trimethoprim--sulfamethoxazole-drug-combination and Granuloma-Inguinale

Topics: AIDS-Related Opportunistic Infections; Diagnosis, Differential; Granuloma Inguinale; Humans; Male; Sexually Transmitted Diseases; Trimethoprim, Sulfamethoxazole Drug Combination

An unusual American epidemic consisting of twenty cases of granuloma inguinale is chronicled. Evidence from this series supports the venereal transmission of the disorder. Trimethoprim/sulfamethoxazole proved to be a safe and effective therapy.

Topics: Administration, Oral; Adult; Balanitis; Clinical Trials as Topic; Drug Combinations; Drug Therapy, Combination; Female; Follow-Up Studies; Granuloma Inguinale; Homosexuality; Humans; Male; Middle Aged; Sex Work; Sulfamethoxazole; Tetracycline; Texas; Time Factors; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination

Granuloma inguinale, or Donovanosis, is a rare, sexually transmitted ulcerative disease primarily affecting the genital area. In this report, we present a case of a 50-year-old man that was diagnosed with granuloma inguinale after a 2-month history of a penile ulcer. Histological analysis demonstrated the presence of Donovan bodies within macrophages, confirming the diagnosis. He was subsequently treated with trimethoprim/sulfamethoxazole with improvement in the ulcer. This case serves as a reminder to clinicians that although granuloma inguinale is rarely encountered in the US, it should still be suspected in patients with non-healing penile ulcers.

Topics: Anti-Bacterial Agents; Granuloma Inguinale; Humans; Male; Middle Aged; Penile Diseases; Trimethoprim, Sulfamethoxazole Drug Combination; Ulcer

An extremely rare case of primary extragenital donovanosis affecting the dorsa of right foot is reported. Clinical and histopathological features of the disease are described and the rarity, absence of genital lesions, and consequent difficulty in diagnosis are discussed.

Topics: Adult; Anti-Infective Agents; Foot Ulcer; Granuloma Inguinale; Humans; Male; Trimethoprim, Sulfamethoxazole Drug Combination

Topics: Drug Combinations; Granuloma Inguinale; Humans; Sulfamethoxazole; Tetracycline; Texas; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination

A case of granuloma inguinale of the oral cavity clinically resembling actinomycosis is reported. This condition should be considered in the differential diagnosis of chronic ulcerative lesions of the mouth, especially in patients with associated genital ulcers.

Topics: Actinomycosis; Adult; Diagnosis, Differential; Drug Combinations; Female; Granuloma Inguinale; Humans; Mouth Diseases; Sulfamethoxazole; Tetracycline; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Vulvar Diseases

A case of Hemophilus ducreyi infection clinically resembling granuloma inguinale is reported. Culture of the causative organism permitted a definitive diagnosis to be made. Combined treatment with tetracycline and sulphamethizole/trimethoprim rapidly cleared the infection.

Topics: Adult; Chancroid; Diagnosis, Differential; Drug Combinations; Drug Therapy, Combination; Granuloma Inguinale; Humans; Male; Skin Ulcer; Tetracycline; Trimethoprim, Sulfamethoxazole Drug Combination

A 21-year-old European male patient presented with a penile sore of two months' duration. Donovan bodies were detected in a tissue smear from the lesion, which healed after treatment with co-trimoxazole. Sclerosing granuloma inguinale was diagnosed.

Topics: Adult; Drug Combinations; Granuloma Inguinale; Humans; Male; Penile Diseases; Penis; Sclerosis; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination