trimethoprim--sulfamethoxazole-drug-combination and Lymphedema

We report three adult cases of very chronic, extensive infection of the lower limbs due to Mycobacterium marinum. The patients were from South Pacific islands and, clinically, the widespread warty plaques resembled chromomycosis. One was associated with severe lymphoedema. All three patients gave a history of at least 20 years duration. The patients were otherwise well and not immunologically compromised. In all cases, the organism was identified on tissue cultures and was not seen on histopathology. The mycobacteria were sensitive to most antibiotics tested in vitro. The patients were treated with a combination of rifampicin and cotrimoxazole with good results.

Topics: Adult; Aged; Anti-Bacterial Agents; Antibiotics, Antitubercular; Chromoblastomycosis; Chronic Disease; Culture Techniques; Diagnosis, Differential; Female; Follow-Up Studies; Humans; Leg Dermatoses; Lymphedema; Male; Mycobacterium Infections, Nontuberculous; Mycobacterium marinum; Pacific Islands; Rifampin; Time Factors; Treatment Outcome; Trimethoprim, Sulfamethoxazole Drug Combination

A case of subcutaneous phycomycosis involving the right thigh for 1 year duration which mimic elephantiasis was reported in a 21-year-old military man. An initial diagnosis was that of a subcutaneous tissue lesion attributed to parasitic manifestation but turned out to be that of subcutaneous fungal infection both clinically and histologically. The lesion was successfully treated with cotrimoxazole for a period of one month, and followed up for 4 1/2 months with complete cure.

Topics: Adult; Anti-Infective Agents; Dermatomycoses; Diagnosis, Differential; Drug Combinations; Elephantiasis; Fungi; Humans; Lymphedema; Male; Sarcoma; Soft Tissue Neoplasms; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination