Compounds > trimethoprim--sulfamethoxazole-drug-combination

trimethoprim--sulfamethoxazole-drug-combination and Hypercalcemia

trimethoprim--sulfamethoxazole-drug-combination has been researched along with Hypercalcemia* in 2 studies

Other Studies

2 other study(ies) available for trimethoprim--sulfamethoxazole-drug-combination and Hypercalcemia

Article	Year
Hypercalcemia Heralding Pneumocystis jirovecii Pneumonia in an HIV-Seronegative Patient with Diffuse Cutaneous Systemic Sclerosis. Mycopathologia, 2019, Volume: 184, Issue:6 Pneumocystis pneumonia (PCP) is a life-threatening fungal infection occurring in immunocompromised patients such as HIV-positive patients with low CD4 cell count or patients under heavy immunosuppressive therapy. We report the case of a 59-year-old male with severe diffuse cutaneous systemic sclerosis presenting with asthenia, dry cough and worsening shortness of breath for the last 15 days. Biological studies were remarkable for PTH-independent severe hypercalcemia with low 25-hydroxyvitamin D and a paradoxically elevated 1,25-dihydroxyvitamin D. Early bronchoalveolar lavage allowed for PCP diagnosis and targeted treatment. We discuss the underlying physiopathology and difficulties regarding prophylaxis and treatment. Topics: Humans; Hypercalcemia; Immunocompromised Host; Immunotherapy; Male; Middle Aged; Opportunistic Infections; Pneumocystis carinii; Pneumonia, Pneumocystis; Scleroderma, Diffuse; Trimethoprim, Sulfamethoxazole Drug Combination	2019
Pneumocystis carinii in a patient with hypercalcemia and renal failure secondary to sarcoidosis. Wiener klinische Wochenschrift, 2002, Sep-30, Volume: 114, Issue:17-18 A case of severe dyspnea, hypercalcemia and renal failure secondary to sarcoidosis is reported. The clinical diagnosis of sarcoidosis in a 48-year-old man was confirmed by histology and cytology. Transiently decreased numbers of CD4+ T cells (282/microliter) indicated impaired immunity in the absence of HIV-infection during the acute phase of the disease. Surprisingly, numerous "trophozoites" of Pneumocystis carinii were detected by immunofluorescence staining and PCR in the bronchoalveolar fluid indicating infection or colonization of the lungs. Corticosteroid therapy was administered together with trimethoprim-sulfamethoxazole and rapidly reduced elevated serum calcium and creatinine concentrations. Since airborne person-to-person transmission of P. carinii to susceptible individuals might be possible, patients with sarcoidosis could be a previously unrecognized reservoir for P. carinii distribution in hospitals and in the community at large. Topics: CD4 Lymphocyte Count; Drug Therapy, Combination; Humans; Hypercalcemia; Immune Tolerance; Male; Middle Aged; Opportunistic Infections; Pneumonia, Pneumocystis; Prednisone; Renal Insufficiency; Sarcoidosis, Pulmonary; Trimethoprim, Sulfamethoxazole Drug Combination	2002

Article

Year

Hypercalcemia Heralding Pneumocystis jirovecii Pneumonia in an HIV-Seronegative Patient with Diffuse Cutaneous Systemic Sclerosis.

Mycopathologia, 2019, Volume: 184, Issue:6

Pneumocystis pneumonia (PCP) is a life-threatening fungal infection occurring in immunocompromised patients such as HIV-positive patients with low CD4 cell count or patients under heavy immunosuppressive therapy. We report the case of a 59-year-old male with severe diffuse cutaneous systemic sclerosis presenting with asthenia, dry cough and worsening shortness of breath for the last 15 days. Biological studies were remarkable for PTH-independent severe hypercalcemia with low 25-hydroxyvitamin D and a paradoxically elevated 1,25-dihydroxyvitamin D. Early bronchoalveolar lavage allowed for PCP diagnosis and targeted treatment. We discuss the underlying physiopathology and difficulties regarding prophylaxis and treatment.

Topics: Humans; Hypercalcemia; Immunocompromised Host; Immunotherapy; Male; Middle Aged; Opportunistic Infections; Pneumocystis carinii; Pneumonia, Pneumocystis; Scleroderma, Diffuse; Trimethoprim, Sulfamethoxazole Drug Combination

2019

Pneumocystis carinii in a patient with hypercalcemia and renal failure secondary to sarcoidosis.

Wiener klinische Wochenschrift, 2002, Sep-30, Volume: 114, Issue:17-18

A case of severe dyspnea, hypercalcemia and renal failure secondary to sarcoidosis is reported. The clinical diagnosis of sarcoidosis in a 48-year-old man was confirmed by histology and cytology. Transiently decreased numbers of CD4+ T cells (282/microliter) indicated impaired immunity in the absence of HIV-infection during the acute phase of the disease. Surprisingly, numerous "trophozoites" of Pneumocystis carinii were detected by immunofluorescence staining and PCR in the bronchoalveolar fluid indicating infection or colonization of the lungs. Corticosteroid therapy was administered together with trimethoprim-sulfamethoxazole and rapidly reduced elevated serum calcium and creatinine concentrations. Since airborne person-to-person transmission of P. carinii to susceptible individuals might be possible, patients with sarcoidosis could be a previously unrecognized reservoir for P. carinii distribution in hospitals and in the community at large.

Topics: CD4 Lymphocyte Count; Drug Therapy, Combination; Humans; Hypercalcemia; Immune Tolerance; Male; Middle Aged; Opportunistic Infections; Pneumonia, Pneumocystis; Prednisone; Renal Insufficiency; Sarcoidosis, Pulmonary; Trimethoprim, Sulfamethoxazole Drug Combination

2002