trimethoprim--sulfamethoxazole-drug-combination and Periodontal-Diseases

Despite a large amount of research of periodontal health seen in HIV infection, much remains to be learned. Very few large controlled studies of infected people at settings not self-selected for oral disease have been reported, and few have investigated the necrotising periodontal diseases described in HIV infection. In this paper we present a brief review of three approaches to identify periodontal changes associated with HIV infection and identify possible aetiological factors for them. First, we summarise the methods and findings of a controlled blinded study of the periodontal health of homosexual men attending a genito-urinary medicine clinic. Second, we precis a case-control study of gingival ulceration among patients at a dedicated dental clinic. Finally, we outline how the validity of diagnostic criteria for HIV-associated periodontal changes were tested against the data collected in the controlled study.

Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Candidiasis, Oral; Case-Control Studies; CD4 Lymphocyte Count; Gingival Diseases; Gingivitis, Necrotizing Ulcerative; HIV Infections; Humans; Male; Oral Ulcer; Periodontal Diseases; Prognosis; Research Design; Trimethoprim, Sulfamethoxazole Drug Combination