trimethoprim--sulfamethoxazole-drug-combination and Muscle-Rigidity

Three patients with antibiotic induced meningitis, one following penicillin with seven episodes, are reported on--the first well documented description of penicillin induced meningitis. In this patient episodes of headache and nuchal rigidity appeared with and without CSF pleocytosis. Two patients had a total of five episodes of antibiotic induced meningitis after trimethoprim-sulphamethoxazole (co-trimoxazole) administration. The features common to all three patients were myalgia, confusion and low CSF glucose. CSF analysis was not a reliable method to differentiate antibiotic induced meningitis from partially treated bacterial meningitis.

Topics: Adolescent; Aged; Aged, 80 and over; Cerebrospinal Fluid; Confusion; Diagnosis, Differential; Female; Glucose; Headache; Humans; Male; Meningitis; Muscle Rigidity; Neck Muscles; Penicillins; Recurrence; Trimethoprim, Sulfamethoxazole Drug Combination