trimethoprim--sulfamethoxazole-drug-combination and Muscle-Spasticity

Joseph's disease, an autosomal dominant, degenerative neurologic disease found in the Portuguese, is clinically manifested by extrapyramidal, pyramidal, and cerebellar dysfunction. A patient with the type II form of the disease reported improvement in gait and lessened spasticity while taking sulfamethoxazole and trimethoprim (Bactrim) for a noninfectious dysuria syndrome. A double-blind, placebo-controlled trial of Bactrim utilizing a subjective performance scale, physical examination, and six timed tests was performed in this patient. Results revealed lessened spasticity, improvement in walker-assisted gait, and correlative subjective responses. These results suggest an antispasticity effect of Bactrim or one of its components in this patient.

Topics: Adult; Double-Blind Method; Drug Combinations; Humans; Locomotion; Male; Motor Skills; Muscle Spasticity; Neurologic Examination; Spinocerebellar Degenerations; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination

Topics: Adult; Anti-Infective Agents; Drug Combinations; Dystonia; Humans; Male; Muscle Spasticity; Spinocerebellar Degenerations; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination