trimethoprim--sulfamethoxazole-drug-combination and Hearing-Loss

A randomized, controlled clinical trial was conducted in 76 children to evaluate the efficacy of trimethoprim-sulfamethoxazole for 4 weeks, prednisone for 2 weeks and aluminum ibuprofen suspension for 2 weeks in resolving chronic otitis media with effusion which had persisted for more than 8 weeks. After 2 weeks of treatment resolution rates of chronic otitis media with effusion in the prednisone and trimethoprim-sulfamethoxazole groups were significantly greater than those in the control (no treatment) and ibuprofen groups. After 4 weeks the differences in resolution rates between the control, trimethoprim-sulfamethoxazole and prednisone groups became smaller. After 12 months of follow-up, differences in hearing sensitivity among study groups were not statistically significant, although 83% of patients had a 15-dB or greater hearing loss. Therefore short term antimicrobial and antiinflammatory treatment did not appear to have a long lasting effect on chronic middle ear inflammation.

Topics: Analysis of Variance; Child; Child, Preschool; Chronic Disease; Follow-Up Studies; Hearing Loss; Humans; Ibuprofen; Infant; Otitis Media with Effusion; Prednisone; Randomized Controlled Trials as Topic; Recurrence; Regression Analysis; Trimethoprim, Sulfamethoxazole Drug Combination

AbstractParacoccidioidomycosis is a systemic mycosis caused by

Topics: Adult; Anti-Infective Agents; Ear, Middle; Hearing Loss; Humans; Male; Middle Ear Ventilation; Nasopharynx; Otitis Media with Effusion; Palate, Soft; Paracoccidioides; Paracoccidioidomycosis; Treatment Outcome; Trimethoprim, Sulfamethoxazole Drug Combination

Granulomatosis with polyangiitis is an uncommon condition characterised by vasculitis and associated granuloma formation with a highly specific autoantibody, namely proteinase 3-anti-neutrophil cytoplasmic antibody (ANCA). The respiratory tract and kidneys are the organ systems most often involved. Symptoms can be non-specific, and isolated hearing loss can predate other symptoms by months, leading to lengthy delays in diagnosis and treatment. Left untreated, hearing loss can be irreversible, and therefore early diagnosis is crucial. We present a case study of severe hearing impairment in an attempt to raise awareness of ear involvement as an early feature of this unusual condition.

Topics: Adult; Azathioprine; Cyclophosphamide; Diagnosis, Differential; Diphosphonates; Female; Granulomatosis with Polyangiitis; Hearing Loss; Humans; Prednisolone; Proton Pump Inhibitors; Toothache; Trimethoprim, Sulfamethoxazole Drug Combination

A 39-year-old man with a 4-month history of transient pins and needles sensations occurring below the waist while walking and difficulty walking presented to our outpatient clinic. He had an approximate 1-year history of bilateral hearing loss, the etiology of which was unknown. His symptoms had been progressive, and there was no significant family history. He demonstrated a spastic gait and required assistance for walking. Deep tendon reflexes were hypertonic; a sensation deficit was defined as originating from the 12th thoracic vertebra. Babinski's sign was positive bilaterally. Sphincter abnormalities were seen in the patient's bladder and bowel functions. Cerebral and spinal magnetic resonance images with contrast media were unremarkable. An analysis of the patient's cerebrospinal fluid was consistent with neurobrucellosis. Owing to spastic paraparesis and hearing loss, the diagnosis of neurobrucellosis was made. Combined antimicrobial therapy was started and continued 6 months. His neurologic condition improved, and he was able to walk without help after 3 months' treatment. Our case illustrates that acquired progressive spastic paraparesis may occur during the course of neurobrucellosis. Neurobrucellosis should be borne in mind when patients present with spastic paraparesis.

Topics: Adult; Anti-Bacterial Agents; Brucellosis; Ceftriaxone; Doxycycline; Hearing Loss; Humans; Male; Paraparesis, Spastic; Rifampin; Trimethoprim, Sulfamethoxazole Drug Combination

Topics: Acute Disease; Adult; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Audiometry; Bone Conduction; Cefuroxime; Cephalosporins; Ciprofloxacin; Drug Therapy, Combination; Facial Paralysis; Female; Follow-Up Studies; Glucocorticoids; Hearing Loss; Hearing Loss, Conductive; Humans; Male; Middle Aged; Otitis Media; Penicillins; Prednisone; Trimethoprim, Sulfamethoxazole Drug Combination; Tympanic Membrane