trimethoprim--sulfamethoxazole-drug-combination and Nasal-Polyps

We treated a patient with an atypical presentation of Wegener's granulomatosis (WG) with dural involvement as the initial clinical manifestation. A 37-year-old man had a dural lesion without lower respiratory tract or renal manifestations in the initial clinical course. His only initial symptom was headache, and at disease onset computed tomography (CT) and magnetic resonance imaging (MRI) of the head revealed bilateral abnormal subdural masses. The diagnosis of WG was made based on the results of needle biopsy of the nasal polyps and the finding of positive circulating antineutrophil cytoplasmic antibodies (c-ANCA). He achieved remission on daily prednisone and cyclophosphamide with the later addition of sulfamethoxazole-trimethoprim.

Topics: Adult; Antibodies, Antineutrophil Cytoplasmic; Autoimmune Diseases; Biopsy; Cyclophosphamide; Dura Mater; Granulomatosis with Polyangiitis; Headache; Hematoma, Subdural; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Male; Nasal Polyps; Prednisone; Tomography, X-Ray Computed; Trimethoprim, Sulfamethoxazole Drug Combination