trimethoprim--sulfamethoxazole-drug-combination has been researched along with Mental-Disorders* in 2 studies
2 other study(ies) available for trimethoprim--sulfamethoxazole-drug-combination and Mental-Disorders
| Article | Year |
|---|---|
'Septrin psychosis' among renal transplant patients with Pneumocystis jirovecii pneumonia.
To report on the temporal relationship between administration of trimethoprim/sulfamethoxazole to medically immunosuppressed HIV-negative renal patients with Pneumocystis jirovecii pneumonia (PCP) and the development of an acute psychosis.. We investigated a retrospective case series of renal transplant and immunosuppressed patients with PCP within an ongoing outbreak in the northwest of England since 2009. Four patients with PCP developed psychosis following treatment with trimethoprim/sulfamethoxazole.. Four of twenty patients developed acute psychoses following administration of trimethoprim/sulfamethoxazole, including one accidental re-challenge. Symptoms resolved within 24 h of changing the therapy. The striking temporal relationship between the initiation and discontinuation of the drug and the behavioural changes suggests a causal relationship.. With increasing solid organ transplantation and the use of immunosuppressants, vigilance regarding trimethoprim/sulfamethoxazole dose modification is required and the routine use of therapeutic drug monitoring should be considered. Topics: Adult; Aged; England; Female; Humans; Kidney Transplantation; Male; Mental Disorders; Middle Aged; Pneumocystis carinii; Pneumonia, Pneumocystis; Retrospective Studies; Transplantation; Trimethoprim, Sulfamethoxazole Drug Combination | 2011 |
Impact of prolonged treatment with trimethoprim-sulfamethoxazole on the human gut flora.
The case of a mentally ill man inadvertently treated with trimethoprim-sulfamethoxazole (TMP-SMX) for 2 y is presented. Quantitative stool cultures revealed a substantially suppressed Gram-negative aerobic flora, while Enterococcus spp. and anaerobes were not affected. Yeasts were moderately increased. TMP-SMX represents an attractive antimicrobial for immunocompromized patients who need the integrity of their intestinal anaerobic flora for colonization resistance. Topics: Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Follow-Up Studies; Humans; Intestinal Mucosa; Long-Term Care; Male; Mental Disorders; Risk Assessment; Trimethoprim, Sulfamethoxazole Drug Combination; Urinary Catheterization; Urinary Tract Infections | 2004 |