trimethoprim--sulfamethoxazole-drug-combination and Hand-Injuries

Topics: Abscess; Adult; Anti-Bacterial Agents; Cellulitis; Ciprofloxacin; Drug Therapy, Combination; Exudates and Transudates; Hand Dermatoses; Hand Injuries; Humans; Immunocompetence; Male; Recurrence; Serratia Infections; Serratia marcescens; Trimethoprim, Sulfamethoxazole Drug Combination; Wound Infection; Wounds, Penetrating

One hundred and thirteen patients were entered into a randomized, prospective double-blind, placebo controlled trial to assess the use of co-trimoxazole in reducing wound infections after dog bites. Although there was a reduction in the wound infection rate from 13.8% in the placebo group to 5.5% in the treatment group this did not reach statistical significance (P = 0.135). If hand wounds are considered separately, no infections occurred in the treatment group and a benefit seems likely.

Topics: Animals; Anti-Infective Agents; Bites and Stings; Clinical Trials as Topic; Dogs; Double-Blind Method; Drug Combinations; Drug Evaluation; Hand Injuries; Humans; Prospective Studies; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Wound Infection

Topics: Accidental Falls; Adult; Anti-Bacterial Agents; Argentina; Community-Acquired Infections; Drug Resistance, Multiple, Bacterial; Gram-Negative Bacterial Infections; Hand Injuries; Humans; Immunocompetence; Male; Soft Tissue Infections; Spain; Stenotrophomonas maltophilia; Trimethoprim, Sulfamethoxazole Drug Combination; Wound Infection; Wounds, Penetrating

The association of paracoccidioidomycosis with AIDS is apparently less frequent than expected. The authors present an unusual case of paracoccidioidomycosis in a 13-year-old female student which was later found to be the first opportunistic infection in the course of the patient's HIV-infection. The clinical presentation followed an accidental incised wound on the palmar region initially described as a 'sporotrichotic-chancre'. After good response under sulfamethoxazole-trimethoprin, the patient relapsed and presented an associated oral candidiasis. HIV-infection was documented and additional investigation showed CD4(+) T-cells=22/mm(3), CD8(+)=280 cell/mm(3) and viral load=4,043 log. This case report presents an uncommon dermatological-clinical picture in the youngest patient in which such association has been reported to date.

Topics: Adolescent; AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Candidiasis, Oral; CD4 Lymphocyte Count; Female; Hand Injuries; HIV Infections; Humans; Paracoccidioidomycosis; Trimethoprim, Sulfamethoxazole Drug Combination; Wound Infection