trimethoprim--sulfamethoxazole-drug-combination and Penile-Diseases

Granuloma inguinale, or Donovanosis, is a rare, sexually transmitted ulcerative disease primarily affecting the genital area. In this report, we present a case of a 50-year-old man that was diagnosed with granuloma inguinale after a 2-month history of a penile ulcer. Histological analysis demonstrated the presence of Donovan bodies within macrophages, confirming the diagnosis. He was subsequently treated with trimethoprim/sulfamethoxazole with improvement in the ulcer. This case serves as a reminder to clinicians that although granuloma inguinale is rarely encountered in the US, it should still be suspected in patients with non-healing penile ulcers.

Topics: Anti-Bacterial Agents; Granuloma Inguinale; Humans; Male; Middle Aged; Penile Diseases; Trimethoprim, Sulfamethoxazole Drug Combination; Ulcer

This is a report of a very rare case of proven postcoital penile drug eruption in a patient following vaginal use of triple sulfa vaginal cream by his partner.. To report the rare case of cross-reaction following vaginal use of triple sulfa vaginal cream in partner.. A case of postcoital penile drug eruption in a patient following vaginal use of triple sulfa vaginal cream in his partner is presented including subjective reporting, physical examination, and laboratory evaluations.. We report a 42-year-old man with known sensitivity to trimethoprim/sulfamethoxazole (co-trimoxazole) who developed a penile drug eruption at the glans after having intercourse with his wife, who was taking sulfathiazole/sulfacetamide/sulfabenzamide (triple sulfa) vaginal cream. The nature of the lesion was confirmed by a rechallenge test.. To our knowledge, this is the fourth case of proven postcoital penile drug eruption in a patient following vaginal use of triple sulfa vaginal cream in his partner. Our case illustrates the importance of history taking. In clinical practice of urology, it is not rare to see patients who present with strange penile lesions following coitus. To reach a correct diagnosis, one should obtain a drug history of the sexual partner and allergic history of the patient in such cases.

Topics: Administration, Intravaginal; Anti-Infective Agents; Coitus; Drug Eruptions; Humans; Male; Penile Diseases; Sexual Partners; Trimethoprim, Sulfamethoxazole Drug Combination

Topics: Adult; Aged; Anti-Infective Agents; Balanitis; Humans; Male; Middle Aged; Penile Diseases; Skin Ulcer; Trimethoprim, Sulfamethoxazole Drug Combination

Absent for several decades, the chancroid reappeared in Algeria in 1988. In the unique department of Dermatology and Venereology of the University Hospital of the country of Tlemcen (more than 700,000 inhabitants), we wanted to know the state of this STD seven years after the report of the first cases. The file of the consulting patients were examined. We looked for the principal characteristics of this STD: age, sex, incubation period, place infection contact, type of relation, clinical presentation, evolution without and with treatment, other associated STD (syphilis, HIV). From August 1988 (1st case) to December 1995, 144 cases of chancroid were collected = 1988: 6, 1989: 5, 1990: 7, 1991: 18, 1992: 11, 1993: 33, 1994: 48, 1995: 16. The presentation is quite stereotyped; it concerns males only, singles in must cases, having had sexual relations with prostitutes. The incubation period is short (less than 10 days), the characteristic ulceration presents, very often, some adenopathies. The treatment by cotrimoxazole is efficient. They are no concomitant syphilis or HIV infection. The chancroid is the first cause of genital ulceration in the world. Since 1991, it is the principal STD in our department. It spreads within a male population, young singles associated with prostitutes. It is well installed in Algeria, and its role, although minor, in the transmission of the HIV infection, should not be neglected.

Topics: Adolescent; Adult; Age Factors; Algeria; Anti-Infective Agents; Chancroid; Genital Diseases, Male; HIV Infections; Humans; Lymph Nodes; Male; Marital Status; Middle Aged; Penile Diseases; Retrospective Studies; Scrotum; Sex Factors; Sex Work; Sexual Partners; Sexually Transmitted Diseases, Bacterial; Skin Ulcer; Syphilis; Trimethoprim, Sulfamethoxazole Drug Combination

We describe a 34-year-old patient with a probable fixed drug eruption caused by trimethoprim-sulphamethoxazole, having developed the eruption after sexual intercourse with his wife, who was taking the drug. The patient was known to be allergic to trimethoprim-sulphamethoxazole by history, and the lesion then recurred at the same site when the drug was administered orally to his wife. To the best of our knowledge, this is the first report describing postcoital fixed drug eruption. Physicians should thus be aware of unusual and atypical forms of fixed drug eruption. Fixed drug eruption (FDE) is an unusual form of adverse drug reaction, in which one or more lesions appear in precisely the same place or places each time the precipitating drug is administered. The entity was first described by Bourns in 1889, but Brocq then coined the name some years later. FDE may occur anywhere on the skin or mucous membranes, but more frequently occurs on the genitalia and lips. Lesions are usually sharply demarcated patches which quickly become urticarial and sometimes vesicular in the centre. Itching or burning may also be present. Lesions generally leave prolonged postinflammatory hyperpigmentation. The exact pathogenesis of FDE has not been determined, but recent reports have underlined the importance of T lymphocytes, mast cells, keratinocytes and cytokines in the origin of the lesions. We now report a case of FDE apparently caused by trimethoprim-sulphamethoxazole in a male after intercourse with his wife, who was taking the drug. Such FDE, caused by contact with a drug seemingly present in the vaginal fluid, has not been previously described in the literature as far as we know.

Topics: Adult; Anti-Infective Agents; Coitus; Drug Eruptions; Humans; Male; Penile Diseases; Trimethoprim, Sulfamethoxazole Drug Combination

Fixed eruption of the penis, due to co-trimoxazole, is described in two boys. The eruption was accompanied by severe swelling of the penis, urine retention, and pain during micturition. The migration inhibiting factor assay for co-trimoxazole was negative, but the mast cell degranulation test was strongly positive, suggesting reaginic hypersensitivity reaction.

Topics: Child; Child, Preschool; Drug Combinations; Drug Eruptions; Humans; Male; Penile Diseases; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination

Topics: Boston; Chancroid; Disease Outbreaks; Drug Combinations; Erythromycin; Female; Genital Diseases, Female; Humans; Male; Penile Diseases; Serologic Tests; Sex Work; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Ulcer

Topics: Adult; Drug Combinations; Enterobacteriaceae Infections; Homosexuality; Humans; Male; Penile Diseases; Sexually Transmitted Diseases; Shigella flexneri; Skin Diseases, Infectious; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination

Topics: Boston; Chancroid; Disease Outbreaks; Drug Combinations; Erythromycin; Female; Genital Diseases, Female; Humans; Male; Penile Diseases; Serologic Tests; Sex Work; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Ulcer

A 39-year-old Norwegian seaman developed penile ulcerations after sexual contact overseas. The diagnosis of syphilitic chancre and of chancroid was confirmed. The ulcers healed after combined treatment with benzathine penicillin and trimethoprim-sulfamethoxazole.

Topics: Adult; Chancre; Chancroid; Drug Combinations; Haemophilus ducreyi; Humans; Male; Penicillin G Benzathine; Penile Diseases; Sulfamethoxazole; Syphilis; Syphilis Serodiagnosis; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination

A 21-year-old European male patient presented with a penile sore of two months' duration. Donovan bodies were detected in a tissue smear from the lesion, which healed after treatment with co-trimoxazole. Sclerosing granuloma inguinale was diagnosed.

Topics: Adult; Drug Combinations; Granuloma Inguinale; Humans; Male; Penile Diseases; Penis; Sclerosis; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination