trimethoprim--sulfamethoxazole-drug-combination and Parotid-Diseases

Late involvement of the parotid gland in a patient with a limited form of Wegener's granulomatosis is presented. We report the full course of the disease and the difficulties encountered in determining the nature of the parotid enlargement. We discuss the contribution of computerized tomography and ultrasonography to elucidate parenchymal morphologic findings and radioisotope studies to determine the functional capacity of the gland. In cases of Wegener's granulomatosis with salivary symptoms, measurement of salivary gland functional capacity, in addition to the c-ANCA test, may help to monitor disease activity. Despite the rarity of the disease, in cases when granulomatous diseases are considered, it should be recognized that Wegener's granulomatosis may result in salivary gland involvement.

Topics: Adult; Antibodies, Antineutrophil Cytoplasmic; Autoantibodies; Biomarkers; Cyclophosphamide; Female; Granulomatosis with Polyangiitis; Humans; Parotid Diseases; Parotid Gland; Prednisone; Technetium Tc 99m Mertiatide; Tomography, X-Ray Computed; Trimethoprim, Sulfamethoxazole Drug Combination; Ultrasonography