Spinal-Diseases

A previously healthy male with subacute onset right leg weakness was suspected to have an astrocytoma as imaging showed a lesion. Subsequent biopsy showed the presence of foamy macrophages containing periodic acid-Schiff staining granules, suggesting Whipple disease as a possible diagnosis.

Topics: Anti-Bacterial Agents; Ceftriaxone; Drug Therapy, Combination; Duodenum; Foam Cells; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Periodic Acid-Schiff Reaction; Recurrence; Spinal Diseases; Trimethoprim, Sulfamethoxazole Drug Combination; Tropheryma; Whipple Disease

The clinical features of 21 episodes of skeletal brucellosis in 17 Iraqi patients are reported. Six had monarthritis of a large joint, six had spondylitis, and five had spondarthritis. Brucellosis remains a major health problem in Iraq. The disease is transmitted to man through the ingestion of unpasteurised milk or milk products but can also be acquired through physical contact.

Topics: Adult; Aged; Anti-Bacterial Agents; Arthritis, Infectious; Brucella abortus; Brucellosis; Drug Combinations; Drug Therapy, Combination; Female; Humans; Iraq; Male; Middle Aged; Spinal Diseases; Sulfamethoxazole; Tetracycline; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination