trimethoprim--sulfamethoxazole-drug-combination and Pericardial-Effusion

We describe a case of disseminated nocardiosis in a 45-year-old male with a history of chronic glomerular nephritis and allograft renal transplantation both treated with immunosuppressive drugs. Clinical symptoms included fever, chest distress, breathlessness, subcutaneous nodules and pustules. Pulmonary computed tomography scans revealed areas of consolidation in both lung fields, pleural effusion and massive pericardial effusion. Bacterial culture of the pus in the subcutaneous abscesses and pericardial effusion showed growth of Nocardia asteroides sensitive to linezolid and trimethoprim-sulfamethoxazole (TMP-SMZ) for both. Treatment with linezolid combined with TMP-SMZ resulted in a clear clinical improvement and bacterial clearance.

Topics: Abscess; Acetamides; Anti-Bacterial Agents; Drug Therapy, Combination; Humans; Immunocompromised Host; Linezolid; Male; Middle Aged; Nocardia Infections; Opportunistic Infections; Oxazolidinones; Pericardial Effusion; Trimethoprim, Sulfamethoxazole Drug Combination