Compounds > trimethoprim--sulfamethoxazole-drug-combination

trimethoprim--sulfamethoxazole-drug-combination and Hepatitis-A

trimethoprim--sulfamethoxazole-drug-combination has been researched along with Hepatitis-A* in 2 studies

Other Studies

2 other study(ies) available for trimethoprim--sulfamethoxazole-drug-combination and Hepatitis-A

Article	Year
Acute renal failure in a 3-year-old child as part of the drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome following hepatitis A. Pediatric nephrology (Berlin, Germany), 2008, Volume: 23, Issue:4 We report on a 3-year-old Melanesian girl admitted for acute renal failure following subfulminant hepatitis A virus infection. While the child was slowly recovering from severe cytolytic hepatitis, she presented 8 weeks of protracted fever and major eosinophilia (30,000/microl); thereafter, acute renal failure (serum creatinine 295 micromol/l) occurred. Renal histology displayed diffuse eosinophilic infiltrate, with severe acute tubulointerstitial lesions associated with mild glomerular endocapillary proliferation and eosinophilic infiltrate, suggesting an immunoallergic mechanism. The child had received cefixime and cotrimoxazole 3 weeks prior to hospitalisation for the hepatitis A virus infection. The final diagnosis was of the syndrome drug reaction with eosinophilia and systemic symptoms or DRESS, induced by cefixime or cotrimoxazole and possibly triggered by the hepatitis A virus infection. Topics: Acute Kidney Injury; Anti-Bacterial Agents; Anti-Infective Agents, Urinary; Cefixime; Child, Preschool; Drug Therapy, Combination; Eosinophilia; Female; Hepatitis A; Humans; Kidney; Syndrome; Trimethoprim, Sulfamethoxazole Drug Combination	2008
Trimethoprim-sulfamethoxazole-associated hepatotoxicity - part of a hypersensitivity syndrome. The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique, 2003,Winter, Volume: 10, Issue:4 Trimethoprim-sulfamethoxazole is a commonly used medication. Side effects are numerous and include drug hypersensitivity syndrome. The case of a 24-year-old woman with severe liver failure is presented. Erythema multiforme and thrombocytopenia developed after the acute onset of hepatotoxicity and after all medications had been stopped. Clinical resolution of all features occurred over weeks but laboratory abnormalities persisted up to eight months later. A causal link with sulfamethoxazole was supported by timing, liver biopsy and lymphocyte toxicity test. This case illustrates one presentation and the possible severity of the drug hypersensitivity syndrome associated with trimethoprim-sulfamethoxazole. Topics: Adult; Anti-Infective Agents; Diagnosis, Differential; Drug Hypersensitivity; Erythema Multiforme; Hepatitis A; Humans; Liver Failure; Male; Syndrome; Thrombocytopenia; Trimethoprim, Sulfamethoxazole Drug Combination	2003

Article

Year

Acute renal failure in a 3-year-old child as part of the drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome following hepatitis A.

Pediatric nephrology (Berlin, Germany), 2008, Volume: 23, Issue:4

We report on a 3-year-old Melanesian girl admitted for acute renal failure following subfulminant hepatitis A virus infection. While the child was slowly recovering from severe cytolytic hepatitis, she presented 8 weeks of protracted fever and major eosinophilia (30,000/microl); thereafter, acute renal failure (serum creatinine 295 micromol/l) occurred. Renal histology displayed diffuse eosinophilic infiltrate, with severe acute tubulointerstitial lesions associated with mild glomerular endocapillary proliferation and eosinophilic infiltrate, suggesting an immunoallergic mechanism. The child had received cefixime and cotrimoxazole 3 weeks prior to hospitalisation for the hepatitis A virus infection. The final diagnosis was of the syndrome drug reaction with eosinophilia and systemic symptoms or DRESS, induced by cefixime or cotrimoxazole and possibly triggered by the hepatitis A virus infection.

Topics: Acute Kidney Injury; Anti-Bacterial Agents; Anti-Infective Agents, Urinary; Cefixime; Child, Preschool; Drug Therapy, Combination; Eosinophilia; Female; Hepatitis A; Humans; Kidney; Syndrome; Trimethoprim, Sulfamethoxazole Drug Combination

2008

Trimethoprim-sulfamethoxazole-associated hepatotoxicity - part of a hypersensitivity syndrome.

The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique, 2003,Winter, Volume: 10, Issue:4

Trimethoprim-sulfamethoxazole is a commonly used medication. Side effects are numerous and include drug hypersensitivity syndrome. The case of a 24-year-old woman with severe liver failure is presented. Erythema multiforme and thrombocytopenia developed after the acute onset of hepatotoxicity and after all medications had been stopped. Clinical resolution of all features occurred over weeks but laboratory abnormalities persisted up to eight months later. A causal link with sulfamethoxazole was supported by timing, liver biopsy and lymphocyte toxicity test. This case illustrates one presentation and the possible severity of the drug hypersensitivity syndrome associated with trimethoprim-sulfamethoxazole.

Topics: Adult; Anti-Infective Agents; Diagnosis, Differential; Drug Hypersensitivity; Erythema Multiforme; Hepatitis A; Humans; Liver Failure; Male; Syndrome; Thrombocytopenia; Trimethoprim, Sulfamethoxazole Drug Combination

2003