trimethoprim--sulfamethoxazole-drug-combination and Pyoderma

Blastomycosis-like pyoderma is an unusual, exaggerated, vegetative-tissue reaction to a prolonged primary or secondary bacterial infection. It is a rare disease, usually seen in immunocompromized patients. We report a case of localized blastomycosis-like pyoderma responding poorly to classic treatments, but that gave a dramatic response to a combination treatment of cotrimoxazol and cryotherapy.

Topics: Aged; Anti-Infective Agents; Blastomycosis; Cryotherapy; Diagnosis, Differential; Female; Humans; Pyoderma; Trimethoprim, Sulfamethoxazole Drug Combination

Topics: Anti-Infective Agents; Child; Human T-lymphotropic virus 1; Humans; Male; Pyoderma; Trimethoprim, Sulfamethoxazole Drug Combination

Topics: Administration, Oral; Administration, Topical; Animals; Anti-Infective Agents; Dog Diseases; Dogs; Insecticides; Male; Mite Infestations; Pyoderma; Skin Diseases, Infectious; Staphylococcal Infections; Toluidines; Trimethoprim, Sulfamethoxazole Drug Combination

The effect of trimethoprim/sulfamethoxazole (T/SMX, 30 mg/kg, PO, q 12 h for 6 weeks) on thyroid function was evaluated in 21 dogs with pyoderma and normal baseline serum thyroxine concentrations. The population mean serum thyroxine concentration, but not the population mean serum triiodothyronine concentration, was significantly decreased at the end of treatment. After 6 weeks of treatment, the response in 3 dogs to thyrotropin administration was substantially reduced. Radionuclide thyroid imaging of 2 dogs after T/SMX treatment revealed higher-than-normal thyroid technetium 99m pertechnetate uptake, suggestive of an interference with iodide metabolism. Use of T/SMX may cause hypothyroidism, and inadequate thyroid function may be incorrectly diagnosed in dogs treated with this antimicrobial.

Topics: Animals; Breeding; Dog Diseases; Dogs; Female; Hypothyroidism; Male; Pyoderma; Radionuclide Imaging; Staphylococcal Skin Infections; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine; Trimethoprim, Sulfamethoxazole Drug Combination

Topics: Animals; Anti-Infective Agents; Arthritis; Dog Diseases; Dogs; Drug Combinations; Female; Pyoderma; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination