trimethoprim--sulfamethoxazole-drug-combination and Radiation-Pneumonitis

We report a case of Nocardia exalbida (N.exalbida)-induced pneumonia in a 70-year old Japanese man with lung cancer and radiation pneumonitis. He initially received doripenem (1.5 g/day) for pneumonia treatment, and N.exalbida was identified by a clone library analysis of bronchoalveolar lavage fluid obtained from the pneumonia lesion. The doripenem dosage was therefore increased to 3.0 g/day with adjunctive trimethoprim/sulfamethoxazole, and his pneumonia improved. N. exalbida is susceptible to antibiotics; thus, in nocardiosis, N. exalbida infection might be associated with a good response to treatment, although its clinical findings are non-specific and similar to those of other Nocardia infections.

Topics: Aged; Anti-Bacterial Agents; Doripenem; Drug Therapy, Combination; Humans; Lung Neoplasms; Male; Nocardia; Nocardia Infections; Opportunistic Infections; Radiation Pneumonitis; Trimethoprim, Sulfamethoxazole Drug Combination

Topics: Aged; Anti-Bacterial Agents; Humans; Male; Middle Aged; Pneumocystis carinii; Pneumonia, Pneumocystis; Radiation Pneumonitis; Steroids; Thoracic Neoplasms; Trimethoprim, Sulfamethoxazole Drug Combination