trimethoprim--sulfamethoxazole-drug-combination and Nasal-Obstruction

Rhinoscleroma is a chronic granulomatous respiratory tract disease. The initial lesion site is often intra-nasal. Giant tumor presentations are rare. The authors report a case of extensive nasal rhinoscleroma.. A 35-year-old African male patient consulted for a large tumor of the nose. The tumor had appeared 25 years before; the initial lesion site was intra-nasal. It presented as a small non-obstructive growth. The tumor was removed 20 years before, and recurred in an exophytic presentation. The main tumor was associated to peripheral, peri-nasal, and upper lip nodules. There was a central granuloma, bleeding on contact. Nasal obstruction was complete. The histological and bacteriological examination of a biopsy specimen confirmed the diagnosis of rhinoscleroma. Trimethoprim-sulfamethoxazole was effective on the infection.. Rhinoscleroma is frequently located on the nasal mucosa, but extra-nasal giant tumor presentations are rare. It can involve the whole respiratory tract. It is endemic in developing countries. Sporadic cases have been described in non-endemic areas, among migrants. The diagnosis is proved by histology. Specific and early antibiotic therapy is effective. It avoids surgical mutilation, sequels, and recurrence.

Topics: Adult; Anti-Infective Agents; Disease Progression; Humans; Klebsiella Infections; Klebsiella pneumoniae; Male; Nasal Obstruction; Nose; Pefloxacin; Plastic Surgery Procedures; Rhinoscleroma; Trimethoprim, Sulfamethoxazole Drug Combination

Topics: Administration, Oral; Fatal Outcome; Female; Humans; Middle Aged; Nasal Obstruction; Stevens-Johnson Syndrome; Trimethoprim, Sulfamethoxazole Drug Combination