trimethoprim--sulfamethoxazole-drug-combination and Hypergammaglobulinemia

Topics: Adolescent; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Antifungal Agents; Blood Sedimentation; Female; Fluconazole; Foot Dermatoses; Hand Dermatoses; Hepatomegaly; Herpes Zoster; HIV Infections; Humans; Hypergammaglobulinemia; Immunocompromised Host; Onychomycosis; Tinea; Trimethoprim, Sulfamethoxazole Drug Combination

Topics: Anti-Infective Agents; Antitubercular Agents; Child, Preschool; Female; Humans; Hypergammaglobulinemia; Immunoglobulin M; Osteomyelitis; Radiography; Syndrome; Trimethoprim, Sulfamethoxazole Drug Combination; Tuberculosis, Cutaneous; Tuberculosis, Osteoarticular; Ulna

At the age of four months, a boy with a normal history and family history, suddenly fell ill with a life-threatening pneumocystis carinii-pneumonia. Surprisingly, this opportunistic infection was not brought about by a T-cell deficiency. However, the patient's diagnosis turned out to be the rare "Hyper-IgM-syndrome", confirmed by: serum levels of IgM always at least normal whereas IgG, IgA and IgE were markedly decreased or absent; the development of neutropenia and occasional diarrhea. Generally, infections with pneumocystis carinii are rare in isolated deficiencies of immunoglobulines, but relatively frequent in primary "Hyper-IgM-syndrome" (approx. 12% of the cases described). The boy finally recovered after receiving Cotrimoxacol (20 mg/kg bw/d) in an intensive care unit. Now, at the age of nearly two his condition is almost good under regular substitution of IgG. Cotrimoxacol (4 mg/kg bw/d) is recommended to prevent further pneumocystis carinii infections and most of the pathogenes which frequently appear in neutropenias.

Topics: Anti-Bacterial Agents; Drug Therapy, Combination; Follow-Up Studies; Humans; Hypergammaglobulinemia; Immunoglobulin G; Immunoglobulin M; Immunoglobulins; Infant; Male; Neutropenia; Opportunistic Infections; Pneumonia, Pneumocystis; Trimethoprim, Sulfamethoxazole Drug Combination